The network for 'substrate adhesion dependent cell spreading' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

substrate adhesion dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FHL2 four and a half LIM domains 2 0.998
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.985
PDIA3 protein disulfide isomerase family A, member 3 0.982
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.964
FN1 fibronectin 1 0.961
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.941
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.928
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.864
PXN paxillin 0.828
S100A9 S100 calcium binding protein A9 0.810
PTK2 PTK2 protein tyrosine kinase 2 0.792
FLNA filamin A, alpha 0.785
ILK integrin-linked kinase 0.783
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.710
LGALS1 lectin, galactoside-binding, soluble, 1 0.612
S100A6 S100 calcium binding protein A6 0.590
S100A8 S100 calcium binding protein A8 0.572
EPHA2 EPH receptor A2 0.497
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.449
BCAR1 breast cancer anti-estrogen resistance 1 0.432
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.414
PSEN2 presenilin 2 (Alzheimer disease 4) 0.410
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.366
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.346
FYN FYN oncogene related to SRC, FGR, YES 0.331
VCL vinculin 0.299
TLN1 talin 1 0.278
CLASP1 cytoplasmic linker associated protein 1 0.275
FLNB filamin B, beta 0.270
S100A4 S100 calcium binding protein A4 0.270
LAMB1 laminin, beta 1 0.238
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.221
COL7A1 collagen, type VII, alpha 1 0.216
LIMS1 LIM and senescent cell antigen-like domains 1 0.209
GAS6 growth arrest-specific 6 0.196
PARVA parvin, alpha 0.193
S100A2 S100 calcium binding protein A2 0.192
ENG endoglin 0.183
ANGPT2 angiopoietin 2 0.181
CALD1 caldesmon 1 0.168
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.159
ANXA2 annexin A2 0.152
ZYX zyxin 0.134
EFNA1 ephrin-A1 0.129
LMNA lamin A/C 0.125
HP haptoglobin 0.124
EFNA5 ephrin-A5 0.123
THBS1 thrombospondin 1 0.120
APOC1 apolipoprotein C-I 0.110
AREG amphiregulin 0.110
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.108
ITGA6 integrin, alpha 6 0.105
VCAM1 vascular cell adhesion molecule 1 0.104
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.098
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.094
NCK2 NCK adaptor protein 2 0.090
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.090
LTBP2 latent transforming growth factor beta binding protein 2 0.085
ANGPT1 angiopoietin 1 0.078
LPXN leupaxin 0.076
MSN moesin 0.075
GRB7 growth factor receptor-bound protein 7 0.075
ANXA1 annexin A1 0.070
TCF4 transcription factor 4 0.068
LAMB3 laminin, beta 3 0.066
STX4 syntaxin 4 0.066
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.066
EPHA7 EPH receptor A7 0.065
LAMC2 laminin, gamma 2 0.065
ZNF746 zinc finger protein 746 0.062
CD63 CD63 molecule 0.058
AHNAK AHNAK nucleoprotein 0.057
TENC1 tensin like C1 domain containing phosphatase (tensin 2) 0.056
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.055
TRIP6 thyroid hormone receptor interactor 6 0.054
PLEC plectin 0.054
RHOC ras homolog gene family, member C 0.051
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.050
ANXA5 annexin A5 0.050
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.050
EPHA3 EPH receptor A3 0.048
GAST gastrin 0.048
RRAS related RAS viral (r-ras) oncogene homolog 0.046
APP amyloid beta (A4) precursor protein 0.045
EPS8 epidermal growth factor receptor pathway substrate 8 0.045
ITGB4 integrin, beta 4 0.045
ITGA7 integrin, alpha 7 0.045
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.043
KRT17 keratin 17 0.043
SORBS3 sorbin and SH3 domain containing 3 0.042
TGFBR1 transforming growth factor, beta receptor 1 0.042
TGFB2 transforming growth factor, beta 2 0.041
ALB albumin 0.041
CLDN1 claudin 1 0.041
COL17A1 collagen, type XVII, alpha 1 0.040
CTGF connective tissue growth factor 0.040
ITGB5 integrin, beta 5 0.039
FAF1 Fas (TNFRSF6) associated factor 1 0.038
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.038
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
if inflated 0.704
LamC Lamin C 0.632
Hem HEM-protein 0.228
lqf liquid facets 0.213
Cg25C Collagen type IV 0.208
Rac2 CG8556 gene product from transcript CG8556-RA 0.153
LanA Laminin A 0.114
wun wunen 0.110
kon kon-tiki 0.101
siz schizo 0.089
mew multiple edematous wings 0.084
rhea CG6831 gene product from transcript CG6831-RA 0.081
Arp66B Actin-related protein 66B 0.080
Pvr PDGF- and VEGF-receptor related 0.080
srp serpent 0.077
mys myospheroid 0.077
Vrp1 Verprolin 1 0.077
atl atlastin 0.074
RhoL rho-like 0.072
spz spatzle 0.066
TER94 CG2331 gene product from transcript CG2331-RA 0.061
Rho1 CG8416 gene product from transcript CG8416-RB 0.058
rt rotated abdomen 0.054
Cont Contactin 0.051
Timp Tissue inhibitor of metalloproteases 0.049
Glt Glutactin 0.049
Mpk2 CG5475 gene product from transcript CG5475-RB 0.046
ics icarus 0.045
slow slowdown 0.041
Cdc42 CG12530 gene product from transcript CG12530-RA 0.041
CG31352 CG31352 gene product from transcript CG31352-RA 0.041
Tsp Thrombospondin 0.040
shot short stop 0.039
Moe Moesin 0.038
vkg viking 0.037
Pglym78 Phosphoglyceromutase 0.037
LanB2 Laminin B2 0.036
Duox Dual oxidase 0.035
chic chickadee 0.034
stumps CG31317 gene product from transcript CG31317-RC 0.034
nec necrotic 0.033
jim CG11352 gene product from transcript CG11352-RB 0.032
Fer1HCH Ferritin 1 heavy chain homologue 0.032
unc-13 CG2999 gene product from transcript CG2999-RA 0.031
drongo CG3365 gene product from transcript CG3365-RH 0.030
Fkbp13 CG9847 gene product from transcript CG9847-RC 0.029
drpr draper 0.029
Rab5 Rab-protein 5 0.029
blow blown fuse 0.028
shark Src homology 2, ankyrin repeat, tyrosine kinase 0.028
NFAT NFAT homolog 0.028
kst karst 0.028
sol small optic lobes 0.027
vri vrille 0.027
Khc-73 Kinesin-73 0.027
Xrp1 CG17836 gene product from transcript CG17836-RB 0.027
CG1600 CG1600 gene product from transcript CG1600-RA 0.026
Pk61C Protein kinase 61C 0.026
htl heartless 0.025
NUCB1 CG32190 gene product from transcript CG32190-RA 0.025
Rab7 Rab-protein 7 0.025
l(3)L1231 lethal (3) L1231 0.024
Nc73EF Neural conserved at 73EF 0.024
CG10627 CG10627 gene product from transcript CG10627-RA 0.024
p130CAS CG1212 gene product from transcript CG1212-RA 0.024
dia diaphanous 0.023
CG14625 CG14625 gene product from transcript CG14625-RB 0.023
alpha-Spec alpha Spectrin 0.023
comm commissureless 0.022
cindr CIN85 and CD2AP orthologue 0.022
Pgk Phosphoglycerate kinase 0.022
CG8121 CG8121 gene product from transcript CG8121-RA 0.022
Smg1 CG32743 gene product from transcript CG32743-RA 0.022
Rab11 Rab-protein 11 0.021
how held out wings 0.021
NetB Netrin-B 0.021
GluRIIA Glutamate receptor IIA 0.021
Dlic Dynein light intermediate chain 0.021
Rac1 CG2248 gene product from transcript CG2248-RA 0.021
l(2)05510 lethal (2) 05510 0.020
robo roundabout 0.020
Vinc Vinculin 0.020
CG9990 CG9990 gene product from transcript CG9990-RA 0.020
Reg-5 Rhythmically expressed gene 5 0.020
Tig Tiggrin 0.020
sar1 CG7073 gene product from transcript CG7073-RB 0.020
ena enabled 0.020
mbc myoblast city 0.020
RpS16 Ribosomal protein S16 0.020
CG6038 CG6038 gene product from transcript CG6038-RA 0.020
hfw halfway 0.020
Cnx99A Calnexin 99A 0.019
CG8449 CG8449 gene product from transcript CG8449-RA 0.019
CG30159 CG30159 gene product from transcript CG30159-RC 0.019
Gli Gliotactin 0.019
CG16947 CG16947 gene product from transcript CG16947-RA 0.019
Pax Paxillin 0.018
CG8709 CG8709 gene product from transcript CG8709-RK 0.018
RpLP2 Ribosomal protein LP2 0.018
CG5798 CG5798 gene product from transcript CG5798-RA 0.018
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Mus musculus
Name Description Probability Func Analog Organism
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.989
Ptk2 PTK2 protein tyrosine kinase 2 0.976
Pxn paxillin 0.952
Axl AXL receptor tyrosine kinase 0.943
Parva parvin, alpha 0.900
Ilk integrin linked kinase 0.832
Gab1 growth factor receptor bound protein 2-associated protein 1 0.793
Lamc1 laminin, gamma 1 0.776
Was Wiskott-Aldrich syndrome homolog (human) 0.723
Nid1 nidogen 1 0.597
Dok1 docking protein 1 0.552
Inpp5d inositol polyphosphate-5-phosphatase D 0.453
Gopc golgi associated PDZ and coiled-coil motif containing 0.341
Psen1 presenilin 1 0.319
Itga3 integrin alpha 3 0.294
Ctnnb1 catenin (cadherin associated protein), beta 1 0.293
Notch2 Notch gene homolog 2 (Drosophila) 0.268
Dlg4 discs, large homolog 4 (Drosophila) 0.265
Wnt5a wingless-related MMTV integration site 5A 0.253
Vcl vinculin 0.238
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.216
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.209
Ikzf1 IKAROS family zinc finger 1 0.208
Lama5 laminin, alpha 5 0.207
Rac2 RAS-related C3 botulinum substrate 2 0.203
Cd151 CD151 antigen 0.191
Tyro3 TYRO3 protein tyrosine kinase 3 0.190
Hif1a hypoxia inducible factor 1, alpha subunit 0.183
Zyx zyxin 0.182
Vegfa vascular endothelial growth factor A 0.180
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.175
Ephb2 Eph receptor B2 0.174
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.170
Efnb2 ephrin B2 0.170
Hcls1 hematopoietic cell specific Lyn substrate 1 0.162
Bcar1 breast cancer anti-estrogen resistance 1 0.162
Lims1 LIM and senescent cell antigen-like domains 1 0.162
Grb2 growth factor receptor bound protein 2 0.161
App amyloid beta (A4) precursor protein 0.155
Cbl Casitas B-lineage lymphoma 0.153
Fzd8 frizzled homolog 8 (Drosophila) 0.147
Wwtr1 WW domain containing transcription regulator 1 0.146
Actn4 actinin alpha 4 0.137
Wnt7b wingless-related MMTV integration site 7B 0.133
Fn1 fibronectin 1 0.133
Cpd carboxypeptidase D 0.127
Gpc3 glypican 3 0.127
Capn2 calpain 2 0.122
Arhgap9 Rho GTPase activating protein 9 0.121
Src Rous sarcoma oncogene 0.117
S100a11 S100 calcium binding protein A11 (calgizzarin) 0.116
Col4a2 collagen, type IV, alpha 2 0.116
Pdgfb platelet derived growth factor, B polypeptide 0.115
Ret ret proto-oncogene 0.115
Cald1 caldesmon 1 0.114
Mertk c-mer proto-oncogene tyrosine kinase 0.110
Cd19 CD19 antigen 0.107
Plcg2 phospholipase C, gamma 2 0.107
Fyn Fyn proto-oncogene 0.104
Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 0.101
Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.101
Cnn2 calponin 2 0.101
Ptpre protein tyrosine phosphatase, receptor type, E 0.100
Ednrb endothelin receptor type B 0.099
Cd22 CD22 antigen 0.097
Fermt2 fermitin family homolog 2 (Drosophila) 0.097
Abcd1 ATP-binding cassette, sub-family D (ALD), member 1 0.097
S1pr4 sphingosine-1-phosphate receptor 4 0.094
Prkcd protein kinase C, delta 0.093
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.089
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.089
Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.087
Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.086
S1pr3 sphingosine-1-phosphate receptor 3 0.085
Igfbp2 insulin-like growth factor binding protein 2 0.085
Tead2 TEA domain family member 2 0.084
Dlg1 discs, large homolog 1 (Drosophila) 0.081
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.081
Lama4 laminin, alpha 4 0.079
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.078
Rac1 RAS-related C3 botulinum substrate 1 0.078
F2r coagulation factor II (thrombin) receptor 0.077
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.077
Rbms1 RNA binding motif, single stranded interacting protein 1 0.077
Emp2 epithelial membrane protein 2 0.074
Grb7 growth factor receptor bound protein 7 0.074
Rnd3 Rho family GTPase 3 0.074
Ddr2 discoidin domain receptor family, member 2 0.071
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.070
Snap25 synaptosomal-associated protein 25 0.070
Stx1a syntaxin 1A (brain) 0.069
Myo1f myosin IF 0.069
Mfap2 microfibrillar-associated protein 2 0.068
Git1 G protein-coupled receptor kinase-interactor 1 0.068
Prkci protein kinase C, iota 0.068
Hs3st3a1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.067
Fstl1 follistatin-like 1 0.067
Cd37 CD37 antigen 0.066
Cd97 CD97 antigen 0.064
Lamb1 laminin B1 0.062
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism