IMP

Process View

Homo sapiens

12 genes annotated in human

dna damage response signal transduction resulting in transcription

A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dna damage response signal transduction resulting in transcription"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dna damage response signal transduction resulting in transcription" (in gray)

Name	Description	Probability	Func Analog Organism
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.626
EP300	E1A binding protein p300	0.553
MAPK14	mitogen-activated protein kinase 14	0.550
CREBBP	CREB binding protein	0.512
TP53	tumor protein p53	0.440
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.392
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.391
CCNE1	cyclin E1	0.355
BRCA1	breast cancer 1, early onset	0.335
DAXX	death-domain associated protein	0.330
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.321
MAPK3	mitogen-activated protein kinase 3	0.234
WWOX	WW domain containing oxidoreductase	0.189
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.153
HIPK2	homeodomain interacting protein kinase 2	0.148
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.143
CDK2	cyclin-dependent kinase 2	0.126
MAPK1	mitogen-activated protein kinase 1	0.111
BARD1	BRCA1 associated RING domain 1	0.108
PML	promyelocytic leukemia	0.077
LIMD1	LIM domains containing 1	0.061
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.054
TP53BP2	tumor protein p53 binding protein, 2	0.050
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.048
CREB1	cAMP responsive element binding protein 1	0.048
ELK1	ELK1, member of ETS oncogene family	0.047
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.045
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.045
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.042
MDC1	mediator of DNA-damage checkpoint 1	0.042
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.039
COASY	CoA synthase	0.038
IFI44L	interferon-induced protein 44-like	0.038
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.037
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.036
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.034
ATM	ataxia telangiectasia mutated	0.034
TOX4	TOX high mobility group box family member 4	0.034
MKRN1	makorin ring finger protein 1	0.034
UBE2C	ubiquitin-conjugating enzyme E2C	0.033
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.032
PLK1	polo-like kinase 1	0.032
NMI	N-myc (and STAT) interactor	0.031
SETD7	SET domain containing (lysine methyltransferase) 7	0.031
USP42	ubiquitin specific peptidase 42	0.029
SP1	Sp1 transcription factor	0.027
DCAF7	DDB1 and CUL4 associated factor 7	0.027
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.027
RNF19A	ring finger protein 19A	0.026
SPRED1	sprouty-related, EVH1 domain containing 1	0.024
IFI16	interferon, gamma-inducible protein 16	0.023
CABLES1	Cdk5 and Abl enzyme substrate 1	0.023
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.022
LIMK2	LIM domain kinase 2	0.022
CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.022
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.022
RB1	retinoblastoma 1	0.021
KRT5	keratin 5	0.020
PIAS4	protein inhibitor of activated STAT, 4	0.020
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.019
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.019
AKT1S1	AKT1 substrate 1 (proline-rich)	0.018
MYST1	MYST histone acetyltransferase 1	0.018	Human
MEST	mesoderm specific transcript homolog (mouse)	0.018
SATB2	SATB homeobox 2	0.018
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.018
SPRR2A	small proline-rich protein 2A	0.018
DUSP1	dual specificity phosphatase 1	0.017
GSK3B	glycogen synthase kinase 3 beta	0.017
ISG15	ISG15 ubiquitin-like modifier	0.017
BANP	BTG3 associated nuclear protein	0.017
MAP2K1	mitogen-activated protein kinase kinase 1	0.016
PIAS2	protein inhibitor of activated STAT, 2	0.016
CUL7	cullin 7	0.016
PTPRR	protein tyrosine phosphatase, receptor type, R	0.016
PHF11	PHD finger protein 11	0.016
REV3L	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	0.016
SP100	SP100 nuclear antigen	0.016
C19orf46	chromosome 19 open reading frame 46	0.016
VPS72	vacuolar protein sorting 72 homolog (S. cerevisiae)	0.015
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.015
PRKCA	protein kinase C, alpha	0.015
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.015
DUSP3	dual specificity phosphatase 3	0.015
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.015
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.015
RBBP5	retinoblastoma binding protein 5	0.014
SAMD9	sterile alpha motif domain containing 9	0.014
KRT6C	keratin 6C	0.014
CDT1	chromatin licensing and DNA replication factor 1	0.014
MAGEA2	melanoma antigen family A, 2	0.014
RICTOR	RPTOR independent companion of MTOR, complex 2	0.014
NQO1	NAD(P)H dehydrogenase, quinone 1	0.014
DMAP1	DNA methyltransferase 1 associated protein 1	0.013
SPTBN4	spectrin, beta, non-erythrocytic 4	0.013
ARIH2	ariadne homolog 2 (Drosophila)	0.013
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.013
MAPK8	mitogen-activated protein kinase 8	0.012
S100A4	S100 calcium binding protein A4	0.012
TPT1	tumor protein, translationally-controlled 1	0.012
GLUL	glutamate-ammonia ligase	0.012
RFWD2	ring finger and WD repeat domain 2	0.012
C10orf116	chromosome 10 open reading frame 116	0.012
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.012
MEN1	multiple endocrine neoplasia I	0.011
CCND3	cyclin D3	0.011
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.011
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.011
DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	0.011
PSRC1	proline/serine-rich coiled-coil 1	0.011
MAPT	microtubule-associated protein tau	0.010
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.010
CFL1	cofilin 1 (non-muscle)	0.010
DUSP7	dual specificity phosphatase 7	0.010
IP6K2	inositol hexakisphosphate kinase 2	0.010