IMP

Process View

Homo sapiens

8 genes annotated in human

embryonic heart tube morphogenesis

The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "embryonic heart tube morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "embryonic heart tube morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.981	Mouse
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.955	Human Zebrafish
TGFB1	transforming growth factor, beta 1	0.953
JAG1	jagged 1	0.935
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.875	Human
TBX5	T-box 5	0.874	Zebrafish
SMAD7	SMAD family member 7	0.809
SMAD1	SMAD family member 1	0.789
FKBP1A	FK506 binding protein 1A, 12kDa	0.769
BMP2	bone morphogenetic protein 2	0.748
NOTCH1	notch 1	0.669	Mouse
SMAD2	SMAD family member 2	0.659
GATA4	GATA binding protein 4	0.550	Zebrafish Mouse
PBX1	pre-B-cell leukemia homeobox 1	0.525
SMAD3	SMAD family member 3	0.472	Mouse
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.435
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.422
GSK3B	glycogen synthase kinase 3 beta	0.421
FSTL1	follistatin-like 1	0.385
BMPR1A	bone morphogenetic protein receptor, type IA	0.336	Human Zebrafish
ENG	endoglin	0.330	Mouse
TGFBR1	transforming growth factor, beta receptor 1	0.277	Human
SMAD4	SMAD family member 4	0.271
PTCH1	patched 1	0.262
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.235
EP300	E1A binding protein p300	0.216
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.184
NOTCH3	notch 3	0.167
HDAC4	histone deacetylase 4	0.163
SASS6	spindle assembly 6 homolog (C. elegans)	0.153
YAP1	Yes-associated protein 1	0.143	Mouse
LRP6	low density lipoprotein receptor-related protein 6	0.133	Mouse
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.115	Mouse
DSP	desmoplakin	0.104
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.101
FZD1	frizzled homolog 1 (Drosophila)	0.101
ACVR1	activin A receptor, type I	0.100
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.099
TJP1	tight junction protein 1 (zona occludens 1)	0.097
GDF5	growth differentiation factor 5	0.096
CAV1	caveolin 1, caveolae protein, 22kDa	0.091
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.086
KAT2B	K(lysine) acetyltransferase 2B	0.086
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.070
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.067
HIPK2	homeodomain interacting protein kinase 2	0.064
EPAS1	endothelial PAS domain protein 1	0.063
SP1	Sp1 transcription factor	0.060
BMP1	bone morphogenetic protein 1	0.059
MARK3	MAP/microtubule affinity-regulating kinase 3	0.057
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.055
DLL1	delta-like 1 (Drosophila)	0.053	Mouse
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.053
MEIS2	Meis homeobox 2	0.051
PRKG1	protein kinase, cGMP-dependent, type I	0.050
NOTCH2	notch 2	0.049	Mouse
GLI1	GLI family zinc finger 1	0.046
PDGFC	platelet derived growth factor C	0.046
BBS2	Bardet-Biedl syndrome 2	0.037
MYOCD	myocardin	0.036
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.036
NRP1	neuropilin 1	0.035
TBK1	TANK-binding kinase 1	0.033
PEX26	peroxisomal biogenesis factor 26	0.033
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.031
MEF2A	myocyte enhancer factor 2A	0.031
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.031
NOG	noggin	0.030
AMOTL1	angiomotin like 1	0.030
TP53BP2	tumor protein p53 binding protein, 2	0.029
NCSTN	nicastrin	0.029
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.029
WNT3A	wingless-type MMTV integration site family, member 3A	0.027	Mouse
SMAD9	SMAD family member 9	0.026
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.026
ZFYVE9	zinc finger, FYVE domain containing 9	0.026
MYOD1	myogenic differentiation 1	0.026
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.024
XIAP	X-linked inhibitor of apoptosis	0.023
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.023
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.022
TP73	tumor protein p73	0.022
JAG2	jagged 2	0.022
PKP4	plakophilin 4	0.022
TRAM1	translocation associated membrane protein 1	0.022
HDAC9	histone deacetylase 9	0.021
BCL2	B-cell CLL/lymphoma 2	0.021
MAML1	mastermind-like 1 (Drosophila)	0.021
YY1	YY1 transcription factor	0.021
BBS9	Bardet-Biedl syndrome 9	0.019
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.018
SMAD5	SMAD family member 5	0.018	Zebrafish
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.017
MKL2	MKL/myocardin-like 2	0.017
BMP4	bone morphogenetic protein 4	0.017	Zebrafish
TGFB3	transforming growth factor, beta 3	0.017
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.016
BBS10	Bardet-Biedl syndrome 10	0.016
LMAN1	lectin, mannose-binding, 1	0.016
SNX5	sorting nexin 5	0.016
HOXA9	homeobox A9	0.016
AR	androgen receptor	0.015
GLI3	GLI family zinc finger 3	0.015
FZD7	frizzled homolog 7 (Drosophila)	0.014
GATA2	GATA binding protein 2	0.014
ATF2	activating transcription factor 2	0.014
TTC8	tetratricopeptide repeat domain 8	0.014
TOP1	topoisomerase (DNA) I	0.014
ZEB2	zinc finger E-box binding homeobox 2	0.014
MYOG	myogenin (myogenic factor 4)	0.014
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.014
TRIP6	thyroid hormone receptor interactor 6	0.013
MAPK8	mitogen-activated protein kinase 8	0.013
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.013
RBBP4	retinoblastoma binding protein 4	0.013
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.012
AMOTL2	angiomotin like 2	0.012
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.012
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.012
KLF13	Kruppel-like factor 13	0.012
EGLN1	egl nine homolog 1 (C. elegans)	0.012
AKAP6	A kinase (PRKA) anchor protein 6	0.012
CNOT4	CCR4-NOT transcription complex, subunit 4	0.011
HAND2	heart and neural crest derivatives expressed 2	0.011	Zebrafish Mouse
CXXC5	CXXC finger protein 5	0.011
NIN	ninein (GSK3B interacting protein)	0.011
FZD8	frizzled homolog 8 (Drosophila)	0.011
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.010
FNDC3B	fibronectin type III domain containing 3B	0.010
CEP164	centrosomal protein 164kDa	0.010
PSEN2	presenilin 2 (Alzheimer disease 4)	0.010
YBX1	Y box binding protein 1	0.010
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.010
NCOR2	nuclear receptor corepressor 2	0.010