IMP

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Homo sapiens

22 genes annotated in human

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regulation of protein depolymerization

GO:1901879

Any process that modulates the frequency, rate or extent of protein depolymerization.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of protein depolymerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of protein depolymerization" (in gray)

Name	Description	Probability	Func Analog Organism
ACTB	actin, beta	0.974
ACTG1	actin, gamma 1	0.959
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.414
TTN	titin	0.310
TPM2	tropomyosin 2 (beta)	0.307	Worm
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.276
INCENP	inner centromere protein antigens 135/155kDa	0.237
APC	adenomatous polyposis coli	0.230
MARK2	MAP/microtubule affinity-regulating kinase 2	0.192
ITGB4	integrin, beta 4	0.167
BIRC5	baculoviral IAP repeat containing 5	0.164
TEX11	testis expressed 11	0.162
FLNA	filamin A, alpha	0.152
TRIM63	tripartite motif containing 63	0.140
TPM1	tropomyosin 1 (alpha)	0.131	Worm
CDK2	cyclin-dependent kinase 2	0.119
MYH9	myosin, heavy chain 9, non-muscle	0.118
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.114
RIPK3	receptor-interacting serine-threonine kinase 3	0.103
RACGAP1	Rac GTPase activating protein 1	0.102
CFL1	cofilin 1 (non-muscle)	0.102	Human Mouse
EXOC1	exocyst complex component 1	0.100
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.092
KIF1B	kinesin family member 1B	0.089
CDK1	cyclin-dependent kinase 1	0.088
KIF23	kinesin family member 23	0.087
SOS1	son of sevenless homolog 1 (Drosophila)	0.084
GLIS2	GLIS family zinc finger 2	0.082
AURKB	aurora kinase B	0.077
PSEN2	presenilin 2 (Alzheimer disease 4)	0.076
MYPN	myopalladin	0.076
ATF7IP	activating transcription factor 7 interacting protein	0.075
CCDC85A	coiled-coil domain containing 85A	0.063
MZT1	mitotic spindle organizing protein 1	0.059
SUFU	suppressor of fused homolog (Drosophila)	0.056
KIF20A	kinesin family member 20A	0.056
RAB11A	RAB11A, member RAS oncogene family	0.054
TAGLN2	transgelin 2	0.054
CORO1C	coronin, actin binding protein, 1C	0.053
LBR	lamin B receptor	0.052
CDCA8	cell division cycle associated 8	0.052
DISC1	disrupted in schizophrenia 1	0.048
TPM4	tropomyosin 4	0.041	Worm
ACTA1	actin, alpha 1, skeletal muscle	0.041
SVIL	supervillin	0.039
SASS6	spindle assembly 6 homolog (C. elegans)	0.039
SPTBN1	spectrin, beta, non-erythrocytic 1	0.038
ZYX	zyxin	0.036
BCL2L1	BCL2-like 1	0.035
TUBA1C	tubulin, alpha 1c	0.035
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.035
OPTN	optineurin	0.034
RHOA	ras homolog gene family, member A	0.033
SQSTM1	sequestosome 1	0.032
ADRBK1	adrenergic, beta, receptor kinase 1	0.030
PFN1	profilin 1	0.030
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.028
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.027
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.027
EXOC2	exocyst complex component 2	0.027
XPO1	exportin 1 (CRM1 homolog, yeast)	0.026
TNIK	TRAF2 and NCK interacting kinase	0.026
ACTN1	actinin, alpha 1	0.025
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.025
CKAP5	cytoskeleton associated protein 5	0.025
PBK	PDZ binding kinase	0.025
ANKRD28	ankyrin repeat domain 28	0.025
CCNB2	cyclin B2	0.024	Human
EPS8	epidermal growth factor receptor pathway substrate 8	0.024	Mouse Worm
LMNA	lamin A/C	0.024
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.024
DSTN	destrin (actin depolymerizing factor)	0.024	Human Mouse
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.023
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.022
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.022
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.021
ANXA4	annexin A4	0.021
MACF1	microtubule-actin crosslinking factor 1	0.021	Fly
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.021
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.020
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.020	Yeast Fly
COL17A1	collagen, type XVII, alpha 1	0.020
ZFP106	zinc finger protein 106 homolog (mouse)	0.019
ERBB2IP	erbb2 interacting protein	0.019
CCNE1	cyclin E1	0.019
CENPE	centromere protein E, 312kDa	0.019
CCNA2	cyclin A2	0.019
SEC23A	Sec23 homolog A (S. cerevisiae)	0.018
EXOC7	exocyst complex component 7	0.018
TUBGCP5	tubulin, gamma complex associated protein 5	0.018
TRIM37	tripartite motif containing 37	0.018
TOM1L1	target of myb1 (chicken)-like 1	0.018
INADL	InaD-like (Drosophila)	0.018
ADNP	activity-dependent neuroprotector homeobox	0.018
AHNAK	AHNAK nucleoprotein	0.017
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.017
CD2AP	CD2-associated protein	0.016
WDR1	WD repeat domain 1	0.016	Yeast Worm
PALLD	palladin, cytoskeletal associated protein	0.016
KIF5B	kinesin family member 5B	0.016
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.016
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.016
RAB10	RAB10, member RAS oncogene family	0.015
KBTBD10	kelch repeat and BTB (POZ) domain containing 10	0.015
CYLD	cylindromatosis (turban tumor syndrome)	0.015
TUBA1A	tubulin, alpha 1a	0.014
ACTA2	actin, alpha 2, smooth muscle, aorta	0.014
SCP2	sterol carrier protein 2	0.014
ARRB1	arrestin, beta 1	0.014
ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.014
SIRT2	sirtuin 2	0.014
CNN1	calponin 1, basic, smooth muscle	0.014
PRMT2	protein arginine methyltransferase 2	0.014
JUP	junction plakoglobin	0.014
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.014
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.014
NBR1	neighbor of BRCA1 gene 1	0.013
GPSM2	G-protein signaling modulator 2	0.013
CNN2	calponin 2	0.013
LXN	latexin	0.013
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.013
TRAPPC1	trafficking protein particle complex 1	0.013
TUBA1B	tubulin, alpha 1b	0.013
NGFR	nerve growth factor receptor	0.013
CFL2	cofilin 2 (muscle)	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.012
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.012
ITGA6	integrin, alpha 6	0.012
DCK	deoxycytidine kinase	0.012
GIGYF2	GRB10 interacting GYF protein 2	0.012
PLDN	pallidin homolog (mouse)	0.012
SYNE1	spectrin repeat containing, nuclear envelope 1	0.012
KIF20B	kinesin family member 20B	0.012
TMSB10	thymosin beta 10	0.012
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.011
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.011
LIMK1	LIM domain kinase 1	0.011
BCLAF1	BCL2-associated transcription factor 1	0.011
CCDC11	coiled-coil domain containing 11	0.011
C10orf46	chromosome 10 open reading frame 46	0.011
DST	dystonin	0.011	Fly
INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	0.011
TRIO	triple functional domain (PTPRF interacting)	0.011
FHL2	four and a half LIM domains 2	0.011
MRPL20	mitochondrial ribosomal protein L20	0.011
DES	desmin	0.011
ATP13A2	ATPase type 13A2	0.011
C16orf53	chromosome 16 open reading frame 53	0.011
MDC1	mediator of DNA-damage checkpoint 1	0.011
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.011
TNNT1	troponin T type 1 (skeletal, slow)	0.011
PHLDB2	pleckstrin homology-like domain, family B, member 2	0.011
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.011
GLI1	GLI family zinc finger 1	0.010
TUBB	tubulin, beta	0.010
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.010
MAPRE2	microtubule-associated protein, RP/EB family, member 2	0.010
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.010
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.010
PDLIM7	PDZ and LIM domain 7 (enigma)	0.010
USP24	ubiquitin specific peptidase 24	0.010
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.010
ITSN1	intersectin 1 (SH3 domain protein)	0.010
NEK4	NIMA (never in mitosis gene a)-related kinase 4	0.010
WDFY3	WD repeat and FYVE domain containing 3	0.010
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.010
TMEM123	transmembrane protein 123	0.010