The network for 'determination of heart left right asymmetry' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

determination of heart left right asymmetry

Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.

Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 0.997
hnf1ba HNF1 homeobox Ba 0.995
smo smoothened homolog (Drosophila) 0.981
cdh2 cadherin 2, neuronal 0.981
pkd2 polycystic kidney disease 2 0.977
tbx1 T-box 1 0.967
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.961
ndr2 nodal-related 2 0.956
gata3 GATA-binding protein 3 0.956
wnt11r wingless-type MMTV integration site family, member 11, related 0.954
flh floating head 0.940
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.937
lrrc6 leucine rich repeat containing 6 0.935
oep one-eyed pinhead 0.914
shha sonic hedgehog a 0.911
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.909
pcdh8 protocadherin 8 0.897
gata4 GATA-binding protein 4 0.890
ift88 intraflagellar transport 88 homolog 0.889
foxa2 forkhead box A2 0.882
foxi1 forkhead box I1 0.876
fzd10 frizzled homolog 10 0.872
gli2a GLI-Kruppel family member GLI2a 0.865
six4b sine oculis homeobox homolog 4b 0.862
wnt11 wingless-type MMTV integration site family, member 11 0.852
shhb sonic hedgehog b 0.851
tp53 tumor protein p53 0.835
dld deltaD 0.833
lft2 lefty2 0.831
fn1 fibronectin 1 0.823
bmp4 bone morphogenetic protein 4 0.819
ror2 receptor tyrosine kinase-like orphan receptor 2 0.814
bmp2a bone morphogenetic protein 2a 0.799
lft1 lefty1 0.784
tbx16 T-box gene 16 0.776
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.770
chd chordin 0.759
gata5 GATA-binding protein 5 0.757
smad9 MAD homolog 9 (Drosophila) 0.752
ptch2 patched 2 0.747
pitx2 paired-like homeodomain transcription factor 2 0.745
gpia glucose phosphate isomerase a 0.739
bmp2b bone morphogenetic protein 2b 0.738
tbx2b T-box 2b 0.718
spaw southpaw 0.701
snai1b snail homolog 1b (Drosophila) 0.696
spry4 sprouty (Drosophila) homolog 4 0.694
plekha7 pleckstrin homology domain containing, family A member 7 0.692
pdlim7 PDZ and LIM domain 7 0.686
etv5b ets variant 5b 0.684
rarab retinoic acid receptor, alpha b 0.674
ntla no tail a 0.662
irx1a iroquois homeobox protein 1, a 0.656
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.654
mespa mesoderm posterior a 0.649
cx27.5 connexin 27.5 0.633
tnni1b troponin I, skeletal, slow b 0.628
nkx2.5 NK2 transcription factor related 5 0.626
sox32 SRY-box containing gene 32 0.611
runx2b runt-related transcription factor 2b 0.606
ndr1 nodal-related 1 0.579
drl draculin 0.579
twist3 twist3 0.568
nkx1.2la NK1 transcription factor related 2-like,a 0.564
dmrt2a doublesex and mab-3 related transcription factor 2a 0.561
tbx20 T-box 20 0.561
prickle1a prickle-like 1 (Drosophila) a 0.547
lhx1a LIM homeobox 1a 0.544
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.536
ephb4b eph receptor B4b 0.531
rbm24a RNA binding motif protein 24a 0.518
sox11a SRY-box containing gene 11a 0.505
ttna titin a 0.504
LOC566708 FL cytokine receptor-like 0.503
cacnb4b calcium channel, voltage-dependent, beta 4b subunit 0.502
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.498
twist1a twist1a 0.496
wnt4a wingless-type MMTV integration site family, member 4a 0.488
vmhc ventricular myosin heavy chain 0.485
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.481
id1 inhibitor of DNA binding 1 0.478
myod1 myogenic differentiation 1 0.477
has2 hyaluronan synthase 2 0.471
lamb1a laminin, beta 1a 0.471
cdh5 cadherin 5 0.460
dkk1b dickkopf 1b 0.460
zgc:100838 zgc:100838 0.458
acvr1b activin A receptor, type IB 0.452
sox19b SRY-box containing gene 19b 0.443
tcf21 transcription factor 21 0.443
lmo4a LIM domain only 4a 0.441
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.440
dusp6 dual specificity phosphatase 6 0.438
tbx24 T-box 24 0.435
axin2 axin 2 (conductin, axil) 0.424
frzb frizzled-related protein 0.416
gbx2 gastrulation brain homeo box 2 0.415
tpm4 tropomyosin 4 0.411
lrrc50 leucine rich repeat containing 50 0.399
gro1 groucho 1 0.398
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.272
JAG1 jagged 1 0.189
TBX5 T-box 5 0.173
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.102
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.091
PBX1 pre-B-cell leukemia homeobox 1 0.080
FSTL1 follistatin-like 1 0.070
BMP2 bone morphogenetic protein 2 0.057
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.057
NOTCH3 notch 3 0.040
SMAD3 SMAD family member 3 0.040
GLI1 GLI family zinc finger 1 0.039
BBS2 Bardet-Biedl syndrome 2 0.037
TJP1 tight junction protein 1 (zona occludens 1) 0.036
GSK3B glycogen synthase kinase 3 beta 0.035
MARK3 MAP/microtubule affinity-regulating kinase 3 0.032
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.030
FZD1 frizzled homolog 1 (Drosophila) 0.028
SNX5 sorting nexin 5 0.028
FGF10 fibroblast growth factor 10 0.027
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.027
BMPR1A bone morphogenetic protein receptor, type IA 0.026
GATA4 GATA binding protein 4 0.024
SASS6 spindle assembly 6 homolog (C. elegans) 0.024
SP1 Sp1 transcription factor 0.022
FGF1 fibroblast growth factor 1 (acidic) 0.022
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.020
PTCH1 patched 1 0.020
LRP6 low density lipoprotein receptor-related protein 6 0.019
ACVR1 activin A receptor, type I 0.019
MKL1 megakaryoblastic leukemia (translocation) 1 0.018
MCM6 minichromosome maintenance complex component 6 0.016
NOTCH1 notch 1 0.016
BBS1 Bardet-Biedl syndrome 1 0.016
HIPK2 homeodomain interacting protein kinase 2 0.015
EPAS1 endothelial PAS domain protein 1 0.015
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.015
PKP4 plakophilin 4 0.014
TGFB1 transforming growth factor, beta 1 0.014
NCOR2 nuclear receptor corepressor 2 0.014
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.013
PRKG1 protein kinase, cGMP-dependent, type I 0.013
PSEN2 presenilin 2 (Alzheimer disease 4) 0.013
DSP desmoplakin 0.013
HMGA1 high mobility group AT-hook 1 0.012
BBS9 Bardet-Biedl syndrome 9 0.012
EP300 E1A binding protein p300 0.011
HDAC1 histone deacetylase 1 0.011
MYOCD myocardin 0.011
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.010
MEIS2 Meis homeobox 2 0.010
CANX calnexin 0.010
NONO non-POU domain containing, octamer-binding 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Pitx2 paired-like homeodomain transcription factor 2 1.000
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Nodal nodal 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Bmp4 bone morphogenetic protein 4 1.000
Fgf8 fibroblast growth factor 8 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Foxc1 forkhead box C1 1.000
Pax3 paired box gene 3 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.999
Tbx1 T-box 1 0.998
Vangl2 vang-like 2 (van gogh, Drosophila) 0.997
Pax2 paired box gene 2 0.996
Gli2 GLI-Kruppel family member GLI2 0.996
Fgfr1 fibroblast growth factor receptor 1 0.995
Tbx3 T-box 3 0.994
Meox2 mesenchyme homeobox 2 0.993
Invs inversin 0.991
Gata4 GATA binding protein 4 0.991
Hoxa13 homeobox A13 0.991
Prrx1 paired related homeobox 1 0.990
Foxh1 forkhead box H1 0.989
Notch1 Notch gene homolog 1 (Drosophila) 0.989
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.985
Zic3 zinc finger protein of the cerebellum 3 0.984
Hoxa1 homeobox A1 0.984
Foxc2 forkhead box C2 0.983
Hand2 heart and neural crest derivatives expressed transcript 2 0.981
Tcfap2a transcription factor AP-2, alpha 0.981
Hand1 heart and neural crest derivatives expressed transcript 1 0.977
Mks1 Meckel syndrome, type 1 0.962
Fgf10 fibroblast growth factor 10 0.961
Nog noggin 0.959
Sox2 SRY-box containing gene 2 0.957
Hoxd13 homeobox D13 0.945
Tgfb2 transforming growth factor, beta 2 0.941
Dnahc11 dynein, axonemal, heavy chain 11 0.938
Notch2 Notch gene homolog 2 (Drosophila) 0.936
Pax6 paired box gene 6 0.934
Lhx1 LIM homeobox protein 1 0.933
Psen1 presenilin 1 0.931
Jag1 jagged 1 0.929
Chd7 chromodomain helicase DNA binding protein 7 0.923
Smad6 MAD homolog 6 (Drosophila) 0.919
Isl1 ISL1 transcription factor, LIM/homeodomain 0.912
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.906
Nos3 nitric oxide synthase 3, endothelial cell 0.897
Pkd1 polycystic kidney disease 1 homolog 0.893
Cfc1 cripto, FRL-1, cryptic family 1 0.893
Rarg retinoic acid receptor, gamma 0.886
Gata6 GATA binding protein 6 0.884
Eya1 eyes absent 1 homolog (Drosophila) 0.876
Pitx1 paired-like homeodomain transcription factor 1 0.869
Vegfa vascular endothelial growth factor A 0.835
Smo smoothened homolog (Drosophila) 0.829
Tbx5 T-box 5 0.813
Hoxa10 homeobox A10 0.812
Mesp1 mesoderm posterior 1 0.794
Col2a1 collagen, type II, alpha 1 0.789
Ctnnb1 catenin (cadherin associated protein), beta 1 0.789
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.788
Gbx2 gastrulation brain homeobox 2 0.777
Ntf3 neurotrophin 3 0.763
Ift88 intraflagellar transport 88 homolog (Chlamydomonas) 0.733
Neurog2 neurogenin 2 0.730
Hes1 hairy and enhancer of split 1 (Drosophila) 0.713
Foxg1 forkhead box G1 0.707
Kif3a kinesin family member 3A 0.686
Pbx1 pre B-cell leukemia transcription factor 1 0.685
Wt1 Wilms tumor 1 homolog 0.672
Alx4 aristaless-like homeobox 4 0.664
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.661
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.658
Foxf1a forkhead box F1a 0.651
Rarb retinoic acid receptor, beta 0.644
Hoxd11 homeobox D11 0.634
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.632
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.626
Rxra retinoid X receptor alpha 0.625
Gsc goosecoid homeobox 0.623
Sox9 SRY-box containing gene 9 0.616
En1 engrailed 1 0.610
Hoxa5 homeobox A5 0.607
Wnt3a wingless-related MMTV integration site 3A 0.607
Acvr1 activin A receptor, type 1 0.600
Msx1 homeobox, msh-like 1 0.586
Apc adenomatosis polyposis coli 0.586
Pten phosphatase and tensin homolog 0.577
Hoxa11 homeobox A11 0.573
Sall4 sal-like 4 (Drosophila) 0.566
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.563
Wnt6 wingless-related MMTV integration site 6 0.554
Lmx1a LIM homeobox transcription factor 1 alpha 0.549
Foxj1 forkhead box J1 0.529
Hoxa2 homeobox A2 0.528
Sox7 SRY-box containing gene 7 0.520
Foxa2 forkhead box A2 0.500
Btbd17 BTB (POZ) domain containing 17 0.492
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.490
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism