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Process View

Danio rerio

10 genes annotated in zebrafish

negative regulation of proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of proteolysis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of proteolysis" (in gray)

Name	Description	Probability	Func Analog Organism
mcl1a	myeloid cell leukemia sequence 1a	0.187
tp53	tumor protein p53	0.154	Mouse
shha	sonic hedgehog a	0.142	Mouse Fly
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.098
cdc20	cell division cycle 20 homolog	0.093	Yeast
hhip	hedgehog interacting protein	0.078
ptch1	patched 1	0.072
tacc3	transforming, acidic coiled-coil containing protein 3	0.072
adipoql	adiponectin, C1Q and collagen domain containing, like	0.066	Zebrafish
cdt1	chromatin licensing and DNA replication factor 1	0.062
adipor2	adiponectin receptor 2	0.058
usp5	ubiquitin specific protease 5	0.058
eng2a	engrailed 2a	0.047
shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.047
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.046
col1a1a	collagen, type I, alpha 1a	0.045
bhmt	betaine-homocysteine methyltransferase	0.044
furina	furin (paired basic amino acid cleaving enzyme) a	0.044	Human
aplp2	amyloid beta (A4) precursor-like protein 2	0.043
si:ch211-244o22.2	si:ch211-244o22.2	0.043
ef1a	elongation factor 1-alpha	0.041
kpna2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.037
baxa	bcl2-associated X protein, a	0.037	Zebrafish
wu:fj39b01	wu:fj39b01	0.037
sox9b	SRY-box containing gene 9b	0.036
kif11	kinesin family member 11	0.035
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.034
kif23	kinesin family member 23	0.034
ptch2	patched 2	0.033
mcl1b	myeloid cell leukemia sequence 1b	0.032
LOC562316	klotho-like	0.032
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.031
supt5h	suppressor of Ty 5 homolog (S. cerevisiae)	0.031
a1cf	apobec1 complementation factor	0.031
mab21l1	mab-21-like 1	0.030
g2e3	G2/M-phase specific E3 ubiquitin ligase	0.027
calcr	calcitonin receptor	0.026
nkx2.2a	NK2 transcription factor related 2a	0.025
ccng1	cyclin G1	0.024
serpina1l	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like	0.024
atp1b3b	ATPase, Na+/K+ transporting, beta 3b polypeptide	0.024
nkx3.2	NK3 homeobox 2	0.024
gro2	groucho 2	0.023
ccna2	cyclin A2	0.023
ctgf	connective tissue growth factor	0.023
acvr1l	activin A receptor, type I like	0.022
sulf2l	sulfatase 2, like	0.022
mnx1	motor neuron and pancreas homeobox 1	0.022
bad	BCL2-antagonist of cell death	0.022
tbx1	T-box 1	0.022
bactin2	bactin2	0.021
ihha	Indian hedgehog homolog a	0.021	Fly
pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.021
ncoa2	nuclear receptor coactivator 2	0.021
ifnphi1	interferon phi 1	0.020
sepp1b	selenoprotein P, plasma, 1b	0.020
frem1a	Fras1 related extracellular matrix 1a	0.020
atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.020
s1pr2	sphingosine-1-phosphate receptor 2	0.020
si:ch211-51m24.3	si:ch211-51m24.3	0.020
zgc:73293	zgc:73293	0.020
zgc:56530	zgc:56530	0.019	Human
bbc3	BCL2 binding component 3	0.019
igf1ra	insulin-like growth factor 1a receptor	0.019
ctsba	cathepsin B, a	0.019
gdf6a	growth differentiation factor 6a	0.019
rtkn2	rhotekin 2	0.019
barx1	BarH-like homeobox 1	0.019
zgc:85866	zgc:85866	0.018
dvl3	dishevelled, dsh homolog 3 (Drosophila)	0.018
mecp2	methyl CpG binding protein 2	0.018
bcl2l1	bcl2-like 1	0.017
smad5	MAD homolog 5 (Drosophila)	0.017
tpt1	tumor protein, translationally-controlled 1	0.017
il8	interleukin 8	0.017
zgc:111944	zgc:111944	0.016
itih2	inter-alpha (globulin) inhibitor H2	0.016
pklr	pyruvate kinase, liver and RBC	0.016
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.016
olfm2	olfactomedin 2	0.016
vwf	von Willebrand factor	0.016
nf1a	neurofibromin 1a	0.016
lpp	LIM domain containing preferred translocation partner in lipoma	0.015
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.015
ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.015
zgc:101723	zgc:101723	0.015
psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.015
fbp1b	fructose-1,6-bisphosphatase 1b	0.015
polr2b	polymerase (RNA) II (DNA directed) polypeptide B	0.014
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.014
zgc:123326	zgc:123326	0.014
zgc:56699	zgc:56699	0.014
pax5	paired box gene 5	0.014
st8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.014
hgfb	hepatocyte growth factor b	0.013
wu:fb80a07	wu:fb80a07	0.013
c9	complement component 9	0.013
fmr1	fragile X mental retardation 1	0.013
neo1	neogenin 1	0.013
msh6	mutS homolog 6 (E. coli)	0.013
adipoql2	adiponectin, C1Q and collagen domain containing, like 2	0.013	Zebrafish
zgc:172246	zgc:172246	0.013
pole	polymerase (DNA directed), epsilon	0.012
nusap1	nucleolar and spindle associated protein 1	0.012
idh3b	isocitrate dehydrogenase 3 (NAD+) beta	0.012
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.012
fgf4	fibroblast growth factor 4	0.012
pcsk9	proprotein convertase subtilisin/kexin type 9	0.012
wnt9a	wingless-type MMTV integration site family, member 9A	0.012	Mouse
calcrla	calcitonin receptor-like a	0.012
ckap5	cytoskeleton associated protein 5	0.012
pitpna	phosphatidylinositol transfer protein, alpha	0.012
rnasel1	ribonuclease like 1	0.012
cdh4	cadherin 4, retinal	0.012
ccnb1	cyclin B1	0.012
polb	polymerase (DNA directed), beta	0.012
bag6	BCL2-associated athanogene 6	0.011
atp1a3a	ATPase, Na+/K+ transporting, alpha 3a polypeptide	0.011
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.011
cry2b	cryptochrome 2b	0.011
nphs1l	nephrosis 1, congenital, Finnish type (nephrin)-like	0.011
faf2	Fas associated factor family member 2	0.011
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.011
zgc:56200	zgc:56200	0.011
plg	plasminogen	0.011
wnt8b	wingless-type MMTV integration site family, member 8b	0.011
ambpl	alpha-1-microglobulin/bikunin precursor, like	0.011	Rat
grin1a	glutamate receptor, ionotropic, N-methyl D-aspartate 1a	0.011
si:ch211-69g19.2	si:ch211-69g19.2	0.011
sod1	superoxide dismutase 1, soluble	0.011
f2	coagulation factor II (thrombin)	0.011	Human
nuf2	NUF2, NDC80 kinetochore complex component, homolog	0.011
serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.011
bida	BH3 interacting domain death agonist	0.011
cdca8	cell division cycle associated 8	0.011
map2k4a	mitogen-activated protein kinase kinase 4a	0.011
slc35b2	solute carrier family 35, member B2	0.010
s1pr3	sphingosine-1-phosphate receptor 3	0.010
rdh1	retinol dehydrogenase 1	0.010
acvrl1	activin A receptor type II-like 1	0.010
pif1	PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)	0.010
eif3hb	eukaryotic translation initiation factor 3, subunit H, b	0.010
si:ch211-195h23.3	si:ch211-195h23.3	0.010
fetub	fetuin B	0.010
nr4a3	nuclear receptor subfamily 4, group A, member 3	0.010
si:ch211-15d5.5	si:ch211-15d5.5	0.010
boka	BCL2-related ovarian killer a	0.010	Zebrafish
ass1	argininosuccinate synthetase 1	0.010
twsg1b	twisted gastrulation homolog 1b (Drosophila)	0.010