The network for 'positive regulation of adenylate cyclase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of adenylate cyclase activity

Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.

Homo sapiens
Name Description Probability Func Analog Organism
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.000
DRD2 dopamine receptor D2 0.996
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.988
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.960
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.958
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.867
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.823
RALBP1 ralA binding protein 1 0.795
MPDZ multiple PDZ domain protein 0.685
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.629
CRH corticotropin releasing hormone 0.623
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.437
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.344
ADORA2A adenosine A2a receptor 0.290
AKAP10 A kinase (PRKA) anchor protein 10 0.285
CP110 CP110 protein 0.264
MEOX2 mesenchyme homeobox 2 0.200
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.198
RALGDS ral guanine nucleotide dissociation stimulator 0.192
MAP2K1 mitogen-activated protein kinase kinase 1 0.177
CALCA calcitonin-related polypeptide alpha 0.176
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.168
NECAB2 N-terminal EF-hand calcium binding protein 2 0.152
ARRDC3 arrestin domain containing 3 0.143
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.138
SRI sorcin 0.123
RIN1 Ras and Rab interactor 1 0.110
NAMPT nicotinamide phosphoribosyltransferase 0.110
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.101
ADORA1 adenosine A1 receptor 0.098
KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1 0.095
SSTR3 somatostatin receptor 3 0.091
SMAD2 SMAD family member 2 0.087
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.076
BAG1 BCL2-associated athanogene 0.076
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.074
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.062
TSHR thyroid stimulating hormone receptor 0.061
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.055
PEBP4 phosphatidylethanolamine-binding protein 4 0.052
PEBP1 phosphatidylethanolamine binding protein 1 0.052
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.051
GABARAPL1 GABA(A) receptor-associated protein like 1 0.045
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.044
GPR6 G protein-coupled receptor 6 0.043
RHEB Ras homolog enriched in brain 0.041
KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.041
FKBP8 FK506 binding protein 8, 38kDa 0.040
GHRHR growth hormone releasing hormone receptor 0.037
RAP1A RAP1A, member of RAS oncogene family 0.036
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.035
EMP3 epithelial membrane protein 3 0.033
NELL2 NEL-like 2 (chicken) 0.030
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.029
PTEN phosphatase and tensin homolog 0.028
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.028
ADRB3 adrenergic, beta-3-, receptor 0.027
CALCR calcitonin receptor 0.027
PAWR PRKC, apoptosis, WT1, regulator 0.026
ODF1 outer dense fiber of sperm tails 1 0.025
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.025
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.024
HTR4 5-hydroxytryptamine (serotonin) receptor 4 0.023
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 0.022
GUCA2B guanylate cyclase activator 2B (uroguanylin) 0.022
RHO rhodopsin 0.022
OPRM1 opioid receptor, mu 1 0.022
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.021
SLC6A7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.021
PAX3 paired box 3 0.021
SCTR secretin receptor 0.021
UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.020
TBC1D10A TBC1 domain family, member 10A 0.020
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.019
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.019
CEND1 cell cycle exit and neuronal differentiation 1 0.018
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.018
PDE4DIP phosphodiesterase 4D interacting protein 0.018
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.018
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.018
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.017
TBR1 T-box, brain, 1 0.017
DRD1 dopamine receptor D1 0.017
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.017
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.017
ADRA1A adrenergic, alpha-1A-, receptor 0.017
ACRV1 acrosomal vesicle protein 1 0.017
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.017
IGSF21 immunoglobin superfamily, member 21 0.016
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.016
FGF4 fibroblast growth factor 4 0.016
SVOP SV2 related protein homolog (rat) 0.016
BZW1 basic leucine zipper and W2 domains 1 0.016
HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 0.015
FEZF2 FEZ family zinc finger 2 0.015
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 0.015
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.015
HCRT hypocretin (orexin) neuropeptide precursor 0.015
RET ret proto-oncogene 0.015
PAM peptidylglycine alpha-amidating monooxygenase 0.015
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG13253 CG13253 gene product from transcript CG13253-RB 0.626
Tbh Tyramine beta hydroxylase 0.544
oa2 octopamine receptor 2 0.297
cry cryptochrome 0.120
dnc dunce 0.103
Atf-2 Activating transcription factor-2 0.095
PIP5K59B CG3682 gene product from transcript CG3682-RE 0.067
per period 0.066
jeb jelly belly 0.065
CG34400 CG34400 gene product from transcript CG34400-RD 0.061
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.055
tim timeless 0.054
CG42629 CG42629 gene product from transcript CG42629-RB 0.032
dnr1 defense repressor 1 0.030
nan nanchung 0.030
CG18437 CG18437 gene product from transcript CG18437-RB 0.029
tau CG31057 gene product from transcript CG31057-RA 0.028
CG34353 CG34353 gene product from transcript CG34353-RA 0.028
Fer2 48 related 2 0.027
dco discs overgrown 0.026
pHCl CG33989 gene product from transcript CG33989-RD 0.024
Nmdar1 NMDA receptor 1 0.022
CCKLR-17D1 CCK-like receptor at 17D1 0.021
fd85E forkhead domain 85E 0.019
Dsk Drosulfakinin 0.018
eag ether a go-go 0.018
CG11317 CG11317 gene product from transcript CG11317-RA 0.017
RanBPM Ran-binding protein M 0.017
CG3857 CG3857 gene product from transcript CG3857-RA 0.016
5-HT1A Serotonin receptor 1A 0.016
Ast-C Allatostatin C 0.016
Sox100B CG15552 gene product from transcript CG15552-RA 0.016
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.016
Tdc2 Tyrosine decarboxylase 2 0.015
Task6 CG9637 gene product from transcript CG9637-RC 0.014
CG4857 CG4857 gene product from transcript CG4857-RD 0.013
CG32635 CG32635 gene product from transcript CG32635-RA 0.012
Ric Ras which interacts with Calmodulin 0.012
nord CG30418 gene product from transcript CG30418-RA 0.012
tkv thickveins 0.012
Clk Clock 0.011
Dh Diuretic hormone 0.011
CG9997 CG9997 gene product from transcript CG9997-RA 0.011
CG34354 CG34354 gene product from transcript CG34354-RA 0.011
CG7191 CG7191 gene product from transcript CG7191-RA 0.010
CG15088 CG15088 gene product from transcript CG15088-RC 0.010
2mit CG42573 gene product from transcript CG42573-RA 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.627
Drd2 dopamine receptor D2 0.569
Esr1 estrogen receptor 1 (alpha) 0.563
Ghr growth hormone receptor 0.487
Ar androgen receptor 0.403
Kl klotho 0.381
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.120
Pnpla2 patatin-like phospholipase domain containing 2 0.111
Gnrh1 gonadotropin releasing hormone 1 0.091
Pgr progesterone receptor 0.091
Lhb luteinizing hormone beta 0.089
Pax8 paired box gene 8 0.088
Sstr4 somatostatin receptor 4 0.073
Mc5r melanocortin 5 receptor 0.070
Cckbr cholecystokinin B receptor 0.066
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.049
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.045
Braf Braf transforming gene 0.043
Pten phosphatase and tensin homolog 0.041
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.040
Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 0.039
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.037
Duox2 dual oxidase 2 0.036
Shc3 src homology 2 domain-containing transforming protein C3 0.036
Cbl Casitas B-lineage lymphoma 0.036
Ctnnb1 catenin (cadherin associated protein), beta 1 0.035
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.033
Pparg peroxisome proliferator activated receptor gamma 0.031
Thrb thyroid hormone receptor beta 0.031
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.030
Vdr vitamin D receptor 0.029
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.028
Prlr prolactin receptor 0.028
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.028
Cga glycoprotein hormones, alpha subunit 0.028
Lep leptin 0.027
Trp53 transformation related protein 53 0.027
Neurog3 neurogenin 3 0.027
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.027
Fgf10 fibroblast growth factor 10 0.025
Adora2a adenosine A2a receptor 0.025
Npy2r neuropeptide Y receptor Y2 0.024
Krt86 keratin 86 0.024
Adrb1 adrenergic receptor, beta 1 0.023
Fgf4 fibroblast growth factor 4 0.023
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.023
Rac1 RAS-related C3 botulinum substrate 1 0.023
Oprk1 opioid receptor, kappa 1 0.022
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.022
Amhr2 anti-Mullerian hormone type 2 receptor 0.021
Kiss1 KiSS-1 metastasis-suppressor 0.021
Npy6r neuropeptide Y receptor Y6 0.021
Slc12a1 solute carrier family 12, member 1 0.020
Gsx1 GS homeobox 1 0.020
Btn1a1 butyrophilin, subfamily 1, member A1 0.020
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.019
Esr2 estrogen receptor 2 (beta) 0.019
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.018
Tacr2 tachykinin receptor 2 0.018
Bglap bone gamma carboxyglutamate protein 0.017
Npy5r neuropeptide Y receptor Y5 0.017
Grid1 glutamate receptor, ionotropic, delta 1 0.017
Ppyr1 pancreatic polypeptide receptor 1 0.017
Tgfb1 transforming growth factor, beta 1 0.017
Syn2 synapsin II 0.016
Hif1a hypoxia inducible factor 1, alpha subunit 0.016
Tpm4 tropomyosin 4 0.016
Prkcc protein kinase C, gamma 0.015
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.015
Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 0.015
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.015
Mdm2 transformed mouse 3T3 cell double minute 2 0.015
Gpr27 G protein-coupled receptor 27 0.014
Mtpn myotrophin 0.014
S100a5 S100 calcium binding protein A5 0.014
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.014
Ccnd1 cyclin D1 0.014
Apc adenomatosis polyposis coli 0.014
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 0.014
Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 0.013
Lmx1b LIM homeobox transcription factor 1 beta 0.013
Sstr1 somatostatin receptor 1 0.013
Tacr1 tachykinin receptor 1 0.013
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.013
Trpc5 transient receptor potential cation channel, subfamily C, member 5 0.013
Zp2 zona pellucida glycoprotein 2 0.013
Slc16a8 solute carrier family 16 (monocarboxylic acid transporters), member 8 0.013
Lhx6 LIM homeobox protein 6 0.013
Ptafr platelet-activating factor receptor 0.012
Rod1 ROD1 regulator of differentiation 1 (S. pombe) 0.012
Gnrhr gonadotropin releasing hormone receptor 0.012
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.012
Crhr1 corticotropin releasing hormone receptor 1 0.012
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.012
Adrb2 adrenergic receptor, beta 2 0.012
Foxf2 forkhead box F2 0.012
Rap2c RAP2C, member of RAS oncogene family 0.012
Khdc1b KH domain containing 1B 0.012
Tac2 tachykinin 2 0.012
Sntb1 syntrophin, basic 1 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ncan neurocan 0.269
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.229
S100a10 S100 calcium binding protein A10 0.198
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.179
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.162
Fgf14 fibroblast growth factor 14 0.147
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.098
Adora1 adenosine A1 receptor 0.093
Plin perilipin 0.090
Calm1 calmodulin 1 0.083
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.080
Gpr6 G protein-coupled receptor 6 0.079
Nfasc neurofascin 0.076
Csf1 colony stimulating factor 1 (macrophage) 0.072
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.067
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.064
Adora2a adenosine A2a receptor 0.061
Kalrn kalirin, RhoGEF kinase 0.059
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.059
Lgals3 lectin, galactoside-binding, soluble, 3 0.056
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.055
Ifitm3 interferon induced transmembrane protein 3 0.051
Drd2 dopamine receptor D2 0.051
Odf4 outer dense fiber of sperm tails 4 0.047
Avp arginine vasopressin 0.044
Camk4 calcium/calmodulin-dependent protein kinase IV 0.043
Hpcal4 hippocalcin-like 4 0.042
Prl2a1 Prolactin family 2, subfamily a, member 1 0.042
Mcpt1 mast cell protease 1 0.040
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.040
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.040
Syt7 synaptotagmin VII 0.039
Gpr176 G protein-coupled receptor 176 0.039
Gad2 glutamate decarboxylase 2 0.038
Vim vimentin 0.038
Hrh2 histamine receptor H 2 0.038
Kitlg KIT ligand 0.037
Taf6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.037
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.035
Folh1 folate hydrolase 1 0.034
Anxa5 annexin A5 0.034
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.033
Calm2 calmodulin 2 0.033
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.033
Insr insulin receptor 0.033
Ptp4a2 protein tyrosine phosphatase 4a2 0.032
Rgs9 regulator of G-protein signaling 9 0.031
Sfrp4 secreted frizzled-related protein 4 0.031
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.031
Hpca hippocalcin 0.031
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.031
Prrx1 paired related homeobox 1 0.030
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.029
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.029
Utrn utrophin 0.028
Grm1 glutamate receptor, metabotropic 1 0.028
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.028
N5 DNA binding protein N5 0.028
Pgam1 phosphoglycerate mutase 1 (brain) 0.028
Cckar cholecystokinin A receptor 0.027
Cav1 caveolin 1, caveolae protein 0.027
Anxa2 annexin A2 0.026
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.026
RGD1564327 similar to integrin alpha 8 0.025
Mchr1 melanin-concentrating hormone receptor 1 0.025
Lims1 LIM and senescent cell antigen-like domains 1 0.025
Olr416 olfactory receptor 416 0.025
Dlx5 distal-less homeobox 5 0.024
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.024
Igf2 insulin-like growth factor 2 0.024
Ptger3 prostaglandin E receptor 3 (subtype EP3) 0.024
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.024
Adam10 ADAM metallopeptidase domain 10 0.023
Cntn3 contactin 3 (plasmacytoma associated) 0.023
S100a4 S100 calcium-binding protein A4 0.023
Uhmk1 U2AF homology motif (UHM) kinase 1 0.023
Sepw1 selenoprotein W, 1 0.023
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.023
Sub1 SUB1 homolog (S. cerevisiae) 0.023
Soat1 sterol O-acyltransferase 1 0.022
Grik3 glutamate receptor, ionotropic, kainate 3 0.022
Unc5a unc-5 homolog A (C. elegans) 0.022
Znf483 zinc finger protein 483 0.022
Crhbp corticotropin releasing hormone binding protein 0.022
Neu2 sialidase 2 (cytosolic sialidase) 0.022
Tpsb2 tryptase beta 2 0.022
Aqp2 aquaporin 2 (collecting duct) 0.022
Myo1b myosin Ib 0.022
Fgf7 fibroblast growth factor 7 0.022
Dynll1 dynein light chain LC8-type 1 0.021
Adam3a ADAM metallopeptidase domain 3A (cyritestin 1) 0.021
Dock8 dedicator of cytokinesis 8 0.021
Map3k3 mitogen activated protein kinase kinase kinase 3 0.021
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.021
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.020
Agtr1a angiotensin II receptor, type 1a 0.020
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.020
Emp1 epithelial membrane protein 1 0.020
Syt8 synaptotagmin VIII 0.020
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
NOP12 Nop12p 0.026
GIS2 Gis2p 0.020
RPF2 Rpf2p 0.017
PRP43 Prp43p 0.015
RRP8 Rrp8p 0.015
RPA12 Rpa12p 0.015
SSB2 Ssb2p 0.015
RIM11 Rim11p 0.014
RPA34 Rpa34p 0.014
NOC2 Noc2p 0.013
DRS1 Drs1p 0.013
ELP2 Elp2p 0.012
UBP15 Ubp15p 0.011
KRE33 Kre33p 0.011
RRP6 Rrp6p 0.011
TPK2 Tpk2p 0.011
NMD3 Nmd3p 0.011
RRP4 Rrp4p 0.010
RRP5 Rrp5p 0.010
SDA1 Sda1p 0.010
UBI4 Ubi4p 0.010
RPL7A Rpl7ap 0.010
LIA1 Lia1p 0.010