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Danio rerio

12 genes annotated in zebrafish

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "leukocyte activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "leukocyte activation" (in gray)

Name	Description	Probability	Func Analog Organism
capns1b	calpain, small subunit 1 b	0.570
fgf3	fibroblast growth factor 3	0.442
cmyb	transcription factor cmyb	0.365	Human Mouse
cdx4	caudal type homeo box transcription factor 4	0.353
lhx3	LIM homeobox 3	0.291
bmp2b	bone morphogenetic protein 2b	0.274
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.240
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.239	Mouse
mmp9	matrix metalloproteinase 9	0.217
fgf8a	fibroblast growth factor 8 a	0.154
lcp1	lymphocyte cytosolic plastin 1	0.121
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.116
ighm	immunoglobulin heavy constant mu and immunoglobulin heavy constant mu	0.111
otx1b	orthodenticle homolog 1b	0.104
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.099
satb2	SATB homeobox 2	0.098
tbx1	T-box 1	0.097
csf3r	colony stimulating factor 3 receptor (granulocyte)	0.096
il6r	interleukin 6 receptor	0.083
ccnd1	cyclin D1	0.081
lyz	lysozyme	0.078
fzd7a	frizzled homolog 7a	0.077
si:dkey-8l13.4	si:dkey-8l13.4	0.075	Mouse
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.074
gata3	GATA-binding protein 3	0.074	Mouse
boc	brother of CDO	0.073
myca	myelocytomatosis oncogene a	0.073
pcdh18b	protocadherin 18b	0.072
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.067
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.065	Mouse
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.063
fzd10	frizzled homolog 10	0.061
nadl1.1	neural adhesion molecule L1.1	0.059
edn1	endothelin 1	0.058
fabp7a	fatty acid binding protein 7, brain, a	0.056
rag1	recombination activating gene 1	0.056	Mouse
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.055	Mouse
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.051
crip2	cysteine-rich protein 2	0.050
shha	sonic hedgehog a	0.049	Mouse
zgc:56039	zgc:56039	0.047
egr2b	early growth response 2b	0.047
tshb	thyroid stimulating hormone, beta subunit	0.047
axin2	axin 2 (conductin, axil)	0.045
efna2	ephrin A2	0.045
il12bb	interleukin 12B, b	0.044	Mouse
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.043
fzd5	frizzled homolog 5	0.042	Mouse
runx2a	runt-related transcription factor 2a	0.041	Mouse
kita	kit receptor a	0.041	Human Mouse
dlc	deltaC	0.039
lft1	lefty1	0.039
il7r	interleukin 7 receptor	0.039
tlr3	toll-like receptor 3	0.038
pdcd2	programmed cell death 2	0.037
wnt9b	wingless-type MMTV integration site family, member 9B	0.037
arrb2b	arrestin, beta 2b	0.035
elk4	ELK4, ETS-domain protein	0.035
zgc:91870	zgc:91870	0.034
nrp2b	neuropilin 2b	0.033
eomesb	eomesodermin homolog b	0.032	Human Mouse
ext2	exostoses (multiple) 2	0.032
fes	feline sarcoma oncogene	0.032
runx3	runt-related transcription factor 3	0.031
crfa31.2	IL-4RA-like protein 2	0.031
zgc:64115	zgc:64115	0.031
fn1	fibronectin 1	0.031
chd	chordin	0.030
wasa	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a	0.030	Mouse
zgc:77517	zgc:77517	0.030
tert	telomerase reverse transcriptase	0.030
ryk	receptor-like tyrosine kinase	0.029
tbx2b	T-box 2b	0.029
cd8a	CD8 antigen, alpha polypeptide	0.029	Mouse
caspa	caspase a	0.029
jak3	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	0.029
scd	stearoyl-CoA desaturase (delta-9-desaturase)	0.028
btk	Bruton agammaglobulinemia tyrosine kinase	0.027
si:dkey-27i16.2	si:dkey-27i16.2	0.027
hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.027
LOC100003514	protein kinase C alpha type-like	0.026
gli1	GLI-Kruppel family member 1	0.025
flh	floating head	0.025
rad21	RAD21 homolog (S. pombe)	0.025
pglyrp6	peptidoglycan recognition protein 6	0.025
ptger4a	prostaglandin E receptor 4 (subtype EP4) a	0.024
hlxb9la	homeo box HB9 like a	0.024
cntn2	contactin 2	0.024
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.024
grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.024
fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.024
ip6k2	inositol hexaphosphate kinase 2	0.024
tp53	tumor protein p53	0.024	Mouse
lrrc33	leucine rich repeat containing 33	0.024
tcf12	transcription factor 12	0.023
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.023
hirip3	HIRA interacting protein 3	0.023
eya2	eyes absent homolog 2 (Drosophila)	0.023
notch3	notch homolog 3	0.023
fcer1gl	Fc receptor, IgE, high affinity I, gamma polypeptide like	0.023
emx3	empty spiracles homeobox 3	0.022
mapk8b	mitogen-activated protein kinase 8b	0.022
impdh1b	inosine 5'-phosphate dehydrogenase 1b	0.022	Mouse
gmnn	geminin, DNA replication inhibitor	0.022
tgfbi	transforming growth factor, beta-induced	0.022
mych	myelocytomatosis oncogene homolog	0.022
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.022	Zebrafish
dlx6a	distal-less homeobox gene 6a	0.022
zgc:64051	zgc:64051	0.022
s100v2	S100 calcium binding protein V2	0.021
prkar1aa	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a	0.021
nap1l1	nucleosome assembly protein 1, like 1	0.021
ncor1	nuclear receptor co-repressor 1	0.021	Mouse
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.021	Mouse
lgals2a	lectin, galactoside-binding, soluble, 2a	0.021	Mouse
mapk14a	mitogen-activated protein kinase 14a	0.020
slc30a7	solute carrier family 30 (zinc transporter), member 7	0.020
ptprc	protein tyrosine phosphatase, receptor type, C	0.020	Human Mouse
gdf6a	growth differentiation factor 6a	0.020
bhmt	betaine-homocysteine methyltransferase	0.020
foxa3	forkhead box A3	0.020
zfp36l1a	zinc finger protein 36, C3H type-like 1a	0.020	Mouse
wt1a	wilms tumor 1a	0.019
ptch2	patched 2	0.019
her6	hairy-related 6	0.019
ildr1b	immunoglobulin-like domain containing receptor 1b	0.019
spry2	sprouty homolog 2	0.019
spns2	spinster homolog 2 (Drosophila)	0.019
met	met proto-oncogene (hepatocyte growth factor receptor)	0.018
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.018
mybl2	myeloblastosis oncogene-like 2	0.018
jag1b	jagged 1b	0.018
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.018
notch1a	notch homolog 1a	0.018
abcg2a	ATP-binding cassette, sub-family G (WHITE), member 2a	0.018
pycard	PYD and CARD domain containing	0.018	Human Mouse
hmgb1a	high-mobility group box 1a	0.018
hk1	hexokinase 1	0.017
dntt	deoxynucleotidyltransferase, terminal	0.017
mtmr8	myotubularin related protein 8	0.017
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.017
csk	c-src tyrosine kinase	0.017
elovl1b	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b	0.017
fabp3	fatty acid binding protein 3, muscle and heart	0.017
tal1	T-cell acute lymphocytic leukemia 1	0.017
tgm2b	transglutaminase 2b	0.017
sox4a	SRY-box containing gene 4a	0.017	Mouse
mpx	myeloid-specific peroxidase	0.016
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.016
six4a	sine oculis homeobox homolog 4a	0.016
rac2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.016
stxbp2	syntaxin binding protein 2	0.016	Human
kitlga	kit ligand a	0.016
pomca	proopiomelanocortin a	0.016
wnk1	WNK lysine deficient protein kinase 1	0.016
plcg1	phospholipase C, gamma 1	0.015
anxa1a	annexin A1a	0.015	Mouse
lfng	lunatic fringe homolog	0.015
ikzf5	IKAROS family zinc finger 5	0.015
pglyrp5	peptidoglycan recognition protein 5	0.015
zgc:56136	zgc:56136	0.015
chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.015
bcl2	B-cell leukemia/lymphoma 2	0.015	Human Mouse
htra1a	HtrA serine peptidase 1a	0.015
sox5	SRY-box containing gene 5	0.015
msh2	mutS homolog 2 (E. coli)	0.015	Mouse
meis1	myeloid ecotropic viral integration 1	0.015
il8	interleukin 8	0.014
LOC564872	monocarboxylate transporter 7-like	0.014
il4r	interleukin 4 receptor	0.014
sox19a	SRY-box containing gene 19a	0.014
rpl7a	ribosomal protein L7a	0.014
krt4	keratin 4	0.014
ca8	carbonic anhydrase VIII	0.014
wnt8a	wingless-type MMTV integration site family, member 8a	0.014
angptl2	angiopoietin-like 2	0.014
pdgfaa	platelet-derived growth factor alpha a	0.013
gata4	GATA-binding protein 4	0.013
cnpy2	canopy 2	0.013
unc45a	unc-45 homolog A (C. elegans)	0.013
epas1b	endothelial PAS domain protein 1b	0.013
camk2g1	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1	0.013
s1pr2	sphingosine-1-phosphate receptor 2	0.013
eml2	echinoderm microtubule associated protein like 2	0.013
tmem144b	transmembrane protein 144b	0.013
fryl	furry homolog-like (Drosophila)	0.013
id1	inhibitor of DNA binding 1	0.013
smoc2	secreted modular calcium binding protein 2	0.013
mpll	myeloproliferative leukemia virus oncogene, like	0.013
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.013
ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.013
f2rl1.2	coagulation factor II (thrombin) receptor-like 1.2	0.013
cldn5a	claudin 5a	0.012
cldn5b	claudin 5b	0.012
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.012
ndr2	nodal-related 2	0.012
pou4f1	POU domain, class 4, transcription factor 1	0.012
col6a2	collagen, type VI, alpha 2	0.012
jak1	Janus kinase 1	0.012
her1	hairy-related 1	0.012
clock3	clock homolog 3 (mouse)	0.012
wnt10a	wingless-type MMTV integration site family, member 10a	0.012
rag2	recombination activating gene 2	0.012	Mouse
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.012
alk	anaplastic lymphoma kinase (Ki-1)	0.012
runx1	runt-related transcription factor 1	0.012
sdprb	serum deprivation response b	0.012
bmp6	bone morphogenetic protein 6	0.012
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.012
sb:cb472	sb:cb472	0.012
itm2bb	integral membrane protein 2Bb	0.012
tagln2	transgelin 2	0.012
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.012	Mouse
pfn1	profilin 1	0.012
camk2g2	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2	0.011
lck	lymphocyte-specific protein tyrosine kinase	0.011	Human Mouse
pknox1.2	pbx/knotted 1 homeobox 1.2	0.011	Mouse
zgc:92481	zgc:92481	0.011
nr1i2	nuclear receptor subfamily 1, group I, member 2	0.011
nitr9	novel immune-type receptor 9	0.011
ephb4b	eph receptor B4b	0.011
iclp1	invariant chain-like protein 1	0.011
zgc:56005	zgc:56005	0.011
sulf2l	sulfatase 2, like	0.011
polb	polymerase (DNA directed), beta	0.011
ap2a1	adaptor-related protein complex 2, alpha 1 subunit	0.011
ptp4a1	protein tyrosine phosphatase type IVA, member 1	0.011
zgc:63721	zgc:63721	0.011
atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	0.011
id3	inhibitor of DNA binding 3	0.011
tardbp	TAR DNA binding protein	0.011
zgc:55582	zgc:55582	0.011
faah2b	fatty acid amide hydrolase 2b	0.011
zgc:162329	zgc:162329	0.011
fn1b	fibronectin 1b	0.011
trim33	tripartite motif-containing 33	0.011
cbfb	core-binding factor, beta subunit	0.011	Mouse
efnb1	ephrin B1	0.011	Mouse
tlr2	toll-like receptor 2	0.011
tbp	TATA box binding protein	0.011
tyrobp	TYRO protein tyrosine kinase binding protein	0.011
clic2	chloride intracellular channel 2	0.011
cd247	CD247 antigen	0.011
nkx2.1a	NK2 homeobox 1a	0.011
entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.011
si:dkey-204f11.66	si:dkey-204f11.66	0.011
cyyr1	cysteine and tyrosine-rich protein 1	0.011
bmi1b	B lymphoma Mo-MLV insertion region 1b	0.011
kbtbd4	kelch repeat and BTB (POZ) domain containing 4	0.011
mbnl2	muscleblind-like 2 (Drosophila)	0.010
anxa11a	annexin A11a	0.010
cav1	caveolin 1	0.010	Human
lgals9l1	lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1	0.010
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.010
mitfa	microphthalmia-associated transcription factor a	0.010
csrp1a	cysteine and glycine-rich protein 1a	0.010
dock8	dedicator of cytokinesis 8	0.010	Mouse
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.010
cldn15la	claudin 15-like a	0.010
vent	ventral expressed homeobox	0.010
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.010
zff9	zinc finger protein 9	0.010
per3	period homolog 3 (Drosophila)	0.010
ihha	Indian hedgehog homolog a	0.010	Mouse
tgfb3	transforming growth factor, beta 3	0.010
axin1	axin 1	0.010