IMP

Process View

Mus musculus

12 genes annotated in mouse

central nervous system myelination

GO:0022010

The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "central nervous system myelination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "central nervous system myelination" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.992
Sox9	SRY-box containing gene 9	0.913
Gli3	GLI-Kruppel family member GLI3	0.910
Fgfr2	fibroblast growth factor receptor 2	0.797	Mouse
Emx1	empty spiracles homolog 1 (Drosophila)	0.793
Otx2	orthodenticle homolog 2 (Drosophila)	0.742
Bmp4	bone morphogenetic protein 4	0.670
Ctnnb1	catenin (cadherin associated protein), beta 1	0.589
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.575
Fgf8	fibroblast growth factor 8	0.468
Nog	noggin	0.448
Isl1	ISL1 transcription factor, LIM/homeodomain	0.439
Sox2	SRY-box containing gene 2	0.425
Foxg1	forkhead box G1	0.407
Foxc1	forkhead box C1	0.402
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.301
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.286
Hand2	heart and neural crest derivatives expressed transcript 2	0.283
Fgf9	fibroblast growth factor 9	0.283
Gli2	GLI-Kruppel family member GLI2	0.259
Eya1	eyes absent 1 homolog (Drosophila)	0.257
Chrd	chordin	0.252
Pax2	paired box gene 2	0.240
Ednra	endothelin receptor type A	0.208
Hes1	hairy and enhancer of split 1 (Drosophila)	0.204	Mouse
Emx2	empty spiracles homolog 2 (Drosophila)	0.173
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.163
Tcf4	transcription factor 4	0.158
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.153
Pthlh	parathyroid hormone-like peptide	0.138
Cckbr	cholecystokinin B receptor	0.130
Otx1	orthodenticle homolog 1 (Drosophila)	0.129
Mog	myelin oligodendrocyte glycoprotein	0.128
Pdx1	pancreatic and duodenal homeobox 1	0.126
Gbx2	gastrulation brain homeobox 2	0.108
Chd7	chromodomain helicase DNA binding protein 7	0.103
Lhx1	LIM homeobox protein 1	0.101
Prox1	prospero-related homeobox 1	0.098
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.092
Ret	ret proto-oncogene	0.092
Pbx1	pre B-cell leukemia transcription factor 1	0.090
Neurod1	neurogenic differentiation 1	0.088
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.086
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.084
Foxc2	forkhead box C2	0.082
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.080
Hoxa5	homeobox A5	0.079
Smo	smoothened homolog (Drosophila)	0.079
Rarb	retinoic acid receptor, beta	0.076
Pou3f3	POU domain, class 3, transcription factor 3	0.076
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.075
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.073
Pax3	paired box gene 3	0.072
Fgf10	fibroblast growth factor 10	0.069
Tcf3	transcription factor 3	0.066
Tcfap2a	transcription factor AP-2, alpha	0.063
Lmx1b	LIM homeobox transcription factor 1 beta	0.062
Insm1	insulinoma-associated 1	0.058
Cux2	cut-like homeobox 2	0.057
Pou3f4	POU domain, class 3, transcription factor 4	0.056
Jag1	jagged 1	0.056
Foxa2	forkhead box A2	0.055	Zebrafish
Vangl2	vang-like 2 (van gogh, Drosophila)	0.055
Hoxd13	homeobox D13	0.054
Rb1	retinoblastoma 1	0.053
Pax6	paired box gene 6	0.052
Fgfr3	fibroblast growth factor receptor 3	0.052
En1	engrailed 1	0.051
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.050
Gpm6b	glycoprotein m6b	0.048	Mouse
Plp1	proteolipid protein (myelin) 1	0.047
Sox11	SRY-box containing gene 11	0.045
Tcf21	transcription factor 21	0.045
Dsg4	desmoglein 4	0.044
Wnt5a	wingless-related MMTV integration site 5A	0.044
Trp53	transformation related protein 53	0.044
Lhx5	LIM homeobox protein 5	0.043
Meis2	Meis homeobox 2	0.043
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.043	Mouse
Sparcl1	SPARC-like 1	0.043
Sall3	sal-like 3 (Drosophila)	0.041
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.041
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.041
Chl1	cell adhesion molecule with homology to L1CAM	0.040
Prnp	prion protein	0.040
Neurod2	neurogenic differentiation 2	0.040
Rarg	retinoic acid receptor, gamma	0.038
Sox4	SRY-box containing gene 4	0.038
Espn	espin	0.038
Dcc	deleted in colorectal carcinoma	0.037
Mobp	myelin-associated oligodendrocytic basic protein	0.036
Tcfap2b	transcription factor AP-2 beta	0.036
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.035
Hoxd3	homeobox D3	0.035
Ncam2	neural cell adhesion molecule 2	0.035
Calb1	calbindin 1	0.034
Hoxa3	homeobox A3	0.033
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.033
Zic1	zinc finger protein of the cerebellum 1	0.033
Ptch1	patched homolog 1	0.033
Rara	retinoic acid receptor, alpha	0.032
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.032	Mouse
Id3	inhibitor of DNA binding 3	0.031	Mouse
Bdnf	brain derived neurotrophic factor	0.031
Fgfr1	fibroblast growth factor receptor 1	0.031	Mouse
Olig1	oligodendrocyte transcription factor 1	0.030
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.030
Mmp24	matrix metallopeptidase 24	0.030
Notch1	Notch gene homolog 1 (Drosophila)	0.030
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.030
Nkx2-1	NK2 homeobox 1	0.029
Hoxd11	homeobox D11	0.029
Hes3	hairy and enhancer of split 3 (Drosophila)	0.028	Mouse
Meox2	mesenchyme homeobox 2	0.028
Bmp5	bone morphogenetic protein 5	0.028
Lgr5	leucine rich repeat containing G protein coupled receptor 5	0.027
Fgf14	fibroblast growth factor 14	0.026
Lhx9	LIM homeobox protein 9	0.026
Syt7	synaptotagmin VII	0.025
Gsc	goosecoid homeobox	0.024
Pitx2	paired-like homeodomain transcription factor 2	0.024
Pax8	paired box gene 8	0.024
Tbx3	T-box 3	0.024
Sstr3	somatostatin receptor 3	0.024
Nobox	NOBOX oogenesis homeobox	0.023
Nfib	nuclear factor I/B	0.023
Hoxa13	homeobox A13	0.023
Gjb6	gap junction protein, beta 6	0.023
Dab1	disabled homolog 1 (Drosophila)	0.022
Olig2	oligodendrocyte transcription factor 2	0.022
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.022
Cntn2	contactin 2	0.022
Gpr37	G protein-coupled receptor 37	0.022
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.021
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.021
Id1	inhibitor of DNA binding 1	0.021	Mouse
Nodal	nodal	0.020
Dlx5	distal-less homeobox 5	0.020
Cdh11	cadherin 11	0.020
Hes5	hairy and enhancer of split 5 (Drosophila)	0.020
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.020
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.019
Myo6	myosin VI	0.019
Rdh10	retinol dehydrogenase 10 (all-trans)	0.019
Alx3	aristaless-like homeobox 3	0.019
Mgat3	mannoside acetylglucosaminyltransferase 3	0.019
Adam22	a disintegrin and metallopeptidase domain 22	0.019
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.019
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.019
Uncx	UNC homeobox	0.019
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.019
Cnr1	cannabinoid receptor 1 (brain)	0.018
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.018
Avp	arginine vasopressin	0.018
Nxph1	neurexophilin 1	0.018
Fgf12	fibroblast growth factor 12	0.018
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.018
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.018
Nrip2	nuclear receptor interacting protein 2	0.018
Hesx1	homeobox gene expressed in ES cells	0.018
Marcks	myristoylated alanine rich protein kinase C substrate	0.018
Efnb2	ephrin B2	0.018
Kl	klotho	0.017
Slc12a1	solute carrier family 12, member 1	0.017
Aqp7	aquaporin 7	0.017
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.017
Glra1	glycine receptor, alpha 1 subunit	0.017
Astn1	astrotactin 1	0.017
Bmp7	bone morphogenetic protein 7	0.017
Ugt8a	UDP galactosyltransferase 8A	0.017
Cnnm1	cyclin M1	0.017
Crhr2	corticotropin releasing hormone receptor 2	0.017
Hsf4	heat shock transcription factor 4	0.017
Inadl	InaD-like (Drosophila)	0.016
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.016
Lhx3	LIM homeobox protein 3	0.016
Klk6	kallikrein related-peptidase 6	0.016
Pten	phosphatase and tensin homolog	0.016
Pclo	piccolo (presynaptic cytomatrix protein)	0.016
Tbx1	T-box 1	0.016
Cntn3	contactin 3	0.016	Mouse
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.016	Mouse
Gas1	growth arrest specific 1	0.016
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.016
Sall4	sal-like 4 (Drosophila)	0.016
Adam23	a disintegrin and metallopeptidase domain 23	0.016
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.016
Gata3	GATA binding protein 3	0.015
Dnase1l2	deoxyribonuclease 1-like 2	0.015
Unc5c	unc-5 homolog C (C. elegans)	0.015
Neurog2	neurogenin 2	0.015
Shc3	src homology 2 domain-containing transforming protein C3	0.015
Ikzf1	IKAROS family zinc finger 1	0.015
Esrrb	estrogen related receptor, beta	0.015
Lepr	leptin receptor	0.015
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.015
Zic4	zinc finger protein of the cerebellum 4	0.015
Id4	inhibitor of DNA binding 4	0.015
Cpe	carboxypeptidase E	0.015
Cdh10	cadherin 10	0.014
Nrg3	neuregulin 3	0.014
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.014
Cplx2	complexin 2	0.014
Gja3	gap junction protein, alpha 3	0.014
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.014
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.014
Grik3	glutamate receptor, ionotropic, kainate 3	0.014
Tgfb2	transforming growth factor, beta 2	0.014
Nefm	neurofilament, medium polypeptide	0.014
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.014
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.014
Ptprd	protein tyrosine phosphatase, receptor type, D	0.014
Apc	adenomatosis polyposis coli	0.014
Dlx6	distal-less homeobox 6	0.014
Fgf15	fibroblast growth factor 15	0.014
Cadm1	cell adhesion molecule 1	0.014
Ppap2b	phosphatidic acid phosphatase type 2B	0.014
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.014
Pnoc	prepronociceptin	0.014
Hoxa2	homeobox A2	0.013
Ntf3	neurotrophin 3	0.013
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.013
Epha5	Eph receptor A5	0.013
Adra1a	adrenergic receptor, alpha 1a	0.013
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.013
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.013
AI118078	expressed sequence AI118078	0.013
Neurog3	neurogenin 3	0.013
Axin2	axin2	0.013
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.013
Gli1	GLI-Kruppel family member GLI1	0.013
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.013
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.013
Bcl2	B-cell leukemia/lymphoma 2	0.013
Cdh8	cadherin 8	0.012
Mmp16	matrix metallopeptidase 16	0.012
Gm98	predicted gene 98	0.012
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.012
Crhr1	corticotropin releasing hormone receptor 1	0.012
Frmd5	FERM domain containing 5	0.012
Wnk2	WNK lysine deficient protein kinase 2	0.012
Gcgr	glucagon receptor	0.012
Sox1	SRY-box containing gene 1	0.012
Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	0.012
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.012
Kcnk3	potassium channel, subfamily K, member 3	0.012
Ntm	neurotrimin	0.012
Per3	period homolog 3 (Drosophila)	0.012
Prrx1	paired related homeobox 1	0.012
Hmx1	H6 homeobox 1	0.012
Cxcl12	chemokine (C-X-C motif) ligand 12	0.012
Tshz2	teashirt zinc finger family member 2	0.012
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.012	Mouse
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.012
Peg3	paternally expressed 3	0.012
Gad2	glutamic acid decarboxylase 2	0.012
Dll1	delta-like 1 (Drosophila)	0.012
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.012
En2	engrailed 2	0.012
Zic2	zinc finger protein of the cerebellum 2	0.012
Msx1	homeobox, msh-like 1	0.012
Bcl11b	B-cell leukemia/lymphoma 11B	0.012
Lrp6	low density lipoprotein receptor-related protein 6	0.012
Fgfrl1	fibroblast growth factor receptor-like 1	0.012
Zscan2	zinc finger and SCAN domain containing 2	0.012
Slc12a5	solute carrier family 12, member 5	0.011
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.011
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.011
Rgs6	regulator of G-protein signaling 6	0.011
Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	0.011
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.011
Ldb2	LIM domain binding 2	0.011
Col2a1	collagen, type II, alpha 1	0.011
Btbd17	BTB (POZ) domain containing 17	0.011
Stx1b	syntaxin 1B	0.011
Gdf11	growth differentiation factor 11	0.011
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.011
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.011
Tlx2	T-cell leukemia, homeobox 2	0.011
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.011
Sim2	single-minded homolog 2 (Drosophila)	0.011
Pde1c	phosphodiesterase 1C	0.011
Grid2	glutamate receptor, ionotropic, delta 2	0.011
Lef1	lymphoid enhancer binding factor 1	0.011
Pax1	paired box gene 1	0.011
Casq2	calsequestrin 2	0.011
Emid2	EMI domain containing 2	0.011
Vegfa	vascular endothelial growth factor A	0.011
Cplx1	complexin 1	0.011
Msx2	homeobox, msh-like 2	0.010
Foxa1	forkhead box A1	0.010
Npr3	natriuretic peptide receptor 3	0.010
Psen1	presenilin 1	0.010
S1pr3	sphingosine-1-phosphate receptor 3	0.010
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.010
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.010
Hcn1	hyperpolarization-activated, cyclic nucleotide-gated K+ 1	0.010
C1ql1	complement component 1, q subcomponent-like 1	0.010
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.010
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.010
Gabra3	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3	0.010
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.010