IMP

Process View

Danio rerio

1 genes annotated in zebrafish

osteoclast development

The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "osteoclast development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "osteoclast development" (in gray)

Name	Description	Probability	Func Analog Organism
tie1	endothelium-specific receptor tyrosine kinase 1	0.933
cdh5	cadherin 5	0.901
sox7	SRY-box containing gene 7	0.813
runx1	runt-related transcription factor 1	0.803
si:ch211-235f6.2	si:ch211-235f6.2	0.737
kita	kit receptor a	0.680	Zebrafish
mitfa	microphthalmia-associated transcription factor a	0.665
cmyb	transcription factor cmyb	0.620
etv2	ets variant gene 2	0.603
lcp1	lymphocyte cytosolic plastin 1	0.504
tie2	endothelium-specific receptor tyrosine kinase 2	0.311
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.297	Zebrafish
gata1a	GATA binding protein 1a	0.296
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.288
csf1ra	colony stimulating factor 1 receptor, a	0.280
tal1	T-cell acute lymphocytic leukemia 1	0.256
tagln2	transgelin 2	0.247
dll4	delta-like 4 (Drosophila)	0.238
kdrl	kinase insert domain receptor like	0.229	Zebrafish
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.224
cyp1a	cytochrome P450, family 1, subfamily A	0.206
flt4	fms-related tyrosine kinase 4	0.196	Zebrafish
sc:d812	sc:d812	0.176
fabp11a	fatty acid binding protein 11a	0.166
fli1a	friend leukemia integration 1a	0.159
bnc2	basonuclin 2	0.158
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.154
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.132
mmp9	matrix metalloproteinase 9	0.127
slc45a2	solute carrier family 45, member 2	0.106
dusp5	dual specificity phosphatase 5	0.102
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.102
stab2	stabilin 2	0.097
fras1	Fraser syndrome 1	0.083
dab2	disabled homolog 2 (Drosophila)	0.077
mpx	myeloid-specific peroxidase	0.076
prox1	prospero-related homeobox gene 1	0.069
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.067	Zebrafish
fancl	Fanconi anemia, complementation group L	0.060
ltk	leukocyte tyrosine kinase	0.059
gpr182	G protein-coupled receptor 182	0.058
vegfaa	vascular endothelial growth factor Aa	0.055
hbbe1.1	hemoglobin beta embryonic-1.1	0.049
vegfc	vascular endothelial growth factor c	0.044
cdh23	cadherin-like 23	0.043
calcrla	calcitonin receptor-like a	0.043
mb	myoglobin	0.039
pink1	PTEN induced putative kinase 1	0.038
ntn4	netrin 4	0.038
fli1b	friend leukemia integration 1b	0.038
vsg1	vessel-specific 1	0.038
aqp1a.1	aquaporin 1a, tandem duplicate 1	0.036
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.035
klf2a	Kruppel-like factor 2a	0.035
tyrp1b	tyrosinase-related protein 1b	0.034
pmela	premelanosome protein a	0.033
dnm2	dynamin 2	0.032
yrk	Yes-related kinase	0.032
mapk3	mitogen-activated protein kinase 3	0.032
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.032
tmem88a	transmembrane protein 88 a	0.030
s100v2	S100 calcium binding protein V2	0.030
anxa1a	annexin A1a	0.030
ift88	intraflagellar transport 88 homolog	0.030
tgfb3	transforming growth factor, beta 3	0.030
pnp4a	purine nucleoside phosphorylase 4a	0.030
mcamb	melanoma cell adhesion molecule b	0.029
mvp	major vault protein	0.029
efnb2a	ephrin B2a	0.029
aqp8a.1	aquaporin 8a, tandem duplicate 1	0.028
aplnrb	apelin receptor b	0.028
ndel1a	nudE nuclear distribution gene E homolog like 1 (A. nidulans) A	0.028
st8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.027
gfi1.1	growth factor independent 1.1	0.027
tyr	tyrosinase	0.026
nrp1a	neuropilin 1a	0.026
elmo1	engulfment and cell motility 1 (ced-12 homolog, C. elegans)	0.026
ccbe1	collagen and calcium binding EGF domains 1	0.026
fcho2	FCH domain only 2	0.026
atp6v1e1b	ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b	0.026
cldnb	claudin b	0.025
zgc:100919	zgc:100919	0.025
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.025
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.024
zgc:110789	zgc:110789	0.024
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.024
bdnf	brain-derived neurotrophic factor	0.024
zgc:112329	zgc:112329	0.024
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.023
lyz	lysozyme	0.023
tbx20	T-box 20	0.023
epas1b	endothelial PAS domain protein 1b	0.023
gch2	GTP cyclohydrolase 2	0.022
hspa12b	heat shock protein 12B	0.022
cntn2	contactin 2	0.022
fev	FEV (ETS oncogene family)	0.022
ednrb1	endothelin receptor B	0.021
lmo2	LIM domain only 2 (rhombotin-like 1)	0.021
socs1	suppressor of cytokine signaling 1	0.021
plxnd1	plexin D1	0.020
crestin	crestin	0.020
esama	endothelial cell adhesion molecule a	0.020
bbs4	Bardet-Biedl syndrome 4	0.020
igfbp7	insulin-like growth factor binding protein 7	0.019
dlx3b	distal-less homeobox gene 3b	0.019
lin28a	lin-28 homolog A (C. elegans)	0.018
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.018
si:dkey-222f8.3	si:dkey-222f8.3	0.017
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.017
notch3	notch homolog 3	0.017
mmp13a	matrix metalloproteinase 13a	0.017
ptprb	protein tyrosine phosphatase, receptor type, b	0.017
capns1a	calpain, small subunit 1 a	0.017
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.016
LOC563527	brain-specific angiogenesis inhibitor 1-like	0.016
mef2cb	myocyte enhancer factor 2cb	0.016
wt1b	wilms tumor 1b	0.016
dlg1	discs, large (Drosophila) homolog 1	0.015
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.015
tagln	transgelin	0.015
cnn2	calponin 2	0.015
aldh1l1	aldehyde dehydrogenase 1 family, member L1	0.014
pax7b	paired box gene 7b	0.014
frem2a	Fras1 related extracellular matrix protein 2a	0.014
lgals2b	lectin, galactoside-binding, soluble, 2b	0.014
robo2	roundabout homolog 2	0.014
ccm2	cerebral cavernous malformation 2	0.014
igf2b	insulin-like growth factor 2b	0.014
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.014
tagln3b	transgelin 3b	0.014
ahcyl2	S-adenosylhomocysteine hydrolase-like 2	0.014
lrrc50	leucine rich repeat containing 50	0.014
s100a10b	S100 calcium binding protein A10b	0.014
musk	muscle, skeletal, receptor tyrosine kinase	0.014
casp8	caspase 8, apoptosis-related cysteine peptidase	0.013
igf1	insulin-like growth factor 1	0.013
kdm4b	lysine (K)-specific demethylase 4B	0.013
anxa6	annexin A6	0.013
stk11	serine/threonine kinase 11	0.013
phox2b	paired-like homeobox 2b	0.013
LOC555739	serine/threonine-protein kinase LMTK1-like	0.013
cav1	caveolin 1	0.013
vps39	vacuolar protein sorting 39 homolog (S. cerevisiae)	0.013
cast	calpastatin	0.013
stat5.2	signal transducer and activator of transcription 5.2	0.013
cald1	caldesmon 1	0.013
atp6v1h	ATPase, H+ transporting, lysosomal, V1 subunit H	0.012
tbp	TATA box binding protein	0.012
plxna4	plexin A4	0.012
mbp	myelin basic protein	0.012
tfec	transcription factor EC	0.012
gria2a	glutamate receptor, ionotropic, AMPA 2a	0.012
cry3	cryptochrome 3	0.012
si:ch73-60e21.1	si:ch73-60e21.1	0.012
mib	mind bomb	0.012
mycbp2	MYC binding protein 2	0.012
syk	spleen tyrosine kinase	0.012
eml2	echinoderm microtubule associated protein like 2	0.012
dct	dopachrome tautomerase	0.012
rrm2b	ribonucleotide reductase M2 b	0.012
slc4a4b	solute carrier family 4, sodium bicarbonate cotransporter, member 4b	0.012
dspa	desmoplakin a	0.012
taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto	0.011
tm4sf4	transmembrane 4 L six family member 4	0.011
foxj1b	forkhead box J1b	0.011
clec14a	C-type lectin domain family 14, member A	0.011
crb2a	crumbs homolog 2a	0.011
acta2	actin, alpha 2, smooth muscle, aorta	0.011
LOC100333708	papilin-like	0.011
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.011
abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.011
hspg2	heparan sulfate proteoglycan 2	0.011
LOC100535549	cytoplasmic polyadenylation element-binding protein 4-like	0.011
odc1	ornithine decarboxylase 1	0.011
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.011
appa	amyloid beta (A4) precursor protein a	0.011
chrna6	cholinergic receptor, nicotinic, alpha 6	0.010
ca2	carbonic anhydrase II	0.010