The network for 'forebrain regionalization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

forebrain regionalization

The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Pax2 paired box gene 2 1.000
Fgf8 fibroblast growth factor 8 1.000
Gli3 GLI-Kruppel family member GLI3 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Lhx1 LIM homeobox protein 1 0.998
Rarg retinoic acid receptor, gamma 0.998
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.997
Sox9 SRY-box containing gene 9 0.997
Dlx5 distal-less homeobox 5 0.996
Emx2 empty spiracles homolog 2 (Drosophila) 0.996
Gli2 GLI-Kruppel family member GLI2 0.995
Chrd chordin 0.994
Pax3 paired box gene 3 0.993
Fgfr2 fibroblast growth factor receptor 2 0.993
Tbx1 T-box 1 0.993
Hand2 heart and neural crest derivatives expressed transcript 2 0.993
Hand1 heart and neural crest derivatives expressed transcript 1 0.992
Tcfap2a transcription factor AP-2, alpha 0.991
Hoxa1 homeobox A1 0.991
Pax6 paired box gene 6 0.991
Msx1 homeobox, msh-like 1 0.987
Nog noggin 0.986
Emx1 empty spiracles homolog 1 (Drosophila) 0.983
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.982
Fgf10 fibroblast growth factor 10 0.982
Nodal nodal 0.977
Smo smoothened homolog (Drosophila) 0.976
Isl1 ISL1 transcription factor, LIM/homeodomain 0.975
Pitx1 paired-like homeodomain transcription factor 1 0.971
Lmx1a LIM homeobox transcription factor 1 alpha 0.953
Sox2 SRY-box containing gene 2 0.950
Eya1 eyes absent 1 homolog (Drosophila) 0.950
Foxc1 forkhead box C1 0.946
Wnt3a wingless-related MMTV integration site 3A 0.943
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.941
Gbx2 gastrulation brain homeobox 2 0.934
Foxg1 forkhead box G1 0.926
Foxc2 forkhead box C2 0.917
Otx1 orthodenticle homolog 1 (Drosophila) 0.912
Hoxa2 homeobox A2 0.912
Pax8 paired box gene 8 0.909
Rarb retinoic acid receptor, beta 0.903
Hoxd3 homeobox D3 0.899
Fgfr3 fibroblast growth factor receptor 3 0.897
Tbx3 T-box 3 0.874
Hoxa3 homeobox A3 0.873
Pou3f3 POU domain, class 3, transcription factor 3 0.863
T brachyury 0.862
Vangl2 vang-like 2 (van gogh, Drosophila) 0.848
Bmp7 bone morphogenetic protein 7 0.839
Hoxb3 homeobox B3 0.815
Prrx1 paired related homeobox 1 0.808
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.799
Lhx3 LIM homeobox protein 3 0.776
En1 engrailed 1 0.770
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.761
Hes5 hairy and enhancer of split 5 (Drosophila) 0.757
Gsc goosecoid homeobox 0.754
Alx4 aristaless-like homeobox 4 0.754
Insm1 insulinoma-associated 1 0.749
Lhx5 LIM homeobox protein 5 0.731
Hoxd13 homeobox D13 0.728
Col2a1 collagen, type II, alpha 1 0.724
Foxf1a forkhead box F1a 0.719
Fgfr1 fibroblast growth factor receptor 1 0.702
Fgf3 fibroblast growth factor 3 0.696
Sox3 SRY-box containing gene 3 0.692
Wt1 Wilms tumor 1 homolog 0.685
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.652
Nkx3-2 NK3 homeobox 2 0.640
Hoxd11 homeobox D11 0.633
Rara retinoic acid receptor, alpha 0.605
Smad6 MAD homolog 6 (Drosophila) 0.598
Bmp4 bone morphogenetic protein 4 0.595
Zic3 zinc finger protein of the cerebellum 3 0.593
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.590
Alx3 aristaless-like homeobox 3 0.549
Vax1 ventral anterior homeobox containing gene 1 0.542
Hmx3 H6 homeobox 3 0.538
Fgf15 fibroblast growth factor 15 0.534
Gdnf glial cell line derived neurotrophic factor 0.531
Lef1 lymphoid enhancer binding factor 1 0.497
Foxa2 forkhead box A2 0.496
Msx2 homeobox, msh-like 2 0.486
Pax9 paired box gene 9 0.485
Gdf3 growth differentiation factor 3 0.476
Atoh7 atonal homolog 7 (Drosophila) 0.476
Uncx UNC homeobox 0.469
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.468
Ctnnb1 catenin (cadherin associated protein), beta 1 0.468
Hoxa13 homeobox A13 0.457
Hmx1 H6 homeobox 1 0.453
Neurog1 neurogenin 1 0.446
Nkx6-1 NK6 homeobox 1 0.442
Dlx6 distal-less homeobox 6 0.431
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.416
Gata4 GATA binding protein 4 0.408
Chd7 chromodomain helicase DNA binding protein 7 0.401
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 0.984
mab21l2 mab-21-like 2 0.980
pax2a paired box gene 2a 0.957
rx3 retinal homeobox gene 3 0.942
six3a sine oculis homeobox homolog 3a 0.921
otx1b orthodenticle homolog 1b 0.898
fgf3 fibroblast growth factor 3 0.895
bmp2b bone morphogenetic protein 2b 0.894
barhl2 BarH-like 2 0.844
hnf1ba HNF1 homeobox Ba 0.830
otx2 orthodenticle homolog 2 0.828
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.811
foxg1a forkhead box G1a 0.808
pax6b paired box gene 6b 0.757
dbx1a developing brain homeobox 1a 0.749
tbx1 T-box 1 0.742
flh floating head 0.738
six3b sine oculis homeobox homolog 3b 0.736
cdh2 cadherin 2, neuronal 0.668
fezf2 FEZ family zinc finger 2 0.668
emx3 empty spiracles homeobox 3 0.660
lef1 lymphocyte enhancer binding factor 1 0.657
robo3 roundabout homolog 3 0.649
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.643
shha sonic hedgehog a 0.629
dld deltaD 0.629
gbx2 gastrulation brain homeo box 2 0.619
pax6a paired box gene 6a 0.616
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.599
ndr2 nodal-related 2 0.587
lhx5 LIM homeobox 5 0.577
bmp4 bone morphogenetic protein 4 0.540
sox1a SRY-box containing gene 1a 0.528
sox2 SRY-box containing gene 2 0.519
apc adenomatosis polyposis coli 0.501
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.501
meis2.1 myeloid ecotropic viral integration site 2.1 0.463
lhx1a LIM homeobox 1a 0.451
pou3f3b POU class 3 homeobox 3b 0.449
hoxa9a homeo box A9a 0.444
wnt4a wingless-type MMTV integration site family, member 4a 0.438
wnt5b wingless-type MMTV integration site family, member 5b 0.433
znf503 zinc finger protein 503 0.425
lhx2b LIM homeobox 2b 0.417
wnt11 wingless-type MMTV integration site family, member 11 0.416
olig2 oligodendrocyte lineage transcription factor 2 0.377
foxn4 forkhead box N4 0.375
wnt8b wingless-type MMTV integration site family, member 8b 0.373
lmo3 LIM domain only 3 0.365
hoxd4a homeo box D4a 0.364
epb4.1l4 erythrocyte protein band 4.1-like 4 0.363
ascl1a achaete-scute complex-like 1a (Drosophila) 0.349
boc brother of CDO 0.325
ptch1 patched 1 0.306
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.304
fzd10 frizzled homolog 10 0.297
pbx4 pre-B-cell leukemia transcription factor 4 0.293
twist1a twist1a 0.272
pax8 paired box gene 8 0.269
tfap2a transcription factor AP-2 alpha 0.265
mib mind bomb 0.259
wnt1 wingless-type MMTV integration site family, member 1 0.251
lfng lunatic fringe homolog 0.251
nkx2.2a NK2 transcription factor related 2a 0.249
dlc deltaC 0.240
foxp2 forkhead box P2 0.235
sox11b SRY-box containing gene 11b 0.232
spry2 sprouty homolog 2 0.229
spaw southpaw 0.224
irx7 iroquois homeobox protein 7 0.216
dmbx1a diencephalon/mesencephalon homeobox 1a 0.212
sema3aa semaphorin 3aa 0.208
dbx1b developing brain homeobox 1b 0.203
chd chordin 0.202
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.189
otpb orthopedia homolog b 0.187
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.186
shhb sonic hedgehog b 0.180
ephb4b eph receptor B4b 0.176
tlc secreted frizzled-related protein 0.165
eng2a engrailed 2a 0.164
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.164
fzd9b frizzled homolog 9b 0.162
fzd5 frizzled homolog 5 0.156
nkx2.1a NK2 homeobox 1a 0.153
pou3f1 POU class 3 homeobox 1 0.153
tll1 tolloid-like 1 0.152
sox9a SRY-box containing gene 9a 0.148
gli2a GLI-Kruppel family member GLI2a 0.146
hhip hedgehog interacting protein 0.144
gdnf glial cell derived neurotrophic factor 0.143
emx1 empty spiracles homeobox 1 0.139
isl1 islet1 0.138
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.133
her5 hairy-related 5 0.130
fgfr3 fibroblast growth factor receptor 3 0.129
wnt7bb wingless-type MMTV integration site family, member 7Bb 0.128
arx aristaless related homeobox 0.126
bon bonnie and clyde 0.126
six2a sine oculis-related homeobox 2a 0.125
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BMPR1A bone morphogenetic protein receptor, type IA 1.000
PML promyelocytic leukemia 1.000
PAX8 paired box 8 0.995
FSTL1 follistatin-like 1 0.948
PTCH1 patched 1 0.945
LGALS8 lectin, galactoside-binding, soluble, 8 0.913
MDFI MyoD family inhibitor 0.879
FGF8 fibroblast growth factor 8 (androgen-induced) 0.846
CTBP2 C-terminal binding protein 2 0.818
LRP6 low density lipoprotein receptor-related protein 6 0.779
NKX2-1 NK2 homeobox 1 0.753
LHX2 LIM homeobox 2 0.715
FGF3 fibroblast growth factor 3 0.630
HES2 hairy and enhancer of split 2 (Drosophila) 0.621
HOXB1 homeobox B1 0.594
EYA2 eyes absent homolog 2 (Drosophila) 0.586
ZFYVE9 zinc finger, FYVE domain containing 9 0.582
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.575
PAX2 paired box 2 0.563
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.553
SOX1 SRY (sex determining region Y)-box 1 0.531
CDX2 caudal type homeobox 2 0.527
RAX retina and anterior neural fold homeobox 0.493
PAX7 paired box 7 0.438
FZD1 frizzled homolog 1 (Drosophila) 0.435
FOXD3 forkhead box D3 0.433
GSK3A glycogen synthase kinase 3 alpha 0.424
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.423
TERT telomerase reverse transcriptase 0.413
LHX5 LIM homeobox 5 0.396
SFRP1 secreted frizzled-related protein 1 0.376
C1QL1 complement component 1, q subcomponent-like 1 0.373
WNT1 wingless-type MMTV integration site family, member 1 0.366
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.349
HOXD9 homeobox D9 0.341
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.341
TLX2 T-cell leukemia homeobox 2 0.341
FOXB1 forkhead box B1 0.333
FZD8 frizzled homolog 8 (Drosophila) 0.326
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.316
WNT3 wingless-type MMTV integration site family, member 3 0.314
HOXD13 homeobox D13 0.305
FOXF2 forkhead box F2 0.299
FGF18 fibroblast growth factor 18 0.295
SIX6 SIX homeobox 6 0.294
WIF1 WNT inhibitory factor 1 0.282
FOXA2 forkhead box A2 0.280
SMAD7 SMAD family member 7 0.280
OTP orthopedia homeobox 0.276
BHLHE23 basic helix-loop-helix family, member e23 0.273
EN1 engrailed homeobox 1 0.268
BMP4 bone morphogenetic protein 4 0.263
ALX4 ALX homeobox 4 0.256
SHH sonic hedgehog 0.254
HOXA11 homeobox A11 0.254
COL2A1 collagen, type II, alpha 1 0.250
AQP5 aquaporin 5 0.249
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.247
STK36 serine/threonine kinase 36 0.242
CTBP1 C-terminal binding protein 1 0.242
SLC18A3 solute carrier family 18 (vesicular acetylcholine), member 3 0.239
ALX3 ALX homeobox 3 0.236
NOG noggin 0.226
NPAS1 neuronal PAS domain protein 1 0.226
OTX2 orthodenticle homeobox 2 0.226
MCC mutated in colorectal cancers 0.222
FOXL1 forkhead box L1 0.204
MSX1 msh homeobox 1 0.204
GBX2 gastrulation brain homeobox 2 0.203
TP73 tumor protein p73 0.198
CRLF1 cytokine receptor-like factor 1 0.191
DLX4 distal-less homeobox 4 0.191
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.190
DIO3 deiodinase, iodothyronine, type III 0.186
WNT4 wingless-type MMTV integration site family, member 4 0.185
HOXD11 homeobox D11 0.174
CSNK1E casein kinase 1, epsilon 0.173
POU3F1 POU class 3 homeobox 1 0.173
SIX1 SIX homeobox 1 0.172
NKX3-2 NK3 homeobox 2 0.170
VSX1 visual system homeobox 1 0.170
NKX2-8 NK2 homeobox 8 0.168
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 0.166
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 0.166
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.165
SOX21 SRY (sex determining region Y)-box 21 0.163
GGN gametogenetin 0.163
SFRP5 secreted frizzled-related protein 5 0.162
IHH Indian hedgehog 0.162
TBX1 T-box 1 0.161
BARX1 BARX homeobox 1 0.157
SOX2 SRY (sex determining region Y)-box 2 0.156
PDX1 pancreatic and duodenal homeobox 1 0.156
MAX MYC associated factor X 0.154
HIC1 hypermethylated in cancer 1 0.150
MESP1 mesoderm posterior 1 homolog (mouse) 0.150
POU3F2 POU class 3 homeobox 2 0.147
WNT10A wingless-type MMTV integration site family, member 10A 0.145
HMX1 H6 family homeobox 1 0.142
FOXN4 forkhead box N4 0.139
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism