IMP

Process View

Mus musculus

13 genes annotated in mouse

negative regulation of microtubule depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of microtubule depolymerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of microtubule depolymerization" (in gray)

Name	Description	Probability	Func Analog Organism
Prc1	protein regulator of cytokinesis 1	0.959	Worm Fly
Cdk1	cyclin-dependent kinase 1	0.952
Ccnb1	cyclin B1	0.876	Human
Ccna2	cyclin A2	0.729
Anln	anillin, actin binding protein	0.720
Ckap2	cytoskeleton associated protein 2	0.706
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.647
Kif20a	kinesin family member 20A	0.597
Birc5	baculoviral IAP repeat-containing 5	0.578
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.565
Ccnb2	cyclin B2	0.563
Dcx	doublecortin	0.455	Worm
Dclk1	doublecortin-like kinase 1	0.431	Worm
Braf	Braf transforming gene	0.423
Plk1	polo-like kinase 1 (Drosophila)	0.361
Kif4	kinesin family member 4	0.360
Trim63	tripartite motif-containing 63	0.356	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.353
Kif11	kinesin family member 11	0.310	Fly
Cdkn3	cyclin-dependent kinase inhibitor 3	0.294
Top2a	topoisomerase (DNA) II alpha	0.291
Racgap1	Rac GTPase-activating protein 1	0.277
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.272
Kif23	kinesin family member 23	0.242
Kif22	kinesin family member 22	0.230
Kif2c	kinesin family member 2C	0.225
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.192
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.190
Gtse1	G two S phase expressed protein 1	0.185
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.177
Mki67	antigen identified by monoclonal antibody Ki 67	0.174
Nf1	neurofibromatosis 1	0.169
Ctnnb1	catenin (cadherin associated protein), beta 1	0.164
Bdnf	brain derived neurotrophic factor	0.163
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.145
Trp63	transformation related protein 63	0.137
Lmna	lamin A	0.129
Smc4	structural maintenance of chromosomes 4	0.126
Fgfr2	fibroblast growth factor receptor 2	0.111
Gsk3b	glycogen synthase kinase 3 beta	0.106
H2afx	H2A histone family, member X	0.097
Fam64a	family with sequence similarity 64, member A	0.094
Egfr	epidermal growth factor receptor	0.093
Mxd3	Max dimerization protein 3	0.093
Cdca8	cell division cycle associated 8	0.088
Pax2	paired box gene 2	0.086
Gata3	GATA binding protein 3	0.083
Trim55	tripartite motif-containing 55	0.082	Mouse
Tbx10	T-box 10	0.079
Tcf21	transcription factor 21	0.072
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.071
Ube2c	ubiquitin-conjugating enzyme E2C	0.070
Aurka	aurora kinase A	0.068	Human
Mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.068
Trp53	transformation related protein 53	0.066
Nkx2-1	NK2 homeobox 1	0.066
Cenpa	centromere protein A	0.065
Smc2	structural maintenance of chromosomes 2	0.064
Ccdc99	coiled-coil domain containing 99	0.061
Cdca5	cell division cycle associated 5	0.056
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.056
Bcl2	B-cell leukemia/lymphoma 2	0.056
Ar	androgen receptor	0.055
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.054
Tbx15	T-box 15	0.052
Atcay	ataxia, cerebellar, Cayman type homolog (human)	0.050
Pou3f4	POU domain, class 3, transcription factor 4	0.050
Mstn	myostatin	0.050
Otx2	orthodenticle homolog 2 (Drosophila)	0.048
Tacc3	transforming, acidic coiled-coil containing protein 3	0.043
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.043
Pgr	progesterone receptor	0.042
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.041
Fgfbp1	fibroblast growth factor binding protein 1	0.041
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.040
Exoc3	exocyst complex component 3	0.039
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.039
Epas1	endothelial PAS domain protein 1	0.036
Cks2	CDC28 protein kinase regulatory subunit 2	0.035
Foxg1	forkhead box G1	0.035
Clasp2	CLIP associating protein 2	0.035
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.034
Socs5	suppressor of cytokine signaling 5	0.033
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.033
Cenpf	centromere protein F	0.031
Cep55	centrosomal protein 55	0.031
Plaa	phospholipase A2, activating protein	0.030
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.029
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.029
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.028
Fam83d	family with sequence similarity 83, member D	0.028
Ids	iduronate 2-sulfatase	0.028
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.028
Btbd3	BTB (POZ) domain containing 3	0.027
Ntf3	neurotrophin 3	0.027
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.027
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.027
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.027
Th	tyrosine hydroxylase	0.027
Ttk	Ttk protein kinase	0.026
Spag5	sperm associated antigen 5	0.025
Nefm	neurofilament, medium polypeptide	0.025
Macf1	microtubule-actin crosslinking factor 1	0.025	Fly
Spna2	spectrin alpha 2	0.025
Tcf19	transcription factor 19	0.024
Shh	sonic hedgehog	0.024
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.024
Diap3	diaphanous homolog 3 (Drosophila)	0.023
Ubr4	ubiquitin protein ligase E3 component n-recognin 4	0.023
Clip1	CAP-GLY domain containing linker protein 1	0.023
Kif3b	kinesin family member 3B	0.023
Ncaph	non-SMC condensin I complex, subunit H	0.022
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.022
Pou4f3	POU domain, class 4, transcription factor 3	0.021
Shc3	src homology 2 domain-containing transforming protein C3	0.021
Trim59	tripartite motif-containing 59	0.021	Mouse
Kif3a	kinesin family member 3A	0.021
Dtna	dystrobrevin alpha	0.020
Dync1h1	dynein cytoplasmic 1 heavy chain 1	0.020
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.020
Adra1a	adrenergic receptor, alpha 1a	0.019
Slc4a2	solute carrier family 4 (anion exchanger), member 2	0.019
Ccnf	cyclin F	0.019
Mis18bp1	MIS18 binding protein 1	0.019
Tsc2	tuberous sclerosis 2	0.018
Ptgs2	prostaglandin-endoperoxide synthase 2	0.018
Irx6	Iroquois related homeobox 6 (Drosophila)	0.018
Plcb1	phospholipase C, beta 1	0.018
Mastl	microtubule associated serine/threonine kinase-like	0.018
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.018
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.018
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.018
Fgf9	fibroblast growth factor 9	0.018	Mouse
Iqcb1	IQ calmodulin-binding motif containing 1	0.018
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.018
Gpr83	G protein-coupled receptor 83	0.017
Zic3	zinc finger protein of the cerebellum 3	0.017
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.017
Itga3	integrin alpha 3	0.017
Zfpm2	zinc finger protein, multitype 2	0.017
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.017
Kitl	kit ligand	0.016
Myo1c	myosin IC	0.016
Trim54	tripartite motif-containing 54	0.016
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.016
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.016
Ckap5	cytoskeleton associated protein 5	0.016
Pten	phosphatase and tensin homolog	0.016
Ect2	ect2 oncogene	0.016
Smad4	MAD homolog 4 (Drosophila)	0.016
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.015
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.015
Spnb2	spectrin beta 2	0.015
Nefl	neurofilament, light polypeptide	0.015
Lmx1a	LIM homeobox transcription factor 1 alpha	0.015
Zfp40	zinc finger protein 40	0.015
Gli3	GLI-Kruppel family member GLI3	0.015
Dpysl2	dihydropyrimidinase-like 2	0.015
Vangl2	vang-like 2 (van gogh, Drosophila)	0.014
Pbx1	pre B-cell leukemia transcription factor 1	0.014
Murc	muscle-related coiled-coil protein	0.014
Nusap1	nucleolar and spindle associated protein 1	0.014
Nsd1	nuclear receptor-binding SET-domain protein 1	0.014
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.014
Tcf15	transcription factor 15	0.014
Hif1a	hypoxia inducible factor 1, alpha subunit	0.014
Casq2	calsequestrin 2	0.014
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.014
Rxra	retinoid X receptor alpha	0.013
Tgfbr3	transforming growth factor, beta receptor III	0.013
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.013
Myom2	myomesin 2	0.013
Tsc1	tuberous sclerosis 1	0.013
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.013
Cc2d1a	coiled-coil and C2 domain containing 1A	0.013
Fgf13	fibroblast growth factor 13	0.013
Mybpc1	myosin binding protein C, slow-type	0.013
Esr2	estrogen receptor 2 (beta)	0.013
Prrx1	paired related homeobox 1	0.013
Tmc6	transmembrane channel-like gene family 6	0.013
Pfn2	profilin 2	0.013
Prkci	protein kinase C, iota	0.013
Lama5	laminin, alpha 5	0.012
Nrap	nebulin-related anchoring protein	0.012
Lats1	large tumor suppressor	0.012
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.012
Napb	N-ethylmaleimide sensitive fusion protein attachment protein beta	0.012
Prdm16	PR domain containing 16	0.012
Tmpo	thymopoietin	0.012
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.012
Twist2	twist homolog 2 (Drosophila)	0.012
Anapc2	anaphase promoting complex subunit 2	0.012
Flii	flightless I homolog (Drosophila)	0.012
Gsg2	germ cell-specific gene 2	0.012
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.012
Fgfr3	fibroblast growth factor receptor 3	0.012
En1	engrailed 1	0.012
Clasp1	CLIP associating protein 1	0.012
Kcnk4	potassium channel, subfamily K, member 4	0.012
Mme	membrane metallo endopeptidase	0.012
Aurkb	aurora kinase B	0.012	Human
Astn1	astrotactin 1	0.011
En2	engrailed 2	0.011
Actn2	actinin alpha 2	0.011
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.011
Lepr	leptin receptor	0.011
Fgf14	fibroblast growth factor 14	0.011	Mouse
Cend1	cell cycle exit and neuronal differentiation 1	0.011
Exoc7	exocyst complex component 7	0.011
Cdh15	cadherin 15	0.011
Utrn	utrophin	0.011
Traf7	TNF receptor-associated factor 7	0.011
Myo18a	myosin XVIIIA	0.011
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.011
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.011
Tuba1a	tubulin, alpha 1A	0.011
D730040F13Rik	RIKEN cDNA D730040F13 gene	0.011
Ppp1r14c	protein phosphatase 1, regulatory (inhibitor) subunit 14c	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Epha1	Eph receptor A1	0.011
Sac3d1	SAC3 domain containing 1	0.011
Invs	inversin	0.011
Stam2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.011
Rapsn	receptor-associated protein of the synapse	0.011
AA516738	expressed sequence AA516738	0.010
Grm8	glutamate receptor, metabotropic 8	0.010
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.010
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.010
Dusp27	dual specificity phosphatase 27 (putative)	0.010
Dctn1	dynactin 1	0.010
Sh3pxd2b	SH3 and PX domains 2B	0.010
Gbx2	gastrulation brain homeobox 2	0.010
Nog	noggin	0.010