IMP

Process View

Mus musculus

13 genes annotated in mouse

spindle assembly

The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "spindle assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "spindle assembly" (in gray)

Name	Description	Probability	Func Analog Organism
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.986
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.943	Fly
Cdk1	cyclin-dependent kinase 1	0.908
Plk1	polo-like kinase 1 (Drosophila)	0.897	Yeast Fly
Ccnb1	cyclin B1	0.857	Yeast
Ccnb2	cyclin B2	0.844	Yeast
Ccna2	cyclin A2	0.826
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.818
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.757
Cct7	chaperonin containing Tcp1, subunit 7 (eta)	0.634	Fly
Kif4	kinesin family member 4	0.630	Fly
Kif20a	kinesin family member 20A	0.629	Worm
Prc1	protein regulator of cytokinesis 1	0.613
Kif2c	kinesin family member 2C	0.594	Fly
Mis18bp1	MIS18 binding protein 1	0.550
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.467
Anln	anillin, actin binding protein	0.452
Plk4	polo-like kinase 4 (Drosophila)	0.409
Spag5	sperm associated antigen 5	0.387
Hspa8	heat shock protein 8	0.354
Racgap1	Rac GTPase-activating protein 1	0.350	Human Fly
Fam64a	family with sequence similarity 64, member A	0.326
Aurkb	aurora kinase B	0.310	Human Fly
Ccnf	cyclin F	0.286
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.285
Ckap2	cytoskeleton associated protein 2	0.263
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.263
Kif11	kinesin family member 11	0.260	Human
Kif23	kinesin family member 23	0.245	Human Worm Fly
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.235
Cdkn3	cyclin-dependent kinase inhibitor 3	0.225
Kif22	kinesin family member 22	0.217
Iqgap3	IQ motif containing GTPase activating protein 3	0.207
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.206
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.201
Cct6a	chaperonin containing Tcp1, subunit 6a (zeta)	0.179
H2afx	H2A histone family, member X	0.170
Nde1	nuclear distribution gene E homolog 1 (A nidulans)	0.165
Gtse1	G two S phase expressed protein 1	0.164
Cct3	chaperonin containing Tcp1, subunit 3 (gamma)	0.161	Fly
Birc5	baculoviral IAP repeat-containing 5	0.157
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.157
Rpgrip1l	Rpgrip1-like	0.155
Tuba1a	tubulin, alpha 1A	0.154
Rac1	RAS-related C3 botulinum substrate 1	0.148
Ncaph	non-SMC condensin I complex, subunit H	0.144
Aurka	aurora kinase A	0.140
Cdca8	cell division cycle associated 8	0.131	Fly
Cct4	chaperonin containing Tcp1, subunit 4 (delta)	0.122	Fly
Trim59	tripartite motif-containing 59	0.117
Cct5	chaperonin containing Tcp1, subunit 5 (epsilon)	0.114	Fly
Cdk4	cyclin-dependent kinase 4	0.103
Foxm1	forkhead box M1	0.091
Cdca5	cell division cycle associated 5	0.090
Stil	Scl/Tal1 interrupting locus	0.090	Zebrafish
Cenpe	centromere protein E	0.089
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.084
Ndel1	nuclear distribution gene E-like homolog 1 (A. nidulans)	0.072
Chek2	CHK2 checkpoint homolog (S. pombe)	0.072	Human
Gsg2	germ cell-specific gene 2	0.066
Smc4	structural maintenance of chromosomes 4	0.064
Top2a	topoisomerase (DNA) II alpha	0.064
Cenpf	centromere protein F	0.063
Sass6	spindle assembly 6 homolog (C. elegans)	0.063
Pbk	PDZ binding kinase	0.061
Brca1	breast cancer 1	0.061
Mybl2	myeloblastosis oncogene-like 2	0.060
Ttk	Ttk protein kinase	0.059	Yeast
Tcp1	t-complex protein 1	0.058	Fly
Iqcb1	IQ calmodulin-binding motif containing 1	0.057
Ckap2l	cytoskeleton associated protein 2-like	0.056
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.055
Lmnb1	lamin B1	0.054
Tuba1b	tubulin, alpha 1B	0.051
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.050
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.050
Tacc3	transforming, acidic coiled-coil containing protein 3	0.049
Ube2c	ubiquitin-conjugating enzyme E2C	0.049
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.048	Fly
Rnf26	ring finger protein 26	0.048
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.046
Cep55	centrosomal protein 55	0.045
Mxd3	Max dimerization protein 3	0.045
Tmpo	thymopoietin	0.044
Spna2	spectrin alpha 2	0.042
Dtl	denticleless homolog (Drosophila)	0.041
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.041
Cdca3	cell division cycle associated 3	0.041
Rad51ap1	RAD51 associated protein 1	0.041
Ect2	ect2 oncogene	0.041	Fly
Nusap1	nucleolar and spindle associated protein 1	0.040
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.039
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.039
Cenpn	centromere protein N	0.039
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.038
Cenpa	centromere protein A	0.036
Wdr1	WD repeat domain 1	0.036
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.034	Fly
Exo1	exonuclease 1	0.034
Tubb2a	tubulin, beta 2A	0.034	Mouse
Blm	Bloom syndrome, RecQ helicase-like	0.033
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.033
Cenpk	centromere protein K	0.033
Taf9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.031
Ran	RAN, member RAS oncogene family	0.030
Kif18a	kinesin family member 18A	0.029	Yeast Fly
Ooep	oocyte expressed protein homolog (dog)	0.029
Brca2	breast cancer 2	0.028
Fam54a	family with sequence similarity 54, member A	0.027
Ruvbl2	RuvB-like protein 2	0.027
Psmd5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.025
Ccdc99	coiled-coil domain containing 99	0.025
Macf1	microtubule-actin crosslinking factor 1	0.024
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.024
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.023
Hn1	hematological and neurological expressed sequence 1	0.023
Mastl	microtubule associated serine/threonine kinase-like	0.022
E2f8	E2F transcription factor 8	0.022
Orc1	origin recognition complex, subunit 1	0.021
Kif3a	kinesin family member 3A	0.021
Fignl1	fidgetin-like 1	0.021
Nphp1	nephronophthisis 1 (juvenile) homolog (human)	0.021
Thra	thyroid hormone receptor alpha	0.020
Psmb4	proteasome (prosome, macropain) subunit, beta type 4	0.020
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.020
Nup93	nucleoporin 93	0.019
Arhgap1	Rho GTPase activating protein 1	0.019
Cks2	CDC28 protein kinase regulatory subunit 2	0.019	Fly
Ncapd2	non-SMC condensin I complex, subunit D2	0.018
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.018
Pole2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.018
Wrn	Werner syndrome homolog (human)	0.018
Incenp	inner centromere protein	0.017
Adam10	a disintegrin and metallopeptidase domain 10	0.017
Tubb3	tubulin, beta 3	0.017	Mouse
Ccnd1	cyclin D1	0.017
Gnb1	guanine nucleotide binding protein (G protein), beta 1	0.017
Tcf19	transcription factor 19	0.016
Dsn1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.016
Mapk8	mitogen-activated protein kinase 8	0.016
Cdk2	cyclin-dependent kinase 2	0.015
Tpm4	tropomyosin 4	0.015
Fam83d	family with sequence similarity 83, member D	0.015
Usp22	ubiquitin specific peptidase 22	0.015
Calm1	calmodulin 1	0.015
Cdc7	cell division cycle 7 (S. cerevisiae)	0.014
Lin9	lin-9 homolog (C. elegans)	0.014
Cenpm	centromere protein M	0.014
Tubb6	tubulin, beta 6	0.014	Mouse
Capzb	capping protein (actin filament) muscle Z-line, beta	0.014
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.014
Ckap5	cytoskeleton associated protein 5	0.014
Ska1	spindle and kinetochore associated complex subunit 1	0.013
Ncapg	non-SMC condensin I complex, subunit G	0.013
Tubb5	tubulin, beta 5	0.013
Tubb2c	tubulin, beta 2C	0.013	Mouse
Espl1	extra spindle poles-like 1 (S. cerevisiae)	0.013
Cfl1	cofilin 1, non-muscle	0.013
Dzip3	DAZ interacting protein 3, zinc finger	0.013
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.013
Sgol1	shugoshin-like 1 (S. pombe)	0.013
Eri2	exoribonuclease 2	0.013
Bard1	BRCA1 associated RING domain 1	0.013
Clip1	CAP-GLY domain containing linker protein 1	0.013
Arid1b	AT rich interactive domain 1B (SWI-like)	0.012
Prim2	DNA primase, p58 subunit	0.012
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.012
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.012
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.012
1110004F10Rik	RIKEN cDNA 1110004F10 gene	0.012
Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.012
Nup88	nucleoporin 88	0.012
Haus4	HAUS augmin-like complex, subunit 4	0.012
Rcn2	reticulocalbin 2	0.011
Mapt	microtubule-associated protein tau	0.011
Mphosph9	M-phase phosphoprotein 9	0.011
Psma5	proteasome (prosome, macropain) subunit, alpha type 5	0.011
Lancl2	LanC (bacterial lantibiotic synthetase component C)-like 2	0.011
Cct8	chaperonin containing Tcp1, subunit 8 (theta)	0.011
Tceb1	transcription elongation factor B (SIII), polypeptide 1	0.011
Kit	kit oncogene	0.011
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.011
Drosha	drosha, ribonuclease type III	0.011
Fkbp1a	FK506 binding protein 1a	0.011
Msh2	mutS homolog 2 (E. coli)	0.011
Sumo1	SMT3 suppressor of mif two 3 homolog 1 (yeast)	0.011
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.011
4930427A07Rik	RIKEN cDNA 4930427A07 gene	0.011
Dynll1	dynein light chain LC8-type 1	0.011
Pafah1b2	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2	0.011
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.010
Atxn10	ataxin 10	0.010
Ppp2r2a	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	0.010
Cdca2	cell division cycle associated 2	0.010
Depdc1b	DEP domain containing 1B	0.010
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.010
Cdc25a	cell division cycle 25 homolog A (S. pombe)	0.010	Fly
Dna2	DNA replication helicase 2 homolog (yeast)	0.010
Actb	actin, beta	0.010
Rqcd1	rcd1 (required for cell differentiation) homolog 1 (S. pombe)	0.010