IMP

Process View

Mus musculus

16 genes annotated in mouse

ruffle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ruffle organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ruffle organization" (in gray)

Name	Description	Probability	Func Analog Organism
Vasp	vasodilator-stimulated phosphoprotein	0.592
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.511
Arpc4	actin related protein 2/3 complex, subunit 4	0.329
Sgpl1	sphingosine phosphate lyase 1	0.251
Kdr	kinase insert domain protein receptor	0.247	Mouse
Actb	actin, beta	0.229
Csf1	colony stimulating factor 1 (macrophage)	0.200
Tgfb1	transforming growth factor, beta 1	0.147
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.147
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.146
Sh3bgrl3	SH3 domain binding glutamic acid-rich protein-like 3	0.144
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.120
Flt4	FMS-like tyrosine kinase 4	0.116	Mouse
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.112
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.109
Shc1	src homology 2 domain-containing transforming protein C1	0.108
Cdh5	cadherin 5	0.091
Necap2	NECAP endocytosis associated 2	0.087
Rac1	RAS-related C3 botulinum substrate 1	0.082
Enah	enabled homolog (Drosophila)	0.074
Vegfa	vascular endothelial growth factor A	0.068
Mapkap1	mitogen-activated protein kinase associated protein 1	0.066
Inpp5d	inositol polyphosphate-5-phosphatase D	0.066	Mouse
Wdr1	WD repeat domain 1	0.061
Stat3	signal transducer and activator of transcription 3	0.061
Bmp2	bone morphogenetic protein 2	0.059
Cbl	Casitas B-lineage lymphoma	0.058
Pecam1	platelet/endothelial cell adhesion molecule 1	0.050
5430411K18Rik	RIKEN cDNA 5430411K18 gene	0.048
Msn	moesin	0.047
Ctnnb1	catenin (cadherin associated protein), beta 1	0.046
Dnm1	dynamin 1	0.045
Rptor	regulatory associated protein of MTOR, complex 1	0.044
Emcn	endomucin	0.043
Grb2	growth factor receptor bound protein 2	0.043
Tgfbr2	transforming growth factor, beta receptor II	0.043
Pld4	phospholipase D family, member 4	0.042
Tyrobp	TYRO protein tyrosine kinase binding protein	0.041
Rhoa	ras homolog gene family, member A	0.041
Plcg1	phospholipase C, gamma 1	0.038
Ldlr	low density lipoprotein receptor	0.038
Gja1	gap junction protein, alpha 1	0.038
Cd68	CD68 antigen	0.037
Unc93b1	unc-93 homolog B1 (C. elegans)	0.037
Vegfc	vascular endothelial growth factor C	0.037
Rhog	ras homolog gene family, member G	0.036
Schip1	schwannomin interacting protein 1	0.036
Hspa1b	heat shock protein 1B	0.034
Laptm5	lysosomal-associated protein transmembrane 5	0.034
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.031
Psen1	presenilin 1	0.031
Rictor	RPTOR independent companion of MTOR, complex 2	0.031
Cav1	caveolin 1, caveolae protein	0.030
Foxc2	forkhead box C2	0.030
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.030	Mouse
Notch2	Notch gene homolog 2 (Drosophila)	0.030
Csnk2b	casein kinase 2, beta polypeptide	0.029
Cyba	cytochrome b-245, alpha polypeptide	0.028
Cd44	CD44 antigen	0.028
Tjap1	tight junction associated protein 1	0.028
Lcp1	lymphocyte cytosolic protein 1	0.026
Itgb2	integrin beta 2	0.026
Esam	endothelial cell-specific adhesion molecule	0.026
Wasf1	WASP family 1	0.026
Fxyd5	FXYD domain-containing ion transport regulator 5	0.026
Capzb	capping protein (actin filament) muscle Z-line, beta	0.026
Csf1r	colony stimulating factor 1 receptor	0.026
Mmp9	matrix metallopeptidase 9	0.025
Sox18	SRY-box containing gene 18	0.025
Nos3	nitric oxide synthase 3, endothelial cell	0.025
Stat6	signal transducer and activator of transcription 6	0.025
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.025
Arf1	ADP-ribosylation factor 1	0.024
Lmf1	lipase maturation factor 1	0.024
Abhd5	abhydrolase domain containing 5	0.024
Ctsd	cathepsin D	0.023
Cfl1	cofilin 1, non-muscle	0.023
Parvg	parvin, gamma	0.022
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.022
Il6st	interleukin 6 signal transducer	0.022
Cdc34	cell division cycle 34 homolog (S. cerevisiae)	0.021
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.021
Pdgfb	platelet derived growth factor, B polypeptide	0.021
Ptprc	protein tyrosine phosphatase, receptor type, C	0.021
Shisa5	shisa homolog 5 (Xenopus laevis)	0.021
Wwox	WW domain-containing oxidoreductase	0.021
Rnd3	Rho family GTPase 3	0.021
Plvap	plasmalemma vesicle associated protein	0.021
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.021
Plxnd1	plexin D1	0.020
Fuz	fuzzy homolog (Drosophila)	0.020
Ednrb	endothelin receptor type B	0.020
Cd97	CD97 antigen	0.020
Litaf	LPS-induced TN factor	0.019
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.019
Tek	endothelial-specific receptor tyrosine kinase	0.019
Cnn2	calponin 2	0.019
Cd300a	CD300A antigen	0.019
Dab2	disabled homolog 2 (Drosophila)	0.019
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	0.019
Arhgap1	Rho GTPase activating protein 1	0.018
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.018	Mouse
Sh3d19	SH3 domain protein D19	0.018
Hcls1	hematopoietic cell specific Lyn substrate 1	0.018
Arf5	ADP-ribosylation factor 5	0.018
Dbnl	drebrin-like	0.017
Spag9	sperm associated antigen 9	0.017
C1qc	complement component 1, q subcomponent, C chain	0.017
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.017
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.017
Slamf1	signaling lymphocytic activation molecule family member 1	0.017
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.016
Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta	0.016
Apoe	apolipoprotein E	0.016
Fermt3	fermitin family homolog 3 (Drosophila)	0.016
Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	0.016
Tmem204	transmembrane protein 204	0.016
Hspa1a	heat shock protein 1A	0.016
Selplg	selectin, platelet (p-selectin) ligand	0.016
H2-DMa	histocompatibility 2, class II, locus DMa	0.016
Kit	kit oncogene	0.016	Mouse
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.015
Lgals9	lectin, galactose binding, soluble 9	0.015
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.015
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.015
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.015
Epor	erythropoietin receptor	0.015
Sirt2	sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)	0.014
Efnb2	ephrin B2	0.014
Cd93	CD93 antigen	0.014
Iqgap1	IQ motif containing GTPase activating protein 1	0.014
Fyn	Fyn proto-oncogene	0.014
Mpeg1	macrophage expressed gene 1	0.013
Eng	endoglin	0.013
Rac2	RAS-related C3 botulinum substrate 2	0.013	Mouse
Heg1	HEG homolog 1 (zebrafish)	0.013
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.013
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.013	Mouse
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.013
Sipa1	signal-induced proliferation associated gene 1	0.013
Slc7a7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	0.013
Sh3gl2	SH3-domain GRB2-like 2	0.013
Trp53	transformation related protein 53	0.012
Nckap1	NCK-associated protein 1	0.012
Cldn5	claudin 5	0.012
Gab1	growth factor receptor bound protein 2-associated protein 1	0.012
Srgn	serglycin	0.012
Egfl7	EGF-like domain 7	0.012
Tmsb10	thymosin, beta 10	0.012
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.012
Rgs10	regulator of G-protein signalling 10	0.012
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.011
Lrrk2	leucine-rich repeat kinase 2	0.011
Cotl1	coactosin-like 1 (Dictyostelium)	0.011
Coro1a	coronin, actin binding protein 1A	0.011
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.011
Telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.011
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.011
Pxn	paxillin	0.011
Tmem176b	transmembrane protein 176B	0.011
Vwf	Von Willebrand factor homolog	0.011
Plin1	perilipin 1	0.011
Frmd8	FERM domain containing 8	0.011
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.011
Foxp3	forkhead box P3	0.010
Lsp1	lymphocyte specific 1	0.010
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.010