IMP

Process View

Mus musculus

4 genes annotated in mouse

negative regulation of glucokinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of glucokinase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of glucokinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.911
Bmp4	bone morphogenetic protein 4	0.802
Pax2	paired box gene 2	0.755
Pax6	paired box gene 6	0.711
Gli3	GLI-Kruppel family member GLI3	0.644
Otx2	orthodenticle homolog 2 (Drosophila)	0.590
Foxc1	forkhead box C1	0.576	Mouse
Tgfb2	transforming growth factor, beta 2	0.466
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.428
Fgfr2	fibroblast growth factor receptor 2	0.407
Nkx2-1	NK2 homeobox 1	0.386
Tbx1	T-box 1	0.374
Hand2	heart and neural crest derivatives expressed transcript 2	0.338
Foxa2	forkhead box A2	0.325
Otx1	orthodenticle homolog 1 (Drosophila)	0.300
Pitx2	paired-like homeodomain transcription factor 2	0.298
Fgf8	fibroblast growth factor 8	0.291
Pax8	paired box gene 8	0.249
Lmx1b	LIM homeobox transcription factor 1 beta	0.241
Foxa1	forkhead box A1	0.231	Mouse
Eya1	eyes absent 1 homolog (Drosophila)	0.224
Hmx3	H6 homeobox 3	0.215
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.202
Foxc2	forkhead box C2	0.194	Mouse
Msx2	homeobox, msh-like 2	0.165
Gbx2	gastrulation brain homeobox 2	0.164
Tcfap2a	transcription factor AP-2, alpha	0.153
Hand1	heart and neural crest derivatives expressed transcript 1	0.150
Gsc	goosecoid homeobox	0.150
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.148
Foxf2	forkhead box F2	0.129
Meox2	mesenchyme homeobox 2	0.128
Nog	noggin	0.117
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.115
Ctnnb1	catenin (cadherin associated protein), beta 1	0.111
Psen1	presenilin 1	0.110
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.107
Vangl2	vang-like 2 (van gogh, Drosophila)	0.106
Nkx3-2	NK3 homeobox 2	0.103
Msx1	homeobox, msh-like 1	0.087
Pax3	paired box gene 3	0.082
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.073
Dlx5	distal-less homeobox 5	0.072
Isl1	ISL1 transcription factor, LIM/homeodomain	0.069
Amh	anti-Mullerian hormone	0.067
Cdx1	caudal type homeobox 1	0.066
Egfr	epidermal growth factor receptor	0.063
Pax9	paired box gene 9	0.062
Evx2	even skipped homeotic gene 2 homolog	0.061
Mecom	MDS1 and EVI1 complex locus	0.057
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.054
Fgfr3	fibroblast growth factor receptor 3	0.054
Efnb2	ephrin B2	0.048
Hmx1	H6 homeobox 1	0.047
Gli2	GLI-Kruppel family member GLI2	0.047
Pdx1	pancreatic and duodenal homeobox 1	0.047
Rb1	retinoblastoma 1	0.046
Emx1	empty spiracles homolog 1 (Drosophila)	0.045
Jag1	jagged 1	0.044
Ntf3	neurotrophin 3	0.042
Neurog1	neurogenin 1	0.041
Hif1a	hypoxia inducible factor 1, alpha subunit	0.041
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.038
Gja1	gap junction protein, alpha 1	0.037
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.036
Matn3	matrilin 3	0.036
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.035
Adam17	a disintegrin and metallopeptidase domain 17	0.033
Bmp7	bone morphogenetic protein 7	0.033
Krit1	KRIT1, ankyrin repeat containing	0.033
Cldn6	claudin 6	0.033
Foxe3	forkhead box E3	0.032	Mouse
Rif1	Rap1 interacting factor 1 homolog (yeast)	0.032
Cldn2	claudin 2	0.032
Cldn3	claudin 3	0.031
Foxb1	forkhead box B1	0.031
Cmtm8	CKLF-like MARVEL transmembrane domain containing 8	0.030
Zeb1	zinc finger E-box binding homeobox 1	0.029
Hoxa1	homeobox A1	0.029
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.029
Pou4f2	POU domain, class 4, transcription factor 2	0.029
Hoxb13	homeobox B13	0.027
Wnt7a	wingless-related MMTV integration site 7A	0.027
Gata4	GATA binding protein 4	0.026
Vegfa	vascular endothelial growth factor A	0.026
Nphs2	nephrosis 2 homolog, podocin (human)	0.024
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.024
Atoh1	atonal homolog 1 (Drosophila)	0.024
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.024
Tlx3	T-cell leukemia, homeobox 3	0.024
Fgfr1	fibroblast growth factor receptor 1	0.024
Dmrt3	doublesex and mab-3 related transcription factor 3	0.023
Hoxd11	homeobox D11	0.023
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.023
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.023
En1	engrailed 1	0.023
Shroom1	shroom family member 1	0.022
Gdnf	glial cell line derived neurotrophic factor	0.022
Foxh1	forkhead box H1	0.021
Irx1	Iroquois related homeobox 1 (Drosophila)	0.021
Onecut1	one cut domain, family member 1	0.021
T	brachyury	0.021
Figla	folliculogenesis specific basic helix-loop-helix	0.020
Foxd3	forkhead box D3	0.020	Mouse
Sox9	SRY-box containing gene 9	0.020
Tmem30b	transmembrane protein 30B	0.019
G6pc2	glucose-6-phosphatase, catalytic, 2	0.019
Il25	interleukin 25	0.019
Vax1	ventral anterior homeobox containing gene 1	0.019
Marveld3	MARVEL (membrane-associating) domain containing 3	0.019
Nup153	nucleoporin 153	0.019
Runx2	runt related transcription factor 2	0.019
Dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.019
Pthlh	parathyroid hormone-like peptide	0.019
Hoxa9	homeobox A9	0.019
Elf3	E74-like factor 3	0.018
Phlda2	pleckstrin homology-like domain, family A, member 2	0.018
Plg	plasminogen	0.018
Prrx2	paired related homeobox 2	0.018
Foxd4	forkhead box D4	0.017	Mouse
Lefty1	left right determination factor 1	0.017
F12	coagulation factor XII (Hageman factor)	0.017
Chrd	chordin	0.017
Rnpc3	RNA-binding region (RNP1, RRM) containing 3	0.017
Ocln	occludin	0.017
Sall1	sal-like 1 (Drosophila)	0.017
Hoxd3	homeobox D3	0.017
Evx1	even skipped homeotic gene 1 homolog	0.017
Hoxa3	homeobox A3	0.017
Nodal	nodal	0.016
Klf5	Kruppel-like factor 5	0.016
Etv2	ets variant gene 2	0.016
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.015
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.015
Clec4f	C-type lectin domain family 4, member f	0.015
Lyzl4	lysozyme-like 4	0.015
Pitx3	paired-like homeodomain transcription factor 3	0.015
Esf1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	0.015
Foxo1	forkhead box O1	0.015
Cdh1	cadherin 1	0.015
Rdh10	retinol dehydrogenase 10 (all-trans)	0.015
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.014
Zic3	zinc finger protein of the cerebellum 3	0.014
Adra2b	adrenergic receptor, alpha 2b	0.014
Sos1	son of sevenless homolog 1 (Drosophila)	0.014
Pten	phosphatase and tensin homolog	0.014
Tcf21	transcription factor 21	0.014
Dmgdh	dimethylglycine dehydrogenase precursor	0.014
Rax	retina and anterior neural fold homeobox	0.014
Bik	BCL2-interacting killer	0.014
Pxdn	peroxidasin homolog (Drosophila)	0.014
Amhr2	anti-Mullerian hormone type 2 receptor	0.014
Chuk	conserved helix-loop-helix ubiquitous kinase	0.014
Cdx2	caudal type homeobox 2	0.013
Foxl2	forkhead box L2	0.013	Mouse
Rbm7	RNA binding motif protein 7	0.013
Col13a1	collagen, type XIII, alpha 1	0.013
Epx	eosinophil peroxidase	0.013
Ppara	peroxisome proliferator activated receptor alpha	0.013
Mesp1	mesoderm posterior 1	0.013
Mycs	myc-like oncogene, s-myc protein	0.013
Alx4	aristaless-like homeobox 4	0.013
Slc26a4	solute carrier family 26, member 4	0.013
Neurod1	neurogenic differentiation 1	0.012
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.012
Sall4	sal-like 4 (Drosophila)	0.012
Sftpb	surfactant associated protein B	0.012
Slc22a18	solute carrier family 22 (organic cation transporter), member 18	0.012
Lmx1a	LIM homeobox transcription factor 1 alpha	0.012
Asgr1	asialoglycoprotein receptor 1	0.012
Ang2	angiogenin, ribonuclease A family, member 2	0.012
Flt4	FMS-like tyrosine kinase 4	0.012
Gck	glucokinase	0.012
Emid2	EMI domain containing 2	0.012
BC057022	cDNA sequence BC057022	0.012
Wfdc2	WAP four-disulfide core domain 2	0.012
Onecut3	one cut domain, family member 3	0.012
Tlx2	T-cell leukemia, homeobox 2	0.012
Nobox	NOBOX oogenesis homeobox	0.012
Proc	protein C	0.012
Uncx	UNC homeobox	0.012
Prrx1	paired related homeobox 1	0.012
Ptch1	patched homolog 1	0.012
Epn3	epsin 3	0.012
Msh5	mutS homolog 5 (E. coli)	0.011
Hoxd4	homeobox D4	0.011
Tulp2	tubby-like protein 2	0.011
F2	coagulation factor II	0.011
Sox2	SRY-box containing gene 2	0.011
Mfn2	mitofusin 2	0.011
Apoc1	apolipoprotein C-I	0.011
Hoxd9	homeobox D9	0.011
Pbx1	pre B-cell leukemia transcription factor 1	0.011
Hnf1b	HNF1 homeobox B	0.011
Apob	apolipoprotein B	0.011
Pcdh12	protocadherin 12	0.011
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.011
Podxl	podocalyxin-like	0.011
BC021785	cDNA sequence BC021785	0.011
Vdr	vitamin D receptor	0.011
Cct6b	chaperonin containing Tcp1, subunit 6b (zeta)	0.011
Vax2	ventral anterior homeobox containing gene 2	0.011
Sp5	trans-acting transcription factor 5	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Miox	myo-inositol oxygenase	0.011
Hnf4a	hepatic nuclear factor 4, alpha	0.011
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.011
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.011
Fgfbp1	fibroblast growth factor binding protein 1	0.011
Gjb3	gap junction protein, beta 3	0.011
Crygn	crystallin, gamma N	0.011
Ptk2	PTK2 protein tyrosine kinase 2	0.011
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
Krt8	keratin 8	0.011
Fshr	follicle stimulating hormone receptor	0.011
Krt7	keratin 7	0.011
Tbx15	T-box 15	0.010
Esrp1	epithelial splicing regulatory protein 1	0.010
Tal2	T-cell acute lymphocytic leukemia 2	0.010
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.010
Sox1	SRY-box containing gene 1	0.010
D730039F16Rik	RIKEN cDNA D730039F16 gene	0.010
Crb3	crumbs homolog 3 (Drosophila)	0.010
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.010
Golt1a	golgi transport 1 homolog A (S. cerevisiae)	0.010
Sox11	SRY-box containing gene 11	0.010
Alx1	ALX homeobox 1	0.010
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.010