The network for 'hindlimb morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hindlimb morphogenesis

The process in which the anatomical structures of the hindlimb are generated and organized.

Homo sapiens
Name Description Probability Func Analog Organism
APC adenomatous polyposis coli 0.991
BMP2 bone morphogenetic protein 2 0.942
SETD8 SET domain containing (lysine methyltransferase) 8 0.877
TNRC6A trinucleotide repeat containing 6A 0.831
AFF1 AF4/FMR2 family, member 1 0.746
PDZD11 PDZ domain containing 11 0.661
NOTCH3 notch 3 0.641
JAG1 jagged 1 0.606
ELL2 elongation factor, RNA polymerase II, 2 0.577
GSK3B glycogen synthase kinase 3 beta 0.569
CHD8 chromodomain helicase DNA binding protein 8 0.544
BMPR1B bone morphogenetic protein receptor, type IB 0.502
SMAD2 SMAD family member 2 0.408
LRRK2 leucine-rich repeat kinase 2 0.403
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.377
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.337
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.330
CDK19 cyclin-dependent kinase 19 0.329
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.314
TNRC6C trinucleotide repeat containing 6C 0.307
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.305
FGF18 fibroblast growth factor 18 0.300
BMP4 bone morphogenetic protein 4 0.288
TARBP2 TAR (HIV-1) RNA binding protein 2 0.287
JUP junction plakoglobin 0.260
BARX1 BARX homeobox 1 0.250
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.227
FANCC Fanconi anemia, complementation group C 0.223
MSX2 msh homeobox 2 0.222
MSX1 msh homeobox 1 0.199
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.189
EAF1 ELL associated factor 1 0.188
ZFYVE9 zinc finger, FYVE domain containing 9 0.186
AXIN1 axin 1 0.182
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.177
CCNT1 cyclin T1 0.143
CHD4 chromodomain helicase DNA binding protein 4 0.138
PML promyelocytic leukemia 0.131
MED26 mediator complex subunit 26 0.123
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.114
WNT1 wingless-type MMTV integration site family, member 1 0.114
WNT3A wingless-type MMTV integration site family, member 3A 0.112
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.103
TCF4 transcription factor 4 0.103
SFRP1 secreted frizzled-related protein 1 0.101
HOXD11 homeobox D11 0.096
NCOR2 nuclear receptor corepressor 2 0.094
SOX2 SRY (sex determining region Y)-box 2 0.093
FSTL1 follistatin-like 1 0.091
FOXF2 forkhead box F2 0.091
FGF3 fibroblast growth factor 3 0.088
FGF8 fibroblast growth factor 8 (androgen-induced) 0.088
PGAM5 phosphoglycerate mutase family member 5 0.084
HIPK2 homeodomain interacting protein kinase 2 0.083
TAL1 T-cell acute lymphocytic leukemia 1 0.083
WNT11 wingless-type MMTV integration site family, member 11 0.082
DAXX death-domain associated protein 0.082
XIAP X-linked inhibitor of apoptosis 0.081
HOXC8 homeobox C8 0.081
WNT10A wingless-type MMTV integration site family, member 10A 0.078
HOXA11 homeobox A11 0.078
HOXD13 homeobox D13 0.077
TBX2 T-box 2 0.074
GLIS2 GLIS family zinc finger 2 0.073
ACAN aggrecan 0.072
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.071
BTRC beta-transducin repeat containing 0.070
LBX1 ladybird homeobox 1 0.068
BMPR1A bone morphogenetic protein receptor, type IA 0.067
WNT4 wingless-type MMTV integration site family, member 4 0.065
RXRA retinoid X receptor, alpha 0.065
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.065
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.064
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.064
NIN ninein (GSK3B interacting protein) 0.064
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.060
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.058
WIF1 WNT inhibitory factor 1 0.057
DLX5 distal-less homeobox 5 0.057
CRABP2 cellular retinoic acid binding protein 2 0.057
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.055
MAML1 mastermind-like 1 (Drosophila) 0.055
MTA1 metastasis associated 1 0.055
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.054
DLL1 delta-like 1 (Drosophila) 0.054
GATA2 GATA binding protein 2 0.054
HOXB13 homeobox B13 0.053
JAG2 jagged 2 0.053
PAX8 paired box 8 0.052
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.052
ELL elongation factor RNA polymerase II 0.050
HES2 hairy and enhancer of split 2 (Drosophila) 0.050
CDX1 caudal type homeobox 1 0.049
FAM101B family with sequence similarity 101, member B 0.047
NKX3-2 NK3 homeobox 2 0.047
PGR progesterone receptor 0.047
COL2A1 collagen, type II, alpha 1 0.047
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.047
MED10 mediator complex subunit 10 0.047
FOXL1 forkhead box L1 0.046
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Shh sonic hedgehog 1.000
Bmp4 bone morphogenetic protein 4 0.999
Tbx3 T-box 3 0.999
Fgf8 fibroblast growth factor 8 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Foxc1 forkhead box C1 0.998
Nodal nodal 0.997
Hand2 heart and neural crest derivatives expressed transcript 2 0.993
Tgfbr2 transforming growth factor, beta receptor II 0.992
Otx2 orthodenticle homolog 2 (Drosophila) 0.992
Ptch1 patched homolog 1 0.992
Pitx1 paired-like homeodomain transcription factor 1 0.989
Pax8 paired box gene 8 0.983
Rarg retinoic acid receptor, gamma 0.981
Pax2 paired box gene 2 0.979
Msx1 homeobox, msh-like 1 0.978
Smo smoothened homolog (Drosophila) 0.974
Pax3 paired box gene 3 0.969
Pten phosphatase and tensin homolog 0.967
Foxc2 forkhead box C2 0.965
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.960
Rara retinoic acid receptor, alpha 0.959
Gli2 GLI-Kruppel family member GLI2 0.954
Hand1 heart and neural crest derivatives expressed transcript 1 0.952
Hoxd13 homeobox D13 0.947
Tbx4 T-box 4 0.942
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.937
Hoxa1 homeobox A1 0.937
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.929
Fgf10 fibroblast growth factor 10 0.925
Hoxa10 homeobox A10 0.915
Hoxa13 homeobox A13 0.904
Msx2 homeobox, msh-like 2 0.904
Pax6 paired box gene 6 0.902
Sall4 sal-like 4 (Drosophila) 0.896
Sox9 SRY-box containing gene 9 0.895
Fgfr1 fibroblast growth factor receptor 1 0.890
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.888
Runx2 runt related transcription factor 2 0.878
Fgf15 fibroblast growth factor 15 0.875
Lhx1 LIM homeobox protein 1 0.872
Chrd chordin 0.854
Ptf1a pancreas specific transcription factor, 1a 0.844
Tbx1 T-box 1 0.829
Hoxd11 homeobox D11 0.826
Hoxd10 homeobox D10 0.822
Eya1 eyes absent 1 homolog (Drosophila) 0.818
Pbx1 pre B-cell leukemia transcription factor 1 0.789
T brachyury 0.772
Prrx1 paired related homeobox 1 0.759
Sox2 SRY-box containing gene 2 0.750
Hoxa11 homeobox A11 0.748
Gdf5 growth differentiation factor 5 0.739
Tgfb2 transforming growth factor, beta 2 0.712
Bmp7 bone morphogenetic protein 7 0.710
Dlx5 distal-less homeobox 5 0.700
Alx4 aristaless-like homeobox 4 0.692
En1 engrailed 1 0.686
Zic3 zinc finger protein of the cerebellum 3 0.682
Wt1 Wilms tumor 1 homolog 0.652
Tbx15 T-box 15 0.644
Prrx2 paired related homeobox 2 0.638
Gdf3 growth differentiation factor 3 0.636
Gbx2 gastrulation brain homeobox 2 0.628
Gsc goosecoid homeobox 0.621
Ctnnb1 catenin (cadherin associated protein), beta 1 0.595
Otx1 orthodenticle homolog 1 (Drosophila) 0.595
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.584
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.580
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.562
Apc adenomatosis polyposis coli 0.533
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.526
Fgfr3 fibroblast growth factor receptor 3 0.516
Bmpr1a bone morphogenetic protein receptor, type 1A 0.507
Rxra retinoid X receptor alpha 0.501
Lrp6 low density lipoprotein receptor-related protein 6 0.497
Fgf9 fibroblast growth factor 9 0.486
Alx3 aristaless-like homeobox 3 0.485
Wnt3a wingless-related MMTV integration site 3A 0.480
Hoxd9 homeobox D9 0.472
Foxh1 forkhead box H1 0.443
Hoxb9 homeobox B9 0.437
Egfr epidermal growth factor receptor 0.431
Tcfap2a transcription factor AP-2, alpha 0.421
Vangl2 vang-like 2 (van gogh, Drosophila) 0.397
Lmx1b LIM homeobox transcription factor 1 beta 0.394
Pax9 paired box gene 9 0.391
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.389
Hoxa2 homeobox A2 0.374
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.374
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.373
Hmx3 H6 homeobox 3 0.365
Jag1 jagged 1 0.361
Emx2 empty spiracles homolog 2 (Drosophila) 0.353
Foxd3 forkhead box D3 0.338
Wnt5a wingless-related MMTV integration site 5A 0.331
Gpc3 glypican 3 0.329
Nog noggin 0.309
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hrasls5 HRAS-like suppressor family, member 5 0.266
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.215
Mmp9 matrix metallopeptidase 9 0.200
Tacr1 tachykinin receptor 1 0.132
Mmp12 matrix metallopeptidase 12 0.132
Ccl4 chemokine (C-C motif) ligand 4 0.121
Il6 interleukin 6 0.121
Egr2 early growth response 2 0.114
Col12a1 collagen, type XII, alpha 1 0.113
Arhgap10 Rho GTPase activating protein 10 0.092
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.086
Cxcl2 chemokine (C-X-C motif) ligand 2 0.085
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.079
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.075
Psgb1 pregnancy-specific beta 1-glycoprotein 0.074
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.071
Plau plasminogen activator, urokinase 0.071
Accn3 amiloride-sensitive cation channel 3 0.070
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.069
Calcb calcitonin-related polypeptide, beta 0.065
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.061
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.059
Reg3g regenerating islet-derived 3 gamma 0.055
Mcpt2 mast cell protease 2 0.055
Il1a interleukin 1 alpha 0.050
Sfrp4 secreted frizzled-related protein 4 0.047
Wnt5a wingless-type MMTV integration site family, member 5A 0.045
Mrgprf MAS-related GPR, member F 0.045
Ibsp integrin-binding sialoprotein 0.044
Fam38b family with sequence similarity 38, member B 0.043
Eln elastin 0.043
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.043
C1qtnf5 C1q and tumor necrosis factor related protein 5 0.042
Prlhr prolactin releasing hormone receptor 0.042
Mmp13 matrix metallopeptidase 13 0.041
Fzd2 frizzled homolog 2 (Drosophila) 0.041
Selp selectin P 0.040
Tfec transcription factor EC 0.040
Csf3 colony stimulating factor 3 (granulocyte) 0.040
Chad chondroadherin 0.040
Mmp7 matrix metallopeptidase 7 0.038
Pip prolactin induced protein 0.038
Fosl1 fos-like antigen 1 0.037
Ereg epiregulin 0.037
Msx1 msh homeobox 1 0.037
Eaf1 ELL associated factor 1 0.037
Dock6 dedicator of cytokinesis 6 0.034
Crisp1 cysteine-rich secretory protein 1 0.034
Col14a1 collagen, type XIV, alpha 1 0.032
Ccl11 chemokine (C-C motif) ligand 11 0.032
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.032
Gja5 gap junction protein, alpha 5 0.031
Cpa3 carboxypeptidase A3, mast cell 0.031
Ccl3 chemokine (C-C motif) ligand 3 0.031
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.031
Foxe3 forkhead box E3 0.031
Mybph myosin binding protein H 0.030
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.030
Fbln5 fibulin 5 0.029
P22k15 cystatin related protein 2 0.029
Serpinb12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 0.029
Icos inducible T-cell co-stimulator 0.029
Slc16a3 solute carrier family 16, member 3 (monocarboxylic acid transporter 4) 0.028
Expi extracellular proteinase inhibitor 0.028
Prkch protein kinase C, eta 0.027
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.027
Ptges prostaglandin E synthase 0.027
Ccna1 cyclin A1 0.026
Fcer2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.026
Gja4 gap junction protein, alpha 4 0.026
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.026
Olfml2b olfactomedin-like 2B 0.026
Glycam1 glycosylation dependent cell adhesion molecule 1 0.025
Nradd neurotrophin receptor associated death domain 0.025
Lef1 lymphoid enhancer binding factor 1 0.025
Sprr3 small proline-rich protein 3 0.025
Dkk3 dickkopf homolog 3 (Xenopus laevis) 0.024
Tchh trichohyalin 0.024
Igfbp5 insulin-like growth factor binding protein 5 0.024
Igf2r insulin-like growth factor 2 receptor 0.024
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.024
Plaur plasminogen activator, urokinase receptor 0.023
Cga glycoprotein hormones, alpha polypeptide 0.023
Sf3b2 splicing factor 3b, subunit 2 0.023
Aspg asparaginase homolog (S. cerevisiae) 0.023
Nfia nuclear factor I/A 0.023
Ptplad2 protein tyrosine phosphatase-like A domain containing 2 0.022
Ctrc chymotrypsin C (caldecrin) 0.022
Mos Moloney sarcoma oncogene 0.022
LOC683313 similar to keratin complex 2, basic, gene 6a 0.022
Lepr leptin receptor 0.022
Meox2 mesenchyme homeobox 2 0.022
Pgf placental growth factor 0.022
Fam69b family with sequence similarity 69, member B 0.022
Dock8 dedicator of cytokinesis 8 0.021
Bst1 bone marrow stromal cell antigen 1 0.021
Accn5 amiloride-sensitive cation channel 5, intestinal 0.021
Crispld2 cysteine-rich secretory protein LCCL domain containing 2 0.021
Prrx1 paired related homeobox 1 0.021
Vom2r31 vomeronasal 2 receptor, 31 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism