IMP

Process View

Mus musculus

1 genes annotated in mouse

canonical wnt signaling pathway involved in neural crest cell differentiation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "canonical wnt signaling pathway involved in neural crest cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "canonical wnt signaling pathway involved in neural crest cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.992
Gli3	GLI-Kruppel family member GLI3	0.925
Fgfr1	fibroblast growth factor receptor 1	0.898
Shh	sonic hedgehog	0.892
Bmp4	bone morphogenetic protein 4	0.853
Ctnnb1	catenin (cadherin associated protein), beta 1	0.790
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.685
Smo	smoothened homolog (Drosophila)	0.619
Apoe	apolipoprotein E	0.568
Vangl2	vang-like 2 (van gogh, Drosophila)	0.520
Tbx3	T-box 3	0.463
Fgfr3	fibroblast growth factor receptor 3	0.422
Bmp7	bone morphogenetic protein 7	0.389
Msx1	homeobox, msh-like 1	0.368
Foxc1	forkhead box C1	0.328
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.318
Otx2	orthodenticle homolog 2 (Drosophila)	0.299
Gsk3b	glycogen synthase kinase 3 beta	0.285
Pkd1	polycystic kidney disease 1 homolog	0.265
Axin1	axin 1	0.253
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.253
Pax3	paired box gene 3	0.212
Foxc2	forkhead box C2	0.182
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.167
Prrx1	paired related homeobox 1	0.153
Zeb1	zinc finger E-box binding homeobox 1	0.151
Runx2	runt related transcription factor 2	0.131
Pitx2	paired-like homeodomain transcription factor 2	0.120
Fgf8	fibroblast growth factor 8	0.114
Sox11	SRY-box containing gene 11	0.112
Gli2	GLI-Kruppel family member GLI2	0.109
Msx2	homeobox, msh-like 2	0.105
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.099
Meox2	mesenchyme homeobox 2	0.091
Npc1	Niemann Pick type C1	0.090
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.088
Ptch1	patched homolog 1	0.086
Psen1	presenilin 1	0.086
Eya1	eyes absent 1 homolog (Drosophila)	0.083
Tcfap2a	transcription factor AP-2, alpha	0.081
Tgfb2	transforming growth factor, beta 2	0.077
Sertad2	SERTA domain containing 2	0.073
Foxg1	forkhead box G1	0.071
Prrx2	paired related homeobox 2	0.071
T	brachyury	0.064
Sox9	SRY-box containing gene 9	0.058
Dlx5	distal-less homeobox 5	0.056
Hand1	heart and neural crest derivatives expressed transcript 1	0.055
Pbx1	pre B-cell leukemia transcription factor 1	0.052
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.052
Jag1	jagged 1	0.050
Lef1	lymphoid enhancer binding factor 1	0.049
Chrd	chordin	0.044
Mks1	Meckel syndrome, type 1	0.042
Apc	adenomatosis polyposis coli	0.042
Smad6	MAD homolog 6 (Drosophila)	0.042
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.042
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.042
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.041
Rarg	retinoic acid receptor, gamma	0.037
Gbx2	gastrulation brain homeobox 2	0.036
Itga3	integrin alpha 3	0.034
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.034
Sox2	SRY-box containing gene 2	0.033
Wnt3a	wingless-related MMTV integration site 3A	0.033
Pofut1	protein O-fucosyltransferase 1	0.032
Bmp2	bone morphogenetic protein 2	0.032
Hes1	hairy and enhancer of split 1 (Drosophila)	0.030
Klf15	Kruppel-like factor 15	0.028
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.028
Rarb	retinoic acid receptor, beta	0.028
Pick1	protein interacting with C kinase 1	0.026
Irf6	interferon regulatory factor 6	0.025
Mesdc2	mesoderm development candidate 2	0.025
Crtc3	CREB regulated transcription coactivator 3	0.025
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.024
Egfr	epidermal growth factor receptor	0.024
App	amyloid beta (A4) precursor protein	0.024
Lrp2	low density lipoprotein receptor-related protein 2	0.024	Mouse
Tbx1	T-box 1	0.024
Rxra	retinoid X receptor alpha	0.023
Nodal	nodal	0.023
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.023
Fn1	fibronectin 1	0.022
Foxa2	forkhead box A2	0.021
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.020
Gas1	growth arrest specific 1	0.020
Bmp5	bone morphogenetic protein 5	0.020
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.020
Wnt5a	wingless-related MMTV integration site 5A	0.020
Apaf1	apoptotic peptidase activating factor 1	0.019
Hoxa1	homeobox A1	0.019
Alx1	ALX homeobox 1	0.018
Gpc3	glypican 3	0.018
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.018
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.018
Zic3	zinc finger protein of the cerebellum 3	0.018
Agtr2	angiotensin II receptor, type 2	0.018
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.018
Chd7	chromodomain helicase DNA binding protein 7	0.017
Nog	noggin	0.017
Vegfa	vascular endothelial growth factor A	0.017
En1	engrailed 1	0.017
Wls	wntless homolog (Drosophila)	0.017
Otx1	orthodenticle homolog 1 (Drosophila)	0.016
Gpx3	glutathione peroxidase 3	0.016
Npr2	natriuretic peptide receptor 2	0.016
Mn1	meningioma 1	0.016
Ptk7	PTK7 protein tyrosine kinase 7	0.016
Bmper	BMP-binding endothelial regulator	0.015
Pax6	paired box gene 6	0.015
Dab1	disabled homolog 1 (Drosophila)	0.015
Ldlr	low density lipoprotein receptor	0.015
Emx2	empty spiracles homolog 2 (Drosophila)	0.015
Bmp1	bone morphogenetic protein 1	0.015
Fgf9	fibroblast growth factor 9	0.014
Gsc	goosecoid homeobox	0.014
Trp63	transformation related protein 63	0.014
Acvr1	activin A receptor, type 1	0.014
Tenc1	tensin like C1 domain-containing phosphatase	0.014
Pparg	peroxisome proliferator activated receptor gamma	0.014
Sall4	sal-like 4 (Drosophila)	0.013
Pax2	paired box gene 2	0.013
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.013
Efnb2	ephrin B2	0.013
Ptprf	protein tyrosine phosphatase, receptor type, F	0.013
Igf1r	insulin-like growth factor I receptor	0.013
Ece1	endothelin converting enzyme 1	0.013
Col4a3	collagen, type IV, alpha 3	0.013
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.013
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.013
Tbx2	T-box 2	0.013
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.013
Mep1a	meprin 1 alpha	0.013
Rdh10	retinol dehydrogenase 10 (all-trans)	0.012
Rara	retinoic acid receptor, alpha	0.012
Efnb1	ephrin B1	0.012
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.012
Igfbp4	insulin-like growth factor binding protein 4	0.011
Lrp4	low density lipoprotein receptor-related protein 4	0.011	Mouse
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.011
Sox13	SRY-box containing gene 13	0.011
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.011
Pltp	phospholipid transfer protein	0.011
Tbx15	T-box 15	0.011
Smagp	small cell adhesion glycoprotein	0.011
Notch2	Notch gene homolog 2 (Drosophila)	0.011
Sntg2	syntrophin, gamma 2	0.010
Col4a4	collagen, type IV, alpha 4	0.010