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Mus musculus

2 genes annotated in mouse

medial motor column neuron differentiation

The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "medial motor column neuron differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "medial motor column neuron differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Otx2	orthodenticle homolog 2 (Drosophila)	1.000
Pax2	paired box gene 2	1.000
Pitx2	paired-like homeodomain transcription factor 2	0.999
Shh	sonic hedgehog	0.998
Emx2	empty spiracles homolog 2 (Drosophila)	0.997
Pax6	paired box gene 6	0.995
Fgf8	fibroblast growth factor 8	0.994
Gli3	GLI-Kruppel family member GLI3	0.992
Lhx9	LIM homeobox protein 9	0.986	Mouse
Pax3	paired box gene 3	0.982
Isl1	ISL1 transcription factor, LIM/homeodomain	0.975	Mouse
Gbx2	gastrulation brain homeobox 2	0.972
Lhx1	LIM homeobox protein 1	0.949	Mouse
Tbx1	T-box 1	0.945
Foxc1	forkhead box C1	0.936
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.934
Tcfap2a	transcription factor AP-2, alpha	0.906
Emx1	empty spiracles homolog 1 (Drosophila)	0.903
Otx1	orthodenticle homolog 1 (Drosophila)	0.861
Foxc2	forkhead box C2	0.845
Eya1	eyes absent 1 homolog (Drosophila)	0.807
Hand2	heart and neural crest derivatives expressed transcript 2	0.700
Wt1	Wilms tumor 1 homolog	0.658
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.618
En1	engrailed 1	0.591
Sox11	SRY-box containing gene 11	0.572
Drd2	dopamine receptor D2	0.561
Lhx3	LIM homeobox protein 3	0.549
Hoxa1	homeobox A1	0.534
Sox9	SRY-box containing gene 9	0.505
Lhx4	LIM homeobox protein 4	0.505
Pou4f2	POU domain, class 4, transcription factor 2	0.471
Foxg1	forkhead box G1	0.463
Sox2	SRY-box containing gene 2	0.456
Bmp4	bone morphogenetic protein 4	0.454
Msx1	homeobox, msh-like 1	0.451
Lmx1b	LIM homeobox transcription factor 1 beta	0.420	Mouse
Hes5	hairy and enhancer of split 5 (Drosophila)	0.416
Chd7	chromodomain helicase DNA binding protein 7	0.408
Hand1	heart and neural crest derivatives expressed transcript 1	0.383
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.297
Fgfr2	fibroblast growth factor receptor 2	0.292
Gsc	goosecoid homeobox	0.290
Gdnf	glial cell line derived neurotrophic factor	0.263
Dlx5	distal-less homeobox 5	0.249
Rarb	retinoic acid receptor, beta	0.242
Pax7	paired box gene 7	0.233
Smo	smoothened homolog (Drosophila)	0.217
Nodal	nodal	0.205
Wnt9b	wingless-type MMTV integration site 9B	0.202
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.192
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.192
Rarg	retinoic acid receptor, gamma	0.188
Msx2	homeobox, msh-like 2	0.176
Pitx3	paired-like homeodomain transcription factor 3	0.163
Neurog2	neurogenin 2	0.156
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.145
Zic3	zinc finger protein of the cerebellum 3	0.138
Insm1	insulinoma-associated 1	0.135
Gata4	GATA binding protein 4	0.130
Nog	noggin	0.129
Phox2b	paired-like homeobox 2b	0.126
Hoxa11	homeobox A11	0.124
Hoxd11	homeobox D11	0.119
Pou4f3	POU domain, class 4, transcription factor 3	0.118
Ret	ret proto-oncogene	0.109
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.107
Pitx1	paired-like homeodomain transcription factor 1	0.103
Hoxd13	homeobox D13	0.102
Fgf10	fibroblast growth factor 10	0.097
Prrx2	paired related homeobox 2	0.096
Osr1	odd-skipped related 1 (Drosophila)	0.094
Foxi1	forkhead box I1	0.093
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.090
Fgf4	fibroblast growth factor 4	0.089
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.086
BC024139	cDNA sequence BC024139	0.083
Neurod1	neurogenic differentiation 1	0.082
Emid2	EMI domain containing 2	0.082
Ptf1a	pancreas specific transcription factor, 1a	0.081
Foxe3	forkhead box E3	0.081
En2	engrailed 2	0.079
Lmx1a	LIM homeobox transcription factor 1 alpha	0.077	Mouse
Pax8	paired box gene 8	0.075
Fgf15	fibroblast growth factor 15	0.074
Fgf3	fibroblast growth factor 3	0.073
Hoxd3	homeobox D3	0.073
Sox3	SRY-box containing gene 3	0.071
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.065
Vangl2	vang-like 2 (van gogh, Drosophila)	0.065
Prrx1	paired related homeobox 1	0.065
Isl2	insulin related protein 2 (islet 2)	0.064	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.063
Zic2	zinc finger protein of the cerebellum 2	0.062
Wnt1	wingless-related MMTV integration site 1	0.060
Hmx3	H6 homeobox 3	0.057
Gli2	GLI-Kruppel family member GLI2	0.056
Prop1	paired like homeodomain factor 1	0.055
T	brachyury	0.055
Fgfr1	fibroblast growth factor receptor 1	0.053
Ednra	endothelin receptor type A	0.052
Cbln3	cerebellin 3 precursor protein	0.051
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.049
Nkx6-1	NK6 homeobox 1	0.048
Bnc1	basonuclin 1	0.047
Dlx6	distal-less homeobox 6	0.046
Col2a1	collagen, type II, alpha 1	0.044
Tbx15	T-box 15	0.044
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.044
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.043
Tcfap2c	transcription factor AP-2, gamma	0.042
Sez6l	seizure related 6 homolog like	0.041
Col22a1	collagen, type XXII, alpha 1	0.041
Sim1	single-minded homolog 1 (Drosophila)	0.040
Atoh7	atonal homolog 7 (Drosophila)	0.040
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.039
Uncx	UNC homeobox	0.038
Fev	FEV (ETS oncogene family)	0.038
Onecut1	one cut domain, family member 1	0.038
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.038
Mab21l2	mab-21-like 2 (C. elegans)	0.037
Kiss1r	KISS1 receptor	0.036
Wnt3a	wingless-related MMTV integration site 3A	0.035
Vsx2	visual system homeobox 2	0.035
Lef1	lymphoid enhancer binding factor 1	0.034
Ebf3	early B-cell factor 3	0.034
Nhlh1	nescient helix loop helix 1	0.033
Otp	orthopedia homolog (Drosophila)	0.033
Ntf3	neurotrophin 3	0.032
Hoxa10	homeobox A10	0.032
Hoxd1	homeobox D1	0.032
Sall3	sal-like 3 (Drosophila)	0.032
Syngr4	synaptogyrin 4	0.031
Hoxb1	homeobox B1	0.031
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.029
Tlx3	T-cell leukemia, homeobox 3	0.029
Mesp1	mesoderm posterior 1	0.028
Bmp7	bone morphogenetic protein 7	0.028
Rara	retinoic acid receptor, alpha	0.028
Hmx1	H6 homeobox 1	0.027
Foxb1	forkhead box B1	0.027
Hoxa4	homeobox A4	0.027
Myf5	myogenic factor 5	0.027
Matn3	matrilin 3	0.027
Dmbx1	diencephalon/mesencephalon homeobox 1	0.026
Meox2	mesenchyme homeobox 2	0.026
Zic1	zinc finger protein of the cerebellum 1	0.026
Gata3	GATA binding protein 3	0.025
Chrd	chordin	0.025
Neurog1	neurogenin 1	0.024
Hoxa3	homeobox A3	0.024
Hoxa2	homeobox A2	0.024
Pou3f4	POU domain, class 3, transcription factor 4	0.024
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.024
Drd4	dopamine receptor D4	0.024
Adra2c	adrenergic receptor, alpha 2c	0.024
Barx1	BarH-like homeobox 1	0.024
Kiss1	KiSS-1 metastasis-suppressor	0.024
Dlx2	distal-less homeobox 2	0.023
Evx1	even skipped homeotic gene 1 homolog	0.023
Zeb1	zinc finger E-box binding homeobox 1	0.023
Odf3	outer dense fiber of sperm tails 3	0.023
Tbx3	T-box 3	0.023
Twist2	twist homolog 2 (Drosophila)	0.023
Foxh1	forkhead box H1	0.023
Dlx1	distal-less homeobox 1	0.022
Col9a1	collagen, type IX, alpha 1	0.022
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.022
Fgf17	fibroblast growth factor 17	0.022
Dll3	delta-like 3 (Drosophila)	0.022
Hoxc8	homeobox C8	0.022
Sall4	sal-like 4 (Drosophila)	0.022
Tgfb2	transforming growth factor, beta 2	0.022
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.022
Tas1r2	taste receptor, type 1, member 2	0.022
Edar	ectodysplasin-A receptor	0.021
Cabp7	calcium binding protein 7	0.021
Hmga2	high mobility group AT-hook 2	0.021
Irs4	insulin receptor substrate 4	0.020
Cdh23	cadherin 23 (otocadherin)	0.020
Oxtr	oxytocin receptor	0.020
Sim2	single-minded homolog 2 (Drosophila)	0.020
Mnx1	motor neuron and pancreas homeobox 1	0.020
Srrm4	serine/arginine repetitive matrix 4	0.020
Tll2	tolloid-like 2	0.020
Sox4	SRY-box containing gene 4	0.020
Myog	myogenin	0.019
Foxl2	forkhead box L2	0.019
Wnt9a	wingless-type MMTV integration site 9A	0.019
Neurod4	neurogenic differentiation 4	0.019
Gpr50	G-protein-coupled receptor 50	0.019
Irx4	Iroquois related homeobox 4 (Drosophila)	0.019
5730559C18Rik	RIKEN cDNA 5730559C18 gene	0.019
Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	0.018
Vegfa	vascular endothelial growth factor A	0.018
Magel2	melanoma antigen, family L, 2	0.018
Fgf21	fibroblast growth factor 21	0.018
Barhl1	BarH-like 1 (Drosophila)	0.018
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.018
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.018
Gdf11	growth differentiation factor 11	0.017
Col25a1	collagen, type XXV, alpha 1	0.017
Hesx1	homeobox gene expressed in ES cells	0.017
Hoxc5	homeobox C5	0.017
Tbx20	T-box 20	0.017
Sox21	SRY-box containing gene 21	0.017
Hes1	hairy and enhancer of split 1 (Drosophila)	0.017
Vstm2b	V-set and transmembrane domain containing 2B	0.017
Eya4	eyes absent 4 homolog (Drosophila)	0.017
Allc	allantoicase	0.016
Slc26a5	solute carrier family 26, member 5	0.016
Gsx2	GS homeobox 2	0.016
Grik3	glutamate receptor, ionotropic, kainate 3	0.016
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.016
Foxn4	forkhead box N4	0.016
Cckbr	cholecystokinin B receptor	0.016
Alx4	aristaless-like homeobox 4	0.016
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.016
Kif12	kinesin family member 12	0.016
Dcx	doublecortin	0.016
Nrk	Nik related kinase	0.016
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.016
Styxl1	serine/threonine/tyrosine interacting-like 1	0.016
Alx3	aristaless-like homeobox 3	0.015
Tlx1	T-cell leukemia, homeobox 1	0.015
Bdnf	brain derived neurotrophic factor	0.015
Pax9	paired box gene 9	0.015
Irx1	Iroquois related homeobox 1 (Drosophila)	0.015
Slc5a4a	solute carrier family 5, member 4a	0.015
Foxd2	forkhead box D2	0.015
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.015
Nphs2	nephrosis 2 homolog, podocin (human)	0.014
Arx	aristaless related homeobox	0.014
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.014
Irx2	Iroquois related homeobox 2 (Drosophila)	0.014
Hoxa13	homeobox A13	0.014
Foxl1	forkhead box L1	0.014
Olig3	oligodendrocyte transcription factor 3	0.014
Irx6	Iroquois related homeobox 6 (Drosophila)	0.014
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.014
Cntn2	contactin 2	0.014
BC027072	cDNA sequence BC027072	0.014
Igfbpl1	insulin-like growth factor binding protein-like 1	0.014
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.014
Hes3	hairy and enhancer of split 3 (Drosophila)	0.014
Rax	retina and anterior neural fold homeobox	0.014
Wnt8b	wingless related MMTV integration site 8b	0.014
Cldn9	claudin 9	0.014
Vgf	VGF nerve growth factor inducible	0.013
Bcl2l10	Bcl2-like 10	0.013
Barhl2	BarH-like 2 (Drosophila)	0.013
Sox10	SRY-box containing gene 10	0.013
Hoxc13	homeobox C13	0.013
Padi3	peptidyl arginine deiminase, type III	0.013
Prokr2	prokineticin receptor 2	0.013
Wnt6	wingless-related MMTV integration site 6	0.013
Calcr	calcitonin receptor	0.013
Twist1	twist homolog 1 (Drosophila)	0.013
Il11	interleukin 11	0.013
Shox2	short stature homeobox 2	0.013
Rsph6a	radial spoke head 6 homolog A (Chlamydomonas)	0.012
Crtac1	cartilage acidic protein 1	0.012
Ubl4b	ubiquitin-like 4B	0.012
Nrtn	neurturin	0.012
Ttc39d	tetratricopeptide repeat domain 39D	0.012
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.012
Hapln1	hyaluronan and proteoglycan link protein 1	0.012
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.012
Nrg1	neuregulin 1	0.012
Dusp9	dual specificity phosphatase 9	0.012
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.012
Wnt16	wingless-related MMTV integration site 16	0.011
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.011
Sost	sclerostin	0.011
Cpa5	carboxypeptidase A5	0.011
Hoxd10	homeobox D10	0.011
Msx3	homeobox, msh-like 3	0.011
4930511I11Rik	RIKEN cDNA 4930511I11 gene	0.011
Slc26a4	solute carrier family 26, member 4	0.011
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.011
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.011
Col11a1	collagen, type XI, alpha 1	0.011
Dcc	deleted in colorectal carcinoma	0.011
Hoxb2	homeobox B2	0.011
Tulp1	tubby like protein 1	0.011
Jag1	jagged 1	0.011
Krt85	keratin 85	0.011
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.011
1700123K08Rik	RIKEN cDNA 1700123K08 gene	0.011
Vgll2	vestigial like 2 homolog (Drosophila)	0.010
Phox2a	paired-like homeobox 2a	0.010
Myoz3	myozenin 3	0.010
Dmrt3	doublesex and mab-3 related transcription factor 3	0.010
Angpt4	angiopoietin 4	0.010
Myo15	myosin XV	0.010
Vax1	ventral anterior homeobox containing gene 1	0.010
Efna2	ephrin A2	0.010
Gja3	gap junction protein, alpha 3	0.010
Onecut3	one cut domain, family member 3	0.010
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.010
Col13a1	collagen, type XIII, alpha 1	0.010
Hoxd9	homeobox D9	0.010
Inhbc	inhibin beta-C	0.010