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Danio rerio

0 genes annotated in zebrafish

synostosis

DOID:11971

A dysostosis that results in abnormal fusing of adjacent bones.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "synostosis" (in gray)

Name	Description	Probability	Func Analog Organism
sema3aa	semaphorin 3aa	0.250
hoxa13b	homeo box A13b	0.172
fgf8a	fibroblast growth factor 8 a	0.131
fgfr1a	fibroblast growth factor receptor 1a	0.126	Human
fstl1b	follistatin-like 1b	0.119
sparc	secreted acidic cysteine rich glycoprotein	0.117
msxd	muscle segment homeobox D	0.114
zgc:158626	zgc:158626	0.098
hoxd10a	homeo box D10a	0.096
runx2b	runt-related transcription factor 2b	0.080
midn	midnolin	0.078
chd	chordin	0.076
pax2a	paired box gene 2a	0.076
bmp4	bone morphogenetic protein 4	0.074
efnb3b	ephrin B3b	0.063
unc5b	unc-5 homolog B (C. elegans)	0.063
mab21l2	mab-21-like 2	0.063
vasp	vasodilator-stimulated phosphoprotein	0.061
wt1a	wilms tumor 1a	0.061
col1a1a	collagen, type I, alpha 1a	0.059
msxe	muscle segment homeobox E	0.056
fgfrl1a	fibroblast growth factor receptor-like 1a	0.055
vax1	ventral anterior homeobox 1	0.050
hoxd12a	homeo box D12a	0.049
snai1b	snail homolog 1b (Drosophila)	0.045
wnt8b	wingless-type MMTV integration site family, member 8b	0.044
spry4	sprouty (Drosophila) homolog 4	0.044
spon1b	spondin 1b	0.043
nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.040
LOC572312	similar to CG10038 CG10038-PB	0.039
fgfr2	fibroblast growth factor receptor 2	0.039	Human
si:ch1073-268b21.1	si:ch1073-268b21.1	0.037
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.037
LOC100537720	hypothetical protein LOC100537720	0.036
tcf12	transcription factor 12	0.035
ankar	ankyrin and armadillo repeat containing	0.033
heatr5a	HEAT repeat containing 5a	0.032
LOC561388	hypothetical protein LOC561388	0.031
tbx18	T-box 18	0.030
LOC792958	nuclear receptor coactivator 7-like	0.030
evx1	even-skipped homeobox 1	0.030
ndr2	nodal-related 2	0.029
LOC557001	tetratricopeptide repeat protein 34-like	0.029
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.027
zgc:123017	zgc:123017	0.026
ptch2	patched 2	0.026
mef2d	myocyte enhancer factor 2d	0.026
wdr96	WD repeat domain 96	0.026
hoxa11a	homeo box A11a	0.026
appb	amyloid beta (A4) precursor protein b	0.026
sh3gl1b	SH3-domain GRB2-like 1b	0.025
LOC100537862	hypothetical protein LOC100537862	0.025
LOC565632	BTB/POZ domain-containing protein 16-like	0.025
kirrela	kin of IRRE like a	0.025
rorab	RAR-related orphan receptor A, paralog b	0.025
col14a1	collagen, type XIV, alpha 1	0.025
esr2a	estrogen receptor 2a	0.024
vax2	ventral anterior homeobox 2	0.023
bmp2b	bone morphogenetic protein 2b	0.023
gli1	GLI-Kruppel family member 1	0.023
rnf32	ring finger protein 32	0.022
LOC100333916	myomegalin-like	0.022
twist3	twist3	0.022
LOC100535597	hypothetical protein LOC100535597	0.021
im:7162646	im:7162646	0.021
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.021
ncor2	nuclear receptor co-repressor 2	0.021
antxr1	anthrax toxin receptor 1	0.021
prrx1b	paired related homeobox 1b	0.020
ved	ventrally expressed dharma/bozozok antagonist	0.020
cdk13	cyclin-dependent kinase 13	0.020
ogn	osteoglycin	0.020
otx1a	orthodenticle homolog 1a	0.020
LOC100536191	dynein beta chain, ciliary-like	0.020
LOC100333241	MLL1/MLL complex subunit KIAA1267-like	0.020
htr5al	5-hydroxytryptamine (serotonin) receptor 5A like	0.020
and2	actinodin2	0.019
crip2	cysteine-rich protein 2	0.019
gata4	GATA-binding protein 4	0.019
spry1	sprouty homolog 1 (Drosophila)	0.019
ephb4a	eph receptor B4a	0.019
LOC100329473	girdin-like	0.019
msxc	muscle segment homeobox C	0.019
cpne3	copine III	0.019
fgf24	fibroblast growth factor 24	0.019
cdh2	cadherin 2, neuronal	0.019
reln	reelin	0.019
mtnr1al	melatonin receptor type 1A like	0.019
fkbp10	FK506 binding protein 10	0.018
LOC795535	hypothetical protein LOC795535	0.018
lama5	laminin, alpha 5	0.018
LOC100331651	zona pellucida sperm-binding protein 4-like	0.018
wu:fi26e04	wu:fi26e04	0.018
LOC100331568	breast cancer anti-estrogen resistance protein 3 homolog	0.018
LOC557250	microtubule-associated tumor suppressor 1 homolog A-like	0.017
si:dkeyp-87a12.1	si:dkeyp-87a12.1	0.017
ctgf	connective tissue growth factor	0.017
dlx5a	distal-less homeobox gene 5a	0.017
si:ch211-81a5.5	si:ch211-81a5.5	0.017
si:dkey-208b23.5	si:dkey-208b23.5	0.017
si:dkey-181i3.1	si:dkey-181i3.1	0.017
LOC556026	afadin- and alpha-actinin-binding protein-like	0.017
lmo7a	LIM domain only 7a	0.017
zgc:114123	zgc:114123	0.017
prdm1a	PR domain containing 1a, with ZNF domain	0.016
mchr1b	melanin-concentrating hormone receptor 1b	0.016
zgc:153674	zgc:153674	0.016
fibin	fin bud initiation factor	0.016
sp7	Sp7 transcription factor	0.016
rtdr1	rhabdoid tumor deletion region gene 1	0.016
cpla2	cytosolic phospholipase a2	0.015
zc3h18	zinc finger CCCH-type containing 18	0.015
wnt1	wingless-type MMTV integration site family, member 1	0.015
si:ch211-209p5.2	si:ch211-209p5.2	0.015
LOC793222	cAMP-dependent protein kinase inhibitor alpha-like	0.015
lft2	lefty2	0.014
zgc:153738	zgc:153738	0.014
LOC100334308	lisH domain-containing protein ARMC9-like	0.014
LOC100535964	hypothetical protein LOC100535964	0.014
ldb2a	LIM-domain binding factor 2a	0.013
LOC100332505	hypothetical protein LOC100332505	0.013
zgc:85866	zgc:85866	0.013
prph2b	peripherin 2b (retinal degeneration, slow)	0.013
adra2da	adrenergic, alpha-2D-, receptor a	0.013
pax8	paired box gene 8	0.013
dusp6	dual specificity phosphatase 6	0.013
wnt5b	wingless-type MMTV integration site family, member 5b	0.013
nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.013
shha	sonic hedgehog a	0.013
sall4	sal-like 4 (Drosophila)	0.013
adra2db	adrenergic, alpha-2D-, receptor b	0.013
rhoub	ras homolog gene family, member Ub	0.013
arx	aristaless related homeobox	0.013
nav3	neuron navigator 3	0.012
ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.012
six4.3	sine oculis homeobox homolog 4.3	0.012
fgfr3	fibroblast growth factor receptor 3	0.012
gdf7	growth/differentiation factor 7	0.012
tgfb1a	transforming growth factor, beta 1a	0.012
gli3	GLI-Kruppel family member GLI3	0.012
sox9b	SRY-box containing gene 9b	0.012
lrrtm1	leucine rich repeat transmembrane neuronal 1	0.012
frem1a	Fras1 related extracellular matrix 1a	0.012
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.012
rbp4	retinol binding protein 4, plasma	0.012
pax7a	paired box gene 7a	0.012
fem1a	fem-1 homolog a (C. elegans)	0.011
ncana	neurocan a	0.011
efna3b	ephrin A3b	0.011
si:dkey-30c15.5	si:dkey-30c15.5	0.011
bmp2a	bone morphogenetic protein 2a	0.011
sox11a	SRY-box containing gene 11a	0.011
zgc:77123	zgc:77123	0.011
rargb	retinoic acid receptor, gamma b	0.011
neo1	neogenin 1	0.011
hmcn1	hemicentin 1	0.010
si:ch73-222h13.1	si:ch73-222h13.1	0.010
zgc:171747	zgc:171747	0.010
usp37	ubiquitin specific peptidase 37	0.010
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.010
robo3	roundabout homolog 3	0.010
wee2	WEE1 homolog 2 (S. pombe)	0.010