The network for 'columnar cuboidal epithelial cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

columnar cuboidal epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pten phosphatase and tensin homolog 1.000
Pax3 paired box gene 3 1.000
Fgf8 fibroblast growth factor 8 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Tcfap2a transcription factor AP-2, alpha 0.999
Foxc1 forkhead box C1 0.998
Sox9 SRY-box containing gene 9 0.998
Gli3 GLI-Kruppel family member GLI3 0.998
Foxc2 forkhead box C2 0.997
Foxa2 forkhead box A2 0.997
Pax8 paired box gene 8 0.997
Meox2 mesenchyme homeobox 2 0.997
Mitf microphthalmia-associated transcription factor 0.997
Isl1 ISL1 transcription factor, LIM/homeodomain 0.996
Fgfr1 fibroblast growth factor receptor 1 0.995
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.994
Gli2 GLI-Kruppel family member GLI2 0.994
Trp53 transformation related protein 53 0.994
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.993
Hand2 heart and neural crest derivatives expressed transcript 2 0.991
Hes1 hairy and enhancer of split 1 (Drosophila) 0.989
Pitx2 paired-like homeodomain transcription factor 2 0.988
Tbx1 T-box 1 0.981
Psen1 presenilin 1 0.979
Vegfa vascular endothelial growth factor A 0.977
Kit kit oncogene 0.972
Ctnnb1 catenin (cadherin associated protein), beta 1 0.970
Ikzf1 IKAROS family zinc finger 1 0.966
Rarg retinoic acid receptor, gamma 0.964
Bmp7 bone morphogenetic protein 7 0.962
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.961
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.954
a nonagouti 0.954
Lyst lysosomal trafficking regulator 0.954
Nodal nodal 0.950
Pax6 paired box gene 6 0.948
Bmp4 bone morphogenetic protein 4 0.948
Lhx1 LIM homeobox protein 1 0.947
Pou5f1 POU domain, class 5, transcription factor 1 0.947
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.946
Notch2 Notch gene homolog 2 (Drosophila) 0.944
Pax2 paired box gene 2 0.931
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.927
Tal1 T-cell acute lymphocytic leukemia 1 0.927
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.923
Rara retinoic acid receptor, alpha 0.916
Nkx2-1 NK2 homeobox 1 0.914
Lhx3 LIM homeobox protein 3 0.900
Prrx1 paired related homeobox 1 0.894
Sox2 SRY-box containing gene 2 0.893
Ahr aryl-hydrocarbon receptor 0.889
Eya1 eyes absent 1 homolog (Drosophila) 0.886
Hoxd3 homeobox D3 0.875
Zic3 zinc finger protein of the cerebellum 3 0.874
Hoxa3 homeobox A3 0.866
Hoxa5 homeobox A5 0.863
Hoxb3 homeobox B3 0.858
Kitl kit ligand 0.854
Hoxb4 homeobox B4 0.842
Insm1 insulinoma-associated 1 0.840
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.839
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.834
Wnt3a wingless-related MMTV integration site 3A 0.823
Grb10 growth factor receptor bound protein 10 0.819
Fgf10 fibroblast growth factor 10 0.818
Pthlh parathyroid hormone-like peptide 0.814
Ret ret proto-oncogene 0.814
Emx1 empty spiracles homolog 1 (Drosophila) 0.812
Rarb retinoic acid receptor, beta 0.809
Emx2 empty spiracles homolog 2 (Drosophila) 0.808
Fyn Fyn proto-oncogene 0.800
Gata4 GATA binding protein 4 0.799
Hoxa11 homeobox A11 0.791
Pou3f3 POU domain, class 3, transcription factor 3 0.789
Nog noggin 0.786
Hand1 heart and neural crest derivatives expressed transcript 1 0.777
Chrd chordin 0.777
En1 engrailed 1 0.772
Chd7 chromodomain helicase DNA binding protein 7 0.764
Neurod1 neurogenic differentiation 1 0.760
Ptf1a pancreas specific transcription factor, 1a 0.759
Tyrp1 tyrosinase-related protein 1 0.751
Sox10 SRY-box containing gene 10 0.748
Gbx2 gastrulation brain homeobox 2 0.745
Csf1 colony stimulating factor 1 (macrophage) 0.740
Vangl2 vang-like 2 (van gogh, Drosophila) 0.736
Fgf15 fibroblast growth factor 15 0.721
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.717
Hoxa13 homeobox A13 0.706
Msx1 homeobox, msh-like 1 0.706
Ednrb endothelin receptor type B 0.683
Epor erythropoietin receptor 0.682
Hoxa1 homeobox A1 0.678
Nos3 nitric oxide synthase 3, endothelial cell 0.670
Msx2 homeobox, msh-like 2 0.662
Notch1 Notch gene homolog 1 (Drosophila) 0.658
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.658
Tcf15 transcription factor 15 0.656
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.994
sox10 SRY-box containing gene 10 0.969
bmp2b bone morphogenetic protein 2b 0.969
tfap2a transcription factor AP-2 alpha 0.963
foxa3 forkhead box A3 0.947
notch1a notch homolog 1a 0.943
mib mind bomb 0.940
isl1 islet1 0.866
gdf6a growth differentiation factor 6a 0.857
tp53 tumor protein p53 0.856
tyr tyrosinase 0.851
kita kit receptor a 0.832
bmp4 bone morphogenetic protein 4 0.817
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.811
cdx4 caudal type homeo box transcription factor 4 0.725
pax6a paired box gene 6a 0.710
fgf8a fibroblast growth factor 8 a 0.709
lef1 lymphocyte enhancer binding factor 1 0.678
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.639
sox2 SRY-box containing gene 2 0.639
otx2 orthodenticle homolog 2 0.623
foxi1 forkhead box I1 0.618
mitfa microphthalmia-associated transcription factor a 0.614
sox1a SRY-box containing gene 1a 0.585
pax6b paired box gene 6b 0.565
gata3 GATA-binding protein 3 0.531
jag1b jagged 1b 0.531
hoxb3a homeo box B3a 0.528
pmela premelanosome protein a 0.518
jag2 jagged 2 0.498
six3a sine oculis homeobox homolog 3a 0.481
sox9b SRY-box containing gene 9b 0.449
mnx1 motor neuron and pancreas homeobox 1 0.434
foxa2 forkhead box A2 0.426
tbx2b T-box 2b 0.426
olig2 oligodendrocyte lineage transcription factor 2 0.419
ins preproinsulin 0.417
pax2a paired box gene 2a 0.404
foxd3 forkhead box D3 0.392
sox19a SRY-box containing gene 19a 0.392
dla deltaA 0.390
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.365
ptch2 patched 2 0.365
evx1 even-skipped homeobox 1 0.363
foxi3a forkhead box I3a 0.361
tfeb transcription factor EB 0.358
hlxb9la homeo box HB9 like a 0.358
otpb orthopedia homolog b 0.344
six3b sine oculis homeobox homolog 3b 0.341
gbx1 gastrulation brain homeobox 1 0.324
msxb muscle segment homeobox B 0.310
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.310
neurod neurogenic differentiation 0.309
slc45a2 solute carrier family 45, member 2 0.309
notch3 notch homolog 3 0.307
nkx2.2a NK2 transcription factor related 2a 0.305
pdx1 pancreatic and duodenal homeobox 1 0.304
gata2a GATA-binding protein 2a 0.301
irx3a iroquois homeobox protein 3a 0.295
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.291
mecp2 methyl CpG binding protein 2 0.288
kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 0.276
wu:fv91b12 wu:fv91b12 0.274
rx3 retinal homeobox gene 3 0.272
hoxd11a homeo box D11a 0.270
mecom MDS1 and EVI1 complex locus 0.260
vsx2 visual system homeobox 2 0.258
nkx6.2 NK6 transcription factor related, locus 2 0.236
rarga retinoic acid receptor gamma a 0.229
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.222
dlc deltaC 0.222
flh floating head 0.216
sox3 SRY-box containing gene 3 0.202
eya1 eyes absent homolog 1 0.199
pitx2 paired-like homeodomain transcription factor 2 0.199
tp63 tumor protein p63 0.196
dlx2a distal-less homeobox gene 2a 0.192
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.191
dlx3b distal-less homeobox gene 3b 0.183
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.183
hmx4 H6 family homeobox 4 0.182
foxg1a forkhead box G1a 0.181
ndr2 nodal-related 2 0.171
dld deltaD 0.169
slc24a5 solute carrier family 24, member 5 0.168
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.163
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.159
hoxd13a homeo box D13a 0.159
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.148
osr1 odd-skipped related 1 (Drosophila) 0.147
otx1b orthodenticle homolog 1b 0.147
tfec transcription factor EC 0.145
tbx1 T-box 1 0.144
lmo4a LIM domain only 4a 0.139
mab21l2 mab-21-like 2 0.137
lhx1a LIM homeobox 1a 0.137
raraa retinoic acid receptor, alpha a 0.129
ntla no tail a 0.129
gli2a GLI-Kruppel family member GLI2a 0.124
nf1a neurofibromin 1a 0.124
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 1.000
ttk tramtrack 1.000
dome domeless 1.000
N Notch 1.000
Rala Ras-related protein 1.000
Stat92E Signal-transducer and activator of transcription protein at 92E 0.999
Ras85D Ras oncogene at 85D 0.999
sqh spaghetti squash 0.999
hpo hippo 0.999
baz bazooka 0.998
par-6 CG5884 gene product from transcript CG5884-RA 0.997
mbc myoblast city 0.997
BicD Bicaudal D 0.997
aop anterior open 0.997
Egfr Epidermal growth factor receptor 0.997
phl pole hole 0.995
rhea CG6831 gene product from transcript CG6831-RA 0.994
alpha-Cat alpha Catenin 0.993
par-1 CG8201 gene product from transcript CG8201-RA 0.993
yki yorkie 0.990
Rab5 Rab-protein 5 0.987
Lis-1 Lissencephaly-1 0.986
shg shotgun 0.986
ci cubitus interruptus 0.984
Cortactin CG3637 gene product from transcript CG3637-RA 0.984
os outstretched 0.982
eya eyes absent 0.981
Rho1 CG8416 gene product from transcript CG8416-RB 0.980
chic chickadee 0.979
Ets97D Ets at 97D 0.977
dia diaphanous 0.977
Ced-12 CG5336 gene product from transcript CG5336-RA 0.973
rl rolled 0.972
emc extra macrochaetae 0.969
kibra kibra ortholog 0.969
gbb glass bottom boat 0.966
jing CG9397 gene product from transcript CG9397-RI 0.963
bsk basket 0.963
cindr CIN85 and CD2AP orthologue 0.961
spn-B spindle B 0.960
CG8155 CG8155 gene product from transcript CG8155-RA 0.959
wts warts 0.957
dpp decapentaplegic 0.951
grk gurken 0.950
E(spl) Enhancer of split 0.949
Dhc64C Dynein heavy chain 64C 0.948
Khc Kinesin heavy chain 0.939
kug kugelei 0.936
put punt 0.934
kuz kuzbanian 0.931
ena enabled 0.930
tkv thickveins 0.930
Shc SHC-adaptor protein 0.929
fz frizzled 0.926
ex expanded 0.926
Src42A Src oncogene at 42A 0.926
dsh dishevelled 0.925
CalpB Calpain-B 0.922
ecd ecdysoneless 0.918
esc extra sexcombs 0.912
Doc2 Dorsocross2 0.907
pnt pointed 0.905
cpb capping protein beta 0.904
zip zipper 0.898
dlg1 discs large 1 0.897
pyd polychaetoid 0.889
sgg shaggy 0.889
pan pangolin 0.887
yu CG3249 gene product from transcript CG3249-RA 0.883
rok Rho-kinase 0.880
p53 CG33336 gene product from transcript CG33336-RB 0.879
rpr reaper 0.874
spn-A spindle A 0.873
Mrtf Myocardin-related transcription factor 0.870
Krn Keren 0.867
stau staufen 0.865
mys myospheroid 0.861
EcR Ecdysone receptor 0.859
babo baboon 0.857
brk brinker 0.856
Tm1 Tropomyosin 1 0.855
CG14869 CG14869 gene product from transcript CG14869-RB 0.853
shi shibire 0.853
fs(1)M3 female sterile (1) M3 0.852
hd humpty dumpty 0.852
Pten CG5671 gene product from transcript CG5671-RB 0.850
nmo nemo 0.849
psd palisade 0.841
Pvr PDGF- and VEGF-receptor related 0.835
Socs36E Suppressor of cytokine signaling at 36E 0.834
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.833
mus301 mutagen-sensitive 301 0.833
tll tailless 0.828
Mad Mothers against dpp 0.828
CG6509 CG6509 gene product from transcript CG6509-RB 0.825
corto CG2530 gene product from transcript CG2530-RA 0.824
srp serpent 0.823
Kr Kruppel 0.818
sens senseless 0.815
Hem HEM-protein 0.813
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Homo sapiens
Name Description Probability Func Analog Organism
TAL1 T-cell acute lymphocytic leukemia 1 0.991
HNF4A hepatocyte nuclear factor 4, alpha 0.755
HDAC2 histone deacetylase 2 0.753
EP300 E1A binding protein p300 0.672
RUNX1 runt-related transcription factor 1 0.588
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.574
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.517
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.461
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.460
TSC2 tuberous sclerosis 2 0.398
PAX3 paired box 3 0.390
PSEN1 presenilin 1 0.342
TP53 tumor protein p53 0.272
PDX1 pancreatic and duodenal homeobox 1 0.247
FGF1 fibroblast growth factor 1 (acidic) 0.212
BMPR1A bone morphogenetic protein receptor, type IA 0.189
POU3F2 POU class 3 homeobox 2 0.176
POU5F1 POU class 5 homeobox 1 0.165
MED25 mediator complex subunit 25 0.155
SFN stratifin 0.150
RAB27A RAB27A, member RAS oncogene family 0.144
CREBBP CREB binding protein 0.131
ESR1 estrogen receptor 1 0.123
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.120
MLPH melanophilin 0.117
NCOA1 nuclear receptor coactivator 1 0.115
TCF4 transcription factor 4 0.107
JAG1 jagged 1 0.103
TNRC6B trinucleotide repeat containing 6B 0.097
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.082
CLOCK clock homolog (mouse) 0.081
STK3 serine/threonine kinase 3 0.081
FGFR1 fibroblast growth factor receptor 1 0.077
RARA retinoic acid receptor, alpha 0.077
BCL2L1 BCL2-like 1 0.073
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.072
FLNB filamin B, beta 0.068
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.067
HNF1A HNF1 homeobox A 0.063
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.063
NCOA3 nuclear receptor coactivator 3 0.062
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.060
HIPK2 homeodomain interacting protein kinase 2 0.060
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.059
BMPR1B bone morphogenetic protein receptor, type IB 0.058
NKX3-1 NK3 homeobox 1 0.056
FGF10 fibroblast growth factor 10 0.054
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.054
NOTCH3 notch 3 0.052
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.051
CTNND1 catenin (cadherin-associated protein), delta 1 0.051
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.049
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.048
AR androgen receptor 0.048
ARRB1 arrestin, beta 1 0.043
CCND1 cyclin D1 0.039
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.038
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.038
GRB7 growth factor receptor-bound protein 7 0.037
EPAS1 endothelial PAS domain protein 1 0.037
NCSTN nicastrin 0.036
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.034
KAT2B K(lysine) acetyltransferase 2B 0.033
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.032
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.032
SOX2 SRY (sex determining region Y)-box 2 0.031
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.031
ONECUT1 one cut homeobox 1 0.030
FOXA2 forkhead box A2 0.028
CDX2 caudal type homeobox 2 0.028
ZFYVE9 zinc finger, FYVE domain containing 9 0.027
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.027
MTA3 metastasis associated 1 family, member 3 0.025
GATA2 GATA binding protein 2 0.025
AHR aryl hydrocarbon receptor 0.024
ZFPM1 zinc finger protein, multitype 1 0.024
HIC1 hypermethylated in cancer 1 0.023
RAX retina and anterior neural fold homeobox 0.023
NOG noggin 0.023
FGF8 fibroblast growth factor 8 (androgen-induced) 0.022
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.022
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.021
PML promyelocytic leukemia 0.021
HOXD12 homeobox D12 0.021
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.020
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.020
MEOX2 mesenchyme homeobox 2 0.020
SATB2 SATB homeobox 2 0.019
SIRT1 sirtuin 1 0.019
PROX1 prospero homeobox 1 0.018
MYOD1 myogenic differentiation 1 0.018
STRADA STE20-related kinase adaptor alpha 0.018
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.018
EGLN1 egl nine homolog 1 (C. elegans) 0.018
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.018
TBX5 T-box 5 0.018
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.018
BMP4 bone morphogenetic protein 4 0.017
SFRP5 secreted frizzled-related protein 5 0.017
TNRC6A trinucleotide repeat containing 6A 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tcf4 transcription factor 4 0.126
Gsk3b glycogen synthase kinase 3 beta 0.057
Abcc1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 0.031
Dpm3 dolichyl-phosphate mannosyltransferase polypeptide 3 0.029
Pax6 paired box 6 0.026
Igfbp5 insulin-like growth factor binding protein 5 0.023
Mid1 midline 1 0.023
Ednrb endothelin receptor type B 0.020
Calcrl calcitonin receptor-like 0.019
Tgfbr2 transforming growth factor, beta receptor II 0.019
Bbx bobby sox homolog (Drosophila) 0.017
Ppara peroxisome proliferator activated receptor alpha 0.017
Efnb1 ephrin B1 0.017
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.016
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.015
Il1r1 interleukin 1 receptor, type I 0.014
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.014
Igsf1 immunoglobulin superfamily, member 1 0.014
Ppm1f protein phosphatase 1F (PP2C domain containing) 0.014
P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 0.013
Elof1 elongation factor 1 homolog (S. cerevisiae) 0.013
Sp4 Sp4 transcription factor 0.013
Whsc2 Wolf-Hirschhorn syndrome candidate 2 (human) 0.012
Hrh2 histamine receptor H 2 0.011
Adam10 ADAM metallopeptidase domain 10 0.011
Lig3 ligase III, DNA, ATP-dependent 0.011
Cdk2 cyclin dependent kinase 2 0.010
Cpm carboxypeptidase M 0.010
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism