The network for 'cartilage development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cartilage development

The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Fgf8 fibroblast growth factor 8 1.000
Prrx1 paired related homeobox 1 0.999
Fgfr3 fibroblast growth factor receptor 3 0.999
Gli3 GLI-Kruppel family member GLI3 0.998
Rarg retinoic acid receptor, gamma 0.997
Col2a1 collagen, type II, alpha 1 0.997
Pax3 paired box gene 3 0.994
Chrd chordin 0.993
Tgfb2 transforming growth factor, beta 2 0.993
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.992
Hand2 heart and neural crest derivatives expressed transcript 2 0.990
Hoxa2 homeobox A2 0.990
Nog noggin 0.989
Eya1 eyes absent 1 homolog (Drosophila) 0.989
Dlx5 distal-less homeobox 5 0.989
Pax2 paired box gene 2 0.988
Col1a1 collagen, type I, alpha 1 0.986
Ednra endothelin receptor type A 0.985
Tbx1 T-box 1 0.985
Bmp4 bone morphogenetic protein 4 0.985
Prrx2 paired related homeobox 2 0.985
Hoxa11 homeobox A11 0.984
Hoxd13 homeobox D13 0.982
Hoxa1 homeobox A1 0.978
En1 engrailed 1 0.975
Hoxd3 homeobox D3 0.974
Hoxa13 homeobox A13 0.972
Sfrp2 secreted frizzled-related protein 2 0.971
Acvr1 activin A receptor, type 1 0.968
Smad3 MAD homolog 3 (Drosophila) 0.968
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.967
Twist1 twist homolog 1 (Drosophila) 0.964
Fgf10 fibroblast growth factor 10 0.962
Sox9 SRY-box containing gene 9 0.961
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.961
Gbx2 gastrulation brain homeobox 2 0.958
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.956
Fzd8 frizzled homolog 8 (Drosophila) 0.953
Gpc3 glypican 3 0.953
Foxc1 forkhead box C1 0.949
Twist2 twist homolog 2 (Drosophila) 0.948
Gas1 growth arrest specific 1 0.945
Pax9 paired box gene 9 0.944
Hoxa5 homeobox A5 0.941
Vegfa vascular endothelial growth factor A 0.941
Lhx3 LIM homeobox protein 3 0.940
Pthlh parathyroid hormone-like peptide 0.937
Hoxa10 homeobox A10 0.936
Isl1 ISL1 transcription factor, LIM/homeodomain 0.936
Lmx1a LIM homeobox transcription factor 1 alpha 0.934
Snai1 snail homolog 1 (Drosophila) 0.931
Tgfbr2 transforming growth factor, beta receptor II 0.931
Nodal nodal 0.926
Mrc2 mannose receptor, C type 2 0.918
Gsc goosecoid homeobox 0.918
Tgfb1 transforming growth factor, beta 1 0.915
Nos3 nitric oxide synthase 3, endothelial cell 0.915
Sox2 SRY-box containing gene 2 0.893
Hoxa3 homeobox A3 0.890
Gdf5 growth differentiation factor 5 0.886
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.879
Hoxd9 homeobox D9 0.879
Pitx2 paired-like homeodomain transcription factor 2 0.878
Fgf15 fibroblast growth factor 15 0.878
Fbn1 fibrillin 1 0.871
Vangl2 vang-like 2 (van gogh, Drosophila) 0.869
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.864
Fgf18 fibroblast growth factor 18 0.862
Wnt3a wingless-related MMTV integration site 3A 0.861
Wnt5a wingless-related MMTV integration site 5A 0.856
Foxc2 forkhead box C2 0.851
Bmp5 bone morphogenetic protein 5 0.840
Gdnf glial cell line derived neurotrophic factor 0.839
Tbx15 T-box 15 0.837
Hes1 hairy and enhancer of split 1 (Drosophila) 0.836
Pbx1 pre B-cell leukemia transcription factor 1 0.833
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.827
Ece1 endothelin converting enzyme 1 0.823
Bgn biglycan 0.822
Pkd1 polycystic kidney disease 1 homolog 0.817
Pitx1 paired-like homeodomain transcription factor 1 0.816
Meox2 mesenchyme homeobox 2 0.809
Pou3f3 POU domain, class 3, transcription factor 3 0.797
Tbx3 T-box 3 0.788
Col11a1 collagen, type XI, alpha 1 0.783
Rara retinoic acid receptor, alpha 0.783
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.768
Bmpr1a bone morphogenetic protein receptor, type 1A 0.765
Mapk14 mitogen-activated protein kinase 14 0.764
Lox lysyl oxidase 0.763
Tcfap2a transcription factor AP-2, alpha 0.753
Bmp7 bone morphogenetic protein 7 0.751
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.749
Zfp503 zinc finger protein 503 0.748
Hoxd11 homeobox D11 0.740
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.738
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.996
jag1b jagged 1b 0.995
sox9a SRY-box containing gene 9a 0.995
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.989
col1a1a collagen, type I, alpha 1a 0.971
fgf3 fibroblast growth factor 3 0.958
prdm1a PR domain containing 1a, with ZNF domain 0.927
foxi1 forkhead box I1 0.922
uxs1 UDP-glucuronic acid decarboxylase 1 0.897
col5a1 procollagen, type V, alpha 1 0.894
edn1 endothelin 1 0.855
barx1 BarH-like homeobox 1 0.853
fn1 fibronectin 1 0.821
gli2a GLI-Kruppel family member GLI2a 0.819
ndr2 nodal-related 2 0.819
snai1a snail homolog 1a (Drosophila) 0.809
eya1 eyes absent homolog 1 0.787
bmp2a bone morphogenetic protein 2a 0.783
gdf6a growth differentiation factor 6a 0.778
osr1 odd-skipped related 1 (Drosophila) 0.771
mef2ca myocyte enhancer factor 2ca 0.768
dlb deltaB 0.766
tp63 tumor protein p63 0.754
csnk1a1 casein kinase 1, alpha 1 0.744
wu:fv91b12 wu:fv91b12 0.738
fli1a friend leukemia integration 1a 0.738
zgc:158603 zgc:158603 0.726
brpf1 bromodomain and PHD finger containing, 1 0.709
col1a2 collagen, type I, alpha 2 0.705
myod1 myogenic differentiation 1 0.686
matn4 matrilin 4 0.684
dlx3b distal-less homeobox gene 3b 0.681
twist1a twist1a 0.680
fgf17 fibroblast growth factor 17 0.664
wnt9b wingless-type MMTV integration site family, member 9B 0.655
spry4 sprouty (Drosophila) homolog 4 0.654
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.638
ctgf connective tissue growth factor 0.634
hand2 heart and neural crest derivatives expressed transcript 2 0.632
rarga retinoic acid receptor gamma a 0.630
boc brother of CDO 0.617
col5a2l collagen, type V, alpha 2-like 0.610
pax9 paired box gene 9 0.606
vcanb versican b 0.592
disp1 dispatched homolog 1 (Drosophila) 0.589
hoxa13b homeo box A13b 0.583
nkx3.2 NK3 homeobox 2 0.581
efnb2a ephrin B2a 0.573
gsc goosecoid 0.570
furina furin (paired basic amino acid cleaving enzyme) a 0.550
flh floating head 0.528
thbs1 thrombospondin 1 0.522
runx3 runt-related transcription factor 3 0.521
xylt1 xylosyltransferase 1 0.518
hapln1a hyaluronan and proteoglycan link protein 1a 0.505
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.501
cmn calymmin 0.498
dlx5a distal-less homeobox gene 5a 0.496
tgfb2 transforming growth factor, beta 2 0.496
dlx6a distal-less homeobox gene 6a 0.494
spns2 spinster homolog 2 (Drosophila) 0.492
dlx4a distal-less homeobox gene 4a 0.488
fras1 Fraser syndrome 1 0.487
fgfr1a fibroblast growth factor receptor 1a 0.476
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.472
tbx2a T-box gene 2a 0.463
ptch1 patched 1 0.440
loxl2b lysyl oxidase-like 2b 0.437
hoxa3a homeo box A3a 0.433
shha sonic hedgehog a 0.430
dmrt2a doublesex and mab-3 related transcription factor 2a 0.428
foxa3 forkhead box A3 0.424
fgfr2 fibroblast growth factor receptor 2 0.422
bmp4 bone morphogenetic protein 4 0.413
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.404
fgf4 fibroblast growth factor 4 0.400
lef1 lymphocyte enhancer binding factor 1 0.398
ptpra protein tyrosine phosphatase, receptor type, A 0.398
cdx4 caudal type homeo box transcription factor 4 0.398
tgfbi transforming growth factor, beta-induced 0.397
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.396
dlx2a distal-less homeobox gene 2a 0.392
notch2 notch homolog 2 0.386
gli1 GLI-Kruppel family member 1 0.378
tfec transcription factor EC 0.378
acvr1l activin A receptor, type I like 0.376
foxa2 forkhead box A2 0.374
hoxb4a homeo box B4a 0.372
sulf1 sulfatase 1 0.371
prrx1a paired related homeobox 1a 0.370
fgfr3 fibroblast growth factor receptor 3 0.368
mecom MDS1 and EVI1 complex locus 0.366
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.365
twist3 twist3 0.363
si:xx-bac7cse.2 si:xx-bac7cse.2 0.361
gbx2 gastrulation brain homeo box 2 0.361
jag2 jagged 2 0.355
col9a2 procollagen, type IX, alpha 2 0.353
nrp1a neuropilin 1a 0.349
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.348
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.997
FBN1 fibrillin 1 0.908
SMAD7 SMAD family member 7 0.904
PAX3 paired box 3 0.782
FN1 fibronectin 1 0.745
LOX lysyl oxidase 0.705
LTBP2 latent transforming growth factor beta binding protein 2 0.685
COL1A1 collagen, type I, alpha 1 0.671
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.653
ELN elastin 0.648
COL3A1 collagen, type III, alpha 1 0.638
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.637
COL1A2 collagen, type I, alpha 2 0.583
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.458
BMP2 bone morphogenetic protein 2 0.420
COL6A1 collagen, type VI, alpha 1 0.408
LUM lumican 0.385
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.365
BMPR1A bone morphogenetic protein receptor, type IA 0.362
FSTL1 follistatin-like 1 0.347
SMAD3 SMAD family member 3 0.347
COL5A2 collagen, type V, alpha 2 0.343
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.326
FGF1 fibroblast growth factor 1 (acidic) 0.326
SMAD4 SMAD family member 4 0.325
COL6A2 collagen, type VI, alpha 2 0.324
CTGF connective tissue growth factor 0.312
NOTCH3 notch 3 0.309
TGFB1 transforming growth factor, beta 1 0.306
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.297
COL5A1 collagen, type V, alpha 1 0.296
FGFR1 fibroblast growth factor receptor 1 0.292
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.233
DCN decorin 0.232
MAPK1 mitogen-activated protein kinase 1 0.216
TNC tenascin C 0.205
BMP7 bone morphogenetic protein 7 0.201
EP300 E1A binding protein p300 0.198
HOXD9 homeobox D9 0.198
THBS1 thrombospondin 1 0.192
RB1 retinoblastoma 1 0.186
SEC31A SEC31 homolog A (S. cerevisiae) 0.180
POSTN periostin, osteoblast specific factor 0.174
COL2A1 collagen, type II, alpha 1 0.172
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.172
HIPK2 homeodomain interacting protein kinase 2 0.166
FGF2 fibroblast growth factor 2 (basic) 0.165
VCAN versican 0.162
CALD1 caldesmon 1 0.160
MSX1 msh homeobox 1 0.156
DDR2 discoidin domain receptor tyrosine kinase 2 0.154
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.148
BMP1 bone morphogenetic protein 1 0.145
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.131
BBS10 Bardet-Biedl syndrome 10 0.128
FOXD3 forkhead box D3 0.127
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.126
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.121
MSN moesin 0.121
HOXA10 homeobox A10 0.120
BGN biglycan 0.118
IGFBP5 insulin-like growth factor binding protein 5 0.115
BMI1 BMI1 polycomb ring finger oncogene 0.115
TWIST1 twist homolog 1 (Drosophila) 0.114
WNT1 wingless-type MMTV integration site family, member 1 0.113
FZD1 frizzled homolog 1 (Drosophila) 0.113
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.112
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.112
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.110
BMPR1B bone morphogenetic protein receptor, type IB 0.110
MFAP5 microfibrillar associated protein 5 0.108
PCOLCE procollagen C-endopeptidase enhancer 0.107
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.106
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.105
RARA retinoic acid receptor, alpha 0.101
TGFBR1 transforming growth factor, beta receptor 1 0.097
EDNRA endothelin receptor type A 0.097
LOXL1 lysyl oxidase-like 1 0.097
NRP1 neuropilin 1 0.092
ACVR1 activin A receptor, type I 0.092
TGFB3 transforming growth factor, beta 3 0.090
GDF5 growth differentiation factor 5 0.090
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.089
FAP fibroblast activation protein, alpha 0.089
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.087
MXRA5 matrix-remodelling associated 5 0.083
TGFB2 transforming growth factor, beta 2 0.081
PTCH1 patched 1 0.079
COL6A3 collagen, type VI, alpha 3 0.076
WNT3A wingless-type MMTV integration site family, member 3A 0.074
FBLN2 fibulin 2 0.073
RUNX1 runt-related transcription factor 1 0.072
TP53 tumor protein p53 0.070
ACAN aggrecan 0.069
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.069
HMGA2 high mobility group AT-hook 2 0.068
SULF1 sulfatase 1 0.068
HDAC6 histone deacetylase 6 0.068
IGFBP3 insulin-like growth factor binding protein 3 0.068
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.067
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.924
Col3a1 collagen, type III, alpha 1 0.905
Col1a2 collagen, type I, alpha 2 0.811
Vim vimentin 0.786
Bgn biglycan 0.756
Col5a2 collagen, type V, alpha 2 0.557
Lum lumican 0.510
Col12a1 collagen, type XII, alpha 1 0.317
Dcn decorin 0.284
Col5a1 collagen, type V, alpha 1 0.246
Eln elastin 0.234
Fn1 fibronectin 1 0.234
Dab2 disabled homolog 2 (Drosophila) 0.131
Loxl1 lysyl oxidase-like 1 0.093
Shox2 short stature homeobox 2 0.080
Lox lysyl oxidase 0.078
Tgfbr2 transforming growth factor, beta receptor II 0.073
Anxa1 annexin A1 0.070
Mfap4 microfibrillar-associated protein 4 0.064
Col4a5 collagen, type IV, alpha 5 0.055
Fgfr2 fibroblast growth factor receptor 2 0.051
Lamc1 laminin, gamma 1 0.049
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.045
Hapln1 hyaluronan and proteoglycan link protein 1 0.043
Pcolce procollagen C-endopeptidase enhancer 0.042
Col15a1 collagen, type XV, alpha 1 0.041
Tgfb3 transforming growth factor, beta 3 0.041
Nup153 nucleoporin 153 0.041
Srpx sushi-repeat-containing protein, X-linked 0.039
Dbp D site of albumin promoter (albumin D-box) binding protein 0.038
Sod3 superoxide dismutase 3, extracellular 0.038
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.037
Irs1 insulin receptor substrate 1 0.037
Col9a1 collagen, type IX, alpha 1 0.037
Fbn1 fibrillin 1 0.036
Aspn asporin 0.036
Ece1 endothelin converting enzyme 1 0.036
Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 0.036
Gpr176 G protein-coupled receptor 176 0.036
Igfbp5 insulin-like growth factor binding protein 5 0.035
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.034
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.034
Postn periostin, osteoblast specific factor 0.033
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.033
Hoxc4 homeo box C4 0.033
Chad chondroadherin 0.031
Angptl2 angiopoietin-like 2 0.031
Rara retinoic acid receptor, alpha 0.030
Smad6 SMAD family member 6 0.030
Ralgds ral guanine nucleotide dissociation stimulator 0.029
Col6a2 collagen, type VI, alpha 2 0.029
Gja1 gap junction protein, alpha 1 0.029
Map3k3 mitogen activated protein kinase kinase kinase 3 0.028
Aebp1 AE binding protein 1 0.028
Ctsk cathepsin K 0.028
S1pr2 sphingosine-1-phosphate receptor 2 0.028
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.027
Lrpap1 low density lipoprotein receptor-related protein associated protein 1 0.027
RGD1305645 similar to RIKEN cDNA 1500015O10 0.027
Col2a1 collagen, type II, alpha 1 0.027
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.026
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.026
Cpz carboxypeptidase Z 0.025
Palm paralemmin 0.025
Sox17 SRY (sex determining region Y)-box 17 0.025
Mgp matrix Gla protein 0.024
Sox10 SRY (sex determining region Y)-box 10 0.023
Sdc2 syndecan 2 0.023
Ccnd3 cyclin D3 0.022
Nbl1 neuroblastoma, suppression of tumorigenicity 1 0.022
Esr1 estrogen receptor 1 0.022
Col8a1 collagen, type VIII, alpha 1 0.022
Sdc3 syndecan 3 0.021
Lect1 leukocyte cell derived chemotaxin 1 0.021
Foxd4 forkhead box D4 0.021
Bmp6 bone morphogenetic protein 6 0.021
Scarf2 scavenger receptor class F, member 2 0.021
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.021
Glt25d1 glycosyltransferase 25 domain containing 1 0.020
Syn3 synapsin III 0.020
Vcan versican 0.020
Cyb5r1 cytochrome b5 reductase 1 0.019
Ar androgen receptor 0.019
Fzd2 frizzled homolog 2 (Drosophila) 0.019
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.019
Fgfr1 Fibroblast growth factor receptor 1 0.019
Tgfbr3 transforming growth factor, beta receptor III 0.019
Psen1 presenilin 1 0.019
Tpo thyroid peroxidase 0.019
Zyx zyxin 0.019
Unc5b unc-5 homolog B (C. elegans) 0.019
Tgfb1 transforming growth factor, beta 1 0.018
Gpx3 glutathione peroxidase 3 0.018
Foxe3 forkhead box E3 0.018
Hapln4 hyaluronan and proteoglycan link protein 4 0.018
Grin2c glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.018
Mag myelin-associated glycoprotein 0.018
Ptbp1 polypyrimidine tract binding protein 1 0.018
Ccdc80 coiled-coil domain containing 80 0.017
LOC100360403 ATP-binding cassette, sub-family C, member 9-like 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism