IMP

Process View

Mus musculus

16 genes annotated in mouse

negative regulation of peptide hormone secretion

Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of peptide hormone secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of peptide hormone secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Lep	leptin	0.970
Esr1	estrogen receptor 1 (alpha)	0.868
Tgfb1	transforming growth factor, beta 1	0.829
Pten	phosphatase and tensin homolog	0.824
Lepr	leptin receptor	0.809
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.737
Nos3	nitric oxide synthase 3, endothelial cell	0.692
Apc	adenomatosis polyposis coli	0.561
Ghr	growth hormone receptor	0.526
Fshr	follicle stimulating hormone receptor	0.526
LOC100048884	novel member of the major urinary protein (Mup) gene family	0.490	Mouse
Insr	insulin receptor	0.455
Tgfbr2	transforming growth factor, beta receptor II	0.412	Mouse
Esr2	estrogen receptor 2 (beta)	0.367
Fst	follistatin	0.365
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.299
Mup10	major urinary protein 10	0.281	Mouse
Mup19	major urinary protein 19	0.272	Mouse
Prlr	prolactin receptor	0.258
Amhr2	anti-Mullerian hormone type 2 receptor	0.255	Mouse
Gata4	GATA binding protein 4	0.247
Trp53	transformation related protein 53	0.226
Kiss1	KiSS-1 metastasis-suppressor	0.226
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.222
Cav1	caveolin 1, caveolae protein	0.221
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.212
Vegfa	vascular endothelial growth factor A	0.210
Mup9	major urinary protein 9	0.201	Mouse
Pim3	proviral integration site 3	0.186
Ldlr	low density lipoprotein receptor	0.173
Ar	androgen receptor	0.168
Irs2	insulin receptor substrate 2	0.166
Mup8	major urinary protein 8	0.164	Mouse
Plin1	perilipin 1	0.130
Tgfbr1	transforming growth factor, beta receptor I	0.128	Mouse
Mup12	major urinary protein 12	0.126	Mouse
Mup1	major urinary protein 1	0.126
Nf1	neurofibromatosis 1	0.123
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.107
Pim2	proviral integration site 2	0.106	Mouse
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.106
Pomc	pro-opiomelanocortin-alpha	0.103
Nos2	nitric oxide synthase 2, inducible	0.097
Mup13	major urinary protein 13	0.096
Mup3	major urinary protein 3	0.092	Mouse
Mup17	major urinary protein 17	0.092
Mup14	major urinary protein 14	0.091	Mouse
LOC100048885	major urinary protein LOC100048885	0.084	Mouse
Pim1	proviral integration site 1	0.082	Mouse
Mup2	major urinary protein 2	0.079	Mouse
Mup7	major urinary protein 7	0.076	Mouse
Mup15	major urinary protein 15	0.076	Mouse
Ncoa3	nuclear receptor coactivator 3	0.074
Prkg1	protein kinase, cGMP-dependent, type I	0.074
Pparg	peroxisome proliferator activated receptor gamma	0.073
Mup11	major urinary protein 11	0.071	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.068
Nos1	nitric oxide synthase 1, neuronal	0.068	Rat
Igf1	insulin-like growth factor 1	0.064
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.064
Drd2	dopamine receptor D2	0.062	Rat
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.059
Sfrp2	secreted frizzled-related protein 2	0.059
Apoe	apolipoprotein E	0.057
Pnpla2	patatin-like phospholipase domain containing 2	0.055
U46068	cDNA sequence U46068	0.054
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.052
Csf1	colony stimulating factor 1 (macrophage)	0.048
Crh	corticotropin releasing hormone	0.046	Rat
Mstn	myostatin	0.046
Svs5	seminal vesicle secretory protein 5	0.043
Shc1	src homology 2 domain-containing transforming protein C1	0.042
Smad4	MAD homolog 4 (Drosophila)	0.042
Wwox	WW domain-containing oxidoreductase	0.040
Cidec	cell death-inducing DFFA-like effector c	0.040
Nodal	nodal	0.040
Mup5	major urinary protein 5	0.040	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.038
Gata6	GATA binding protein 6	0.036
Mup4	major urinary protein 4	0.036	Mouse
Gja1	gap junction protein, alpha 1	0.036
Sik3	SIK family kinase 3	0.036
Col1a1	collagen, type I, alpha 1	0.035
Klk1b26	kallikrein 1-related petidase b26	0.033
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.032	Mouse
Adipoq	adiponectin, C1Q and collagen domain containing	0.031
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.031
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.031
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.030
Mbl1	mannose-binding lectin (protein A) 1	0.029
Inhba	inhibin beta-A	0.028	Mouse
Vav2	vav 2 oncogene	0.028
Cd70	CD70 antigen	0.027
En1	engrailed 1	0.026
Rxra	retinoid X receptor alpha	0.026
Accn5	amiloride-sensitive cation channel 5, intestinal	0.025
Egfr	epidermal growth factor receptor	0.025
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.024
Jag1	jagged 1	0.024
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.023
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.022
Srf	serum response factor	0.022
Inhbb	inhibin beta-B	0.022
Klk1b4	kallikrein 1-related pepidase b4	0.022
Socs1	suppressor of cytokine signaling 1	0.021
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.021
Fgf8	fibroblast growth factor 8	0.021
Irs3	insulin receptor substrate 3	0.021
Ptgs2	prostaglandin-endoperoxide synthase 2	0.021
Btn1a1	butyrophilin, subfamily 1, member A1	0.021
Ifnb1	interferon beta 1, fibroblast	0.021
Kiss1r	KISS1 receptor	0.021
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.021
Pkm2	pyruvate kinase, muscle	0.021
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.020
Apoa4	apolipoprotein A-IV	0.020
Pdx1	pancreatic and duodenal homeobox 1	0.020
Bglap	bone gamma carboxyglutamate protein	0.020
Kl	klotho	0.020
Zbtb7a	zinc finger and BTB domain containing 7a	0.020
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.019
Ros1	Ros1 proto-oncogene	0.019
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.019
Clock	circadian locomotor output cycles kaput	0.018
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.018
Sstr3	somatostatin receptor 3	0.018
Thra	thyroid hormone receptor alpha	0.018
Ang2	angiogenin, ribonuclease A family, member 2	0.018
Agrp	agouti related protein	0.018
Obp1a	odorant binding protein Ia	0.018	Mouse
Eng	endoglin	0.017
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.017
Adam17	a disintegrin and metallopeptidase domain 17	0.017
Krt19	keratin 19	0.017
Gcgr	glucagon receptor	0.017
Klk1b8	kallikrein 1-related peptidase b8	0.017
Pde8b	phosphodiesterase 8B	0.017	Rat
Htt	huntingtin	0.017
Vdr	vitamin D receptor	0.017	Mouse
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.016
Hoxd13	homeobox D13	0.015
Foxo3	forkhead box O3	0.015
Myh10	myosin, heavy polypeptide 10, non-muscle	0.015
Stat3	signal transducer and activator of transcription 3	0.015
Krt36	keratin 36	0.015
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.015
Plcg1	phospholipase C, gamma 1	0.015
Gnrh1	gonadotropin releasing hormone 1	0.015
Krtap8-2	keratin associated protein 8-2	0.015
Adrb3	adrenergic receptor, beta 3	0.014
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.014
Epas1	endothelial PAS domain protein 1	0.014
Klk1b1	kallikrein 1-related peptidase b1	0.014
Otc	ornithine transcarbamylase	0.014
Hdac2	histone deacetylase 2	0.013
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.013
Npc1	Niemann Pick type C1	0.013
Skil	SKI-like	0.013
Sult1d1	sulfotransferase family 1D, member 1	0.013
Ryr2	ryanodine receptor 2, cardiac	0.013
Ece1	endothelin converting enzyme 1	0.013
Prodh2	proline dehydrogenase (oxidase) 2	0.013
Mta2	metastasis-associated gene family, member 2	0.013
Gpr37	G protein-coupled receptor 37	0.013
Stat5b	signal transducer and activator of transcription 5B	0.013
Reg3a	regenerating islet-derived 3 alpha	0.013
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.012
Tnp2	transition protein 2	0.012
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.012
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.012
Cfd	complement factor D (adipsin)	0.012
Klf3	Kruppel-like factor 3 (basic)	0.012
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.012
Smyd1	SET and MYND domain containing 1	0.012
Art1	ADP-ribosyltransferase 1	0.012
Mark4	MAP/microtubule affinity-regulating kinase 4	0.012
Homer1	homer homolog 1 (Drosophila)	0.012
Mapk8	mitogen-activated protein kinase 8	0.012
Sox9	SRY-box containing gene 9	0.012
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.012
a	nonagouti	0.011
Sardh	sarcosine dehydrogenase	0.011
Muc3	mucin 3, intestinal	0.011
Cps1	carbamoyl-phosphate synthetase 1	0.011
Scd1	stearoyl-Coenzyme A desaturase 1	0.011
Ces3a	carboxylesterase 3A	0.011
Hoxb13	homeobox B13	0.011
Naa11	N(alpha)-acetyltransferase 11, NatA catalytic subunit	0.011
Lipe	lipase, hormone sensitive	0.011
Npy1r	neuropeptide Y receptor Y1	0.011
Fzd4	frizzled homolog 4 (Drosophila)	0.011
Bcl6	B-cell leukemia/lymphoma 6	0.011
Fam83f	family with sequence similarity 83, member F	0.011
Sry	sex determining region of Chr Y	0.011
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.011
Drd1a	dopamine receptor D1A	0.011
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.011
Orm2	orosomucoid 2	0.010
Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	0.010
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.010
Idua	iduronidase, alpha-L-	0.010
Acvr2a	activin receptor IIA	0.010
Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	0.010
Phox2b	paired-like homeobox 2b	0.010
Adra1b	adrenergic receptor, alpha 1b	0.010
Tff3	trefoil factor 3, intestinal	0.010
St6galnac1	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	0.010
Mug2	murinoglobulin 2	0.010
Svs2	seminal vesicle secretory protein 2	0.010
Neurog3	neurogenin 3	0.010
Sntb1	syntrophin, basic 1	0.010