The network for 'heart formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart formation

The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.

Homo sapiens
Name Description Probability Func Analog Organism
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
BMPR1A bone morphogenetic protein receptor, type IA 0.999
BMP2 bone morphogenetic protein 2 0.998
AXIN1 axin 1 0.994
SUFU suppressor of fused homolog (Drosophila) 0.993
FOXD3 forkhead box D3 0.984
LRP6 low density lipoprotein receptor-related protein 6 0.975
PAX3 paired box 3 0.962
JAG1 jagged 1 0.960
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.960
ZNF512B zinc finger protein 512B 0.959
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.956
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.919
MAML1 mastermind-like 1 (Drosophila) 0.918
APC adenomatous polyposis coli 0.916
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.907
SP1 Sp1 transcription factor 0.904
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.888
SOX10 SRY (sex determining region Y)-box 10 0.866
TCF4 transcription factor 4 0.839
LRRK2 leucine-rich repeat kinase 2 0.819
SPEN spen homolog, transcriptional regulator (Drosophila) 0.744
CTNNBIP1 catenin, beta interacting protein 1 0.741
STK36 serine/threonine kinase 36 0.733
SOX2 SRY (sex determining region Y)-box 2 0.729
HDAC4 histone deacetylase 4 0.722
CTNND1 catenin (cadherin-associated protein), delta 1 0.719
NOTCH3 notch 3 0.698
EP300 E1A binding protein p300 0.696
ATXN1L ataxin 1-like 0.688
TBX5 T-box 5 0.652
NCOR2 nuclear receptor corepressor 2 0.640
WT1 Wilms tumor 1 0.631
FSTL1 follistatin-like 1 0.624
GSK3B glycogen synthase kinase 3 beta 0.609
CREBBP CREB binding protein 0.560
GATA4 GATA binding protein 4 0.548
BTRC beta-transducin repeat containing 0.496
CSNK1E casein kinase 1, epsilon 0.455
CEP164 centrosomal protein 164kDa 0.386
SNIP1 Smad nuclear interacting protein 1 0.385
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.384
LHX3 LIM homeobox 3 0.365
C1orf31 chromosome 1 open reading frame 31 0.357
BMP4 bone morphogenetic protein 4 0.345
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.344
TP73 tumor protein p73 0.300
LMX1A LIM homeobox transcription factor 1, alpha 0.293
SOX11 SRY (sex determining region Y)-box 11 0.288
SMAD7 SMAD family member 7 0.287
AR androgen receptor 0.266
JUP junction plakoglobin 0.254
SMAD3 SMAD family member 3 0.247
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.242
FZD1 frizzled homolog 1 (Drosophila) 0.229
GLIS2 GLIS family zinc finger 2 0.228
JAG2 jagged 2 0.228
HDAC9 histone deacetylase 9 0.221
SRP19 signal recognition particle 19kDa 0.218
PAX2 paired box 2 0.217
SOX1 SRY (sex determining region Y)-box 1 0.209
ISL1 ISL LIM homeobox 1 0.204
MYST2 MYST histone acetyltransferase 2 0.199
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.192
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.189
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.187
YAP1 Yes-associated protein 1 0.186
MYOD1 myogenic differentiation 1 0.183
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.183
RAX retina and anterior neural fold homeobox 0.182
MCC mutated in colorectal cancers 0.177
SIX6 SIX homeobox 6 0.174
LBX1 ladybird homeobox 1 0.164
DSP desmoplakin 0.164
LHX1 LIM homeobox 1 0.163
SFRP5 secreted frizzled-related protein 5 0.160
FGF3 fibroblast growth factor 3 0.154
HOXC8 homeobox C8 0.152
PTS 6-pyruvoyltetrahydropterin synthase 0.150
NOTCH2 notch 2 0.147
BAHD1 bromo adjacent homology domain containing 1 0.138
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.137
HCFC1 host cell factor C1 (VP16-accessory protein) 0.130
PAX6 paired box 6 0.129
NCOA2 nuclear receptor coactivator 2 0.127
FOXB1 forkhead box B1 0.126
FZD8 frizzled homolog 8 (Drosophila) 0.122
VAX2 ventral anterior homeobox 2 0.122
EMD emerin 0.119
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.117
MDFI MyoD family inhibitor 0.116
DLL1 delta-like 1 (Drosophila) 0.115
SOX21 SRY (sex determining region Y)-box 21 0.115
PDX1 pancreatic and duodenal homeobox 1 0.113
LHX5 LIM homeobox 5 0.113
POU3F3 POU class 3 homeobox 3 0.112
KLF13 Kruppel-like factor 13 0.111
NKX6-1 NK6 homeobox 1 0.111
OTP orthopedia homeobox 0.111
PITX1 paired-like homeodomain 1 0.107
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.999
tbx5a T-box 5a 0.945
chd chordin 0.935
gata6 GATA-binding protein 6 0.847
ndr2 nodal-related 2 0.766
robo3 roundabout homolog 3 0.747
shha sonic hedgehog a 0.746
gata5 GATA-binding protein 5 0.722
runx1 runt-related transcription factor 1 0.673
lft1 lefty1 0.665
pax2a paired box gene 2a 0.644
eya1 eyes absent homolog 1 0.629
bmp4 bone morphogenetic protein 4 0.603
cdh2 cadherin 2, neuronal 0.574
bmp2b bone morphogenetic protein 2b 0.574
tbx20 T-box 20 0.554
flh floating head 0.511
spaw southpaw 0.441
lft2 lefty2 0.372
pitx2 paired-like homeodomain transcription factor 2 0.325
has2 hyaluronan synthase 2 0.300
fn1 fibronectin 1 0.293
mef2cb myocyte enhancer factor 2cb 0.282
dlx5a distal-less homeobox gene 5a 0.281
pcdh8 protocadherin 8 0.274
tal1 T-cell acute lymphocytic leukemia 1 0.272
mib mind bomb 0.262
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.262
sox4b SRY-box containing gene 4b 0.259
vent ventral expressed homeobox 0.252
spry4 sprouty (Drosophila) homolog 4 0.238
pkd2 polycystic kidney disease 2 0.231
cdx4 caudal type homeo box transcription factor 4 0.225
wnt5b wingless-type MMTV integration site family, member 5b 0.214
sox3 SRY-box containing gene 3 0.208
sulf1 sulfatase 1 0.199
fgf10a fibroblast growth factor 10a 0.196
oep one-eyed pinhead 0.191
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.185
hnf1ba HNF1 homeobox Ba 0.184
gata2a GATA-binding protein 2a 0.180
mmp2 matrix metalloproteinase 2 0.178
dld deltaD 0.169
igf1rb insulin-like growth factor 1b receptor 0.168
nkx2.5 NK2 transcription factor related 5 0.159
evx1 even-skipped homeobox 1 0.156
tfap2a transcription factor AP-2 alpha 0.152
ndr1 nodal-related 1 0.149
axin1 axin 1 0.147
etv2 ets variant gene 2 0.137
notch3 notch homolog 3 0.137
tbx2a T-box gene 2a 0.134
myod1 myogenic differentiation 1 0.132
runx2b runt-related transcription factor 2b 0.132
her7 hairy and enhancer of split related-7 0.128
jag2 jagged 2 0.125
eomesa eomesodermin homolog a 0.125
kdrl kinase insert domain receptor like 0.124
six4b sine oculis homeobox homolog 4b 0.122
tbx16 T-box gene 16 0.117
gsc goosecoid 0.115
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.111
sox17 SRY-box containing gene 17 0.107
ttna titin a 0.107
fgf8a fibroblast growth factor 8 a 0.105
dlx3b distal-less homeobox gene 3b 0.105
foxg1a forkhead box G1a 0.100
osr1 odd-skipped related 1 (Drosophila) 0.100
foxa3 forkhead box A3 0.100
fzd10 frizzled homolog 10 0.099
dzip1 DAZ interacting protein 1 0.099
wnt3 wingless-type MMTV integration site family, member 3 0.095
wnt11 wingless-type MMTV integration site family, member 11 0.095
wls wntless homolog (Drosophila) 0.094
hoxa11a homeo box A11a 0.091
ntla no tail a 0.090
foxa1 forkhead box A1 0.089
klf4 Kruppel-like factor 4 0.088
wnt11r wingless-type MMTV integration site family, member 11, related 0.087
lfng lunatic fringe homolog 0.084
znf503 zinc finger protein 503 0.084
otx2 orthodenticle homolog 2 0.082
cdh1 cadherin 1, epithelial 0.080
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.079
gata4 GATA-binding protein 4 0.077
si:ch211-235f6.2 si:ch211-235f6.2 0.076
wnt4a wingless-type MMTV integration site family, member 4a 0.070
her1 hairy-related 1 0.068
snai1b snail homolog 1b (Drosophila) 0.068
foxi1 forkhead box I1 0.068
foxn4 forkhead box N4 0.067
dlx2a distal-less homeobox gene 2a 0.066
emx1 empty spiracles homeobox 1 0.066
neo1 neogenin 1 0.066
hmx3 homeo box (H6 family) 3 0.064
sox1a SRY-box containing gene 1a 0.062
rarga retinoic acid receptor gamma a 0.062
irx5a iroquois homeobox protein 5a 0.062
wnt9a wingless-type MMTV integration site family, member 9A 0.059
fgf3 fibroblast growth factor 3 0.057
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.974
hh hedgehog 0.885
slp1 sloppy paired 1 0.799
HLH54F CG5005 gene product from transcript CG5005-RA 0.564
en engrailed 0.484
ci cubitus interruptus 0.422
lea leak 0.401
dpp decapentaplegic 0.398
Ubx Ultrabithorax 0.308
sli slit 0.264
nkd naked cuticle 0.218
CG14869 CG14869 gene product from transcript CG14869-RB 0.174
eya eyes absent 0.169
tin tinman 0.119
hth homothorax 0.094
twi twist 0.092
hkb huckebein 0.089
jeb jelly belly 0.072
gsb gooseberry 0.063
dsh dishevelled 0.056
N Notch 0.046
stumps CG31317 gene product from transcript CG31317-RC 0.041
slou slouch 0.040
mid midline 0.038
run runt 0.033
arm armadillo 0.033
Lim1 CG11354 gene product from transcript CG11354-RA 0.031
ey eyeless 0.031
pnr pannier 0.030
Egfr Epidermal growth factor receptor 0.025
Dl Delta 0.024
pdm2 POU domain protein 2 0.023
Doc2 Dorsocross2 0.022
ush u-shaped 0.022
brk brinker 0.021
Ser Serrate 0.021
zfh2 Zn finger homeodomain 2 0.020
abd-A abdominal A 0.020
sim single-minded 0.019
tsh teashirt 0.018
byn brachyenteron 0.018
so sine oculis 0.016
tll tailless 0.016
slp2 sloppy paired 2 0.015
C15 CG7937 gene product from transcript CG7937-RA 0.015
tup tailup 0.015
bab2 CG9102 gene product from transcript CG9102-RA 0.015
kni knirps 0.014
robo roundabout 0.014
vg vestigial 0.013
dally division abnormally delayed 0.013
numb CG3779 gene product from transcript CG3779-RB 0.011
Smox Smad on X 0.011
nub nubbin 0.011
Notum CG13076 gene product from transcript CG13076-RB 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Bmp4 bone morphogenetic protein 4 0.999
Gata4 GATA binding protein 4 0.999
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.999
Fgf8 fibroblast growth factor 8 0.996
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.995
Pax2 paired box gene 2 0.989
Pax3 paired box gene 3 0.989
Nodal nodal 0.988
Fgfr2 fibroblast growth factor receptor 2 0.988
Gli3 GLI-Kruppel family member GLI3 0.985
Foxc1 forkhead box C1 0.984
Sox2 SRY-box containing gene 2 0.977
Tcfap2a transcription factor AP-2, alpha 0.972
Vangl2 vang-like 2 (van gogh, Drosophila) 0.967
Pitx1 paired-like homeodomain transcription factor 1 0.965
Foxh1 forkhead box H1 0.950
Jag1 jagged 1 0.948
Foxc2 forkhead box C2 0.947
Apc adenomatosis polyposis coli 0.947
Gsc goosecoid homeobox 0.939
Tbx1 T-box 1 0.934
Gli2 GLI-Kruppel family member GLI2 0.931
Emx1 empty spiracles homolog 1 (Drosophila) 0.927
Hoxa1 homeobox A1 0.907
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.903
Pax6 paired box gene 6 0.898
Hand2 heart and neural crest derivatives expressed transcript 2 0.890
Lmx1b LIM homeobox transcription factor 1 beta 0.870
Foxg1 forkhead box G1 0.868
Emx2 empty spiracles homolog 2 (Drosophila) 0.855
Smad6 MAD homolog 6 (Drosophila) 0.842
Ptf1a pancreas specific transcription factor, 1a 0.833
Tbx3 T-box 3 0.831
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.826
Lhx1 LIM homeobox protein 1 0.823
Isl1 ISL1 transcription factor, LIM/homeodomain 0.814
Neurog2 neurogenin 2 0.782
Hand1 heart and neural crest derivatives expressed transcript 1 0.746
Rarg retinoic acid receptor, gamma 0.737
Tgfb2 transforming growth factor, beta 2 0.736
En1 engrailed 1 0.727
Lhx3 LIM homeobox protein 3 0.713
Neurod1 neurogenic differentiation 1 0.707
Fgf10 fibroblast growth factor 10 0.686
Gata6 GATA binding protein 6 0.685
Chrd chordin 0.668
Sox11 SRY-box containing gene 11 0.628
Lef1 lymphoid enhancer binding factor 1 0.625
Hoxd13 homeobox D13 0.607
Hes1 hairy and enhancer of split 1 (Drosophila) 0.606
Wnt3a wingless-related MMTV integration site 3A 0.605
Meox2 mesenchyme homeobox 2 0.602
T brachyury 0.601
Notch1 Notch gene homolog 1 (Drosophila) 0.596
Tgfbr2 transforming growth factor, beta receptor II 0.586
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.580
Hoxa13 homeobox A13 0.580
Zic3 zinc finger protein of the cerebellum 3 0.573
Zfpm2 zinc finger protein, multitype 2 0.551
Gbx2 gastrulation brain homeobox 2 0.551
Sall4 sal-like 4 (Drosophila) 0.542
Psen1 presenilin 1 0.519
Sox9 SRY-box containing gene 9 0.518
Efna2 ephrin A2 0.499
Pkd1 polycystic kidney disease 1 homolog 0.498
Wt1 Wilms tumor 1 homolog 0.489
Fgfr3 fibroblast growth factor receptor 3 0.477
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.461
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.430
Hoxa11 homeobox A11 0.425
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.421
Smad7 MAD homolog 7 (Drosophila) 0.408
Fgfr1 fibroblast growth factor receptor 1 0.400
Tlx3 T-cell leukemia, homeobox 3 0.395
Chd7 chromodomain helicase DNA binding protein 7 0.386
Slit3 slit homolog 3 (Drosophila) 0.384
Cfc1 cripto, FRL-1, cryptic family 1 0.357
Myod1 myogenic differentiation 1 0.352
Twist2 twist homolog 2 (Drosophila) 0.349
Robo1 roundabout homolog 1 (Drosophila) 0.349
Nhlh1 nescient helix loop helix 1 0.345
Foxf1a forkhead box F1a 0.315
Hoxa2 homeobox A2 0.311
Vangl1 vang-like 1 (van gogh, Drosophila) 0.310
Notch2 Notch gene homolog 2 (Drosophila) 0.310
Nog noggin 0.305
Pitx3 paired-like homeodomain transcription factor 3 0.303
Lefty1 left right determination factor 1 0.302
Neurod4 neurogenic differentiation 4 0.298
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.278
Sox3 SRY-box containing gene 3 0.277
Rxra retinoid X receptor alpha 0.277
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.273
Sox7 SRY-box containing gene 7 0.271
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.257
Zeb1 zinc finger E-box binding homeobox 1 0.255
Dll4 delta-like 4 (Drosophila) 0.252
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Rattus norvegicus
Name Description Probability Func Analog Organism
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.038
Dchs1 dachsous 1 (Drosophila) 0.027
Cxxc4 CXXC finger 4 0.027
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.024
Tcf4 transcription factor 4 0.023
Tcf3 transcription factor 3 0.021
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.020
Sox13 SRY (sex determining region Y)-box 13 0.019
Cast calpastatin 0.019
Fgfr2 fibroblast growth factor receptor 2 0.019
Cdc2l5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 0.018
Axin1 axin 1 0.017
Bbx bobby sox homolog (Drosophila) 0.017
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.017
Phox2a paired-like homeobox 2a 0.015
Unc5b unc-5 homolog B (C. elegans) 0.015
Dock6 dedicator of cytokinesis 6 0.014
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.014
Atp2c1 ATPase, Ca++ transporting, type 2C, member 1 0.014
Cald1 caldesmon 1 0.014
Igfbp5 insulin-like growth factor binding protein 5 0.014
Dcc deleted in colorectal carcinoma 0.013
Epha7 Eph receptor A7 0.013
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.012
Elk3 ELK3, ETS-domain protein 0.012
Tns1 tensin 1 0.012
Smad7 SMAD family member 7 0.012
Znf597 zinc finger protein 597 0.012
Timp3 TIMP metallopeptidase inhibitor 3 0.012
Rnasen ribonuclease type III, nuclear 0.012
Ebf1 early B-cell factor 1 0.012
Itga6 integrin, alpha 6 0.011
Gdf11 growth differentiation factor 11 0.011
Klk1c10 T-kininogenase 0.011
Flt1 FMS-related tyrosine kinase 1 0.011
Deaf1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.011
Ptms parathymosin 0.011
Slit3 slit homolog 3 (Drosophila) 0.011
Dock1 dedicator of cyto-kinesis 1 0.011
Col12a1 collagen, type XII, alpha 1 0.011
Foxs1 forkhead box S1 0.010
Phldb1 pleckstrin homology-like domain, family B, member 1 0.010
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.010
Utrn utrophin 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism