The network for 'brain morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

brain morphogenesis

The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Fgfr2 fibroblast growth factor receptor 2 0.999
Pax2 paired box gene 2 0.999
Gli2 GLI-Kruppel family member GLI2 0.998
Bmp4 bone morphogenetic protein 4 0.998
Bmp7 bone morphogenetic protein 7 0.997
Pax3 paired box gene 3 0.997
Ctnnb1 catenin (cadherin associated protein), beta 1 0.996
Sox9 SRY-box containing gene 9 0.996
Fgf8 fibroblast growth factor 8 0.995
Foxc1 forkhead box C1 0.992
Msx1 homeobox, msh-like 1 0.992
Emx1 empty spiracles homolog 1 (Drosophila) 0.989
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.988
Foxc2 forkhead box C2 0.982
Rarg retinoic acid receptor, gamma 0.978
Meox2 mesenchyme homeobox 2 0.975
Nog noggin 0.972
Pitx2 paired-like homeodomain transcription factor 2 0.970
Eya1 eyes absent 1 homolog (Drosophila) 0.966
Wnt3a wingless-related MMTV integration site 3A 0.964
Prrx1 paired related homeobox 1 0.952
Fgfr1 fibroblast growth factor receptor 1 0.948
Rarb retinoic acid receptor, beta 0.945
Psen1 presenilin 1 0.937
Chrd chordin 0.925
Sox2 SRY-box containing gene 2 0.917
Hes1 hairy and enhancer of split 1 (Drosophila) 0.907
Fgf10 fibroblast growth factor 10 0.891
Emx2 empty spiracles homolog 2 (Drosophila) 0.888
Hand1 heart and neural crest derivatives expressed transcript 1 0.886
Tcfap2a transcription factor AP-2, alpha 0.867
Lhx1 LIM homeobox protein 1 0.864
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.864
Ret ret proto-oncogene 0.857
Pax8 paired box gene 8 0.856
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.839
Fgfr3 fibroblast growth factor receptor 3 0.824
Alx4 aristaless-like homeobox 4 0.820
Lef1 lymphoid enhancer binding factor 1 0.815
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.794
Gbx2 gastrulation brain homeobox 2 0.739
Isl1 ISL1 transcription factor, LIM/homeodomain 0.729
Rara retinoic acid receptor, alpha 0.729
Hoxa2 homeobox A2 0.705
Msx2 homeobox, msh-like 2 0.705
Smo smoothened homolog (Drosophila) 0.703
Fgf15 fibroblast growth factor 15 0.694
Bbs4 Bardet-Biedl syndrome 4 (human) 0.682
Vegfa vascular endothelial growth factor A 0.676
Otx1 orthodenticle homolog 1 (Drosophila) 0.674
Pax6 paired box gene 6 0.672
Hand2 heart and neural crest derivatives expressed transcript 2 0.662
Hoxb3 homeobox B3 0.640
Tbx1 T-box 1 0.621
Lmx1b LIM homeobox transcription factor 1 beta 0.616
En1 engrailed 1 0.612
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.601
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.575
Hoxd3 homeobox D3 0.553
Gata6 GATA binding protein 6 0.503
Pthlh parathyroid hormone-like peptide 0.495
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.486
Ptch1 patched homolog 1 0.472
Hoxd11 homeobox D11 0.457
Tbx2 T-box 2 0.452
Hoxa11 homeobox A11 0.448
Gdnf glial cell line derived neurotrophic factor 0.431
Hoxa1 homeobox A1 0.430
Sox11 SRY-box containing gene 11 0.418
Foxg1 forkhead box G1 0.412
Tcf21 transcription factor 21 0.409
Nodal nodal 0.404
Col4a3 collagen, type IV, alpha 3 0.404
Gsc goosecoid homeobox 0.403
Phox2b paired-like homeobox 2b 0.398
Tgfb2 transforming growth factor, beta 2 0.394
Uncx UNC homeobox 0.388
Notch1 Notch gene homolog 1 (Drosophila) 0.377
Hoxd13 homeobox D13 0.376
Pou3f3 POU domain, class 3, transcription factor 3 0.366
Sox3 SRY-box containing gene 3 0.364
Hoxb2 homeobox B2 0.361
Bbs2 Bardet-Biedl syndrome 2 (human) 0.352
Hoxa5 homeobox A5 0.350
Sox17 SRY-box containing gene 17 0.331
Hesx1 homeobox gene expressed in ES cells 0.330
Hes3 hairy and enhancer of split 3 (Drosophila) 0.324
Kdr kinase insert domain protein receptor 0.320
Prrx2 paired related homeobox 2 0.315
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.296
Zic2 zinc finger protein of the cerebellum 2 0.295
En2 engrailed 2 0.289
T brachyury 0.289
Wt1 Wilms tumor 1 homolog 0.279
Lmx1a LIM homeobox transcription factor 1 alpha 0.275
Wnt6 wingless-related MMTV integration site 6 0.274
Chd7 chromodomain helicase DNA binding protein 7 0.272
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
otx2 orthodenticle homolog 2 0.899
pax6a paired box gene 6a 0.857
robo3 roundabout homolog 3 0.818
lhx2b LIM homeobox 2b 0.724
zic4 zic family member 4 0.721
gli1 GLI-Kruppel family member 1 0.715
six3b sine oculis homeobox homolog 3b 0.690
six3a sine oculis homeobox homolog 3a 0.664
dla deltaA 0.664
chd chordin 0.660
rx3 retinal homeobox gene 3 0.562
crabp2a cellular retinoic acid binding protein 2, a 0.507
meis2.1 myeloid ecotropic viral integration site 2.1 0.497
pax2a paired box gene 2a 0.463
mdkb midkine-related growth factor b 0.442
tfap2a transcription factor AP-2 alpha 0.433
pax8 paired box gene 8 0.421
fezf2 FEZ family zinc finger 2 0.415
nf1a neurofibromin 1a 0.415
otx1b orthodenticle homolog 1b 0.357
her6 hairy-related 6 0.355
fgf8b fibroblast growth factor 8 b 0.354
boc brother of CDO 0.354
gbx2 gastrulation brain homeo box 2 0.349
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.339
barhl2 BarH-like 2 0.325
ephb3a eph receptor B3a 0.285
sox11a SRY-box containing gene 11a 0.282
irx7 iroquois homeobox protein 7 0.275
foxp2 forkhead box P2 0.258
axin2 axin 2 (conductin, axil) 0.253
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.253
fgfr1b fibroblast growth factor receptor 1b 0.246
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.245
sox19a SRY-box containing gene 19a 0.234
irx1a iroquois homeobox protein 1, a 0.232
alcamb activated leukocyte cell adhesion molecule b 0.232
mespa mesoderm posterior a 0.231
fzd8a frizzled homolog 8a 0.217
scrt2 scratch homolog 2, zinc finger protein (Drosophila) 0.209
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.207
mcoln1 mucolipin 1 0.206
hoxb1b homeo box B1b 0.193
msxc muscle segment homeobox C 0.171
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.169
shha sonic hedgehog a 0.165
sox3 SRY-box containing gene 3 0.164
pcdh8 protocadherin 8 0.163
meis2.2 myeloid ecotropic viral integration site 2.2 0.161
pcdh10b protocadherin 10b 0.156
her15.1 hairy and enhancer of split-related 15.1 0.155
wnt8b wingless-type MMTV integration site family, member 8b 0.150
her5 hairy-related 5 0.148
emx1 empty spiracles homeobox 1 0.144
adarb1 adenosine deaminase, RNA-specific, B1 0.140
fabp7a fatty acid binding protein 7, brain, a 0.139
gli3 GLI-Kruppel family member GLI3 0.131
sox2 SRY-box containing gene 2 0.131
gli2a GLI-Kruppel family member GLI2a 0.128
dbx1a developing brain homeobox 1a 0.125
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.122
olig2 oligodendrocyte lineage transcription factor 2 0.120
otpb orthopedia homolog b 0.118
fgfr2 fibroblast growth factor receptor 2 0.118
rxrga retinoid x receptor, gamma a 0.114
tbx24 T-box 24 0.112
foxg1a forkhead box G1a 0.107
lhx5 LIM homeobox 5 0.107
LOC796298 isotocin receptor-like 1 0.106
col14a1 collagen, type XIV, alpha 1 0.106
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.105
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.105
znf503 zinc finger protein 503 0.078
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.076
eng2a engrailed 2a 0.076
ndr2 nodal-related 2 0.076
her8a hairy-related 8a 0.075
dmd dystrophin 0.072
prdm5 PR domain containing 5 0.071
sfrp5 secreted frizzled-related protein 5 0.071
mpped2 metallophosphoesterase domain containing 2 0.068
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.067
nf1b neurofibromin 1b 0.067
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.066
chst11 carbohydrate (chondroitin 4) sulfotransferase 11 0.065
fzd7a frizzled homolog 7a 0.065
lrrtm1 leucine rich repeat transmembrane neuronal 1 0.065
hmgb1a high-mobility group box 1a 0.064
tll1 tolloid-like 1 0.063
fgf3 fibroblast growth factor 3 0.063
mab21l2 mab-21-like 2 0.063
pax6b paired box gene 6b 0.063
pth2r parathyroid hormone 2 receptor 0.060
ctbp2 C-terminal binding protein 2 0.059
LOC795916 mucolipin-1-like 0.058
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.058
her1 hairy-related 1 0.058
dync1h1 dynein, cytoplasmic 1, heavy chain 1 0.058
nkx2.1a NK2 homeobox 1a 0.054
hesx1 homeo box (expressed in ES cells) 1 0.054
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Drosophila melanogaster
Name Description Probability Func Analog Organism
E(spl) Enhancer of split 0.668
HLHmdelta E(spl) region transcript mdelta 0.456
eyg eyegone 0.407
lea leak 0.274
HLHm7 E(spl) region transcript m7 0.226
malpha E(spl) region transcript malpha 0.152
fra frazzled 0.133
HLHmgamma E(spl) region transcript mgamma 0.133
Ras85D Ras oncogene at 85D 0.125
nmo nemo 0.121
sca scabrous 0.109
Tom Twin of m4 0.103
ato atonal 0.100
drl derailed 0.097
mod(mdg4) modifier of mdg4 0.076
CG32711 CG32711 gene product from transcript CG32711-RA 0.067
m4 E(spl) region transcript m4 0.055
HLHm5 E(spl) region transcript m5 0.052
ttk tramtrack 0.050
sxc super sex combs 0.050
sli slit 0.049
spi spitz 0.043
HLHm3 E(spl) region transcript m3 0.042
oc ocelliless 0.041
bib big brain 0.040
ac achaete 0.039
HLHmbeta E(spl) region transcript mbeta 0.038
comm commissureless 0.038
amos absent MD neurons and olfactory sensilla 0.037
caup caupolican 0.035
emc extra macrochaetae 0.034
JIL-1 CG6297 gene product from transcript CG6297-RA 0.033
B-H2 BarH2 0.031
for foraging 0.030
lab labial 0.030
eya eyes absent 0.029
pros prospero 0.029
hth homothorax 0.026
Ptp69D Protein tyrosine phosphatase 69D 0.025
opa odd paired 0.025
plexA plexin A 0.025
brk brinker 0.024
Dad Daughters against dpp 0.024
Dfd Deformed 0.023
noc no ocelli 0.022
m2 E(spl) region transcript m2 0.022
klu klumpfuss 0.022
Hr51 Hormone receptor 51 0.022
sc scute 0.022
tll tailless 0.022
Sdc Syndecan 0.021
gcm glial cells missing 0.021
twe twine 0.021
argos CG4531 gene product from transcript CG4531-RA 0.021
ara araucan 0.020
CG12424 CG12424 gene product from transcript CG12424-RC 0.020
ro rough 0.020
Eph Eph receptor tyrosine kinase 0.019
kel kelch 0.019
CG14478 CG14478 gene product from transcript CG14478-RA 0.019
bip2 CG2009 gene product from transcript CG2009-RA 0.019
Poxn Pox neuro 0.018
fl(2)d female lethal d 0.018
ey eyeless 0.018
dac dachshund 0.018
lola longitudinals lacking 0.018
Wnt6 CG4969 gene product from transcript CG4969-RB 0.017
Parg Poly(ADP-ribose) glycohydrolase 0.017
rpr reaper 0.016
put punt 0.016
Abd-B Abdominal B 0.016
repo reversed polarity 0.016
CG6234 CG6234 gene product from transcript CG6234-RA 0.016
Taf1 TBP-associated factor 1 0.016
MED26 Mediator complex subunit 26 0.015
CG34449 CG34449 gene product from transcript CG34449-RB 0.015
Mi-2 CG8103 gene product from transcript CG8103-RA 0.015
Mkk4 MAP kinase kinase 4 0.015
slp1 sloppy paired 1 0.015
run runt 0.014
Antp Antennapedia 0.014
l(2)k16918 lethal (2) k16918 0.014
Gef64C Guanine nucleotide exchange factor GEF64C 0.014
BobA Brother of Bearded A 0.013
CG2519 CG2519 gene product from transcript CG2519-RB 0.013
Trim9 CG31721 gene product from transcript CG31721-RB 0.013
lz lozenge 0.013
pb proboscipedia 0.013
sens senseless 0.012
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.012
Ser Serrate 0.012
Dip3 Dorsal interacting protein 3 0.012
CG9007 CG9007 gene product from transcript CG9007-RA 0.012
CG42256 CG42256 gene product from transcript CG42256-RH 0.012
Su(H) Suppressor of Hairless 0.012
mam mastermind 0.012
Notum CG13076 gene product from transcript CG13076-RB 0.012
ss spineless 0.012
Ten-a Tenascin accessory 0.012
Ephrin CG1862 gene product from transcript CG1862-RA 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
PSEN2 presenilin 2 (Alzheimer disease 4) 0.903
UBQLN1 ubiquilin 1 0.850
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.839
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.830
PSEN1 presenilin 1 0.739
FLNB filamin B, beta 0.732
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.717
SUFU suppressor of fused homolog (Drosophila) 0.646
CAV1 caveolin 1, caveolae protein, 22kDa 0.609
POU5F1 POU class 5 homeobox 1 0.361
APP amyloid beta (A4) precursor protein 0.349
LGALS8 lectin, galactoside-binding, soluble, 8 0.344
PKP4 plakophilin 4 0.331
PTN pleiotrophin 0.327
BBS1 Bardet-Biedl syndrome 1 0.302
PDIA3 protein disulfide isomerase family A, member 3 0.292
CIB1 calcium and integrin binding 1 (calmyrin) 0.236
CPE carboxypeptidase E 0.200
NCSTN nicastrin 0.193
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.174
SORBS1 sorbin and SH3 domain containing 1 0.165
BCL2L1 BCL2-like 1 0.154
RAD23B RAD23 homolog B (S. cerevisiae) 0.145
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.140
FOXD3 forkhead box D3 0.118
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.114
BCAM basal cell adhesion molecule (Lutheran blood group) 0.101
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.091
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.091
ATP13A2 ATPase type 13A2 0.089
PCM1 pericentriolar material 1 0.085
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.083
FZD1 frizzled homolog 1 (Drosophila) 0.077
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.075
ADRM1 adhesion regulating molecule 1 0.072
TAL1 T-cell acute lymphocytic leukemia 1 0.072
P4HB prolyl 4-hydroxylase, beta polypeptide 0.071
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.071
ZHX1 zinc fingers and homeoboxes 1 0.070
STK36 serine/threonine kinase 36 0.069
VHL von Hippel-Lindau tumor suppressor 0.068
CTBP1 C-terminal binding protein 1 0.067
TTC8 tetratricopeptide repeat domain 8 0.065
KIF14 kinesin family member 14 0.063
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.062
SALL2 sal-like 2 (Drosophila) 0.062
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 0.061
MYOD1 myogenic differentiation 1 0.060
TCF4 transcription factor 4 0.060
TRIM32 tripartite motif containing 32 0.060
ATXN3 ataxin 3 0.059
AXIN1 axin 1 0.058
ERBB2IP erbb2 interacting protein 0.057
CTBP2 C-terminal binding protein 2 0.055
ZFYVE1 zinc finger, FYVE domain containing 1 0.055
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.053
UBQLN4 ubiquilin 4 0.053
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.053
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.053
MED31 mediator complex subunit 31 0.052
YY1 YY1 transcription factor 0.051
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.050
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.049
SH3RF1 SH3 domain containing ring finger 1 0.049
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.048
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.048
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.047
FLNA filamin A, alpha 0.047
COL7A1 collagen, type VII, alpha 1 0.046
SRI sorcin 0.045
PDIA4 protein disulfide isomerase family A, member 4 0.042
GJA1 gap junction protein, alpha 1, 43kDa 0.042
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.042
EPS15 epidermal growth factor receptor pathway substrate 15 0.041
PAX2 paired box 2 0.040
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.039
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.038
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.038
ATF3 activating transcription factor 3 0.036
SORBS2 sorbin and SH3 domain containing 2 0.036
BANP BTG3 associated nuclear protein 0.036
EXOC7 exocyst complex component 7 0.035
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.035
LHX2 LIM homeobox 2 0.034
SNCAIP synuclein, alpha interacting protein 0.033
HK2 hexokinase 2 0.032
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.032
HSCB HscB iron-sulfur cluster co-chaperone homolog (E. coli) 0.031
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.031
GSK3B glycogen synthase kinase 3 beta 0.031
BAD BCL2-associated agonist of cell death 0.030
BIK BCL2-interacting killer (apoptosis-inducing) 0.030
GLI2 GLI family zinc finger 2 0.029
MAPK7 mitogen-activated protein kinase 7 0.028
BICD2 bicaudal D homolog 2 (Drosophila) 0.028
NAT15 N-acetyltransferase 15 (GCN5-related, putative) 0.028
SOX11 SRY (sex determining region Y)-box 11 0.027
CDX2 caudal type homeobox 2 0.027
TWIST1 twist homolog 1 (Drosophila) 0.026
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.026
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism