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Process View

Homo sapiens

19 genes annotated in human

negative regulation of stress activated protein kinase signaling cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of stress activated protein kinase signaling cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of stress activated protein kinase signaling cascade" (in gray)

Name	Description	Probability	Func Analog Organism
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.874
MAPK8	mitogen-activated protein kinase 8	0.843	Fly
ZNF43	zinc finger protein 43	0.777
MAP2K4	mitogen-activated protein kinase kinase 4	0.753
CREBBP	CREB binding protein	0.692
MAPK1	mitogen-activated protein kinase 1	0.597
CREB1	cAMP responsive element binding protein 1	0.578
MAPK14	mitogen-activated protein kinase 14	0.452
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.452
ZNF253	zinc finger protein 253	0.405
ZNF273	zinc finger protein 273	0.373	Human
CCNE1	cyclin E1	0.244
ILK	integrin-linked kinase	0.231
NCOR1	nuclear receptor corepressor 1	0.216
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.213
SIRT1	sirtuin 1	0.198
ZNF746	zinc finger protein 746	0.180
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.174
ZNF675	zinc finger protein 675	0.168
CHUK	conserved helix-loop-helix ubiquitous kinase	0.168
SMAD2	SMAD family member 2	0.156
AXIN1	axin 1	0.153
PPP6C	protein phosphatase 6, catalytic subunit	0.147
AR	androgen receptor	0.120
MAP2K7	mitogen-activated protein kinase kinase 7	0.119
ZNF254	zinc finger protein 254	0.118	Human
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.099
ZNF91	zinc finger protein 91	0.096
WWOX	WW domain containing oxidoreductase	0.088
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.073
PPARA	peroxisome proliferator-activated receptor alpha	0.068
CSNK1E	casein kinase 1, epsilon	0.068
ZNF430	zinc finger protein 430	0.064	Human
ZNF708	zinc finger protein 708	0.062	Human
ATF2	activating transcription factor 2	0.058
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.050
ZNF93	zinc finger protein 93	0.047
ZNF85	zinc finger protein 85	0.045	Human
JUN	jun proto-oncogene	0.044
ARRB2	arrestin, beta 2	0.044
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.044	Mouse
ZNF117	zinc finger protein 117	0.043	Human
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.043	Fly
NCOA1	nuclear receptor coactivator 1	0.043
MAPK3	mitogen-activated protein kinase 3	0.041
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.041
KAT2B	K(lysine) acetyltransferase 2B	0.039
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.038
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.037
CAV1	caveolin 1, caveolae protein, 22kDa	0.036
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.036
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.036
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.035
GSK3B	glycogen synthase kinase 3 beta	0.035	Fly
DUSP1	dual specificity phosphatase 1	0.035
ZNF680	zinc finger protein 680	0.035	Human
MAP2K1	mitogen-activated protein kinase kinase 1	0.034
RALBP1	ralA binding protein 1	0.034
HDAC3	histone deacetylase 3	0.033
LIMD1	LIM domains containing 1	0.030
ZNF107	zinc finger protein 107	0.028
TRAF6	TNF receptor-associated factor 6	0.028
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.027
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.026
ZNF92	zinc finger protein 92	0.026	Human
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.026
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.024
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.024
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.022
NCOA2	nuclear receptor coactivator 2	0.021
NCK2	NCK adaptor protein 2	0.021
SKIL	SKI-like oncogene	0.021
LPXN	leupaxin	0.021
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.021
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.020
RNF11	ring finger protein 11	0.019
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.019
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.019
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.019	Fly
RAB21	RAB21, member RAS oncogene family	0.019
NCOR2	nuclear receptor corepressor 2	0.019	Human
RCHY1	ring finger and CHY zinc finger domain containing 1	0.019
EIF4E	eukaryotic translation initiation factor 4E	0.019
CD2AP	CD2-associated protein	0.019
RAB10	RAB10, member RAS oncogene family	0.018
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.018
TRAF5	TNF receptor-associated factor 5	0.018
KIAA1377	KIAA1377	0.018
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.018
DLG1	discs, large homolog 1 (Drosophila)	0.018
NCOA6	nuclear receptor coactivator 6	0.017
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.017
GPS2	G protein pathway suppressor 2	0.016
ANXA7	annexin A7	0.016
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.016
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.016
RANBP3	RAN binding protein 3	0.016
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.015
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.015	Rat
TOX4	TOX high mobility group box family member 4	0.014
PPP4C	protein phosphatase 4, catalytic subunit	0.014
NCOA3	nuclear receptor coactivator 3	0.014
CUL1	cullin 1	0.014
EP300	E1A binding protein p300	0.014
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.014
ZNF682	zinc finger protein 682	0.013	Human
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.013
PEA15	phosphoprotein enriched in astrocytes 15	0.013
RARA	retinoic acid receptor, alpha	0.013
DCTN1	dynactin 1	0.013
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.012
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.012
CLIP1	CAP-GLY domain containing linker protein 1	0.012
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.012
HSPH1	heat shock 105kDa/110kDa protein 1	0.012
CAV2	caveolin 2	0.012
BBS10	Bardet-Biedl syndrome 10	0.012
FOXO3	forkhead box O3	0.011	Human
ATXN3	ataxin 3	0.011
PINK1	PTEN induced putative kinase 1	0.011
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.011
PARVA	parvin, alpha	0.011
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.011
RB1	retinoblastoma 1	0.011
BTRC	beta-transducin repeat containing	0.010
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.010
CAPNS1	calpain, small subunit 1	0.010
DTX1	deltex homolog 1 (Drosophila)	0.010
PTPRR	protein tyrosine phosphatase, receptor type, R	0.010
ZNF506	zinc finger protein 506	0.010	Human
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.010	Fly
DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.010	Human
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.010	Rat