IMP
Process View
erythropoietin mediated signaling pathway
A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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Click on a gene's description to view its network relationships with genes known to be involved in "erythropoietin mediated signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.991 | ||
| Vegfa | vascular endothelial growth factor A | 0.903 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.543 | ||
| Cdh5 | cadherin 5 | 0.541 | ||
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.504 | ||
| Ank1 | ankyrin 1, erythroid | 0.471 | ||
| Kdr | kinase insert domain protein receptor | 0.406 | Mouse | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.398 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.386 | Mouse | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.384 | ||
| Slc9a3r2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.357 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.338 | ||
| Kitl | kit ligand | 0.328 | ||
| Sox18 | SRY-box containing gene 18 | 0.259 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.209 | ||
| Epas1 | endothelial PAS domain protein 1 | 0.208 | ||
| Tek | endothelial-specific receptor tyrosine kinase | 0.201 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.196 | ||
| Eng | endoglin | 0.195 | ||
| Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 0.189 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.171 | ||
| Foxc2 | forkhead box C2 | 0.161 | ||
| Pdgfb | platelet derived growth factor, B polypeptide | 0.158 | ||
| Esam | endothelial cell-specific adhesion molecule | 0.157 | ||
| Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.146 | ||
| Meox2 | mesenchyme homeobox 2 | 0.143 | ||
| Flt1 | FMS-like tyrosine kinase 1 | 0.141 | Mouse | |
| Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.141 | Mouse | |
| Ednrb | endothelin receptor type B | 0.131 | ||
| Lepr | leptin receptor | 0.125 | ||
| Acvrl1 | activin A receptor, type II-like 1 | 0.125 | ||
| Vegfc | vascular endothelial growth factor C | 0.118 | ||
| Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | 0.102 | ||
| Mpeg1 | macrophage expressed gene 1 | 0.100 | ||
| Gucy1b3 | guanylate cyclase 1, soluble, beta 3 | 0.092 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.075 | ||
| Emcn | endomucin | 0.074 | ||
| Klf1 | Kruppel-like factor 1 (erythroid) | 0.073 | ||
| Cldn5 | claudin 5 | 0.072 | ||
| Aplnr | apelin receptor | 0.066 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.065 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.061 | ||
| Psen1 | presenilin 1 | 0.061 | ||
| Ldb2 | LIM domain binding 2 | 0.061 | ||
| Slc4a1 | solute carrier family 4 (anion exchanger), member 1 | 0.060 | ||
| Robo4 | roundabout homolog 4 (Drosophila) | 0.060 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.059 | ||
| Ctss | cathepsin S | 0.058 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.057 | ||
| Adcy4 | adenylate cyclase 4 | 0.054 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.052 | ||
| Egfl7 | EGF-like domain 7 | 0.048 | ||
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.048 | ||
| She | src homology 2 domain-containing transforming protein E | 0.048 | ||
| Tmem204 | transmembrane protein 204 | 0.047 | ||
| Cxcl12 | chemokine (C-X-C motif) ligand 12 | 0.044 | ||
| Cbl | Casitas B-lineage lymphoma | 0.043 | ||
| Sema6d | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 0.042 | ||
| Pten | phosphatase and tensin homolog | 0.042 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.042 | ||
| Ptch1 | patched homolog 1 | 0.040 | ||
| Spna1 | spectrin alpha 1 | 0.039 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.038 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.038 | ||
| Podxl | podocalyxin-like | 0.038 | ||
| Nrp1 | neuropilin 1 | 0.035 | ||
| S1pr3 | sphingosine-1-phosphate receptor 3 | 0.035 | ||
| Apc | adenomatosis polyposis coli | 0.035 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.034 | ||
| Plxnd1 | plexin D1 | 0.034 | ||
| Ldlr | low density lipoprotein receptor | 0.033 | ||
| Gja1 | gap junction protein, alpha 1 | 0.032 | ||
| Kit | kit oncogene | 0.031 | ||
| Unc93b1 | unc-93 homolog B1 (C. elegans) | 0.030 | ||
| Trp53 | transformation related protein 53 | 0.029 | ||
| Shank3 | SH3/ankyrin domain gene 3 | 0.029 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.028 | ||
| Rxra | retinoid X receptor alpha | 0.027 | ||
| Rasip1 | Ras interacting protein 1 | 0.027 | ||
| Sox17 | SRY-box containing gene 17 | 0.026 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.025 | ||
| Runx2 | runt related transcription factor 2 | 0.025 | ||
| C1qb | complement component 1, q subcomponent, beta polypeptide | 0.025 | ||
| Cd93 | CD93 antigen | 0.025 | ||
| Col6a1 | collagen, type VI, alpha 1 | 0.024 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.024 | ||
| Eltd1 | EGF, latrophilin seven transmembrane domain containing 1 | 0.024 | ||
| Plvap | plasmalemma vesicle associated protein | 0.024 | ||
| Stab1 | stabilin 1 | 0.022 | ||
| Pkd1 | polycystic kidney disease 1 homolog | 0.022 | ||
| Thbd | thrombomodulin | 0.022 | ||
| Hbb-b2 | hemoglobin, beta adult minor chain | 0.022 | ||
| Tgfbr3 | transforming growth factor, beta receptor III | 0.021 | ||
| Fgd5 | FYVE, RhoGEF and PH domain containing 5 | 0.021 | ||
| Lrp1 | low density lipoprotein receptor-related protein 1 | 0.021 | ||
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.021 | ||
| 4632428N05Rik | RIKEN cDNA 4632428N05 gene | 0.021 | ||
| Sdc3 | syndecan 3 | 0.020 | ||
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.020 | ||
| Acvr1 | activin A receptor, type 1 | 0.020 | ||
| Slc11a2 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.019 | ||
| Fyn | Fyn proto-oncogene | 0.019 | ||
| Hlx | H2.0-like homeobox | 0.019 | ||
| Ramp2 | receptor (calcitonin) activity modifying protein 2 | 0.019 | ||
| Sox7 | SRY-box containing gene 7 | 0.019 | ||
| Nid1 | nidogen 1 | 0.018 | ||
| Hic1 | hypermethylated in cancer 1 | 0.018 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.018 | ||
| Gja4 | gap junction protein, alpha 4 | 0.018 | ||
| Icam2 | intercellular adhesion molecule 2 | 0.017 | ||
| Mmrn2 | multimerin 2 | 0.017 | ||
| Clec4n | C-type lectin domain family 4, member n | 0.017 | ||
| Ar | androgen receptor | 0.017 | ||
| Fbln1 | fibulin 1 | 0.017 | ||
| Gpr182 | G protein-coupled receptor 182 | 0.016 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.016 | ||
| Fzd4 | frizzled homolog 4 (Drosophila) | 0.016 | ||
| C1qc | complement component 1, q subcomponent, C chain | 0.016 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.016 | ||
| Lyz2 | lysozyme 2 | 0.016 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.016 | ||
| Cacna1c | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.015 | ||
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.015 | ||
| C1qtnf1 | C1q and tumor necrosis factor related protein 1 | 0.015 | ||
| Flt4 | FMS-like tyrosine kinase 4 | 0.015 | Mouse | |
| Plcg2 | phospholipase C, gamma 2 | 0.014 | ||
| Col4a2 | collagen, type IV, alpha 2 | 0.014 | ||
| Nf1 | neurofibromatosis 1 | 0.014 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.014 | ||
| Agtr1a | angiotensin II receptor, type 1a | 0.014 | ||
| Efnb2 | ephrin B2 | 0.014 | ||
| C1qa | complement component 1, q subcomponent, alpha polypeptide | 0.014 | ||
| Bcl6b | B-cell CLL/lymphoma 6, member B | 0.013 | ||
| Vwf | Von Willebrand factor homolog | 0.013 | ||
| Dab2 | disabled homolog 2 (Drosophila) | 0.013 | ||
| Gata2 | GATA binding protein 2 | 0.013 | ||
| Ushbp1 | Usher syndrome 1C binding protein 1 | 0.013 | ||
| Foxc1 | forkhead box C1 | 0.012 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.012 | ||
| Ptprm | protein tyrosine phosphatase, receptor type, M | 0.012 | ||
| Src | Rous sarcoma oncogene | 0.012 | ||
| Add2 | adducin 2 (beta) | 0.012 | ||
| Lama4 | laminin, alpha 4 | 0.011 | ||
| Sfpi1 | SFFV proviral integration 1 | 0.011 | ||
| Stard8 | START domain containing 8 | 0.011 | ||
| Prkag1 | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 0.011 | ||
| Mn1 | meningioma 1 | 0.011 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.011 | ||
| Rarb | retinoic acid receptor, beta | 0.011 | ||
| Nrgn | neurogranin | 0.011 | ||
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.011 | ||
| Bgn | biglycan | 0.011 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.010 | ||
| Ptgs1 | prostaglandin-endoperoxide synthase 1 | 0.010 | ||
| Hbb-b1 | hemoglobin, beta adult major chain | 0.010 | ||
| Gpr116 | G protein-coupled receptor 116 | 0.010 | ||
| Sgpl1 | sphingosine phosphate lyase 1 | 0.010 | ||
| Prrx1 | paired related homeobox 1 | 0.010 |