The network for 'regulation of symbiosis encompassing mutualism through parasitism' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of symbiosis encompassing mutualism through parasitism

Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.

Homo sapiens
Name Description Probability Func Analog Organism
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.997
OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 0.997
IFI44 interferon-induced protein 44 0.993
SP110 SP110 nuclear body protein 0.993
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.990
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.989
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.989
SP1 Sp1 transcription factor 0.988
JUN jun proto-oncogene 0.986
MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.981
ISG15 ISG15 ubiquitin-like modifier 0.972
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.972
TRIM21 tripartite motif containing 21 0.971
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.964
IFI44L interferon-induced protein 44-like 0.950
CXCL10 chemokine (C-X-C motif) ligand 10 0.942
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.920
DTX3L deltex 3-like (Drosophila) 0.917
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.916
MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.915
IRF9 interferon regulatory factor 9 0.905
MYD88 myeloid differentiation primary response gene (88) 0.905
HDAC1 histone deacetylase 1 0.888
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.878
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.874
IFIH1 interferon induced with helicase C domain 1 0.874
SKIL SKI-like oncogene 0.839
SMAD3 SMAD family member 3 0.821
XAF1 XIAP associated factor 1 0.820
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.810
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.788
STAT1 signal transducer and activator of transcription 1, 91kDa 0.756
CXCL2 chemokine (C-X-C motif) ligand 2 0.746
TP53 tumor protein p53 0.743
OASL 2'-5'-oligoadenylate synthetase-like 0.740
FHL2 four and a half LIM domains 2 0.728
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.727
HIPK2 homeodomain interacting protein kinase 2 0.727
IL8 interleukin 8 0.721
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.719
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.708
IFI35 interferon-induced protein 35 0.706
IFI6 interferon, alpha-inducible protein 6 0.704
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.698
CXCL3 chemokine (C-X-C motif) ligand 3 0.695
IRF7 interferon regulatory factor 7 0.687
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.680
SMAD4 SMAD family member 4 0.647
FOS FBJ murine osteosarcoma viral oncogene homolog 0.643
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.636
CXCL9 chemokine (C-X-C motif) ligand 9 0.620
CXCL11 chemokine (C-X-C motif) ligand 11 0.615
TAPBP TAP binding protein (tapasin) 0.611
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.609
CCR5 chemokine (C-C motif) receptor 5 0.595
TRIM39 tripartite motif containing 39 0.593
DICER1 dicer 1, ribonuclease type III 0.574
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.564
CCL4 chemokine (C-C motif) ligand 4 0.554
CCL8 chemokine (C-C motif) ligand 8 0.532
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.526
DPP4 dipeptidyl-peptidase 4 0.518
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.498
IFI27 interferon, alpha-inducible protein 27 0.460
PML promyelocytic leukemia 0.449
SP100 SP100 nuclear antigen 0.438
IL6 interleukin 6 (interferon, beta 2) 0.417
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.411
ESR1 estrogen receptor 1 0.406
PARP12 poly (ADP-ribose) polymerase family, member 12 0.394
CXCL5 chemokine (C-X-C motif) ligand 5 0.390
NCOR1 nuclear receptor corepressor 1 0.389
CCR7 chemokine (C-C motif) receptor 7 0.388
RNF126 ring finger protein 126 0.378
GFM1 G elongation factor, mitochondrial 1 0.369
KDM6A lysine (K)-specific demethylase 6A 0.368
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.361
FN1 fibronectin 1 0.361
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.351
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.335
CCL5 chemokine (C-C motif) ligand 5 0.335
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.330
ADAR adenosine deaminase, RNA-specific 0.330
CCL20 chemokine (C-C motif) ligand 20 0.320
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.317
CCL2 chemokine (C-C motif) ligand 2 0.300
VCAM1 vascular cell adhesion molecule 1 0.296
RSAD2 radical S-adenosyl methionine domain containing 2 0.296
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.292
TRIM22 tripartite motif containing 22 0.282
TRIM41 tripartite motif containing 41 0.277
PLSCR1 phospholipid scramblase 1 0.273
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.265
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.263
BST2 bone marrow stromal cell antigen 2 0.261
RBBP4 retinoblastoma binding protein 4 0.254
ZNF263 zinc finger protein 263 0.251
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.248
SRPK2 SRSF protein kinase 2 0.247
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.242
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ifnphi1 interferon phi 1 0.172
tp53 tumor protein p53 0.158
pkz protein kinase containing Z-DNA binding domains 0.139
xbp1 X-box binding protein 1 0.139
LOC557072 caspase recruitment domain-containing protein 11-like 0.135
mib mind bomb 0.108
wnt3 wingless-type MMTV integration site family, member 3 0.093
stc1l stanniocalcin 1, like 0.085
itgb3b integrin beta 3b 0.077
il1b interleukin 1, beta and interleukin 1, beta 0.067
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.066
il6st interleukin 6 signal transducer 0.065
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.062
sult3st1 sulfotransferase family 3, cytosolic sulfotransferase 1 0.060
stat1b signal transducer and activator of transcription 1b 0.059
tlr9 toll-like receptor 9 0.059
ash1l ash1 (absent, small, or homeotic)-like (Drosophila) 0.057
tm9sf2 transmembrane 9 superfamily member 2 0.055
prox1 prospero-related homeobox gene 1 0.053
LOC100004946 transient receptor potential cation channel subfamily M member 4-like 0.052
cp ceruloplasmin 0.052
LOC100005232 Gig2-like protein DreD 0.050
nos2a nitric oxide synthase 2a, inducible 0.047
nod1 nucleotide-binding oligomerization domain containing 1 0.047
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.045
ifng1-2 interferon, gamma 1-2 0.045
dzip1 DAZ interacting protein 1 0.045
tlr3 toll-like receptor 3 0.044
LOC100000934 hypothetical protein LOC100000934 0.044
LOC566020 Gig2-like protein DreO 0.044
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.043
si:ch211-51m24.3 si:ch211-51m24.3 0.043
slc15a1b solute carrier family 15 (oligopeptide transporter), member 1b 0.043
chmp4b chromatin modifying protein 4B 0.043
masp2 mannan-binding lectin serine peptidase 2 0.042
casp8 caspase 8, apoptosis-related cysteine peptidase 0.042
tlr20f toll-like receptor 20f 0.042
baxa bcl2-associated X protein, a 0.041
pbrm1l polybromo 1, like 0.041
bactin1 bactin1 0.040
zgc:56596 zgc:56596 0.040
srsf2 serine/arginine-rich splicing factor 2 0.039
sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.039
ilf3a interleukin enhancer binding factor 3a 0.038
ppig peptidyl-prolyl isomerase G (cyclophilin G) 0.038
tardbp TAR DNA binding protein 0.037
cd8a CD8 antigen, alpha polypeptide 0.036
puf60b poly-U binding splicing factor b 0.036
mbtps1 membrane-bound transcription factor protease, site 1 0.036
fadd Fas (tnfrsf6)-associated via death domain 0.035
card14 caspase recruitment domain family, member 14 0.035
tpd52l2a tumor protein D52-like 2a 0.035
cul1a cullin 1a 0.035
zgc:55671 zgc:55671 0.035
mxa myxovirus (influenza) resistance A 0.034
zgc:112425 zgc:112425 0.033
ewsr1a Ewing sarcoma breakpoint region 1a 0.033
snrnp70 small nuclear ribonucleoprotein 70 (U1) 0.033
srrt serrate RNA effector molecule homolog (Arabidopsis) 0.033
irf3 interferon regulatory factor 3 0.033
barhl1.2 BarH-like 1.2 0.032
prkci protein kinase C, iota 0.032
trpc6 transient receptor potential cation channel, subfamily C, member 6 0.032
barhl1.1 BarH-like 1.1 0.032
pdcd2 programmed cell death 2 0.032
hnrnpm heterogeneous nuclear ribonucleoprotein M 0.031
lrmp lymphoid-restricted membrane protein 0.031
cdk7 cyclin-dependent kinase 7 0.031
card9 caspase recruitment domain family, member 9 0.030
zgc:64115 zgc:64115 0.030
vasa vasa homolog 0.030
si:ch211-59d15.5 si:ch211-59d15.5 0.030
esr1 estrogen receptor 1 0.030
pbx4 pre-B-cell leukemia transcription factor 4 0.030
nos2b nitric oxide synthase 2b, inducible 0.029
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.029
itih2 inter-alpha (globulin) inhibitor H2 0.029
fras1 Fraser syndrome 1 0.029
myd88 myeloid differentiation primary response gene (88) 0.029
ss18 synovial sarcoma translocation, chromosome 18 (H. sapiens) 0.029
cxc46 CXC chemokine 46 0.028
cyp2aa1 cytochrome P450, family 2, subfamily AA, polypeptide 1 0.028
smad5 MAD homolog 5 (Drosophila) 0.028
tlr22 toll-like receptor 22 0.028
aldh8a1 aldehyde dehydrogenase 8 family, member A1 0.028
lhb luteinizing hormone, beta polypeptide 0.028
itk IL2-inducible T-cell kinase 0.028
psma6b proteasome (prosome, macropain) subunit, alpha type, 6b 0.028
acvr1l activin A receptor, type I like 0.027
zgc:55392 zgc:55392 0.027
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.027
sdf4 stromal cell derived factor 4 0.027
ip6k2 inositol hexaphosphate kinase 2 0.027
ticam1 toll-like receptor adaptor molecule 1 0.027
rab5ab RAB5A, member RAS oncogene family, b 0.027
slc37a4a solute carrier family 37 (glucose-6-phosphate transporter), member 4a 0.027
acp5b acid phosphatase 5b, tartrate resistant 0.027
tlr20a toll-like receptor 20a 0.027
hdac1 histone deacetylase 1 0.027
sart3 squamous cell carcinoma antigen recognised by T cells 3 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CTCF CG8591 gene product from transcript CG8591-RA 0.074
CG3918 CG3918 gene product from transcript CG3918-RA 0.063
CG10103 CG10103 gene product from transcript CG10103-RA 0.057
CHMP2B Charged multivesicular body protein 2b 0.051
milt milton 0.045
vps2 CG14542 gene product from transcript CG14542-RA 0.041
shrb shrub 0.037
LanB2 Laminin B2 0.037
nub nubbin 0.037
Hmgcr HMG Coenzyme A reductase 0.033
lwr lesswright 0.033
CG4968 CG4968 gene product from transcript CG4968-RA 0.030
CG6259 CG6259 gene product from transcript CG6259-RA 0.029
Chmp1 CG4108 gene product from transcript CG4108-RA 0.028
emb embargoed 0.027
Vps25 Vacuolar protein sorting 25 0.023
CG7967 CG7967 gene product from transcript CG7967-RA 0.023
vps24 Charged multivesicular body protein 3 0.021
Mtor Megator 0.020
rho-7 rhomboid-7 0.020
Mcr Macroglobulin complement-related 0.020
jub Ajuba LIM protein 0.019
Vps20 Vacuolar protein sorting 20 0.018
M6 CG7540 gene product from transcript CG7540-RA 0.017
ird1 immune response deficient 1 0.016
CG10107 CG10107 gene product from transcript CG10107-RA 0.015
Rfabg Retinoid- and fatty acid-binding glycoprotein 0.014
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.014
Khc Kinesin heavy chain 0.013
CG8108 CG8108 gene product from transcript CG8108-RA 0.013
shn schnurri 0.013
CG2224 CG2224 gene product from transcript CG2224-RA 0.013
Scm Sex comb on midleg 0.013
CG14317 CG14317 gene product from transcript CG14317-RA 0.013
18w 18 wheeler 0.012
ph-p polyhomeotic proximal 0.012
Rpd3 CG7471 gene product from transcript CG7471-RA 0.012
ATP7 CG1886 gene product from transcript CG1886-RB 0.012
wun wunen 0.012
CdsA CDP diglyceride synthetase 0.012
coro CG9446 gene product from transcript CG9446-RC 0.012
Bap55 Brahma associated protein 55kD 0.012
Ten-m Tenascin major 0.012
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.012
Dlic Dynein light intermediate chain 0.011
glo glorund 0.011
Sgt1 CG9617 gene product from transcript CG9617-RA 0.011
Drp1 Dynamin related protein 1 0.011
SPE Spatzle-Processing Enzyme 0.011
Axn Axin 0.011
CG14071 CG14071 gene product from transcript CG14071-RA 0.011
Pez CG9493 gene product from transcript CG9493-RA 0.011
CG4686 CG4686 gene product from transcript CG4686-RA 0.011
Stim Stromal interaction molecule 0.010
Fak56D Focal Adhesion Kinase 0.010
TSG101 tumor suppressor protein 101 0.010
rhea CG6831 gene product from transcript CG6831-RA 0.010
sinu sinuous 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Irf7 interferon regulatory factor 7 0.960
Tnf tumor necrosis factor 0.937
Rtp4 receptor transporter protein 4 0.906
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.902
Gbp7 guanylate binding protein 7 0.871
Rsad2 radical S-adenosyl methionine domain containing 2 0.869
Slfn4 schlafen 4 0.862
Parp14 poly (ADP-ribose) polymerase family, member 14 0.859
Usp18 ubiquitin specific peptidase 18 0.844
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.838
Cxcl10 chemokine (C-X-C motif) ligand 10 0.830
Oas3 2'-5' oligoadenylate synthetase 3 0.828
Ifng interferon gamma 0.826
Ccl2 chemokine (C-C motif) ligand 2 0.819
Ccl4 chemokine (C-C motif) ligand 4 0.775
Mx2 myxovirus (influenza virus) resistance 2 0.773
Zbp1 Z-DNA binding protein 1 0.770
Ifi44 interferon-induced protein 44 0.745
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.734
Tor3a torsin family 3, member A 0.731
Uba7 ubiquitin-like modifier activating enzyme 7 0.720
Trp53 transformation related protein 53 0.670
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.669
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.621
Ctsg cathepsin G 0.617
Isg15 ISG15 ubiquitin-like modifier 0.592
Il10 interleukin 10 0.573
Ifi35 interferon-induced protein 35 0.554
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.553
Tapbp TAP binding protein 0.549
Trim30a tripartite motif-containing 30A 0.542
Oasl1 2'-5' oligoadenylate synthetase-like 1 0.497
Trim30d tripartite motif-containing 30D 0.496
Irf1 interferon regulatory factor 1 0.463
Mx1 myxovirus (influenza virus) resistance 1 0.459
Irf9 interferon regulatory factor 9 0.449
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.446
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.444
Mpo myeloperoxidase 0.419
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.409
Irgm1 immunity-related GTPase family M member 1 0.388
Ube2l6 ubiquitin-conjugating enzyme E2L 6 0.378
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.362
Irf8 interferon regulatory factor 8 0.353
Bcl2 B-cell leukemia/lymphoma 2 0.325
Camp cathelicidin antimicrobial peptide 0.313
Xcl1 chemokine (C motif) ligand 1 0.299
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.299
Fasl Fas ligand (TNF superfamily, member 6) 0.298
Stat1 signal transducer and activator of transcription 1 0.298
Gzmb granzyme B 0.289
Unc93b1 unc-93 homolog B1 (C. elegans) 0.282
Oas1a 2'-5' oligoadenylate synthetase 1A 0.279
Icam1 intercellular adhesion molecule 1 0.273
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.270
Tlr4 toll-like receptor 4 0.266
Bak1 BCL2-antagonist/killer 1 0.259
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.246
Ngp neutrophilic granule protein 0.245
Socs1 suppressor of cytokine signaling 1 0.240
Samhd1 SAM domain and HD domain, 1 0.235
Casp1 caspase 1 0.233
Parp12 poly (ADP-ribose) polymerase family, member 12 0.229
Sp3 trans-acting transcription factor 3 0.217
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.212
Oas2 2'-5' oligoadenylate synthetase 2 0.208
Cd19 CD19 antigen 0.208
Eif2c1 eukaryotic translation initiation factor 2C, 1 0.206
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.201
Igtp interferon gamma induced GTPase 0.199
Hdac2 histone deacetylase 2 0.182
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.179
Cd44 CD44 antigen 0.177
Plac8 placenta-specific 8 0.173
Trim25 tripartite motif-containing 25 0.170
Trim21 tripartite motif-containing 21 0.169
Sfpi1 SFFV proviral integration 1 0.160
Ccr2 chemokine (C-C motif) receptor 2 0.157
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.155
Lag3 lymphocyte-activation gene 3 0.153
Tlr2 toll-like receptor 2 0.153
Xaf1 XIAP associated factor 1 0.152
Ifi47 interferon gamma inducible protein 47 0.150
Irgm2 immunity-related GTPase family M member 2 0.150
Elane elastase, neutrophil expressed 0.149
Ubd ubiquitin D 0.147
Ltf lactotransferrin 0.146
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.144
Ifih1 interferon induced with helicase C domain 1 0.143
Irg1 immunoresponsive gene 1 0.142
Apoe apolipoprotein E 0.142
Gbp3 guanylate binding protein 3 0.140
Nos2 nitric oxide synthase 2, inducible 0.140
Ifitm3 interferon induced transmembrane protein 3 0.139
Mtf2 metal response element binding transcription factor 2 0.134
Slfn1 schlafen 1 0.133
Slfn8 schlafen 8 0.130
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.130
Rbbp4 retinoblastoma binding protein 4 0.129
Il23a interleukin 23, alpha subunit p19 0.125
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rpl35 ribosomal protein L35 0.038
Rps17 ribosomal protein S17 0.024
Rps15 ribosomal protein S15 0.012
Rpl7a ribosomal protein L7a 0.012
Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism