The network for 'establishment or maintenance of neuroblast polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of neuroblast polarity

Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.996
Gli3 GLI-Kruppel family member GLI3 0.988
Pax2 paired box gene 2 0.982
Eya1 eyes absent 1 homolog (Drosophila) 0.965
Tbx10 T-box 10 0.961
Bdnf brain derived neurotrophic factor 0.957
Chrd chordin 0.951
Fgfr2 fibroblast growth factor receptor 2 0.945
Ntf3 neurotrophin 3 0.939
Hoxa1 homeobox A1 0.888
Gli2 GLI-Kruppel family member GLI2 0.843
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.823
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.800
Foxg1 forkhead box G1 0.793
Sox2 SRY-box containing gene 2 0.788
Pitx2 paired-like homeodomain transcription factor 2 0.779
Fgfr3 fibroblast growth factor receptor 3 0.768
Zeb1 zinc finger E-box binding homeobox 1 0.732
Foxc1 forkhead box C1 0.729
Wnt5a wingless-related MMTV integration site 5A 0.723
Fgf10 fibroblast growth factor 10 0.693
Ptch1 patched homolog 1 0.635
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.621
Pax3 paired box gene 3 0.620
Prrx1 paired related homeobox 1 0.607
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.551
Vangl2 vang-like 2 (van gogh, Drosophila) 0.550
Fgf8 fibroblast growth factor 8 0.512
Trp63 transformation related protein 63 0.489
Hmx3 H6 homeobox 3 0.468
Sox9 SRY-box containing gene 9 0.445
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.437
Pax6 paired box gene 6 0.402
Hoxd13 homeobox D13 0.400
Msx2 homeobox, msh-like 2 0.399
Gbx2 gastrulation brain homeobox 2 0.396
Nkx2-1 NK2 homeobox 1 0.348
Dlx5 distal-less homeobox 5 0.341
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.339
Meox2 mesenchyme homeobox 2 0.339
Isl1 ISL1 transcription factor, LIM/homeodomain 0.321
Jag1 jagged 1 0.318
Zfpm2 zinc finger protein, multitype 2 0.313
Pou4f3 POU domain, class 4, transcription factor 3 0.300
Tcfap2a transcription factor AP-2, alpha 0.287
Emx2 empty spiracles homolog 2 (Drosophila) 0.279
Pthlh parathyroid hormone-like peptide 0.277
Chd7 chromodomain helicase DNA binding protein 7 0.276
Otx2 orthodenticle homolog 2 (Drosophila) 0.272
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.269
Twist2 twist homolog 2 (Drosophila) 0.263
Fgf14 fibroblast growth factor 14 0.261
Ret ret proto-oncogene 0.253
Rac1 RAS-related C3 botulinum substrate 1 0.244
Gata3 GATA binding protein 3 0.242
Lmx1a LIM homeobox transcription factor 1 alpha 0.241
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.236
Foxc2 forkhead box C2 0.235
Tbx15 T-box 15 0.230
Ctnnb1 catenin (cadherin associated protein), beta 1 0.212
Sox11 SRY-box containing gene 11 0.208
Pou3f4 POU domain, class 3, transcription factor 4 0.200
Hand2 heart and neural crest derivatives expressed transcript 2 0.175
Phox2a paired-like homeobox 2a 0.168
Msx1 homeobox, msh-like 1 0.163
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.162
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.160
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.151
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.140
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.139
Tgfb2 transforming growth factor, beta 2 0.133
Fgf3 fibroblast growth factor 3 0.132
Nrg1 neuregulin 1 0.130
Sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.127
Emx1 empty spiracles homolog 1 (Drosophila) 0.124
Bmp5 bone morphogenetic protein 5 0.123
Alx4 aristaless-like homeobox 4 0.121
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.121
Efnb2 ephrin B2 0.119
Cntn4 contactin 4 0.117
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.116
Chrng cholinergic receptor, nicotinic, gamma polypeptide 0.116
Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) 0.112
Tbx1 T-box 1 0.110
Pten phosphatase and tensin homolog 0.110
Gal galanin 0.107
Socs5 suppressor of cytokine signaling 5 0.099
Fgfbp1 fibroblast growth factor binding protein 1 0.096
Tcf21 transcription factor 21 0.095
Epha3 Eph receptor A3 0.095
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.089
Esr2 estrogen receptor 2 (beta) 0.088
Bmpr1a bone morphogenetic protein receptor, type 1A 0.088
Fgf9 fibroblast growth factor 9 0.087
Msh2 mutS homolog 2 (E. coli) 0.086
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.086
Pnoc prepronociceptin 0.086
Vti1a vesicle transport through interaction with t-SNAREs homolog 1A (yeast) 0.084
Odz2 odd Oz/ten-m homolog 2 (Drosophila) 0.083
Bmp4 bone morphogenetic protein 4 0.083
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Cdc42 CG12530 gene product from transcript CG12530-RA 0.780
par-1 CG8201 gene product from transcript CG8201-RA 0.217
Rho1 CG8416 gene product from transcript CG8416-RB 0.198
baz bazooka 0.164
rok Rho-kinase 0.123
Eb1 CG3265 gene product from transcript CG3265-RF 0.037
CG7239 CG7239 gene product from transcript CG7239-RA 0.036
wdb widerborst 0.032
Dlic Dynein light intermediate chain 0.028
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.027
CG14667 CG14667 gene product from transcript CG14667-RA 0.022
Shc SHC-adaptor protein 0.021
drk downstream of receptor kinase 0.021
CG13142 CG13142 gene product from transcript CG13142-RB 0.020
G-ialpha65A G protein alphai subunit 65A 0.020
G-oalpha47A G protein oalpha 47A 0.019
lkb1 CG9374 gene product from transcript CG9374-RJ 0.016
BicD Bicaudal D 0.016
Myb Myb oncogene-like 0.015
CG4813 CG4813 gene product from transcript CG4813-RA 0.014
CG7928 CG7928 gene product from transcript CG7928-RA 0.014
loqs loquacious 0.014
CG10267 CG10267 gene product from transcript CG10267-RB 0.014
CG11560 CG11560 gene product from transcript CG11560-RA 0.013
Akt1 CG4006 gene product from transcript CG4006-RA 0.013
CG3368 CG3368 gene product from transcript CG3368-RA 0.011
CG2617 CG2617 gene product from transcript CG2617-RA 0.010
CG15601 CG15601 gene product from transcript CG15601-RA 0.010
CG17568 CG17568 gene product from transcript CG17568-RA 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TCP1 t-complex 1 0.997
PRKCZ protein kinase C, zeta 0.991
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.990
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.981
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.872
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.838
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.807
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.680
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.501
STRADA STE20-related kinase adaptor alpha 0.426
PRKCI protein kinase C, iota 0.320
SKA3 spindle and kinetochore associated complex subunit 3 0.264
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.226
PLCG1 phospholipase C, gamma 1 0.195
BCAR1 breast cancer anti-estrogen resistance 1 0.135
NGF nerve growth factor (beta polypeptide) 0.126
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.125
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.123
TNIP2 TNFAIP3 interacting protein 2 0.117
CDH5 cadherin 5, type 2 (vascular endothelium) 0.086
STRADB STE20-related kinase adaptor beta 0.077
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.052
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.050
IQGAP1 IQ motif containing GTPase activating protein 1 0.050
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.049
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.045
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.041
PPME1 protein phosphatase methylesterase 1 0.039
ZNF71 zinc finger protein 71 0.037
ITSN1 intersectin 1 (SH3 domain protein) 0.035
NCF2 neutrophil cytosolic factor 2 0.032
SERTAD4 SERTA domain containing 4 0.032
PPP4C protein phosphatase 4, catalytic subunit 0.032
MARK4 MAP/microtubule affinity-regulating kinase 4 0.031
NTF4 neurotrophin 4 0.031
IQGAP2 IQ motif containing GTPase activating protein 2 0.029
TNK2 tyrosine kinase, non-receptor, 2 0.026
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.025
TRIP10 thyroid hormone receptor interactor 10 0.023
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.023
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.021
EXT2 exostosin 2 0.021
LRRK2 leucine-rich repeat kinase 2 0.020
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.020
DDR2 discoidin domain receptor tyrosine kinase 2 0.020
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.018
MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 0.018
WASL Wiskott-Aldrich syndrome-like 0.018
SQSTM1 sequestosome 1 0.018
F11R F11 receptor 0.017
NUMB numb homolog (Drosophila) 0.016
BAIAP2 BAI1-associated protein 2 0.015
WIPF1 WAS/WASL interacting protein family, member 1 0.015
INSR insulin receptor 0.014
LAT linker for activation of T cells 0.014
ZNF431 zinc finger protein 431 0.014
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.013
RPP14 ribonuclease P/MRP 14kDa subunit 0.013
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.013
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.013
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.013
TMSB4X thymosin beta 4, X-linked 0.013
DOCK8 dedicator of cytokinesis 8 0.012
MET met proto-oncogene (hepatocyte growth factor receptor) 0.012
NMT2 N-myristoyltransferase 2 0.011
KIAA0802 KIAA0802 0.011
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.011
VAV1 vav 1 guanine nucleotide exchange factor 0.011
GRB7 growth factor receptor-bound protein 7 0.010
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Canx calnexin 0.520
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.037
Ube2a ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.030
Zfp706 zinc finger protein 706 0.028
Cdc42 cell division cycle 42 (GTP binding protein) 0.025
Rbbp7 retinoblastoma binding protein 7 0.014
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.014
Fkbp1a FK506 binding protein 1a 0.012
Cox7a2l cytochrome c oxidase subunit VIIa polypeptide 2 like 0.012
Rab10 RAB10, member RAS oncogene family 0.012
Eif4h eukaryotic translation initiation factor 4H 0.011
Sod2 superoxide dismutase 2, mitochondrial 0.011
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.011
Acan aggrecan 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism