IMP

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Mus musculus

1 genes annotated in mouse

pma inducible membrane protein ectodomain proteolysis

The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pma inducible membrane protein ectodomain proteolysis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "pma inducible membrane protein ectodomain proteolysis" (in gray)

Name	Description	Probability	Func Analog Organism
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.974	Mouse
Jag1	jagged 1	0.785
Egfr	epidermal growth factor receptor	0.575
Tgfb2	transforming growth factor, beta 2	0.379
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.303	Mouse
Tm9sf3	transmembrane 9 superfamily member 3	0.289
Klf3	Kruppel-like factor 3 (basic)	0.282
Efnb2	ephrin B2	0.268
Hbegf	heparin-binding EGF-like growth factor	0.226
Adam15	a disintegrin and metallopeptidase domain 15 (metargidin)	0.170	Mouse
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.166	Human Mouse
Hif1a	hypoxia inducible factor 1, alpha subunit	0.145
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.134
Rp2h	retinitis pigmentosa 2 homolog (human)	0.128
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.123
Sos1	son of sevenless homolog 1 (Drosophila)	0.100
Cd44	CD44 antigen	0.098
Cxcr7	chemokine (C-X-C motif) receptor 7	0.092
Ntf3	neurotrophin 3	0.075
Nptn	neuroplastin	0.074
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.063
BC100451	cDNA sequence BC100451	0.061
Vmn1r44	vomeronasal 1 receptor 44	0.058
Odf1	outer dense fiber of sperm tails 1	0.054
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.052
Gnao1	guanine nucleotide binding protein, alpha O	0.046
Tgfbr1	transforming growth factor, beta receptor I	0.046
Sirpa	signal-regulatory protein alpha	0.045
Adam4	a disintegrin and metallopeptidase domain 4	0.045
Cd46	CD46 antigen, complement regulatory protein	0.044
Glipr2	GLI pathogenesis-related 2	0.043
H2afb1	H2A histone family, member B1	0.038
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.034
Allc	allantoicase	0.033
Ncam2	neural cell adhesion molecule 2	0.033
Tsga13	testis specific gene A13	0.033
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.032
Lyzl1	lysozyme-like 1	0.030
Grb2	growth factor receptor bound protein 2	0.030
Pros1	protein S (alpha)	0.030
Serpina5	serine (or cysteine) peptidase inhibitor, clade A, member 5	0.030
Il6st	interleukin 6 signal transducer	0.030
Apaf1	apoptotic peptidase activating factor 1	0.029
Adam2	a disintegrin and metallopeptidase domain 2	0.029	Mouse
Idua	iduronidase, alpha-L-	0.029
Cabyr	calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)	0.029
Dlg4	discs, large homolog 4 (Drosophila)	0.029
Npff	neuropeptide FF-amide peptide precursor	0.028
1700029F12Rik	RIKEN cDNA 1700029F12 gene	0.028
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.027
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.027
Dnm1	dynamin 1	0.027
Aff2	AF4/FMR2 family, member 2	0.027
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.026
Boll	bol, boule-like (Drosophila)	0.026
Cplx2	complexin 2	0.026
2610015P09Rik	RIKEN cDNA 2610015P09 gene	0.025
Mfsd1	major facilitator superfamily domain containing 1	0.025
Slc4a8	solute carrier family 4 (anion exchanger), member 8	0.024
Col20a1	collagen, type XX, alpha 1	0.024
Ctnnb1	catenin (cadherin associated protein), beta 1	0.023
Zfpm2	zinc finger protein, multitype 2	0.023
Gata4	GATA binding protein 4	0.023
Fkbp6	FK506 binding protein 6	0.023
Asah1	N-acylsphingosine amidohydrolase 1	0.023
Eps8	epidermal growth factor receptor pathway substrate 8	0.023
Gfra4	glial cell line derived neurotrophic factor family receptor alpha 4	0.022
Prnp	prion protein	0.022
Kif17	kinesin family member 17	0.022
Cpne3	copine III	0.022
Olfr66	olfactory receptor 66	0.022
Bpil1	bactericidal/permeability-increasing protein-like 1	0.022
Dpysl4	dihydropyrimidinase-like 4	0.022
Odf4	outer dense fiber of sperm tails 4	0.021
4930544G11Rik	RIKEN cDNA 4930544G11 gene	0.021
Fhl5	four and a half LIM domains 5	0.021
Fam71f1	family with sequence similarity 71, member F1	0.021
Actl7a	actin-like 7a	0.021
Slc25a2	solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2	0.020
Ncam1	neural cell adhesion molecule 1	0.020
Mpl	myeloproliferative leukemia virus oncogene	0.020
Zfp444	zinc finger protein 444	0.020
1700129C05Rik	RIKEN cDNA 1700129C05 gene	0.020
Jup	junction plakoglobin	0.020
Nt5c1b	5'-nucleotidase, cytosolic IB	0.020
P4ha1	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	0.019
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.019
Syt11	synaptotagmin XI	0.019
1700018F24Rik	RIKEN cDNA 1700018F24 gene	0.019
Epyc	epiphycan	0.018
Col6a2	collagen, type VI, alpha 2	0.018
Ubl4b	ubiquitin-like 4B	0.018
Olfr64	olfactory receptor 64	0.018
Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.018
Far1	fatty acyl CoA reductase 1	0.018
Tmod3	tropomodulin 3	0.018
Rxfp2	relaxin/insulin-like family peptide receptor 2	0.018
Plekho2	pleckstrin homology domain containing, family O member 2	0.018
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.018
Cd209c	CD209c antigen	0.018
Gja1	gap junction protein, alpha 1	0.017
Tas1r1	taste receptor, type 1, member 1	0.017
Adarb1	adenosine deaminase, RNA-specific, B1	0.017
Hoxc9	homeobox C9	0.017
Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	0.017
Ugdh	UDP-glucose dehydrogenase	0.017
Zfp651	zinc finger protein 651	0.017
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.017
Mtl5	metallothionein-like 5, testis-specific (tesmin)	0.017
Sycp1	synaptonemal complex protein 1	0.017
Prss40	protease, serine, 40	0.017
Speer4f	spermatogenesis associated glutamate (E)-rich protein 4f	0.017
D15Ertd621e	DNA segment, Chr 15, ERATO Doi 621, expressed	0.017
Darc	Duffy blood group, chemokine receptor	0.016
9930013L23Rik	RIKEN cDNA 9930013L23 gene	0.016
Scn1b	sodium channel, voltage-gated, type I, beta	0.016
Trim62	tripartite motif-containing 62	0.016
Ovgp1	oviductal glycoprotein 1	0.016
9530002B09Rik	RIKEN cDNA 9530002B09 gene	0.016
1700019N19Rik	RIKEN cDNA 1700019N19 gene	0.015
Spnb4	spectrin beta 4	0.015
Ugcg	UDP-glucose ceramide glucosyltransferase	0.015
Cnga1	cyclic nucleotide gated channel alpha 1	0.015
LOC100042689	y-linked testis-specific protein 1-like	0.015
Tnp2	transition protein 2	0.015
Npcd	neuronal pentraxin chromo domain	0.015
Hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.015
Snap23	synaptosomal-associated protein 23	0.015
Adam17	a disintegrin and metallopeptidase domain 17	0.015
Treml1	triggering receptor expressed on myeloid cells-like 1	0.015
Pkdrej	polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly, sea urchin homolog)-like	0.015
Elk4	ELK4, member of ETS oncogene family	0.015
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.014
Pcdhb1	protocadherin beta 1	0.014
Galntl1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1	0.014
4930430A15Rik	RIKEN cDNA 4930430A15 gene	0.014
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.014
Olfr870	olfactory receptor 870	0.014
Cenpj	centromere protein J	0.014
Vmn2r1	vomeronasal 2, receptor 1	0.014
Ftmt	ferritin mitochondrial	0.014
Tlr4	toll-like receptor 4	0.014
Rttn	rotatin	0.014
Mrgprh	MAS-related GPR, member H	0.014
Ndst4	N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4	0.014
Foxf1a	forkhead box F1a	0.014
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.014
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.014
Htra3	HtrA serine peptidase 3	0.013
Ubtd1	ubiquitin domain containing 1	0.013
Gm5142	predicted gene 5142	0.013
Prl7c1	prolactin family 7, subfamily c, member 1	0.013
Kcnab1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0.013
Oas1h	2'-5' oligoadenylate synthetase 1H	0.013
Nlrp5	NLR family, pyrin domain containing 5	0.013
Rnf112	ring finger protein 112	0.013
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.013
Olfr73	olfactory receptor 73	0.013
Klk1b24	kallikrein 1-related peptidase b24	0.013
Nlrp3	NLR family, pyrin domain containing 3	0.012
Cdrt4	CMT1A duplicated region transcript 4	0.012
1810065E05Rik	RIKEN cDNA 1810065E05 gene	0.012
Olfr480	olfactory receptor 480	0.012
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.012
Sdc3	syndecan 3	0.012
Lrrc18	leucine rich repeat containing 18	0.012
Msn	moesin	0.012
Stac2	SH3 and cysteine rich domain 2	0.012
Nxf2	nuclear RNA export factor 2	0.012
Meis3	Meis homeobox 3	0.012
Ropn1	ropporin, rhophilin associated protein 1	0.012
Vamp1	vesicle-associated membrane protein 1	0.012
4921530L21Rik	RIKEN cDNA 4921530L21 gene	0.012
Gprc6a	G protein-coupled receptor, family C, group 6, member A	0.012
Acrv1	acrosomal vesicle protein 1	0.012
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.012
Mbd3l1	methyl-CpG binding domain protein 3-like 1	0.012
4930524B15Rik	RIKEN cDNA 4930524B15 gene	0.012
Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.012
Spata21	spermatogenesis associated 21	0.012
Gp5	glycoprotein 5 (platelet)	0.012
Ankrd36	ankyrin repeat domain 36	0.012
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.012
Slco6c1	solute carrier organic anion transporter family, member 6c1	0.011
Gbgt1	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1	0.011
1700034I23Rik	RIKEN cDNA 1700034I23 gene	0.011
Pcdhb8	protocadherin beta 8	0.011
Lamp2	lysosomal-associated membrane protein 2	0.011
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.011
Spata3	spermatogenesis associated 3	0.011
Cntn1	contactin 1	0.011
Cd38	CD38 antigen	0.011
Rel	reticuloendotheliosis oncogene	0.011
Pcdhb10	protocadherin beta 10	0.011
Sntb2	syntrophin, basic 2	0.011
4921510H08Rik	RIKEN cDNA 4921510H08 gene	0.011
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.011
Fmnl1	formin-like 1	0.011
1700057G04Rik	RIKEN cDNA 1700057G04 gene	0.011
Pbp2	phosphatidylethanolamine binding protein 2	0.011
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.011
G6pd2	glucose-6-phosphate dehydrogenase 2	0.011
Speer3	spermatogenesis associated glutamate (E)-rich protein 3	0.011
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.011
Dok1	docking protein 1	0.011
Irak4	interleukin-1 receptor-associated kinase 4	0.011
Lce1a2	late cornified envelope 1A2	0.011
Cpd	carboxypeptidase D	0.011
Cuzd1	CUB and zona pellucida-like domains 1	0.011
Adam1b	a disintegrin and metallopeptidase domain 1b	0.011	Mouse
Zfp385a	zinc finger protein 385A	0.011
Fmr1nb	fragile X mental retardation 1 neighbor	0.011
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
4933421I07Rik	RIKEN cDNA 4933421I07 gene	0.011
Bcl7a	B-cell CLL/lymphoma 7A	0.011
Ccnb3	cyclin B3	0.011
Foxc2	forkhead box C2	0.011
Fes	feline sarcoma oncogene	0.011
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.011
4930549C01Rik	RIKEN cDNA 4930549C01 gene	0.011
Nmur2	neuromedin U receptor 2	0.011
Serp1	stress-associated endoplasmic reticulum protein 1	0.011
Flna	filamin, alpha	0.011
Adam1a	a disintegrin and metallopeptidase domain 1a	0.011	Mouse
Oscar	osteoclast associated receptor	0.011
Clcn1	chloride channel 1	0.011
Galntl5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	0.011
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.011
Epha6	Eph receptor A6	0.010
4932438H23Rik	RIKEN cDNA 4932438H23 gene	0.010
4930519G04Rik	RIKEN cDNA 4930519G04 gene	0.010
Shc3	src homology 2 domain-containing transforming protein C3	0.010
Rpe65	retinal pigment epithelium 65	0.010
Ttc39d	tetratricopeptide repeat domain 39D	0.010
4933415F23Rik	RIKEN cDNA 4933415F23 gene	0.010
Lat2	linker for activation of T cells family, member 2	0.010
Ggt5	gamma-glutamyltransferase 5	0.010
Cyp11b2	cytochrome P450, family 11, subfamily b, polypeptide 2	0.010
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.010
Shc1	src homology 2 domain-containing transforming protein C1	0.010
Smc1b	structural maintenance of chromosomes 1B	0.010
Ifna12	interferon alpha 12	0.010
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.010
Nfya	nuclear transcription factor-Y alpha	0.010
Rgs14	regulator of G-protein signaling 14	0.010
Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	0.010
Tgfb1	transforming growth factor, beta 1	0.010
4933411G06Rik	RIKEN cDNA 4933411G06 gene	0.010
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.010
Mtpn	myotrophin	0.010
Dnajc5g	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma	0.010