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Process View

Danio rerio

15 genes annotated in zebrafish

optic nerve development

The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "optic nerve development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "optic nerve development" (in gray)

Name	Description	Probability	Func Analog Organism
mib	mind bomb	0.848
lhx2b	LIM homeobox 2b	0.745
tubb5	tubulin, beta 5	0.431
dla	deltaA	0.369
shha	sonic hedgehog a	0.366
pax2a	paired box gene 2a	0.282	Mouse
tbx16	T-box gene 16	0.264	Zebrafish
ndr2	nodal-related 2	0.229
isl1	islet1	0.166	Zebrafish
dld	deltaD	0.159
cdh2	cadherin 2, neuronal	0.159
dlc	deltaC	0.136
atoh7	atonal homolog 7	0.136	Human
tbx5a	T-box 5a	0.135
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.129
dlb	deltaB	0.129
tgfb2	transforming growth factor, beta 2	0.087
scn1ba	sodium channel, voltage-gated, type I, beta a	0.083
bmp4	bone morphogenetic protein 4	0.077
neurog1	neurogenin 1	0.074
dcc	deleted in colorectal carcinoma	0.073
spaw	southpaw	0.072
robo2	roundabout homolog 2	0.071
barhl1.2	BarH-like 1.2	0.070
tbx2b	T-box 2b	0.068	Zebrafish
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.068
her1	hairy-related 1	0.068
jag2	jagged 2	0.068
fn1	fibronectin 1	0.064	Zebrafish
olig2	oligodendrocyte lineage transcription factor 2	0.062
foxp2	forkhead box P2	0.061
fezf2	FEZ family zinc finger 2	0.060
sall1a	sal-like 1a (Drosophila)	0.058
isl2a	islet2a	0.058	Zebrafish
zgc:195154	zgc:195154	0.057
rtn1a	reticulon 1a	0.054	Zebrafish
eng2b	engrailed 2b	0.054
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.053
barhl2	BarH-like 2	0.053
foxg1a	forkhead box G1a	0.051
mitfa	microphthalmia-associated transcription factor a	0.051
vcana	versican a	0.051
eya1	eyes absent homolog 1	0.047
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.046
oep	one-eyed pinhead	0.043
rtn4a	reticulon 4a	0.043
rx3	retinal homeobox gene 3	0.041
tgfb3	transforming growth factor, beta 3	0.041
flh	floating head	0.040
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.040
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.039
six4b	sine oculis homeobox homolog 4b	0.039
nt5c2l1	5'-nucleotidase, cytosolic II, like 1	0.038
sncb	synuclein, beta	0.038
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.037
grem2	gremlin 2, cysteine knot superfamily	0.037
emx3	empty spiracles homeobox 3	0.036
insm1b	insulinoma-associated 1b	0.036
cntn2	contactin 2	0.036
foxn4	forkhead box N4	0.035
pou3f3b	POU class 3 homeobox 3b	0.034
lhx5	LIM homeobox 5	0.034	Zebrafish
tac1	tachykinin 1	0.033
foxa1	forkhead box A1	0.033
hand2	heart and neural crest derivatives expressed transcript 2	0.032
axin1	axin 1	0.032
ptch1	patched 1	0.031
vldlr	very low density lipoprotein receptor	0.030
dlx2b	distal-less homeobox gene 2b	0.029
flot1	flotillin 1	0.029
si:dkey-24g18.2	si:dkey-24g18.2	0.028
dbx1a	developing brain homeobox 1a	0.028
cdh4	cadherin 4, retinal	0.028
oprd1b	opioid receptor, delta 1b	0.027
her7	hairy and enhancer of split related-7	0.027
ctnnd2b	catenin (cadherin-associated protein), delta 2b	0.026
hoxa13b	homeo box A13b	0.026
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.026
dpysl3	dihydropyrimidinase-like 3	0.026
adcyap1r1	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	0.026
itgav	integrin, alpha V	0.025
tgfbi	transforming growth factor, beta-induced	0.025
atp6v1ba	ATPase, H+ transporting, lysosomal, V1 subunit B, member a	0.025
coe2	coe2	0.024
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.024
osr2	odd-skipped related 2 (Drosophila)	0.024
myl7	myosin, light polypeptide 7, regulatory	0.024
ppp1cbl	protein phosphatase 1, catalytic subunit, beta isoform, like	0.024
alcama	activated leukocyte cell adhesion molecule a	0.023
evlb	Enah/Vasp-like b	0.023
pea3	ETS-domain transcription factor pea3	0.023
marcksa	myristoylated alanine rich protein kinase C substrate a	0.023
has2	hyaluronan synthase 2	0.022
ncam1b	neural cell adhesion molecule 1b	0.022
dlx2a	distal-less homeobox gene 2a	0.022
cntn1a	contactin 1a	0.022
otx1a	orthodenticle homolog 1a	0.022
dspa	desmoplakin a	0.022
wnt8b	wingless-type MMTV integration site family, member 8b	0.022
unc45b	unc-45 homolog B (C. elegans)	0.022
mecom	MDS1 and EVI1 complex locus	0.021
fgf10a	fibroblast growth factor 10a	0.021
csnk1a1	casein kinase 1, alpha 1	0.021
ptpra	protein tyrosine phosphatase, receptor type, A	0.021
ap3m2	adaptor-related protein complex 3, mu 2 subunit	0.021
slc2a15b	solute carrier family 2 (facilitated glucose transporter), member 15b	0.021
gdf6a	growth differentiation factor 6a	0.020
nkx2.1a	NK2 homeobox 1a	0.020
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.020
atoh8	atonal homolog 8	0.020
gamt	guanidinoacetate N-methyltransferase	0.020
hbbe3	hemoglobin beta embryonic-3	0.019
tmsb	thymosin, beta	0.019
tp63	tumor protein p63	0.019
klf2a	Kruppel-like factor 2a	0.019
slc17a6b	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b	0.019
cdh6	cadherin 6	0.018
otpb	orthopedia homolog b	0.018
barhl1.1	BarH-like 1.1	0.018
gnao1a	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a	0.018
robo1	roundabout homolog 1	0.018
neurod4	neurogenic differentiation 4	0.018
snai1b	snail homolog 1b (Drosophila)	0.018
fgf8a	fibroblast growth factor 8 a	0.018
tbx3	T-box 3	0.018	Zebrafish
cd99l2	CD99 antigen-like 2	0.017
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.017
msgn1	mesogenin 1	0.017
tbx1	T-box 1	0.017	Zebrafish
pitx2	paired-like homeodomain transcription factor 2	0.017
tlx2	T-cell leukemia, homeobox 2	0.017
pygmb	phosphorylase, glycogen (muscle) b	0.017
gng3	guanine nucleotide binding protein (G protein), gamma 3	0.016
pkp1	plakophilin 1	0.016
lft1	lefty1	0.016
rxrga	retinoid x receptor, gamma a	0.016
rtn4b	reticulon 4b	0.016
nkx2.3	NK2 transcription factor related 3	0.016
itgb1a	integrin, beta 1a	0.015
fzd9b	frizzled homolog 9b	0.015
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.015
rtn1b	reticulon 1b	0.015	Zebrafish
rpl23	ribosomal protein L23	0.015
gbx2	gastrulation brain homeo box 2	0.015
foxi1	forkhead box I1	0.015
blf	bloody fingers	0.015
crip2	cysteine-rich protein 2	0.015
fgf3	fibroblast growth factor 3	0.015
dab1b	disabled homolog 1b (Drosophila)	0.015
alas2	aminolevulinate, delta-, synthetase 2	0.014
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.014
dlg4	discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila)	0.014
rtn3	reticulon 3	0.014
eomesa	eomesodermin homolog a	0.014	Zebrafish
hmx3	homeo box (H6 family) 3	0.014
lgi1a	leucine-rich, glioma inactivated 1a	0.014
tbx20	T-box 20	0.013	Zebrafish
hpca	hippocalcin	0.013
cpe	carboxypeptidase E	0.013
gch2	GTP cyclohydrolase 2	0.013
foxh1	forkhead box H1	0.013
qars	glutaminyl-tRNA synthetase	0.013
vax1	ventral anterior homeobox 1	0.013
hlxb9lb	homeo box HB9 like b	0.013
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.013
olfm1b	olfactomedin 1b	0.013
cebp1	CCAAT/enhancer binding protein (C/EBP) 1	0.013
fzd5	frizzled homolog 5	0.013
csrnp1b	cysteine-serine-rich nuclear protein 1b	0.013
sox32	SRY-box containing gene 32	0.013
pou4f1	POU domain, class 4, transcription factor 1	0.013
nrp2b	neuropilin 2b	0.013
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.013
rpl35a	ribosomal protein L35a	0.013
tspan13b	tetraspanin 13b	0.013
atp6v1b2	ATPase, H+ transporting, lysosomal V1 subunit B2	0.012
lox	lysyl oxidase	0.012
rap2ip	Rap2 interacting protein	0.012
gdi1	GDP dissociation inhibitor 1	0.012
foxd3	forkhead box D3	0.012
cdx4	caudal type homeo box transcription factor 4	0.012
rest	RE1-silencing transcription factor	0.012
pou3f2	POU class 3 homeobox 2	0.012
dpysl5a	dihydropyrimidinase-like 5a	0.012
otx2	orthodenticle homolog 2	0.012
wnt11	wingless-type MMTV integration site family, member 11	0.012
lhx3	LIM homeobox 3	0.012
oprk1	opioid receptor, kappa 1	0.012
nkx2.5	NK2 transcription factor related 5	0.012
tal2	T-cell acute lymphocytic leukemia 2	0.012
six3b	sine oculis homeobox homolog 3b	0.012
cyfip2	cytoplasmic FMR1 interacting protein 2	0.012
nkx2.1b	NK2 homeobox 1b	0.012
slit2	slit (Drosophila) homolog 2	0.012
opa3	optic atrophy 3	0.012
cplx2l	complexin 2, like	0.011
dlg2	discs, large (Drosophila) homolog 2	0.011
vsx1	visual system homeobox 1 homolog, chx10-like	0.011
notch1b	notch homolog 1b	0.011
mmp2	matrix metalloproteinase 2	0.011
zgc:114188	zgc:114188	0.011
celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	0.011
si:ch211-69i14.7	si:ch211-69i14.7	0.011
urod	uroporphyrinogen decarboxylase	0.011
bmp2b	bone morphogenetic protein 2b	0.011
vax2	ventral anterior homeobox 2	0.011
msi1	musashi homolog 1 (Drosophila)	0.011
pcdh8	protocadherin 8	0.011
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.011
igfbp3	insulin-like growth factor binding protein 3	0.011
met	met proto-oncogene (hepatocyte growth factor receptor)	0.011
scrt2	scratch homolog 2, zinc finger protein (Drosophila)	0.011
camkvb	CaM kinase-like vesicle-associated b	0.011
mrpl23	mitochondrial ribosomal protein L23	0.011
otpa	orthopedia homolog a	0.011
uros	uroporphyrinogen III synthase	0.011
six2a	sine oculis-related homeobox 2a	0.011
scube2	signal peptide, CUB domain, EGF-like 2	0.011
arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.010
wnt3a	wingless-type MMTV integration site family, member 3A	0.010
foxa3	forkhead box A3	0.010
foxa2	forkhead box A2	0.010
dbx1b	developing brain homeobox 1b	0.010
pom121	POM121 membrane glycoprotein (rat)	0.010
gdf6b	growth differentiation factor 6b	0.010
wnt1	wingless-type MMTV integration site family, member 1	0.010
zgc:64051	zgc:64051	0.010
ptf1a	pancreas specific transcription factor, 1a	0.010
scrt1b	scratch homolog 1, zinc finger protein b (Drosophila)	0.010
pax6b	paired box gene 6b	0.010
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.010
slc25a26	solute carrier family 25, member 26	0.010
tbx22	T-box 22	0.010
zgc:100994	zgc:100994	0.010