The network for 'positive regulation of vasoconstriction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of vasoconstriction

Any process that activates or increases the frequency, rate or extent of vasoconstriction.

Mus musculus
Name Description Probability Func Analog Organism
Klk1b5 kallikrein 1-related peptidase b5 0.996
Klk1b8 kallikrein 1-related peptidase b8 0.978
Klk1 kallikrein 1 0.946
Klk1b26 kallikrein 1-related petidase b26 0.945
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.931
Lepr leptin receptor 0.926
Klk1b11 kallikrein 1-related peptidase b11 0.921
Klk1b1 kallikrein 1-related peptidase b1 0.896
Klk1b16 kallikrein 1-related peptidase b16 0.884
Klk1b21 kallikrein 1-related peptidase b21 0.867
Klk1b9 kallikrein 1-related peptidase b9 0.779
Insr insulin receptor 0.716
Klk1b3 kallikrein 1-related peptidase b3 0.711
Klk1b24 kallikrein 1-related peptidase b24 0.703
Klk1b27 kallikrein 1-related peptidase b27 0.673
Dmd dystrophin, muscular dystrophy 0.600
Alox5ap arachidonate 5-lipoxygenase activating protein 0.582
Ptrf polymerase I and transcript release factor 0.508
Lmna lamin A 0.506
Ptgs2 prostaglandin-endoperoxide synthase 2 0.486
Fgf23 fibroblast growth factor 23 0.462
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.387
Pparg peroxisome proliferator activated receptor gamma 0.359
Plau plasminogen activator, urokinase 0.334
5430421N21Rik RIKEN cDNA 5430421N21 gene 0.332
Nos1 nitric oxide synthase 1, neuronal 0.326
Nos3 nitric oxide synthase 3, endothelial cell 0.315
Lep leptin 0.278
Egfbp2 epidermal growth factor binding protein type B 0.247
Klk1b4 kallikrein 1-related pepidase b4 0.247
Ccl2 chemokine (C-C motif) ligand 2 0.241
Oxt oxytocin 0.229
Cav1 caveolin 1, caveolae protein 0.202
Vdr vitamin D receptor 0.201
Art1 ADP-ribosyltransferase 1 0.179
Try5 trypsin 5 0.173
Hr hairless 0.151
Grb2 growth factor receptor bound protein 2 0.130
Pcdh12 protocadherin 12 0.124
Smr3a submaxillary gland androgen regulated protein 3A 0.122
Phldb2 pleckstrin homology-like domain, family B, member 2 0.117
Col4a3 collagen, type IV, alpha 3 0.116
Csf1 colony stimulating factor 1 (macrophage) 0.114
Orai1 ORAI calcium release-activated calcium modulator 1 0.114
Vegfa vascular endothelial growth factor A 0.110
Ptgs1 prostaglandin-endoperoxide synthase 1 0.109
Lrrk1 leucine-rich repeat kinase 1 0.103
Myoz1 myozenin 1 0.103
Ilk integrin linked kinase 0.099
Ptges prostaglandin E synthase 0.097
Egfr epidermal growth factor receptor 0.095
Kl klotho 0.091
Cuzd1 CUB and zona pellucida-like domains 1 0.088
Ctrb1 chymotrypsinogen B1 0.087
Snta1 syntrophin, acidic 1 0.087
Klk1b22 kallikrein 1-related peptidase b22 0.086
Gja1 gap junction protein, alpha 1 0.082
Aqp7 aquaporin 7 0.079
Ar androgen receptor 0.079
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.075
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.075
Egf epidermal growth factor 0.074
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.073
Plin1 perilipin 1 0.072
Ren1 renin 1 structural 0.072
Hck hemopoietic cell kinase 0.071
Tjp1 tight junction protein 1 0.069
Mas1 MAS1 oncogene 0.069
Ccr2 chemokine (C-C motif) receptor 2 0.069
Sypl2 synaptophysin-like 2 0.069
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.068
Tal2 T-cell acute lymphocytic leukemia 2 0.068
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.067
Pkd2 polycystic kidney disease 2 0.066
Stat3 signal transducer and activator of transcription 3 0.066
Dsc3 desmocollin 3 0.064
Adm adrenomedullin 0.064
Fam20c family with sequence similarity 20, member C 0.063
Dmbt1 deleted in malignant brain tumors 1 0.063
Sycn syncollin 0.062
Gab1 growth factor receptor bound protein 2-associated protein 1 0.062
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.062
Epyc epiphycan 0.062
Thbd thrombomodulin 0.061
Nos2 nitric oxide synthase 2, inducible 0.056
Expi extracellular proteinase inhibitor 0.056
Apoa4 apolipoprotein A-IV 0.056
Bdkrb2 bradykinin receptor, beta 2 0.055
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.055
Il1r1 interleukin 1 receptor, type I 0.055
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.054
Esrrg estrogen-related receptor gamma 0.054
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.054
Otp orthopedia homolog (Drosophila) 0.053
Dsg4 desmoglein 4 0.053
Fxyd2 FXYD domain-containing ion transport regulator 2 0.052
Alkbh1 alkB, alkylation repair homolog 1 (E. coli) 0.052
Psp parotid secretory protein 0.052
Adipoq adiponectin, C1Q and collagen domain containing 0.052
Tm4sf1 transmembrane 4 superfamily member 1 0.052
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TEK TEK tyrosine kinase, endothelial 1.000
FGB fibrinogen beta chain 0.998
FGA fibrinogen alpha chain 0.996
CAV2 caveolin 2 0.963
FGG fibrinogen gamma chain 0.956
COTL1 coactosin-like 1 (Dictyostelium) 0.942
CRP C-reactive protein, pentraxin-related 0.535
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.405
ANGPT2 angiopoietin 2 0.348
GRB7 growth factor receptor-bound protein 7 0.317
IGF1R insulin-like growth factor 1 receptor 0.290
PTEN phosphatase and tensin homolog 0.281
ANGPT1 angiopoietin 1 0.281
F2 coagulation factor II (thrombin) 0.242
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.216
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.215
PTPRF protein tyrosine phosphatase, receptor type, F 0.207
IL6 interleukin 6 (interferon, beta 2) 0.194
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.163
APOA1 apolipoprotein A-I 0.135
HCK hemopoietic cell kinase 0.124
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.117
PRKCDBP protein kinase C, delta binding protein 0.109
DLG4 discs, large homolog 4 (Drosophila) 0.104
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.091
LRP1 low density lipoprotein receptor-related protein 1 0.089
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.084
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.081
RPTOR regulatory associated protein of MTOR, complex 1 0.077
SDPR serum deprivation response 0.074
TXNRD1 thioredoxin reductase 1 0.069
PROCR protein C receptor, endothelial 0.068
CDH5 cadherin 5, type 2 (vascular endothelium) 0.066
ALB albumin 0.064
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.063
CARD11 caspase recruitment domain family, member 11 0.062
PTGIS prostaglandin I2 (prostacyclin) synthase 0.062
PEBP4 phosphatidylethanolamine-binding protein 4 0.062
PDPK1 3-phosphoinositide dependent protein kinase-1 0.061
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.059
IER3 immediate early response 3 0.058
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.057
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.057
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.055
CAV1 caveolin 1, caveolae protein, 22kDa 0.055
GAB2 GRB2-associated binding protein 2 0.055
MPEG1 macrophage expressed 1 0.052
IL8 interleukin 8 0.050
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.049
EFNA2 ephrin-A2 0.048
CD33 CD33 molecule 0.047
TAC1 tachykinin, precursor 1 0.046
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.046
EDNRB endothelin receptor type B 0.044
MYH11 myosin, heavy chain 11, smooth muscle 0.041
F2R coagulation factor II (thrombin) receptor 0.040
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.039
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.038
SYK spleen tyrosine kinase 0.038
AR androgen receptor 0.038
ABI2 abl-interactor 2 0.037
CXCL2 chemokine (C-X-C motif) ligand 2 0.037
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.037
AHSG alpha-2-HS-glycoprotein 0.036
THBD thrombomodulin 0.035
CXCL3 chemokine (C-X-C motif) ligand 3 0.034
HRG histidine-rich glycoprotein 0.034
NUMB numb homolog (Drosophila) 0.033
VNN1 vanin 1 0.033
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.032
EPS8 epidermal growth factor receptor pathway substrate 8 0.032
GRB2 growth factor receptor-bound protein 2 0.032
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.031
CLEC10A C-type lectin domain family 10, member A 0.031
MUC1 mucin 1, cell surface associated 0.030
IRS1 insulin receptor substrate 1 0.030
APP amyloid beta (A4) precursor protein 0.030
DCTN1 dynactin 1 0.030
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.030
IGSF6 immunoglobulin superfamily, member 6 0.030
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 0.030
RARA retinoic acid receptor, alpha 0.030
CXCR2 chemokine (C-X-C motif) receptor 2 0.030
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.029
NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) 0.029
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.028
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.028
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.028
ITGB5 integrin, beta 5 0.028
LPA lipoprotein, Lp(a) 0.028
DPT dermatopontin 0.028
NYX nyctalopin 0.027
LYL1 lymphoblastic leukemia derived sequence 1 0.027
LRP6 low density lipoprotein receptor-related protein 6 0.027
LTC4S leukotriene C4 synthase 0.027
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.027
F13B coagulation factor XIII, B polypeptide 0.027
OGN osteoglycin 0.027
CD93 CD93 molecule 0.026
FETUB fetuin B 0.026
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Rattus norvegicus
Name Description Probability Func Analog Organism
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.021
Il3 interleukin 3 0.018
LOC100362824 caveolin 2-like 0.017
Nrg1 neuregulin 1 0.015
Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.015
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.013
Fgf2 fibroblast growth factor 2 0.013
Olr1278 olfactory receptor 1278 0.013
Klk1c10l2 kallikrein 1-related peptidase c10-like 2 0.013
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.013
Grb2 growth factor receptor bound protein 2 0.012
Olr226 olfactory receptor 226 0.012
Pnlip pancreatic lipase 0.012
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.012
Gfi1 growth factor independent 1 transcription repressor 0.012
Il4 interleukin 4 0.012
Mag myelin-associated glycoprotein 0.012
Vom2r27 vomeronasal 2 receptor, 27 0.012
Pecam1 platelet/endothelial cell adhesion molecule 1 0.012
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.011
Zp1 zona pellucida glycoprotein 1 (sperm receptor) 0.011
Aqp6 aquaporin 6, kidney specific 0.011
Foxd3 forkhead box D3 0.011
Fev FEV (ETS oncogene family) 0.011
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.010
Smad3 SMAD family member 3 0.010
F9 coagulation factor IX 0.010
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.010
Syt8 synaptotagmin VIII 0.010
Mca32 mast cell antigen 32 0.010
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.010
Cd14 CD14 molecule 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism