The network for 'negative regulation of cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell fate commitment

Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

Homo sapiens
Name Description Probability Func Analog Organism
AR androgen receptor 0.997
CSNK1E casein kinase 1, epsilon 0.993
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.990
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.987
LRP6 low density lipoprotein receptor-related protein 6 0.981
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.979
BMPR1A bone morphogenetic protein receptor, type IA 0.971
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.926
AXIN1 axin 1 0.901
DAXX death-domain associated protein 0.885
FZD1 frizzled homolog 1 (Drosophila) 0.856
CDK11B cyclin-dependent kinase 11B 0.856
SMAD1 SMAD family member 1 0.778
CREBBP CREB binding protein 0.715
BMP2 bone morphogenetic protein 2 0.677
NCOA2 nuclear receptor coactivator 2 0.602
ZNF512B zinc finger protein 512B 0.579
APC adenomatous polyposis coli 0.552
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.540
MYST2 MYST histone acetyltransferase 2 0.510
CTNNBIP1 catenin, beta interacting protein 1 0.488
RFWD2 ring finger and WD repeat domain 2 0.487
LRRK2 leucine-rich repeat kinase 2 0.459
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.448
FGF1 fibroblast growth factor 1 (acidic) 0.425
TCF4 transcription factor 4 0.408
CEP164 centrosomal protein 164kDa 0.404
BBS10 Bardet-Biedl syndrome 10 0.373
ZFYVE9 zinc finger, FYVE domain containing 9 0.356
TWIST2 twist homolog 2 (Drosophila) 0.353
JUN jun proto-oncogene 0.348
FGF2 fibroblast growth factor 2 (basic) 0.303
WT1 Wilms tumor 1 0.285
FSTL1 follistatin-like 1 0.283
WNT5A wingless-type MMTV integration site family, member 5A 0.270
FOXO1 forkhead box O1 0.259
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.244
FOXD3 forkhead box D3 0.223
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.222
CTNND1 catenin (cadherin-associated protein), delta 1 0.219
NKX3-1 NK3 homeobox 1 0.205
ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.155
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.151
NCOA1 nuclear receptor coactivator 1 0.148
WNT3A wingless-type MMTV integration site family, member 3A 0.123
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.121
NDP Norrie disease (pseudoglioma) 0.115
ZBTB8A zinc finger and BTB domain containing 8A 0.111
REPS2 RALBP1 associated Eps domain containing 2 0.109
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide 0.109
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.109
SFRP1 secreted frizzled-related protein 1 0.106
GSK3B glycogen synthase kinase 3 beta 0.105
GLIS2 GLIS family zinc finger 2 0.103
PITX1 paired-like homeodomain 1 0.100
MCC mutated in colorectal cancers 0.097
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.090
EMD emerin 0.090
PLCG1 phospholipase C, gamma 1 0.087
FOXA1 forkhead box A1 0.084
DUSP1 dual specificity phosphatase 1 0.078
BMP4 bone morphogenetic protein 4 0.077
FBXW11 F-box and WD repeat domain containing 11 0.076
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.075
DSP desmoplakin 0.073
TAOK1 TAO kinase 1 0.072
CSNK1D casein kinase 1, delta 0.071
NOG noggin 0.070
LAT linker for activation of T cells 0.069
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.069
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.068
CRMP1 collapsin response mediator protein 1 0.067
BAHD1 bromo adjacent homology domain containing 1 0.067
RBPMS RNA binding protein with multiple splicing 0.063
FAM110A family with sequence similarity 110, member A 0.059
RGS2 regulator of G-protein signaling 2, 24kDa 0.058
SCAF1 SR-related CTD-associated factor 1 0.056
JUND jun D proto-oncogene 0.055
ZMYND8 zinc finger, MYND-type containing 8 0.055
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.053
FAM110C family with sequence similarity 110, member C 0.051
PML promyelocytic leukemia 0.049
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.049
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 0.048
FHL2 four and a half LIM domains 2 0.048
MXRA5 matrix-remodelling associated 5 0.047
FGFR1 fibroblast growth factor receptor 1 0.047
C9orf100 chromosome 9 open reading frame 100 0.047
FBLN1 fibulin 1 0.046
ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.044
FZD2 frizzled homolog 2 (Drosophila) 0.043
NCOA6 nuclear receptor coactivator 6 0.042
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.042
FOXO3 forkhead box O3 0.041
DSG2 desmoglein 2 0.041
FOXF2 forkhead box F2 0.040
FOS FBJ murine osteosarcoma viral oncogene homolog 0.039
HOXC8 homeobox C8 0.039
KAT5 K(lysine) acetyltransferase 5 0.039
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.038
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
gli1 GLI-Kruppel family member 1 0.683
fgf17 fibroblast growth factor 17 0.582
hmx4 H6 family homeobox 4 0.546
wnt5b wingless-type MMTV integration site family, member 5b 0.522
bmp2b bone morphogenetic protein 2b 0.522
sfrp1a secreted frizzled-related protein 1a 0.499
wnt8b wingless-type MMTV integration site family, member 8b 0.484
bmp4 bone morphogenetic protein 4 0.435
wnt4a wingless-type MMTV integration site family, member 4a 0.359
wnt10a wingless-type MMTV integration site family, member 10a 0.357
dkk1b dickkopf 1b 0.313
wnt11r wingless-type MMTV integration site family, member 11, related 0.289
tbx1 T-box 1 0.266
twist1b twist1b 0.263
notch2 notch homolog 2 0.261
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.236
wnt9a wingless-type MMTV integration site family, member 9A 0.224
bmp2a bone morphogenetic protein 2a 0.219
tbx20 T-box 20 0.172
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.164
gata4 GATA-binding protein 4 0.140
msxc muscle segment homeobox C 0.136
twist3 twist3 0.135
oep one-eyed pinhead 0.133
gbx2 gastrulation brain homeo box 2 0.129
dharma dharma 0.121
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.120
tbx5a T-box 5a 0.120
her5 hairy-related 5 0.119
fgf10a fibroblast growth factor 10a 0.118
wnt11 wingless-type MMTV integration site family, member 11 0.117
fzd7a frizzled homolog 7a 0.108
notch3 notch homolog 3 0.108
hoxd11a homeo box D11a 0.106
six4b sine oculis homeobox homolog 4b 0.105
hnf1ba HNF1 homeobox Ba 0.104
pcdh8 protocadherin 8 0.102
foxa3 forkhead box A3 0.096
mespb mesoderm posterior b 0.093
jag1b jagged 1b 0.087
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.086
tagln2 transgelin 2 0.084
pdlim7 PDZ and LIM domain 7 0.074
flh floating head 0.072
wif1 wnt inhibitory factor 1 0.066
wnt1 wingless-type MMTV integration site family, member 1 0.065
fgf3 fibroblast growth factor 3 0.061
ndr2 nodal-related 2 0.061
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.058
dusp6 dual specificity phosphatase 6 0.057
sox17 SRY-box containing gene 17 0.056
hoxa11a homeo box A11a 0.055
spry4 sprouty (Drosophila) homolog 4 0.054
tbx6 T-box gene 6 0.053
foxd5 forkhead box D5 0.052
wnt10b wingless-type MMTV integration site family, member 10b 0.052
meis3 myeloid ecotropic viral integration site 3 0.052
msxb muscle segment homeobox B 0.052
dmrta2 doublesex and mab-3 related transcription factor like family A2 0.052
hapln3 hyaluronan and proteoglycan link protein 3 0.050
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.050
neo1 neogenin 1 0.048
axin1 axin 1 0.047
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.046
rest RE1-silencing transcription factor 0.045
lef1 lymphocyte enhancer binding factor 1 0.044
chd chordin 0.044
tbx18 T-box 18 0.044
gdnf glial cell derived neurotrophic factor 0.042
frem3 Fras1 related extracellular matrix 3 0.042
col2a1a collagen type II, alpha-1a 0.040
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.040
hoxb5a homeo box B5a 0.040
hoxd13a homeo box D13a 0.040
gata6 GATA-binding protein 6 0.040
ef1 ETS-related factor1 0.039
etv5b ets variant 5b 0.038
hhip hedgehog interacting protein 0.038
lama5 laminin, alpha 5 0.037
perp PERP, TP53 apoptosis effector 0.036
cdh1 cadherin 1, epithelial 0.036
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.036
mapk6 mitogen-activated protein kinase 6 0.035
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.035
wnt3 wingless-type MMTV integration site family, member 3 0.034
rx1 retinal homeobox gene 1 0.034
waca WW domain containing adaptor with coiled-coil a 0.032
hoxd10a homeo box D10a 0.032
osr2 odd-skipped related 2 (Drosophila) 0.032
epha4b eph receptor A4b 0.031
sox11b SRY-box containing gene 11b 0.031
hmx3 homeo box (H6 family) 3 0.031
jag2 jagged 2 0.030
gata2a GATA-binding protein 2a 0.029
tnfsf10l3 tumor necrosis factor (ligand) superfamily, member 10 like 3 0.029
wnt2 wingless-type MMTV integration site family member 2 0.029
hoxa13b homeo box A13b 0.028
fli1a friend leukemia integration 1a 0.028
mespa mesoderm posterior a 0.028
tgfb3 transforming growth factor, beta 3 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dpp decapentaplegic 0.256
H Hairless 0.199
hh hedgehog 0.199
wg wingless 0.122
run runt 0.119
en engrailed 0.113
Ubx Ultrabithorax 0.081
hbs hibris 0.077
slp2 sloppy paired 2 0.075
gt giant 0.075
Egfr Epidermal growth factor receptor 0.074
slp1 sloppy paired 1 0.072
argos CG4531 gene product from transcript CG4531-RA 0.069
bnl branchless 0.064
sli slit 0.064
Ser Serrate 0.063
tld tolloid 0.062
N Notch 0.059
sty sprouty 0.059
kirre kin of irre 0.058
rho rhomboid 0.057
slou slouch 0.039
spi spitz 0.038
wb wing blister 0.036
Rala Ras-related protein 0.032
Vrp1 Verprolin 1 0.030
dac dachshund 0.029
tin tinman 0.029
tll tailless 0.029
nkd naked cuticle 0.028
gsb gooseberry 0.027
sog short gastrulation 0.027
pb proboscipedia 0.026
eve even skipped 0.026
edl ETS-domain lacking 0.026
crb crumbs 0.025
zfh1 Zn finger homeodomain 1 0.025
Tollo CG6890 gene product from transcript CG6890-RA 0.023
ci cubitus interruptus 0.022
foxo forkhead box, sub-group O 0.022
twi twist 0.022
ara araucan 0.022
dos daughter of sevenless 0.021
btl breathless 0.021
inv invected 0.021
Traf4 TNF-receptor-associated factor 4 0.020
brk brinker 0.020
rst roughest 0.019
pnt pointed 0.019
bab2 CG9102 gene product from transcript CG9102-RA 0.019
frc fringe connection 0.018
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.018
ro rough 0.018
pdm2 POU domain protein 2 0.018
vg vestigial 0.018
neur neuralized 0.018
lbe ladybird early 0.017
Kr Kruppel 0.017
cno canoe 0.017
ftz fushi tarazu 0.017
abd-A abdominal A 0.017
hth homothorax 0.017
byn brachyenteron 0.016
kni knirps 0.016
zen zerknullt 0.016
pzg putzig 0.016
Wnt4 Wnt oncogene analog 4 0.016
Pp2B-14D Protein phosphatase 2B at 14D 0.015
Hr4 CG16902 gene product from transcript CG16902-RC 0.015
tsl torso-like 0.015
Doc2 Dorsocross2 0.015
nub nubbin 0.014
Dsor1 Downstream of raf1 0.014
ph-p polyhomeotic proximal 0.014
Su(var)3-7 Suppressor of variegation 3-7 0.014
Su(dx) Suppressor of deltex 0.014
Mnt CG13316 gene product from transcript CG13316-RD 0.014
CG12496 CG12496 gene product from transcript CG12496-RA 0.014
htl heartless 0.014
Notum CG13076 gene product from transcript CG13076-RB 0.014
dgo diego 0.014
tsg twisted gastrulation 0.013
trk trunk 0.013
dib disembodied 0.013
aop anterior open 0.013
ac achaete 0.013
rok Rho-kinase 0.013
stumps CG31317 gene product from transcript CG31317-RC 0.013
fz frizzled 0.013
B-H1 BarH1 0.013
hkb huckebein 0.013
Dad Daughters against dpp 0.012
nau nautilus 0.012
CG14869 CG14869 gene product from transcript CG14869-RB 0.012
ome omega 0.012
rib ribbon 0.012
InR Insulin-like receptor 0.012
wor worniu 0.012
pnr pannier 0.012
cg combgap 0.012
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.840
Fgfr2 fibroblast growth factor receptor 2 0.657
Foxc1 forkhead box C1 0.593
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.536
Vangl2 vang-like 2 (van gogh, Drosophila) 0.411
Hand1 heart and neural crest derivatives expressed transcript 1 0.409
Otx2 orthodenticle homolog 2 (Drosophila) 0.409
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.397
Pax3 paired box gene 3 0.381
Fgf8 fibroblast growth factor 8 0.348
Tcfap2a transcription factor AP-2, alpha 0.284
Foxc2 forkhead box C2 0.232
Bmp4 bone morphogenetic protein 4 0.229
Gli3 GLI-Kruppel family member GLI3 0.223
Rarg retinoic acid receptor, gamma 0.217
Sox9 SRY-box containing gene 9 0.174
Isl1 ISL1 transcription factor, LIM/homeodomain 0.147
Hand2 heart and neural crest derivatives expressed transcript 2 0.143
Pou5f1 POU domain, class 5, transcription factor 1 0.124
Prrx1 paired related homeobox 1 0.122
Meox2 mesenchyme homeobox 2 0.113
Fgfr1 fibroblast growth factor receptor 1 0.103
Vangl1 vang-like 1 (van gogh, Drosophila) 0.103
Smo smoothened homolog (Drosophila) 0.098
Eya1 eyes absent 1 homolog (Drosophila) 0.094
Ednra endothelin receptor type A 0.086
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.073
Rara retinoic acid receptor, alpha 0.072
Msx1 homeobox, msh-like 1 0.063
Dlx5 distal-less homeobox 5 0.061
Foxg1 forkhead box G1 0.061
Alx4 aristaless-like homeobox 4 0.060
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.056
Sall4 sal-like 4 (Drosophila) 0.054
Bmp7 bone morphogenetic protein 7 0.052
Sfrp2 secreted frizzled-related protein 2 0.050
Tbx1 T-box 1 0.047
Pax2 paired box gene 2 0.047
Hes1 hairy and enhancer of split 1 (Drosophila) 0.045
Pax6 paired box gene 6 0.044
Prrx2 paired related homeobox 2 0.043
Gbx2 gastrulation brain homeobox 2 0.043
Sall3 sal-like 3 (Drosophila) 0.042
Wnt3a wingless-related MMTV integration site 3A 0.040
Acvr1 activin A receptor, type 1 0.040
Nkx2-1 NK2 homeobox 1 0.040
Sox4 SRY-box containing gene 4 0.037
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.036
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.033
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.028
Eda ectodysplasin-A 0.027
Emx1 empty spiracles homolog 1 (Drosophila) 0.026
Smad6 MAD homolog 6 (Drosophila) 0.026
Lrp6 low density lipoprotein receptor-related protein 6 0.026
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.025
Fgfr3 fibroblast growth factor receptor 3 0.025
Gata4 GATA binding protein 4 0.025
Gsc goosecoid homeobox 0.025
Sox2 SRY-box containing gene 2 0.024
Gli2 GLI-Kruppel family member GLI2 0.022
En1 engrailed 1 0.022
Pitx1 paired-like homeodomain transcription factor 1 0.021
Chrd chordin 0.021
Chd7 chromodomain helicase DNA binding protein 7 0.020
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.020
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.020
Pitx2 paired-like homeodomain transcription factor 2 0.020
Ret ret proto-oncogene 0.019
Sfrp1 secreted frizzled-related protein 1 0.018
Dll1 delta-like 1 (Drosophila) 0.018
Sharpin SHANK-associated RH domain interacting protein 0.018
Efnb2 ephrin B2 0.018
Nkx3-2 NK3 homeobox 2 0.016
Whrn whirlin 0.016
Rxra retinoid X receptor alpha 0.016
Smad3 MAD homolog 3 (Drosophila) 0.015
Foxf1a forkhead box F1a 0.015
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.015
Pax8 paired box gene 8 0.015
Sox3 SRY-box containing gene 3 0.015
Smad7 MAD homolog 7 (Drosophila) 0.014
Alx3 aristaless-like homeobox 3 0.013
Nodal nodal 0.013
Hoxa5 homeobox A5 0.013
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.013
Tcf15 transcription factor 15 0.013
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.013
T brachyury 0.012
She src homology 2 domain-containing transforming protein E 0.012
Lrp2 low density lipoprotein receptor-related protein 2 0.012
Axin1 axin 1 0.012
Nf1 neurofibromatosis 1 0.012
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.012
Alx1 ALX homeobox 1 0.012
Sox10 SRY-box containing gene 10 0.011
Sox13 SRY-box containing gene 13 0.011
Cldn7 claudin 7 0.011
Hoxa3 homeobox A3 0.011
Nog noggin 0.011
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism