IMP

Process View

Homo sapiens

17 genes annotated in human

negative regulation of microtubule polymerization or depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of microtubule polymerization or depolymerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of microtubule polymerization or depolymerization" (in gray)

Name	Description	Probability	Func Analog Organism
RACGAP1	Rac GTPase activating protein 1	0.891
BIRC5	baculoviral IAP repeat containing 5	0.833
AURKB	aurora kinase B	0.769
ITGB4	integrin, beta 4	0.719
CDK1	cyclin-dependent kinase 1	0.663
CDK2	cyclin-dependent kinase 2	0.649
KIF23	kinesin family member 23	0.521
INCENP	inner centromere protein antigens 135/155kDa	0.445
KIF1B	kinesin family member 1B	0.430
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.368
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.364	Human
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.349
PSEN2	presenilin 2 (Alzheimer disease 4)	0.347
SASS6	spindle assembly 6 homolog (C. elegans)	0.303
CDCA8	cell division cycle associated 8	0.299
MAPRE2	microtubule-associated protein, RP/EB family, member 2	0.254	Human
CDKN3	cyclin-dependent kinase inhibitor 3	0.218
PRC1	protein regulator of cytokinesis 1	0.216	Worm Fly
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.212
APC	adenomatous polyposis coli	0.199
MAPT	microtubule-associated protein tau	0.186
ARL2	ADP-ribosylation factor-like 2	0.186
SPTBN1	spectrin, beta, non-erythrocytic 1	0.164
KIF20A	kinesin family member 20A	0.160
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.151
TUBB	tubulin, beta	0.149
CKS2	CDC28 protein kinase regulatory subunit 2	0.144
EXOC1	exocyst complex component 1	0.142
MARK2	MAP/microtubule affinity-regulating kinase 2	0.141
DST	dystonin	0.133	Fly
LMO2	LIM domain only 2 (rhombotin-like 1)	0.130
AURKA	aurora kinase A	0.120
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.112
GLIS2	GLIS family zinc finger 2	0.110
CKAP5	cytoskeleton associated protein 5	0.107
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.100
CENPE	centromere protein E, 312kDa	0.100
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.096
XPO1	exportin 1 (CRM1 homolog, yeast)	0.091
CCDC85A	coiled-coil domain containing 85A	0.084
ADRBK1	adrenergic, beta, receptor kinase 1	0.078
LBR	lamin B receptor	0.078
ANKRD28	ankyrin repeat domain 28	0.075
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.073
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.072
CENPJ	centromere protein J	0.069
CCNA2	cyclin A2	0.067
ATF7IP	activating transcription factor 7 interacting protein	0.067
GPSM2	G-protein signaling modulator 2	0.059
EXOC7	exocyst complex component 7	0.059
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.056
SMC4	structural maintenance of chromosomes 4	0.055
TEX11	testis expressed 11	0.054
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.052
CENPF	centromere protein F, 350/400kDa (mitosin)	0.051
KIF5B	kinesin family member 5B	0.051
CCNE1	cyclin E1	0.051
CCNB2	cyclin B2	0.050	Human
EXOC2	exocyst complex component 2	0.049
KIF4A	kinesin family member 4A	0.046
TUBA1C	tubulin, alpha 1c	0.044
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.042
WASL	Wiskott-Aldrich syndrome-like	0.040
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.040
MZT1	mitotic spindle organizing protein 1	0.038
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.037
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.037
UBE2S	ubiquitin-conjugating enzyme E2S	0.035
TTK	TTK protein kinase	0.033
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.033
PTTG1	pituitary tumor-transforming 1	0.032
CCNB1	cyclin B1	0.031
SNCAIP	synuclein, alpha interacting protein	0.031
DOCK7	dedicator of cytokinesis 7	0.031
KIF20B	kinesin family member 20B	0.030
TUBG1	tubulin, gamma 1	0.030
TNIK	TRAF2 and NCK interacting kinase	0.029
CEP55	centrosomal protein 55kDa	0.028
ZFP106	zinc finger protein 106 homolog (mouse)	0.027
SMAD9	SMAD family member 9	0.027
NCAPD2	non-SMC condensin I complex, subunit D2	0.026
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.026
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.025
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.025
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.025
PSRC1	proline/serine-rich coiled-coil 1	0.024
TUBA1B	tubulin, alpha 1b	0.024
TUBGCP5	tubulin, gamma complex associated protein 5	0.024
SEPT2	septin 2	0.024
KIF2C	kinesin family member 2C	0.024
GAS2L3	growth arrest-specific 2 like 3	0.023	Human
TIAM1	T-cell lymphoma invasion and metastasis 1	0.023
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.022
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.022
SUFU	suppressor of fused homolog (Drosophila)	0.022
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.022
TUBB2C	tubulin, beta 2C	0.021
THRAP3	thyroid hormone receptor associated protein 3	0.021
DISC1	disrupted in schizophrenia 1	0.021
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.021
CYLD	cylindromatosis (turban tumor syndrome)	0.021
HMGB2	high mobility group box 2	0.021
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.020
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.020
UBE2C	ubiquitin-conjugating enzyme E2C	0.020
TUBA1A	tubulin, alpha 1a	0.019
MACF1	microtubule-actin crosslinking factor 1	0.018	Fly
FOXM1	forkhead box M1	0.017
CP110	CP110 protein	0.017
ZRANB1	zinc finger, RAN-binding domain containing 1	0.017
APC2	adenomatosis polyposis coli 2	0.017	Human
PKP4	plakophilin 4	0.017
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.017
MYO9B	myosin IXB	0.016
PDE4DIP	phosphodiesterase 4D interacting protein	0.016
STIL	SCL/TAL1 interrupting locus	0.016
ATP13A2	ATPase type 13A2	0.016
ANAPC5	anaphase promoting complex subunit 5	0.016
H2AFV	H2A histone family, member V	0.016
GSK3B	glycogen synthase kinase 3 beta	0.015
BTRC	beta-transducin repeat containing	0.015
YAP1	Yes-associated protein 1	0.015
WEE1	WEE1 homolog (S. pombe)	0.015
CLIP1	CAP-GLY domain containing linker protein 1	0.015
GIGYF2	GRB10 interacting GYF protein 2	0.015
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.015
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.015
DLG4	discs, large homolog 4 (Drosophila)	0.015
OSBPL3	oxysterol binding protein-like 3	0.014
SIRT2	sirtuin 2	0.014
CDT1	chromatin licensing and DNA replication factor 1	0.014
EDC3	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	0.014
NUSAP1	nucleolar and spindle associated protein 1	0.014
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.014
NCAPG	non-SMC condensin I complex, subunit G	0.013
CTTN	cortactin	0.013
TJP2	tight junction protein 2 (zona occludens 2)	0.013
SAC3D1	SAC3 domain containing 1	0.013
TACC1	transforming, acidic coiled-coil containing protein 1	0.013
LMNA	lamin A/C	0.013
ACOT7	acyl-CoA thioesterase 7	0.013
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.013
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.013
KIF18A	kinesin family member 18A	0.013
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.012
NGFR	nerve growth factor receptor	0.012
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.012
S100A2	S100 calcium binding protein A2	0.012
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.012
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.012
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.012
PBK	PDZ binding kinase	0.012
RAI14	retinoic acid induced 14	0.012
S100A6	S100 calcium binding protein A6	0.012
ECT2	epithelial cell transforming sequence 2 oncogene	0.011
PRKCA	protein kinase C, alpha	0.011
PLXND1	plexin D1	0.011
TPPP	tubulin polymerization promoting protein	0.011
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.011
RASAL2	RAS protein activator like 2	0.011
MZT2B	mitotic spindle organizing protein 2B	0.011
APLP1	amyloid beta (A4) precursor-like protein 1	0.011
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.011
SIAH1	seven in absentia homolog 1 (Drosophila)	0.011
MPHOSPH9	M-phase phosphoprotein 9	0.011
NUMA1	nuclear mitotic apparatus protein 1	0.010
KLC2	kinesin light chain 2	0.010
NUP93	nucleoporin 93kDa	0.010
CBX5	chromobox homolog 5	0.010
MIS18BP1	MIS18 binding protein 1	0.010
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.010