The network for 'cell migration involved in sprouting angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell migration involved in sprouting angiogenesis

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 1.000
VEGFA vascular endothelial growth factor A 1.000
FGFR2 fibroblast growth factor receptor 2 0.999
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.999
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.999
NOTCH1 notch 1 0.999
EGR1 early growth response 1 0.995
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.992
NOTCH3 notch 3 0.937
KLF4 Kruppel-like factor 4 (gut) 0.936
NRP1 neuropilin 1 0.936
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.924
EGR3 early growth response 3 0.889
FGFR1 fibroblast growth factor receptor 1 0.885
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.882
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.867
ENG endoglin 0.865
NCOR2 nuclear receptor corepressor 2 0.859
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.817
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.815
FGF1 fibroblast growth factor 1 (acidic) 0.811
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.723
EGR2 early growth response 2 0.696
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.678
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.652
PLCG1 phospholipase C, gamma 1 0.650
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.637
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.589
JUN jun proto-oncogene 0.572
IER2 immediate early response 2 0.515
LCK lymphocyte-specific protein tyrosine kinase 0.482
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.456
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.420
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.381
FOS FBJ murine osteosarcoma viral oncogene homolog 0.364
DUSP1 dual specificity phosphatase 1 0.356
MEF2C myocyte enhancer factor 2C 0.337
EFNA1 ephrin-A1 0.314
CD247 CD247 molecule 0.279
BCL6 B-cell CLL/lymphoma 6 0.271
EFNA5 ephrin-A5 0.261
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.242
GRB7 growth factor receptor-bound protein 7 0.239
CYR61 cysteine-rich, angiogenic inducer, 61 0.228
CTGF connective tissue growth factor 0.226
FN1 fibronectin 1 0.216
HSPG2 heparan sulfate proteoglycan 2 0.209
EPHA7 EPH receptor A7 0.201
DLL1 delta-like 1 (Drosophila) 0.200
KLF6 Kruppel-like factor 6 0.195
ATF3 activating transcription factor 3 0.194
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.175
THBS1 thrombospondin 1 0.157
FGF10 fibroblast growth factor 10 0.154
LAT linker for activation of T cells 0.148
FGF7 fibroblast growth factor 7 0.147
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.144
FAF1 Fas (TNFRSF6) associated factor 1 0.137
FBLN1 fibulin 1 0.133
FOSL2 FOS-like antigen 2 0.130
FHL2 four and a half LIM domains 2 0.125
JAG2 jagged 2 0.122
MAPK7 mitogen-activated protein kinase 7 0.117
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.103
MKL1 megakaryoblastic leukemia (translocation) 1 0.100
HES1 hairy and enhancer of split 1, (Drosophila) 0.097
PSEN2 presenilin 2 (Alzheimer disease 4) 0.097
NOTCH2 notch 2 0.096
PGF placental growth factor 0.087
EGFR epidermal growth factor receptor 0.087
FLNA filamin A, alpha 0.086
PXN paxillin 0.084
JUNB jun B proto-oncogene 0.079
CPE carboxypeptidase E 0.076
ZNF746 zinc finger protein 746 0.075
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.072
TGFB1 transforming growth factor, beta 1 0.071
HDAC4 histone deacetylase 4 0.071
LTBP4 latent transforming growth factor beta binding protein 4 0.065
EFNB2 ephrin-B2 0.065
PDGFA platelet-derived growth factor alpha polypeptide 0.061
PDGFC platelet derived growth factor C 0.061
ITGA6 integrin, alpha 6 0.061
NCK2 NCK adaptor protein 2 0.060
ATN1 atrophin 1 0.058
GEM GTP binding protein overexpressed in skeletal muscle 0.057
FLT4 fms-related tyrosine kinase 4 0.056
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.056
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.055
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.054
FOXP3 forkhead box P3 0.053
EMP1 epithelial membrane protein 1 0.052
GDF9 growth differentiation factor 9 0.048
BTG2 BTG family, member 2 0.048
ZNF331 zinc finger protein 331 0.047
GFI1B growth factor independent 1B transcription repressor 0.047
MYOCD myocardin 0.046
EPHA3 EPH receptor A3 0.042
MAML1 mastermind-like 1 (Drosophila) 0.041
VEGFC vascular endothelial growth factor C 0.041
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.995
efnb2a ephrin B2a 0.823
itgb1b.2 integrin, beta 1b.2 0.522
plcg1 phospholipase C, gamma 1 0.338
cdh5 cadherin 5 0.292
itgb1b integrin, beta 1b 0.257
itgb1a integrin, beta 1a 0.218
antxr1 anthrax toxin receptor 1 0.217
tie2 endothelium-specific receptor tyrosine kinase 2 0.205
emx3 empty spiracles homeobox 3 0.155
sulf1 sulfatase 1 0.153
vegfc vascular endothelial growth factor c 0.148
cdh2 cadherin 2, neuronal 0.134
fbn2b fibrillin 2b 0.130
prkcq protein kinase C, theta 0.117
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.112
dlc deltaC 0.100
pxn paxillin 0.099
sb:cb560 sb:cb560 0.099
wt1b wilms tumor 1b 0.089
dmd dystrophin 0.085
notch3 notch homolog 3 0.084
itgb3b integrin beta 3b 0.075
traf4a tnf receptor-associated factor 4a 0.074
col17a1b collagen, type XVII, alpha 1b 0.072
dll4 delta-like 4 (Drosophila) 0.070
ptprf protein tyrosine phosphatase, receptor type, F 0.068
utrn utrophin 0.065
foxp2 forkhead box P2 0.065
itgb1b.1 integrin, beta 1b.1 0.057
pdgfrb2 platelet derived growth factor receptor beta 2 0.056
ilk integrin linked kinase 0.056
mpll myeloproliferative leukemia virus oncogene, like 0.051
etv2 ets variant gene 2 0.049
prkcbb protein kinase C, beta b 0.049
nrarpa notch-regulated ankyrin repeat protein a 0.048
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.048
nrp1a neuropilin 1a 0.047
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.046
vegfaa vascular endothelial growth factor Aa 0.045
nrp2a neuropilin 2a 0.045
col17a1a collagen, type XVII, alpha 1a 0.044
dusp5 dual specificity phosphatase 5 0.042
ptgs1 prostaglandin-endoperoxide synthase 1 0.042
col4a3 collagen, type IV, alpha 3 0.042
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.042
ccm2 cerebral cavernous malformation 2 0.041
ptk2.1 protein tyrosine kinase 2a 0.041
boc brother of CDO 0.040
tal1 T-cell acute lymphocytic leukemia 1 0.039
btg2 B-cell translocation gene 2 0.037
gata2a GATA-binding protein 2a 0.036
cav1 caveolin 1 0.036
myf5 myogenic factor 5 0.034
prkcea protein kinase C, epsilon a 0.033
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.033
calcrla calcitonin receptor-like a 0.031
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.030
klf2a Kruppel-like factor 2a 0.029
cxcr4a chemokine (C-X-C motif) receptor 4a 0.029
vcl vinculin 0.028
fabp11a fatty acid binding protein 11a 0.028
arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.028
epha4a eph receptor A4a 0.027
tgfb1a transforming growth factor, beta 1a 0.027
mcamb melanoma cell adhesion molecule b 0.027
si:ch211-272f3.4 si:ch211-272f3.4 0.026
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.026
zgc:153148 zgc:153148 0.026
mef2d myocyte enhancer factor 2d 0.025
si:ch211-235f6.2 si:ch211-235f6.2 0.025
tfec transcription factor EC 0.024
col4a2 collagen, type IV, alpha 2 0.024
pea3 ETS-domain transcription factor pea3 0.024
lmo4a LIM domain only 4a 0.024
ptprc protein tyrosine phosphatase, receptor type, C 0.024
zgc:63721 zgc:63721 0.024
bcam basal cell adhesion molecule (Lutheran blood group) 0.024
tll1 tolloid-like 1 0.023
col4a4 collagen, type IV, alpha 4 0.023
lef1 lymphocyte enhancer binding factor 1 0.023
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.023
tie1 endothelium-specific receptor tyrosine kinase 1 0.023
tgfbi transforming growth factor, beta-induced 0.022
podxl podocalyxin-like 0.022
sox7 SRY-box containing gene 7 0.022
fam43b family with sequence similarity 43, member B 0.021
epb4.1l4 erythrocyte protein band 4.1-like 4 0.021
pabpc1b poly A binding protein, cytoplasmic 1 b 0.021
flt4 fms-related tyrosine kinase 4 0.021
plxnd1 plexin D1 0.020
znf609 zinc finger protein 609 0.020
dld deltaD 0.020
LOC100003514 protein kinase C alpha type-like 0.020
cdh23 cadherin-like 23 0.019
hspa12b heat shock protein 12B 0.019
pak2a p21 (CDKN1A)-activated kinase 2a 0.019
cxcr4b chemokine (C-X-C motif), receptor 4b 0.019
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.019
guca1c guanylate cyclase activator 1C 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Foxc1 forkhead box C1 0.967
Efnb2 ephrin B2 0.964
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.924
Foxc2 forkhead box C2 0.905
Jag1 jagged 1 0.861
Tgfb2 transforming growth factor, beta 2 0.842
Fgfr1 fibroblast growth factor receptor 1 0.782
Eng endoglin 0.694
Tbx1 T-box 1 0.678
Vegfa vascular endothelial growth factor A 0.652
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.560
Pax6 paired box gene 6 0.552
Pax3 paired box gene 3 0.552
Foxa2 forkhead box A2 0.518
Otx2 orthodenticle homolog 2 (Drosophila) 0.504
Slit3 slit homolog 3 (Drosophila) 0.472
Fgfr2 fibroblast growth factor receptor 2 0.437
Nos3 nitric oxide synthase 3, endothelial cell 0.411
Csf1 colony stimulating factor 1 (macrophage) 0.382
Bmp4 bone morphogenetic protein 4 0.377
Psen1 presenilin 1 0.374
Notch2 Notch gene homolog 2 (Drosophila) 0.355
Notch1 Notch gene homolog 1 (Drosophila) 0.337
Prrx1 paired related homeobox 1 0.331
Tgfbr2 transforming growth factor, beta receptor II 0.316
Vangl2 vang-like 2 (van gogh, Drosophila) 0.285
Shh sonic hedgehog 0.266
Fgf8 fibroblast growth factor 8 0.240
Plxnd1 plexin D1 0.214
Ednra endothelin receptor type A 0.211
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.204
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.201
Eya1 eyes absent 1 homolog (Drosophila) 0.196
Gata4 GATA binding protein 4 0.186
Gbx2 gastrulation brain homeobox 2 0.183
Ntf3 neurotrophin 3 0.169
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.163
Cdh5 cadherin 5 0.162
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.158
Gli3 GLI-Kruppel family member GLI3 0.157
Ncor2 nuclear receptor co-repressor 2 0.157
Ptk2 PTK2 protein tyrosine kinase 2 0.156
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.146
Meox2 mesenchyme homeobox 2 0.140
Hand2 heart and neural crest derivatives expressed transcript 2 0.135
Pax2 paired box gene 2 0.134
Mef2d myocyte enhancer factor 2D 0.127
Kdr kinase insert domain protein receptor 0.127
Gdnf glial cell line derived neurotrophic factor 0.120
Hoxa1 homeobox A1 0.118
Acvr1 activin A receptor, type 1 0.116
Efna1 ephrin A1 0.112
Cxcl12 chemokine (C-X-C motif) ligand 12 0.102
Acvrl1 activin A receptor, type II-like 1 0.097
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.089
Egr1 early growth response 1 0.088
Pecam1 platelet/endothelial cell adhesion molecule 1 0.086
Zeb1 zinc finger E-box binding homeobox 1 0.085
Itga5 integrin alpha 5 (fibronectin receptor alpha) 0.084
Ctnnb1 catenin (cadherin associated protein), beta 1 0.083
Sox9 SRY-box containing gene 9 0.081
Lmx1b LIM homeobox transcription factor 1 beta 0.079
Egfr epidermal growth factor receptor 0.075
Nrp1 neuropilin 1 0.074
Flt4 FMS-like tyrosine kinase 4 0.072
Lrp1 low density lipoprotein receptor-related protein 1 0.069
Hmx3 H6 homeobox 3 0.068
Pitx2 paired-like homeodomain transcription factor 2 0.068
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.067
Ptprb protein tyrosine phosphatase, receptor type, B 0.067
Apoe apolipoprotein E 0.065
Nog noggin 0.065
Robo2 roundabout homolog 2 (Drosophila) 0.063
Tcfap2a transcription factor AP-2, alpha 0.061
Slit2 slit homolog 2 (Drosophila) 0.059
Dock1 dedicator of cytokinesis 1 0.058
Gja1 gap junction protein, alpha 1 0.057
Smad6 MAD homolog 6 (Drosophila) 0.056
Robo1 roundabout homolog 1 (Drosophila) 0.056
Klf2 Kruppel-like factor 2 (lung) 0.056
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.055
Hand1 heart and neural crest derivatives expressed transcript 1 0.055
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.054
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.054
Foxf2 forkhead box F2 0.053
Sox18 SRY-box containing gene 18 0.052
Hif1a hypoxia inducible factor 1, alpha subunit 0.052
Emx1 empty spiracles homolog 1 (Drosophila) 0.051
Col4a2 collagen, type IV, alpha 2 0.051
Cldn5 claudin 5 0.050
Mmp9 matrix metallopeptidase 9 0.048
Pax8 paired box gene 8 0.045
Rarb retinoic acid receptor, beta 0.044
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.041
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.039
Wnt7a wingless-related MMTV integration site 7A 0.039
Ece1 endothelin converting enzyme 1 0.039
Flt1 FMS-like tyrosine kinase 1 0.038
Cyr61 cysteine rich protein 61 0.037
Snai1 snail homolog 1 (Drosophila) 0.037
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fos FBJ osteosarcoma oncogene 0.696
Dusp1 dual specificity phosphatase 1 0.103
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.072
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.055
Egr1 early growth response 1 0.051
Lamc1 laminin, gamma 1 0.037
Btg2 BTG family, member 2 0.037
Dusp6 dual specificity phosphatase 6 0.024
Jun Jun oncogene 0.023
Nfib nuclear factor I/B 0.021
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.018
LOC100365152 adaptor-related protein complex 1, gamma 2 subunit-like 0.018
Cyr61 cysteine-rich, angiogenic inducer, 61 0.018
Zfp36 zinc finger protein 36 0.017
Elk3 ELK3, ETS-domain protein 0.016
Egr2 early growth response 2 0.016
Sh2b3 SH2B adaptor protein 3 0.014
Pecam1 platelet/endothelial cell adhesion molecule 1 0.014
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.013
Adam17 ADAM metallopeptidase domain 17 0.012
Dusp5 dual specificity phosphatase 5 0.012
Errfi1 ERBB receptor feedback inhibitor 1 0.012
Myo1b myosin Ib 0.012
Ahnak AHNAK nucleoprotein 0.011
Ptprc protein tyrosine phosphatase, receptor type, C 0.011
Bgn biglycan 0.011
Ier2 immediate early response 2 0.011
Anxa4 annexin A4 0.011
Vcan versican 0.011
Klf2 Kruppel-like factor 2 (lung) 0.010
Calu calumenin 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism