IMP

Process View

Homo sapiens

10 genes annotated in human

regulation of antigen receptor mediated signaling pathway

Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of antigen receptor mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of antigen receptor mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
LCK	lymphocyte-specific protein tyrosine kinase	1.000	Mouse
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.996
CD2	CD2 molecule	0.939
CD247	CD247 molecule	0.912
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.864
PTK2	PTK2 protein tyrosine kinase 2	0.807
VAV1	vav 1 guanine nucleotide exchange factor	0.708
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.586
CARD11	caspase recruitment domain family, member 11	0.526
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.395
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.327	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.287
NCK2	NCK adaptor protein 2	0.259
MAPK1	mitogen-activated protein kinase 1	0.258
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.258
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.244	Mouse
SYK	spleen tyrosine kinase	0.231
GHR	growth hormone receptor	0.227
LAT	linker for activation of T cells	0.181
LPXN	leupaxin	0.173
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.157
TFF1	trefoil factor 1	0.148
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.137
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.133
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.112
C9orf89	chromosome 9 open reading frame 89	0.107
LIMS1	LIM and senescent cell antigen-like domains 1	0.101	Human
HDAC7	histone deacetylase 7	0.101
PXN	paxillin	0.085	Human
NCF1	neutrophil cytosolic factor 1	0.081
PTPRC	protein tyrosine phosphatase, receptor type, C	0.077	Mouse
PRKCD	protein kinase C, delta	0.073
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.059
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.057
BCL10	B-cell CLL/lymphoma 10	0.055	Mouse
HOXA1	homeobox A1	0.055
CD22	CD22 molecule	0.055
CDH5	cadherin 5, type 2 (vascular endothelium)	0.053
ILK	integrin-linked kinase	0.049
PRKCQ	protein kinase C, theta	0.048
TRAF6	TNF receptor-associated factor 6	0.047
MICA	MHC class I polypeptide-related sequence A	0.046
PLCG1	phospholipase C, gamma 1	0.042
MAP2K1	mitogen-activated protein kinase kinase 1	0.042
SH3BP2	SH3-domain binding protein 2	0.038
GRB2	growth factor receptor-bound protein 2	0.038
NCK1	NCK adaptor protein 1	0.038
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.037
PILRA	paired immunoglobin-like type 2 receptor alpha	0.035
MAPK3	mitogen-activated protein kinase 3	0.034
PLK3	polo-like kinase 3	0.032
CD33	CD33 molecule	0.031
SH2D2A	SH2 domain containing 2A	0.028
RABAC1	Rab acceptor 1 (prenylated)	0.027
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.026
PHC2	polyhomeotic homolog 2 (Drosophila)	0.025
PRKCB	protein kinase C, beta	0.024	Human Mouse
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.024
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.024
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.023
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.021
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.021
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.021
MEST	mesoderm specific transcript homolog (mouse)	0.021
PRKCA	protein kinase C, alpha	0.019	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.018
CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1	0.017
GORASP1	golgi reassembly stacking protein 1, 65kDa	0.017
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.017
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.016
UBASH3B	ubiquitin associated and SH3 domain containing B	0.015
TRIP6	thyroid hormone receptor interactor 6	0.015
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.015
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.015
DPPA4	developmental pluripotency associated 4	0.015
CTNND1	catenin (cadherin-associated protein), delta 1	0.015
THAP2	THAP domain containing, apoptosis associated protein 2	0.014
TRIM9	tripartite motif containing 9	0.014
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.013
VCL	vinculin	0.013
BTN2A1	butyrophilin, subfamily 2, member A1	0.013	Mouse
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.013
SQSTM1	sequestosome 1	0.013
FHL2	four and a half LIM domains 2	0.012
MED15	mediator complex subunit 15	0.012
BTN3A1	butyrophilin, subfamily 3, member A1	0.012
PHF21A	PHD finger protein 21A	0.012
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.012
BTN2A2	butyrophilin, subfamily 2, member A2	0.011	Mouse
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.011
DPYSL4	dihydropyrimidinase-like 4	0.011
BBS10	Bardet-Biedl syndrome 10	0.011
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.011
MAPK14	mitogen-activated protein kinase 14	0.011
RRAS2	related RAS viral (r-ras) oncogene homolog 2	0.010