IMP

Process View

Homo sapiens

4 genes annotated in human

Multi-species View

t helper cell differentiation

GO:0042093

The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t helper cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t helper cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
IL4R	interleukin 4 receptor	0.905	Mouse
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.864
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.642
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.507
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.505
MED25	mediator complex subunit 25	0.427
RXRA	retinoid X receptor, alpha	0.412
IL2RG	interleukin 2 receptor, gamma	0.387
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.331
CREBBP	CREB binding protein	0.325
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.315
NCOR2	nuclear receptor corepressor 2	0.280
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.277	Mouse
LIN9	lin-9 homolog (C. elegans)	0.231
SOCS3	suppressor of cytokine signaling 3	0.220
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.170
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.159
PDZD11	PDZ domain containing 11	0.122
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.111
KLHL24	kelch-like 24 (Drosophila)	0.100
NCOA1	nuclear receptor coactivator 1	0.097
LIN54	lin-54 homolog (C. elegans)	0.096
RARA	retinoic acid receptor, alpha	0.092
NLK	nemo-like kinase	0.090
PPARA	peroxisome proliferator-activated receptor alpha	0.079
ESR1	estrogen receptor 1	0.061
EP300	E1A binding protein p300	0.060
IL6R	interleukin 6 receptor	0.055
NCOR1	nuclear receptor corepressor 1	0.050
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.048
IL4	interleukin 4	0.047	Mouse
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.046
PLXND1	plexin D1	0.044
BIRC3	baculoviral IAP repeat containing 3	0.043
TMEM173	transmembrane protein 173	0.041
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.040
E2F1	E2F transcription factor 1	0.038
ICAM1	intercellular adhesion molecule 1	0.036
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.036
RUNX1	runt-related transcription factor 1	0.036
BCL10	B-cell CLL/lymphoma 10	0.034
CD40	CD40 molecule, TNF receptor superfamily member 5	0.033
FOSL2	FOS-like antigen 2	0.033
PML	promyelocytic leukemia	0.029
NOD2	nucleotide-binding oligomerization domain containing 2	0.029
IL8	interleukin 8	0.028
PCDH9	protocadherin 9	0.027
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.025
CCR7	chemokine (C-C motif) receptor 7	0.024
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.024
CXCL2	chemokine (C-X-C motif) ligand 2	0.024
NOD1	nucleotide-binding oligomerization domain containing 1	0.024
E2F3	E2F transcription factor 3	0.021
HIPK2	homeodomain interacting protein kinase 2	0.021
RBL1	retinoblastoma-like 1 (p107)	0.021
PLXNB2	plexin B2	0.020
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.020
PPAP2B	phosphatidic acid phosphatase type 2B	0.019
HDAC9	histone deacetylase 9	0.019
KANK2	KN motif and ankyrin repeat domains 2	0.019
SPOP	speckle-type POZ protein	0.018
CCDC115	coiled-coil domain containing 115	0.018
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.018
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.017
CD6	CD6 molecule	0.017
PRKD2	protein kinase D2	0.017
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.017
SBNO2	strawberry notch homolog 2 (Drosophila)	0.016
NCOA3	nuclear receptor coactivator 3	0.016
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.016
SLAMF1	signaling lymphocytic activation molecule family member 1	0.015
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.015
IL21R	interleukin 21 receptor	0.015
IL1B	interleukin 1, beta	0.015
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.015
SOD2	superoxide dismutase 2, mitochondrial	0.015
RXRG	retinoid X receptor, gamma	0.015
RXRB	retinoid X receptor, beta	0.015
EBF1	early B-cell factor 1	0.014
MAVS	mitochondrial antiviral signaling protein	0.014
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.014
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.014
IL15RA	interleukin 15 receptor, alpha	0.013
STAT5A	signal transducer and activator of transcription 5A	0.013
E2F4	E2F transcription factor 4, p107/p130-binding	0.013
TNF	tumor necrosis factor	0.013
C5orf41	chromosome 5 open reading frame 41	0.013
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.013
MAPK7	mitogen-activated protein kinase 7	0.013
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.013
PNRC1	proline-rich nuclear receptor coactivator 1	0.013
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.013
PLAUR	plasminogen activator, urokinase receptor	0.012
RIPK4	receptor-interacting serine-threonine kinase 4	0.012
CH25H	cholesterol 25-hydroxylase	0.012
IRF4	interferon regulatory factor 4	0.012	Mouse
CCL20	chemokine (C-C motif) ligand 20	0.012
LITAF	lipopolysaccharide-induced TNF factor	0.012
CCL22	chemokine (C-C motif) ligand 22	0.012
NINJ1	ninjurin 1	0.012
NCOA6	nuclear receptor coactivator 6	0.012
CAMSAP1L1	calmodulin regulated spectrin-associated protein 1-like 1	0.012
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.012
JUNB	jun B proto-oncogene	0.011
IL2RA	interleukin 2 receptor, alpha	0.011
CXCL13	chemokine (C-X-C motif) ligand 13	0.011
CXCL3	chemokine (C-X-C motif) ligand 3	0.011
PTX3	pentraxin 3, long	0.011
BAD	BCL2-associated agonist of cell death	0.011
TGIF1	TGFB-induced factor homeobox 1	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.011
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.011
WDR26	WD repeat domain 26	0.011
TAL1	T-cell acute lymphocytic leukemia 1	0.011
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.011	Human
SELE	selectin E	0.011
ZC3H12A	zinc finger CCCH-type containing 12A	0.011
IL12RB1	interleukin 12 receptor, beta 1	0.011
PRIC285	peroxisomal proliferator-activated receptor A interacting complex 285	0.011
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.011
ACY3	aspartoacylase (aminocyclase) 3	0.011
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.011
IL13	interleukin 13	0.011
NLRC4	NLR family, CARD domain containing 4	0.010
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.010
CD83	CD83 molecule	0.010
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.010
SIRT1	sirtuin 1	0.010
ERC2	ELKS/RAB6-interacting/CAST family member 2	0.010
CSF1	colony stimulating factor 1 (macrophage)	0.010
ZNF71	zinc finger protein 71	0.010
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.010
MSC	musculin	0.010
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.010
RUNX2	runt-related transcription factor 2	0.010
CLTC	clathrin, heavy chain (Hc)	0.010
SORBS3	sorbin and SH3 domain containing 3	0.010
EPOR	erythropoietin receptor	0.010
RTKN	rhotekin	0.010