IMP
Process View
The network for 'signal transduction involved in mitotic g1 dna damage checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
signal transduction involved in mitotic g1 dna damage checkpoint
A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.996 | |
| XIAP | X-linked inhibitor of apoptosis | 0.937 | |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.874 | |
| RB1 | retinoblastoma 1 | 0.846 | |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.820 | |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.706 | |
| PAX3 | paired box 3 | 0.690 | |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.588 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.444 | |
| LRDD | leucine-rich repeats and death domain containing | 0.383 | |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.337 | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.277 | |
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.247 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.202 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.199 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.175 | |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.167 | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.152 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.142 | |
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.134 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.123 | |
| IER3 | immediate early response 3 | 0.118 | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.098 | |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.088 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.082 | |
| POU5F1 | POU class 5 homeobox 1 | 0.079 | |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.077 | |
| BRCA1 | breast cancer 1, early onset | 0.063 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.054 | |
| POU3F2 | POU class 3 homeobox 2 | 0.046 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.035 | |
| SMAD7 | SMAD family member 7 | 0.034 | |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.032 | |
| CCND3 | cyclin D3 | 0.029 | |
| NOTCH1 | notch 1 | 0.029 | |
| ATM | ataxia telangiectasia mutated | 0.025 | |
| CDK2 | cyclin-dependent kinase 2 | 0.024 | |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.024 | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.024 | |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.021 | |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.020 | |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.019 | |
| TTI1 | Tel2 interacting protein 1 homolog (S. pombe) | 0.017 | |
| NUCB2 | nucleobindin 2 | 0.017 | |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.017 | |
| CDK6 | cyclin-dependent kinase 6 | 0.017 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.016 | |
| CCND1 | cyclin D1 | 0.016 | |
| RBL2 | retinoblastoma-like 2 (p130) | 0.015 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.014 | |
| SMC1A | structural maintenance of chromosomes 1A | 0.014 | |
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | 0.013 | |
| IFI16 | interferon, gamma-inducible protein 16 | 0.013 | |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.012 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.012 | |
| SALL2 | sal-like 2 (Drosophila) | 0.012 | |
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.012 | |
| PARP1 | poly (ADP-ribose) polymerase 1 | 0.011 | |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.011 | |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Trp53 | transformation related protein 53 | 1.000 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.627 | |
| Pten | phosphatase and tensin homolog | 0.612 | |
| Rb1 | retinoblastoma 1 | 0.409 | |
| Rara | retinoic acid receptor, alpha | 0.386 | |
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.351 | |
| Apc | adenomatosis polyposis coli | 0.261 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.237 | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.197 | |
| Col1a1 | collagen, type I, alpha 1 | 0.186 | |
| Sox9 | SRY-box containing gene 9 | 0.186 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.143 | |
| Shh | sonic hedgehog | 0.143 | |
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.127 | |
| Meox2 | mesenchyme homeobox 2 | 0.121 | |
| Daxx | Fas death domain-associated protein | 0.096 | |
| Sfn | stratifin | 0.092 | |
| Kit | kit oncogene | 0.088 | |
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.086 | |
| Nf1 | neurofibromatosis 1 | 0.085 | |
| Rxra | retinoid X receptor alpha | 0.062 | |
| Braf | Braf transforming gene | 0.058 | |
| Esr1 | estrogen receptor 1 (alpha) | 0.055 | |
| Skil | SKI-like | 0.055 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.052 | |
| Vegfa | vascular endothelial growth factor A | 0.050 | |
| Runx1 | runt related transcription factor 1 | 0.047 | |
| Thbs1 | thrombospondin 1 | 0.046 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.046 | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.043 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.041 | |
| Trp63 | transformation related protein 63 | 0.037 | |
| Psen1 | presenilin 1 | 0.034 | |
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.034 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.032 | |
| Rarg | retinoic acid receptor, gamma | 0.032 | |
| Arid1a | AT rich interactive domain 1A (SWI-like) | 0.031 | |
| Cdx2 | caudal type homeobox 2 | 0.031 | |
| Brca1 | breast cancer 1 | 0.031 | |
| Tcf3 | transcription factor 3 | 0.029 | |
| Rarb | retinoic acid receptor, beta | 0.029 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.028 | |
| Tgfb1 | transforming growth factor, beta 1 | 0.027 | |
| Hdac7 | histone deacetylase 7 | 0.026 | |
| Rab25 | RAB25, member RAS oncogene family | 0.025 | |
| Hhat | hedgehog acyltransferase | 0.024 | |
| Ccnd1 | cyclin D1 | 0.023 | |
| E2f1 | E2F transcription factor 1 | 0.023 | |
| Ptch1 | patched homolog 1 | 0.022 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.022 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.021 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.021 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.021 | |
| Apoe | apolipoprotein E | 0.020 | |
| Nf2 | neurofibromatosis 2 | 0.020 | |
| Smo | smoothened homolog (Drosophila) | 0.020 | |
| Lrrc23 | leucine rich repeat containing 23 | 0.019 | |
| Bmp4 | bone morphogenetic protein 4 | 0.019 | |
| Irf6 | interferon regulatory factor 6 | 0.017 | |
| Tsc1 | tuberous sclerosis 1 | 0.017 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.017 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.017 | |
| Ahr | aryl-hydrocarbon receptor | 0.016 | |
| Yap1 | yes-associated protein 1 | 0.016 | |
| Itga3 | integrin alpha 3 | 0.016 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.016 | |
| Mybl2 | myeloblastosis oncogene-like 2 | 0.015 | |
| Brca2 | breast cancer 2 | 0.015 | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.015 | |
| Gata3 | GATA binding protein 3 | 0.015 | |
| Hr | hairless | 0.015 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.014 | |
| Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 0.014 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.014 | |
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.013 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.013 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.013 | |
| Sars2 | seryl-aminoacyl-tRNA synthetase 2 | 0.013 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.012 | |
| Pax3 | paired box gene 3 | 0.012 | |
| Ar | androgen receptor | 0.012 | |
| Sox11 | SRY-box containing gene 11 | 0.012 | |
| Unk | unkempt homolog (Drosophila) | 0.012 | |
| Il17re | interleukin 17 receptor E | 0.011 | |
| E2f4 | E2F transcription factor 4 | 0.011 | |
| Med23 | mediator complex subunit 23 | 0.011 | |
| Rag1 | recombination activating gene 1 | 0.011 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.011 | |
| Stk11 | serine/threonine kinase 11 | 0.011 | |
| Tcof1 | Treacher Collins Franceschetti syndrome 1, homolog | 0.011 | |
| Krt14 | keratin 14 | 0.011 | |
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.011 | |
| Elf3 | E74-like factor 3 | 0.011 | |
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.011 | |
| Men1 | multiple endocrine neoplasia 1 | 0.011 | |
| Xpa | xeroderma pigmentosum, complementation group A | 0.010 | |
| Tnf | tumor necrosis factor | 0.010 | |
| Foxp3 | forkhead box P3 | 0.010 | |
| E130303B06Rik | RIKEN cDNA E130303B06 gene | 0.010 | |
| Fanca | Fanconi anemia, complementation group A | 0.010 |