The network for 'positive regulation of cytokine secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cytokine secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.

Homo sapiens
Name Description Probability Func Analog Organism
TAL1 T-cell acute lymphocytic leukemia 1 0.878
NLRC4 NLR family, CARD domain containing 4 0.804
BTN3A2 butyrophilin, subfamily 3, member A2 0.792
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.692
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.626
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.624
CD80 CD80 molecule 0.453
LAT linker for activation of T cells 0.421
BTN3A3 butyrophilin, subfamily 3, member A3 0.417
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.358
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.350
BCAR1 breast cancer anti-estrogen resistance 1 0.349
BTN3A1 butyrophilin, subfamily 3, member A1 0.328
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.314
CCR2 chemokine (C-C motif) receptor 2 0.264
LCK lymphocyte-specific protein tyrosine kinase 0.258
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.244
APOE apolipoprotein E 0.232
EGFR epidermal growth factor receptor 0.231
IL10RA interleukin 10 receptor, alpha 0.221
CCL4 chemokine (C-C motif) ligand 4 0.198
TRAF1 TNF receptor-associated factor 1 0.197
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.193
ANGPT2 angiopoietin 2 0.192
TLR2 toll-like receptor 2 0.170
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.169
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.164
VEGFA vascular endothelial growth factor A 0.155
IL1R1 interleukin 1 receptor, type I 0.152
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.151
MEFV Mediterranean fever 0.148
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.137
CCR5 chemokine (C-C motif) receptor 5 0.130
IL4 interleukin 4 0.119
CDH5 cadherin 5, type 2 (vascular endothelium) 0.110
IL10 interleukin 10 0.106
CXCL9 chemokine (C-X-C motif) ligand 9 0.100
RIN1 Ras and Rab interactor 1 0.094
IFNG interferon, gamma 0.091
GPR171 G protein-coupled receptor 171 0.091
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.088
ANGPT1 angiopoietin 1 0.080
IL18RAP interleukin 18 receptor accessory protein 0.078
SPRR2A small proline-rich protein 2A 0.078
ITGB1BP3 integrin beta 1 binding protein 3 0.078
NRP1 neuropilin 1 0.076
CRP C-reactive protein, pentraxin-related 0.075
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.068
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.064
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.061
KITLG KIT ligand 0.060
IDE insulin-degrading enzyme 0.057
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.056
CAV1 caveolin 1, caveolae protein, 22kDa 0.055
CAV2 caveolin 2 0.055
PGF placental growth factor 0.055
ITK IL2-inducible T-cell kinase 0.054
CD28 CD28 molecule 0.052
CCR7 chemokine (C-C motif) receptor 7 0.052
HP haptoglobin 0.052
FGA fibrinogen alpha chain 0.051
IL1RN interleukin 1 receptor antagonist 0.051
CLEC2B C-type lectin domain family 2, member B 0.050
SOS1 son of sevenless homolog 1 (Drosophila) 0.049
A2M alpha-2-macroglobulin 0.049
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.048
FGB fibrinogen beta chain 0.047
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.047
CCR1 chemokine (C-C motif) receptor 1 0.047
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.046
PYDC2 pyrin domain containing 2 0.046
COTL1 coactosin-like 1 (Dictyostelium) 0.045
CFI complement factor I 0.045
CFH complement factor H 0.044
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.044
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.043
CYBB cytochrome b-245, beta polypeptide 0.042
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.042
IL1R2 interleukin 1 receptor, type II 0.042
CCL5 chemokine (C-C motif) ligand 5 0.042
IL22RA2 interleukin 22 receptor, alpha 2 0.041
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.040
GATA4 GATA binding protein 4 0.040
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.040
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.040
IRF8 interferon regulatory factor 8 0.039
FZD1 frizzled homolog 1 (Drosophila) 0.039
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.038
NLRP3 NLR family, pyrin domain containing 3 0.038
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.037
CD86 CD86 molecule 0.037
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.036
PTEN phosphatase and tensin homolog 0.036
SYK spleen tyrosine kinase 0.035
PTPRB protein tyrosine phosphatase, receptor type, B 0.035
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.035
IL7R interleukin 7 receptor 0.035
TRAF5 TNF receptor-associated factor 5 0.035
DARC Duffy blood group, chemokine receptor 0.035
GZMK granzyme K (granzyme 3; tryptase II) 0.034
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.993
Ccl8 chemokine (C-C motif) ligand 8 0.949
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.927
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.913
Ccr2 chemokine (C-C motif) receptor 2 0.896
Il1r1 interleukin 1 receptor, type I 0.894
Il1b interleukin 1 beta 0.892
Tlr4 toll-like receptor 4 0.888
Casp1 caspase 1 0.861
Ccl7 chemokine (C-C motif) ligand 7 0.837
Tnf tumor necrosis factor 0.830
Ccl2 chemokine (C-C motif) ligand 2 0.806
Lyz2 lysozyme 2 0.798
Mmp12 matrix metallopeptidase 12 0.778
Trem3 triggering receptor expressed on myeloid cells 3 0.778
C3ar1 complement component 3a receptor 1 0.755
Pax2 paired box gene 2 0.749
Itgax integrin alpha X 0.705
Il1rn interleukin 1 receptor antagonist 0.691
Cd4 CD4 antigen 0.690
Cd80 CD80 antigen 0.675
Fas Fas (TNF receptor superfamily member 6) 0.662
Msr1 macrophage scavenger receptor 1 0.645
Agtr1a angiotensin II receptor, type 1a 0.644
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.641
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.640
Ccr1 chemokine (C-C motif) receptor 1 0.605
Il1rl1 interleukin 1 receptor-like 1 0.600
Lta lymphotoxin A 0.584
Fcgr1 Fc receptor, IgG, high affinity I 0.571
Gbp5 guanylate binding protein 5 0.563
Ccl24 chemokine (C-C motif) ligand 24 0.561
Mmp8 matrix metallopeptidase 8 0.559
Ccl22 chemokine (C-C motif) ligand 22 0.556
Apoe apolipoprotein E 0.552
AF251705 cDNA sequence AF251705 0.545
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.535
Cd33 CD33 antigen 0.526
Il10ra interleukin 10 receptor, alpha 0.509
Mefv Mediterranean fever 0.494
Pycard PYD and CARD domain containing 0.485
Nos2 nitric oxide synthase 2, inducible 0.481
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.472
Cd28 CD28 antigen 0.460
Folr2 folate receptor 2 (fetal) 0.446
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.425
Cybb cytochrome b-245, beta polypeptide 0.424
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.408
Cd86 CD86 antigen 0.386
C1qa complement component 1, q subcomponent, alpha polypeptide 0.385
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.373
Ren1 renin 1 structural 0.354
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.350
Clec4d C-type lectin domain family 4, member d 0.347
Ccr6 chemokine (C-C motif) receptor 6 0.346
Cd14 CD14 antigen 0.344
Ptgir prostaglandin I receptor (IP) 0.342
Slpi secretory leukocyte peptidase inhibitor 0.328
Tbxas1 thromboxane A synthase 1, platelet 0.325
Cd300ld CD300 molecule-like family member d 0.319
C1qtnf1 C1q and tumor necrosis factor related protein 1 0.316
Pdcd1 programmed cell death 1 0.310
C1qc complement component 1, q subcomponent, C chain 0.310
Gpr35 G protein-coupled receptor 35 0.308
Clec4b1 C-type lectin domain family 4, member b1 0.308
Cd44 CD44 antigen 0.307
Fcgr2b Fc receptor, IgG, low affinity IIb 0.304
Lair1 leukocyte-associated Ig-like receptor 1 0.302
Gpr33 G protein-coupled receptor 33 0.294
Cd209b CD209b antigen 0.294
Cd40 CD40 antigen 0.288
Ccl12 chemokine (C-C motif) ligand 12 0.287
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.284
Slamf8 SLAM family member 8 0.284
Il18r1 interleukin 18 receptor 1 0.283
C1qb complement component 1, q subcomponent, beta polypeptide 0.281
Eln elastin 0.274
Ltc4s leukotriene C4 synthase 0.269
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.266
Lcp2 lymphocyte cytosolic protein 2 0.265
Aim2 absent in melanoma 2 0.262
Pcdh12 protocadherin 12 0.254
Tlr7 toll-like receptor 7 0.252
Csf1 colony stimulating factor 1 (macrophage) 0.250
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.245
Cd8a CD8 antigen, alpha chain 0.239
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.238
Sfrp4 secreted frizzled-related protein 4 0.235
Mrc1 mannose receptor, C type 1 0.231
Ptk2 PTK2 protein tyrosine kinase 2 0.228
Pparg peroxisome proliferator activated receptor gamma 0.218
Itk IL2-inducible T-cell kinase 0.217
Btk Bruton agammaglobulinemia tyrosine kinase 0.210
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.208
Cd300lb CD300 antigen like family member B 0.203
Selp selectin, platelet 0.198
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.195
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.193
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.193
Dok1 docking protein 1 0.192
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il1b interleukin 1 beta 0.746
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.306
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.281
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.209
Plau plasminogen activator, urokinase 0.164
Il2rg interleukin 2 receptor, gamma 0.151
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.149
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.128
Ccr5 chemokine (C-C motif) receptor 5 0.118
Ptprc protein tyrosine phosphatase, receptor type, C 0.102
Jak2 Janus kinase 2 0.100
Cybb cytochrome b-245, beta polypeptide 0.076
S1pr2 sphingosine-1-phosphate receptor 2 0.062
Psen1 presenilin 1 0.061
Ccl4 chemokine (C-C motif) ligand 4 0.057
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.057
Hsp90b1 heat shock protein 90, beta, member 1 0.056
Cd14 CD14 molecule 0.055
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.054
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.052
Adam17 ADAM metallopeptidase domain 17 0.050
Marcks myristoylated alanine rich protein kinase C substrate 0.050
Ctsc cathepsin C 0.049
Vcan versican 0.048
Casp3 caspase 3 0.047
Il6 interleukin 6 0.046
Cd86 CD86 molecule 0.045
Sirpa signal-regulatory protein alpha 0.045
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.043
Selp selectin P 0.043
Ncf4 neutrophil cytosolic factor 4 0.042
Casp1 caspase 1 0.041
Cd44 Cd44 molecule 0.040
LOC619574 hypothetical protein LOC619574 0.039
Klrc2 killer cell lectin-like receptor subfamily C, member 2 0.036
Vom1r90 vomeronasal 1 receptor 90 0.036
Bdkrb2 bradykinin receptor B2 0.035
Skap2 src kinase associated phosphoprotein 2 0.034
Csk c-src tyrosine kinase 0.033
LOC24906 RoBo-1 0.033
Il1rl1 interleukin 1 receptor-like 1 0.032
Anpep alanyl (membrane) aminopeptidase 0.031
Neurl3 neuralized homolog 3 (Drosophila) 0.030
Hck hemopoietic cell kinase 0.030
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.028
Pros1 protein S (alpha) 0.026
Ccl2 chemokine (C-C motif) ligand 2 0.026
Tcfe2a transcription factor E2a 0.026
Olr1082 olfactory receptor 1082 0.025
Arrb2 arrestin, beta 2 0.024
Socs3 suppressor of cytokine signaling 3 0.023
Casp8 caspase 8 0.023
Tpm3 tropomyosin 3, gamma 0.023
Lgals9 lectin, galactoside-binding, soluble, 9 0.021
Tlr4 toll-like receptor 4 0.021
Lbr lamin B receptor 0.021
Casp6 caspase 6 0.021
Cxcr3 chemokine (C-X-C motif) receptor 3 0.020
Crot carnitine O-octanoyltransferase 0.020
Ccl5 chemokine (C-C motif) ligand 5 0.020
Il2rb interleukin 2 receptor, beta 0.020
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.020
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.019
Cxcl10 chemokine (C-X-C motif) ligand 10 0.019
Ccl3 chemokine (C-C motif) ligand 3 0.019
Klhl6 kelch-like 6 (Drosophila) 0.018
Tpm4 tropomyosin 4 0.018
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.018
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.018
Ccr2 chemokine (C-C motif) receptor 2 0.018
Akap8l A kinase (PRKA) anchor protein 8-like 0.017
Il1a interleukin 1 alpha 0.017
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.017
Matk megakaryocyte-associated tyrosine kinase 0.016
Ms4a11 membrane-spanning 4-domains, subfamily A, member 11 0.016
Ptafr platelet-activating factor receptor 0.016
Prrx1 paired related homeobox 1 0.016
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.015
Nras neuroblastoma ras oncogene 0.015
Ptges prostaglandin E synthase 0.015
Smad1 SMAD family member 1 0.015
Ltbp1 latent transforming growth factor beta binding protein 1 0.014
Lama5 laminin, alpha 5 0.014
A3galt2 alpha 1,3-galactosyltransferase 2 0.014
Gzmk granzyme K 0.014
Cd47 Cd47 molecule 0.014
Bst1 bone marrow stromal cell antigen 1 0.014
Cd200r1 CD200 receptor 1 0.014
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.014
Tbxas1 thromboxane A synthase 1, platelet 0.014
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.014
LOC100363783 rCG53773-like 0.013
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.013
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.013
Egfr epidermal growth factor receptor 0.013
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.013
Ocln occludin 0.013
Mmp12 matrix metallopeptidase 12 0.013
Tlr2 toll-like receptor 2 0.013
Pax8 paired box 8 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism