The network for 'pharyngeal system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pharyngeal system development

The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.

Homo sapiens
Name Description Probability Func Analog Organism
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.967
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.907
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.893
TBX5 T-box 5 0.889
GATA4 GATA binding protein 4 0.250
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.248
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.236
SPDEF SAM pointed domain containing ets transcription factor 0.233
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.223
ARID1B AT rich interactive domain 1B (SWI1-like) 0.191
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.183
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.153
SMO smoothened homolog (Drosophila) 0.152
PBRM1 polybromo 1 0.139
SMAD7 SMAD family member 7 0.139
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.130
ARID1A AT rich interactive domain 1A (SWI-like) 0.130
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.124
TGFB1 transforming growth factor, beta 1 0.092
HOXD9 homeobox D9 0.085
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.074
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.071
FN1 fibronectin 1 0.052
BBS10 Bardet-Biedl syndrome 10 0.051
SP1 Sp1 transcription factor 0.050
NRP1 neuropilin 1 0.046
COL1A1 collagen, type I, alpha 1 0.045
PIAS1 protein inhibitor of activated STAT, 1 0.044
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.039
ADAM12 ADAM metallopeptidase domain 12 0.037
NCOR1 nuclear receptor corepressor 1 0.034
CSNK1E casein kinase 1, epsilon 0.033
ITGB5 integrin, beta 5 0.029
YY1 YY1 transcription factor 0.029
PTK2 PTK2 protein tyrosine kinase 2 0.029
CHD4 chromodomain helicase DNA binding protein 4 0.027
CARM1 coactivator-associated arginine methyltransferase 1 0.025
PAX9 paired box 9 0.024
FNDC3B fibronectin type III domain containing 3B 0.024
PBX2 pre-B-cell leukemia homeobox 2 0.024
TBX21 T-box 21 0.024
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.024
JAG1 jagged 1 0.024
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0.023
EYA2 eyes absent homolog 2 (Drosophila) 0.023
ZNF331 zinc finger protein 331 0.022
MTA2 metastasis associated 1 family, member 2 0.022
MYOD1 myogenic differentiation 1 0.022
SORBS3 sorbin and SH3 domain containing 3 0.022
PDGFC platelet derived growth factor C 0.022
MDFI MyoD family inhibitor 0.021
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.021
EYA1 eyes absent homolog 1 (Drosophila) 0.021
TBX1 T-box 1 0.020
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.020
PABPN1 poly(A) binding protein, nuclear 1 0.020
ACAN aggrecan 0.020
THBS1 thrombospondin 1 0.019
BCL2 B-cell CLL/lymphoma 2 0.019
FSTL1 follistatin-like 1 0.019
SOX18 SRY (sex determining region Y)-box 18 0.019
TAL1 T-cell acute lymphocytic leukemia 1 0.019
GATAD2B GATA zinc finger domain containing 2B 0.019
NLRP2 NLR family, pyrin domain containing 2 0.019
RCOR1 REST corepressor 1 0.019
KIAA1199 KIAA1199 0.019
AXIN1 axin 1 0.019
GATA5 GATA binding protein 5 0.019
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.019
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.018
HOXB13 homeobox B13 0.018
SKIL SKI-like oncogene 0.018
SKI v-ski sarcoma viral oncogene homolog (avian) 0.018
COL3A1 collagen, type III, alpha 1 0.018
ANTXR2 anthrax toxin receptor 2 0.018
FAM110C family with sequence similarity 110, member C 0.017
ENG endoglin 0.017
IGFBP7 insulin-like growth factor binding protein 7 0.017
FANCC Fanconi anemia, complementation group C 0.017
SMAD2 SMAD family member 2 0.016
TP53BP1 tumor protein p53 binding protein 1 0.016
HOXB9 homeobox B9 0.016
FANCE Fanconi anemia, complementation group E 0.016
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.016
RAX retina and anterior neural fold homeobox 0.016
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.016
ACACA acetyl-CoA carboxylase alpha 0.016
SIX2 SIX homeobox 2 0.016
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.016
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.016
CALD1 caldesmon 1 0.015
ZFYVE9 zinc finger, FYVE domain containing 9 0.015
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.015
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.015
MCC mutated in colorectal cancers 0.015
PAM peptidylglycine alpha-amidating monooxygenase 0.015
SMAD1 SMAD family member 1 0.015
RNF8 ring finger protein 8 0.015
CTGF connective tissue growth factor 0.015
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.864
hnf1ba HNF1 homeobox Ba 0.785
bmp2b bone morphogenetic protein 2b 0.708
chd chordin 0.538
dlc deltaC 0.514
myf5 myogenic factor 5 0.502
myod1 myogenic differentiation 1 0.490
atoh1a atonal homolog 1a 0.392
fgf10a fibroblast growth factor 10a 0.369
bmp4 bone morphogenetic protein 4 0.352
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.322
tbx2a T-box gene 2a 0.298
col2a1a collagen type II, alpha-1a 0.277
atoh1b atonal homolog 1b 0.273
raraa retinoic acid receptor, alpha a 0.271
gbx2 gastrulation brain homeo box 2 0.262
bmp2a bone morphogenetic protein 2a 0.259
nkx3.2 NK3 homeobox 2 0.254
wnt9b wingless-type MMTV integration site family, member 9B 0.249
kctd12.1 potassium channel tetramerisation domain containing 12.1 0.246
wnt5b wingless-type MMTV integration site family, member 5b 0.243
sema3aa semaphorin 3aa 0.233
dacha dachshund a 0.221
fgf3 fibroblast growth factor 3 0.221
hand2 heart and neural crest derivatives expressed transcript 2 0.214
hoxd4a homeo box D4a 0.198
tfap2a transcription factor AP-2 alpha 0.189
msxc muscle segment homeobox C 0.175
eya1 eyes absent homolog 1 0.172
her1 hairy-related 1 0.171
six2a sine oculis-related homeobox 2a 0.162
wnt11 wingless-type MMTV integration site family, member 11 0.158
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.157
msxe muscle segment homeobox E 0.141
neurod4 neurogenic differentiation 4 0.139
notch1a notch homolog 1a 0.137
wnt4a wingless-type MMTV integration site family, member 4a 0.135
si:ch211-173o4.2 si:ch211-173o4.2 0.118
twist1a twist1a 0.111
sox1a SRY-box containing gene 1a 0.111
robo2 roundabout homolog 2 0.110
pax2a paired box gene 2a 0.110
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.109
tp63 tumor protein p63 0.108
hoxb6a homeo box B6a 0.106
grem2 gremlin 2, cysteine knot superfamily 0.102
flh floating head 0.095
tbx24 T-box 24 0.095
rxrga retinoid x receptor, gamma a 0.094
meis2.1 myeloid ecotropic viral integration site 2.1 0.092
notch1b notch homolog 1b 0.092
prrx1a paired related homeobox 1a 0.090
dld deltaD 0.090
mab21l2 mab-21-like 2 0.084
otx5 orthodenticle homolog 5 0.082
hoxa13b homeo box A13b 0.081
foxi1 forkhead box I1 0.080
prdm1a PR domain containing 1a, with ZNF domain 0.079
nkx2.2b NK2 transcription factor related 2b 0.077
tbx18 T-box 18 0.074
twist3 twist3 0.070
foxg1a forkhead box G1a 0.069
vsx1 visual system homeobox 1 homolog, chx10-like 0.069
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.068
wnt8b wingless-type MMTV integration site family, member 8b 0.067
map2k4a mitogen-activated protein kinase kinase 4a 0.067
hoxa2b homeo box A2b 0.066
nppa natriuretic peptide precursor A 0.066
lft1 lefty1 0.065
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.065
tbx6 T-box gene 6 0.065
dmrt3a doublesex and mab-3 related transcription factor 3a 0.063
wnt10b wingless-type MMTV integration site family, member 10b 0.062
otx1b orthodenticle homolog 1b 0.062
rarab retinoic acid receptor, alpha b 0.062
unc5b unc-5 homolog B (C. elegans) 0.061
rxraa retinoid X receptor, alpha a 0.061
neurod6b neurogenic differentiation 6b 0.061
brpf1 bromodomain and PHD finger containing, 1 0.060
meis2.2 myeloid ecotropic viral integration site 2.2 0.060
tbx5a T-box 5a 0.058
pcdh10b protocadherin 10b 0.058
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.058
dlx2a distal-less homeobox gene 2a 0.058
fgf8a fibroblast growth factor 8 a 0.057
hmx3 homeo box (H6 family) 3 0.057
six4b sine oculis homeobox homolog 4b 0.056
dlx3b distal-less homeobox gene 3b 0.056
hoxb5a homeo box B5a 0.055
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.054
vcanb versican b 0.053
wnt2 wingless-type MMTV integration site family member 2 0.053
rarga retinoic acid receptor gamma a 0.053
dlx5a distal-less homeobox gene 5a 0.053
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.052
sox9a SRY-box containing gene 9a 0.052
mef2a myocyte enhancer factor 2a 0.051
otx2 orthodenticle homolog 2 0.050
rxrab retinoid x receptor, alpha b 0.049
rx2 retinal homeobox gene 2 0.048
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fgf8 fibroblast growth factor 8 0.998
Otx2 orthodenticle homolog 2 (Drosophila) 0.992
Pax2 paired box gene 2 0.985
Tbx1 T-box 1 0.969
Tbx3 T-box 3 0.948
Eya1 eyes absent 1 homolog (Drosophila) 0.945
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.945
Shh sonic hedgehog 0.937
Hoxa1 homeobox A1 0.922
Sox2 SRY-box containing gene 2 0.920
Emx2 empty spiracles homolog 2 (Drosophila) 0.919
Pitx2 paired-like homeodomain transcription factor 2 0.901
Hoxa13 homeobox A13 0.897
Rarg retinoic acid receptor, gamma 0.886
Nog noggin 0.848
Foxg1 forkhead box G1 0.810
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.803
Gbx2 gastrulation brain homeobox 2 0.787
Emx1 empty spiracles homolog 1 (Drosophila) 0.757
Sox9 SRY-box containing gene 9 0.746
Lhx1 LIM homeobox protein 1 0.715
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.712
Lhx3 LIM homeobox protein 3 0.707
Hand2 heart and neural crest derivatives expressed transcript 2 0.674
Gata4 GATA binding protein 4 0.657
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.613
Fgfr2 fibroblast growth factor receptor 2 0.591
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.540
Chd7 chromodomain helicase DNA binding protein 7 0.511
Fgfr3 fibroblast growth factor receptor 3 0.484
Gli3 GLI-Kruppel family member GLI3 0.483
Pitx1 paired-like homeodomain transcription factor 1 0.426
Dlx2 distal-less homeobox 2 0.408
Dlx1 distal-less homeobox 1 0.396
Lhx9 LIM homeobox protein 9 0.395
Tgfbr2 transforming growth factor, beta receptor II 0.364
Sall4 sal-like 4 (Drosophila) 0.353
Col2a1 collagen, type II, alpha 1 0.344
Gata6 GATA binding protein 6 0.338
Dlx5 distal-less homeobox 5 0.337
Hes5 hairy and enhancer of split 5 (Drosophila) 0.310
Prrx2 paired related homeobox 2 0.287
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.279
Rxra retinoid X receptor alpha 0.264
Pou3f4 POU domain, class 3, transcription factor 4 0.263
Hoxd3 homeobox D3 0.253
Rara retinoic acid receptor, alpha 0.249
Vegfa vascular endothelial growth factor A 0.243
Fgf10 fibroblast growth factor 10 0.236
Otx1 orthodenticle homolog 1 (Drosophila) 0.236
Pou5f1 POU domain, class 5, transcription factor 1 0.232
Lmx1a LIM homeobox transcription factor 1 alpha 0.225
Smad6 MAD homolog 6 (Drosophila) 0.222
En1 engrailed 1 0.221
Nrp1 neuropilin 1 0.216
Creb1 cAMP responsive element binding protein 1 0.216
Acvr1 activin A receptor, type 1 0.214
Dnmt3a DNA methyltransferase 3A 0.201
Gsc goosecoid homeobox 0.197
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.185
Lhx5 LIM homeobox protein 5 0.182
Sox3 SRY-box containing gene 3 0.170
Tlx3 T-cell leukemia, homeobox 3 0.165
Lmx1b LIM homeobox transcription factor 1 beta 0.156
Tcfap2a transcription factor AP-2, alpha 0.148
Pax1 paired box gene 1 0.146
Wnt1 wingless-related MMTV integration site 1 0.140
Hand1 heart and neural crest derivatives expressed transcript 1 0.138
Pou4f3 POU domain, class 4, transcription factor 3 0.136
Apc adenomatosis polyposis coli 0.136
Tbx5 T-box 5 0.135
Isl1 ISL1 transcription factor, LIM/homeodomain 0.135
Pax3 paired box gene 3 0.133
Scn5a sodium channel, voltage-gated, type V, alpha 0.132
Uncx UNC homeobox 0.132
Bmp4 bone morphogenetic protein 4 0.129
Sall3 sal-like 3 (Drosophila) 0.123
Hoxd13 homeobox D13 0.122
Pthlh parathyroid hormone-like peptide 0.119
Lef1 lymphoid enhancer binding factor 1 0.119
Wnt3a wingless-related MMTV integration site 3A 0.119
Fgfr1 fibroblast growth factor receptor 1 0.116
Ednra endothelin receptor type A 0.111
Hoxa3 homeobox A3 0.111
Hes1 hairy and enhancer of split 1 (Drosophila) 0.109
Wt1 Wilms tumor 1 homolog 0.096
Gdnf glial cell line derived neurotrophic factor 0.093
Shox2 short stature homeobox 2 0.093
Smad3 MAD homolog 3 (Drosophila) 0.091
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.089
Arid1b AT rich interactive domain 1B (SWI-like) 0.088
Efna2 ephrin A2 0.087
Inha inhibin alpha 0.081
T brachyury 0.081
Ece1 endothelin converting enzyme 1 0.080
Gata3 GATA binding protein 3 0.074
Chrd chordin 0.073
Dlx6 distal-less homeobox 6 0.073
Tgfbr1 transforming growth factor, beta receptor I 0.071
En2 engrailed 2 0.070
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism