The network for 'g protein coupled acetylcholine receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

g protein coupled acetylcholine receptor signaling pathway

Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.

Mus musculus
Name Description Probability Func Analog Organism
Ush1g Usher syndrome 1G homolog (human) 0.687
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.649
Thrb thyroid hormone receptor beta 0.529
Thra thyroid hormone receptor alpha 0.519
Tgfb1 transforming growth factor, beta 1 0.506
Lepr leptin receptor 0.398
Hrh2 histamine receptor H2 0.388
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.367
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.358
Cbl Casitas B-lineage lymphoma 0.343
Cav1 caveolin 1, caveolae protein 0.289
Pcp2 Purkinje cell protein 2 (L7) 0.283
Chrm3 cholinergic receptor, muscarinic 3, cardiac 0.265
Epor erythropoietin receptor 0.260
Vdr vitamin D receptor 0.229
Insr insulin receptor 0.211
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.203
Flt1 FMS-like tyrosine kinase 1 0.203
Agrp agouti related protein 0.171
Slc12a1 solute carrier family 12, member 1 0.164
Plxna1 plexin A1 0.155
Grb10 growth factor receptor bound protein 10 0.145
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.144
Atxn1 ataxin 1 0.135
Prkcc protein kinase C, gamma 0.133
Inpp5d inositol polyphosphate-5-phosphatase D 0.130
Nos1 nitric oxide synthase 1, neuronal 0.128
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.126
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.122
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.121
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.120
Sstr4 somatostatin receptor 4 0.116
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.115
Zfp444 zinc finger protein 444 0.102
Ghr growth hormone receptor 0.099
Smad3 MAD homolog 3 (Drosophila) 0.096
Dr1 down-regulator of transcription 1 0.093
Cckbr cholecystokinin B receptor 0.093
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.093
Gna11 guanine nucleotide binding protein, alpha 11 0.091
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.090
S1pr2 sphingosine-1-phosphate receptor 2 0.088
Aip aryl-hydrocarbon receptor-interacting protein 0.085
Stat3 signal transducer and activator of transcription 3 0.085
a nonagouti 0.083
Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 0.082
Cplx2 complexin 2 0.080
Dpysl2 dihydropyrimidinase-like 2 0.080
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.076
Grid1 glutamate receptor, ionotropic, delta 1 0.076
Ids iduronate 2-sulfatase 0.076
Tmed8 transmembrane emp24 domain containing 8 0.076
Drd2 dopamine receptor D2 0.075
Kit kit oncogene 0.075
Syn2 synapsin II 0.074
Rgs9 regulator of G-protein signaling 9 0.074
Cdk14 cyclin-dependent kinase 14 0.074
Gpr27 G protein-coupled receptor 27 0.074
Npas2 neuronal PAS domain protein 2 0.073
Adrb1 adrenergic receptor, beta 1 0.073
Flii flightless I homolog (Drosophila) 0.071
Npy2r neuropeptide Y receptor Y2 0.069
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.069
Plcb1 phospholipase C, beta 1 0.066
Ncoa3 nuclear receptor coactivator 3 0.066
Prkch protein kinase C, eta 0.064
Homer1 homer homolog 1 (Drosophila) 0.063
Grxcr1 glutaredoxin, cysteine rich 1 0.062
Shc3 src homology 2 domain-containing transforming protein C3 0.062
Mmp24 matrix metallopeptidase 24 0.061
Tacr1 tachykinin receptor 1 0.061
Klf7 Kruppel-like factor 7 (ubiquitous) 0.060
Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 0.060
Sh3kbp1 SH3-domain kinase binding protein 1 0.059
Kcnh3 potassium voltage-gated channel, subfamily H (eag-related), member 3 0.058
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.057
Ilk integrin linked kinase 0.057
Scn5a sodium channel, voltage-gated, type V, alpha 0.054
Igf2 insulin-like growth factor 2 0.053
Rac1 RAS-related C3 botulinum substrate 1 0.053
Pdcd6ip programmed cell death 6 interacting protein 0.053
Ctdsp2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.052
Igf1r insulin-like growth factor I receptor 0.051
Syt1 synaptotagmin I 0.051
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.051
L1cam L1 cell adhesion molecule 0.050
Smtn smoothelin 0.050
Ssr3 signal sequence receptor, gamma 0.050
Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial 0.049
Igf2r insulin-like growth factor 2 receptor 0.048
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.048
Shc1 src homology 2 domain-containing transforming protein C1 0.048
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.047
Igh immunoglobulin heavy chain complex 0.047
Pnpla2 patatin-like phospholipase domain containing 2 0.047
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.046
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.045
Dynlt1b dynein light chain Tctex-type 1D 0.045
Itpr1 inositol 1,4,5-trisphosphate receptor 1 0.045
Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) 0.045
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.504
NCF2 neutrophil cytosolic factor 2 0.207
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.199
NCF1 neutrophil cytosolic factor 1 0.077
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.030
NCF4 neutrophil cytosolic factor 4, 40kDa 0.027
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.021
MYH9 myosin, heavy chain 9, non-muscle 0.020
PLD3 phospholipase D family, member 3 0.020
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.014
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.013
RGS19 regulator of G-protein signaling 19 0.012
CAPZB capping protein (actin filament) muscle Z-line, beta 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.356
Camk4 calcium/calmodulin-dependent protein kinase IV 0.266
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.185
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.152
Gabbr2 gamma-aminobutyric acid (GABA) B receptor 2 0.143
Cckbr cholecystokinin B receptor 0.142
Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 0.140
Htr4 5-hydroxytryptamine (serotonin) receptor 4 0.117
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.117
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.104
Nlgn3 neuroligin 3 0.101
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.079
Trhr thyrotropin releasing hormone receptor 0.078
Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 0.075
Syn1 synapsin I 0.074
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.071
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.069
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.068
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.067
Mpp3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.063
Hpca hippocalcin 0.057
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.057
Chrm3 cholinergic receptor, muscarinic 3 0.057
Nlgn2 neuroligin 2 0.057
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.053
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.045
Hpcal4 hippocalcin-like 4 0.045
Ncan neurocan 0.044
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.043
Unc5a unc-5 homolog A (C. elegans) 0.042
Egr4 early growth response 4 0.040
Gria1 glutamate receptor, ionotropic, AMPA 1 0.038
Trhr2 thyrotropin releasing hormone receptor 2 0.038
Crhr1 corticotropin releasing hormone receptor 1 0.037
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.037
Dlg4 discs, large homolog 4 (Drosophila) 0.036
Lrrc7 leucine rich repeat containing 7 0.036
Insrr insulin receptor-related receptor 0.034
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.033
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.033
Syt3 synaptotagmin III 0.032
Pspn persephin 0.031
Fgf14 fibroblast growth factor 14 0.030
Drd1a dopamine receptor D1A 0.030
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.029
Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.028
Syt7 synaptotagmin VII 0.028
Hlf hepatic leukemia factor 0.026
Irf2 interferon regulatory factor 2 0.026
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.024
Cntfr ciliary neurotrophic factor receptor 0.024
Kalrn kalirin, RhoGEF kinase 0.024
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.024
Arl15 ADP-ribosylation factor-like 15 0.023
Slc6a17 solute carrier family 6 (neurotransmitter transporter), member 17 0.023
Grm7 glutamate receptor, metabotropic 7 0.023
Prkg2 protein kinase, cGMP-dependent, type II 0.023
Kcnt1 potassium channel, subfamily T, member 1 0.022
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.022
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.021
Mchr1 melanin-concentrating hormone receptor 1 0.021
Sstr1 somatostatin receptor 1 0.020
Bsn bassoon 0.020
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.020
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.020
Pgr progesterone receptor 0.019
Igf2 insulin-like growth factor 2 0.019
Camk1g calcium/calmodulin-dependent protein kinase IG 0.019
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.018
Tff3 trefoil factor 3, intestinal 0.018
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.017
Begain brain-enriched guanylate kinase-associated 0.017
Chrm4 cholinergic receptor, muscarinic 4 0.017
Rims1 regulating synaptic membrane exocytosis 1 0.017
Hes3 hairy and enhancer of split 3 (Drosophila) 0.017
Kcnh4 potassium voltage-gated channel, subfamily H (eag-related), member 4 0.017
Cngb1 cyclic nucleotide gated channel beta 1 0.017
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.017
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.016
Amph amphiphysin 0.016
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.016
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.016
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.016
Tff1 trefoil factor 1 0.016
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.016
Grm5 glutamate receptor, metabotropic 5 0.016
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.016
Gabrd gamma-aminobutyric acid (GABA) A receptor, delta 0.015
Cacnb4 calcium channel, voltage-dependent, beta 4 subunit 0.015
Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.015
Gnrhr gonadotropin releasing hormone receptor 0.015
Rgs14 regulator of G-protein signaling 14 0.015
Slit1 slit homolog 1 (Drosophila) 0.015
Nfasc neurofascin 0.015
Tnr tenascin R 0.015
Slc14a1 solute carrier family 14 (urea transporter), member 1 0.015
Grp gastrin releasing peptide 0.014
Sstr4 somatostatin receptor 4 0.014
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.014
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism