IMP

Process View

Mus musculus

19 genes annotated in mouse

execution phase of apoptosis

A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "execution phase of apoptosis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "execution phase of apoptosis" (in gray)

Name	Description	Probability	Func Analog Organism
Gbp5	guanylate binding protein 5	0.750
Pycard	PYD and CARD domain containing	0.487
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.363
Gopc	golgi associated PDZ and coiled-coil motif containing	0.356
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.191	Mouse Worm
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.165
Igh	immunoglobulin heavy chain complex	0.122
Ikbkb	inhibitor of kappaB kinase beta	0.119
Dlg4	discs, large homolog 4 (Drosophila)	0.116
Bcl2	B-cell leukemia/lymphoma 2	0.089
Dffb	DNA fragmentation factor, beta subunit	0.086
Il18	interleukin 18	0.075
Ikbkg	inhibitor of kappaB kinase gamma	0.070
Casp1	caspase 1	0.066	Mouse Worm
Wnt5a	wingless-related MMTV integration site 5A	0.052
Sharpin	SHANK-associated RH domain interacting protein	0.046
Axin1	axin 1	0.046
Nmi	N-myc (and STAT) interactor	0.044
Dlg1	discs, large homolog 1 (Drosophila)	0.044
Akt1	thymoma viral proto-oncogene 1	0.042
Rnf31	ring finger protein 31	0.040
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.038
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.037
Adam10	a disintegrin and metallopeptidase domain 10	0.034
Plin1	perilipin 1	0.032
Prc1	protein regulator of cytokinesis 1	0.032
Ldb3	LIM domain binding 3	0.029
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.029
Cd28	CD28 antigen	0.029
Tgfbr1	transforming growth factor, beta receptor I	0.028
Fzd8	frizzled homolog 8 (Drosophila)	0.028	Mouse
Safb	scaffold attachment factor B	0.027
Erh	enhancer of rudimentary homolog (Drosophila)	0.027
Tbx3	T-box 3	0.027
Dlg2	discs, large homolog 2 (Drosophila)	0.026
Atr	ataxia telangiectasia and Rad3 related	0.026
Casp8	caspase 8	0.025	Human Mouse
Cxcl9	chemokine (C-X-C motif) ligand 9	0.025
H2afz	H2A histone family, member Z	0.025
Scn5a	sodium channel, voltage-gated, type V, alpha	0.024
Dck	deoxycytidine kinase	0.023
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.022
Bag6	BCL2-associated athanogene 6	0.022
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.022
Bak1	BCL2-antagonist/killer 1	0.022
Mtx2	metaxin 2	0.021
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.021
Rbl1	retinoblastoma-like 1 (p107)	0.020
Gpc3	glypican 3	0.020
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.020
Becn1	beclin 1, autophagy related	0.020
Nfya	nuclear transcription factor-Y alpha	0.019
Sardh	sarcosine dehydrogenase	0.019
Apaf1	apoptotic peptidase activating factor 1	0.019
Csnk1g2	casein kinase 1, gamma 2	0.019
Add1	adducin 1 (alpha)	0.019
Ighmbp2	immunoglobulin mu binding protein 2	0.018
Hif1a	hypoxia inducible factor 1, alpha subunit	0.018
Sfrp2	secreted frizzled-related protein 2	0.018
Eya2	eyes absent 2 homolog (Drosophila)	0.017
Coro1b	coronin, actin binding protein 1B	0.017
Rbm42	RNA binding motif protein 42	0.017
Aim2	absent in melanoma 2	0.017
Ctdnep1	CTD nuclear envelope phosphatase 1	0.016
Hsf1	heat shock factor 1	0.016
Sfrp1	secreted frizzled-related protein 1	0.016
Hmgb1	high mobility group box 1	0.016
Bbc3	BCL2 binding component 3	0.016
Fjx1	four jointed box 1 (Drosophila)	0.016
Tlr4	toll-like receptor 4	0.016
Hmgb2	high mobility group box 2	0.016
Akt2	thymoma viral proto-oncogene 2	0.016	Mouse
Pygo2	pygopus 2	0.015
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.015
Hibch	3-hydroxyisobutyryl-Coenzyme A hydrolase	0.015
Gja5	gap junction protein, alpha 5	0.015
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.015
Cidea	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A	0.015
Drosha	drosha, ribonuclease type III	0.015
Vhl	von Hippel-Lindau tumor suppressor	0.015
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.015
Fam96a	family with sequence similarity 96, member A	0.015
Rbck1	RanBP-type and C3HC4-type zinc finger containing 1	0.014	Mouse
Tspan12	tetraspanin 12	0.014
Mfap2	microfibrillar-associated protein 2	0.014
Smo	smoothened homolog (Drosophila)	0.014
Vars	valyl-tRNA synthetase	0.014
Cd40	CD40 antigen	0.014
Ptgfr	prostaglandin F receptor	0.014
Hcfc1	host cell factor C1	0.014
Nsa2	NSA2 ribosome biogenesis homolog (S. cerevisiae)	0.014
Ncln	nicalin homolog (zebrafish)	0.014
Adprhl2	ADP-ribosylhydrolase like 2	0.014
Tfam	transcription factor A, mitochondrial	0.014
Ldb1	LIM domain binding 1	0.014
Tmpo	thymopoietin	0.014
Tead2	TEA domain family member 2	0.014
Nr1h2	nuclear receptor subfamily 1, group H, member 2	0.014
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.013
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.013
Gas1	growth arrest specific 1	0.013
Ly96	lymphocyte antigen 96	0.013
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.013
Uqcrb	ubiquinol-cytochrome c reductase binding protein	0.013
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.013
Gli3	GLI-Kruppel family member GLI3	0.013
Mta2	metastasis-associated gene family, member 2	0.013
Bid	BH3 interacting domain death agonist	0.012
Casp3	caspase 3	0.012
Cdk1	cyclin-dependent kinase 1	0.012
Smad5	MAD homolog 5 (Drosophila)	0.012
Icos	inducible T-cell co-stimulator	0.012
Traf2	TNF receptor-associated factor 2	0.012
Crb2	crumbs homolog 2 (Drosophila)	0.012
Fgfr2	fibroblast growth factor receptor 2	0.012
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.012
Lep	leptin	0.012
Cxadr	coxsackie virus and adenovirus receptor	0.012
Hdac7	histone deacetylase 7	0.012
Npr3	natriuretic peptide receptor 3	0.012
Cycs	cytochrome c, somatic	0.012	Human
Ctsl	cathepsin L	0.012
Srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.011
Hoxd9	homeobox D9	0.011
Cidec	cell death-inducing DFFA-like effector c	0.011	Mouse
Col4a5	collagen, type IV, alpha 5	0.011
Clic1	chloride intracellular channel 1	0.011
Bmp7	bone morphogenetic protein 7	0.011
Fkbp3	FK506 binding protein 3	0.011
Dctn1	dynactin 1	0.011
Cyld	cylindromatosis (turban tumor syndrome)	0.011
Il1b	interleukin 1 beta	0.011
Mdfi	MyoD family inhibitor	0.011
Plekha5	pleckstrin homology domain containing, family A member 5	0.011
Mstn	myostatin	0.011
Alkbh1	alkB, alkylation repair homolog 1 (E. coli)	0.011
Ncoa3	nuclear receptor coactivator 3	0.011
Safb2	scaffold attachment factor B2	0.011
Gja1	gap junction protein, alpha 1	0.011
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.011
Ctsw	cathepsin W	0.010
Mllt1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.010
Fgfr3	fibroblast growth factor receptor 3	0.010
Invs	inversin	0.010
Grk6	G protein-coupled receptor kinase 6	0.010
Med12	mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)	0.010