The network for 'pancreas development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pancreas development

The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.

Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 0.994
hnf1ba HNF1 homeobox Ba 0.993
tbx1 T-box 1 0.987
hoxb8a homeo box B8a 0.983
mib mind bomb 0.968
pax2a paired box gene 2a 0.959
jag2 jagged 2 0.955
hoxa4a homeo box A4a 0.955
pax8 paired box gene 8 0.950
isl1 islet1 0.947
shha sonic hedgehog a 0.942
hoxb5b homeo box B5b 0.913
hoxc8a homeo box C8a 0.905
pax6b paired box gene 6b 0.905
hand2 heart and neural crest derivatives expressed transcript 2 0.904
foxa3 forkhead box A3 0.885
lhx1a LIM homeobox 1a 0.876
ptf1a pancreas specific transcription factor, 1a 0.856
tp53 tumor protein p53 0.851
hoxc4a homeo box C4a 0.840
fgfr2 fibroblast growth factor receptor 2 0.836
gdf6a growth differentiation factor 6a 0.834
hoxb5a homeo box B5a 0.797
wnt4a wingless-type MMTV integration site family, member 4a 0.786
foxa1 forkhead box A1 0.779
hhex hematopoietically expressed homeobox 0.778
hoxb6b homeo box B6b 0.774
sox9b SRY-box containing gene 9b 0.749
nkx2.2a NK2 transcription factor related 2a 0.729
hoxb3a homeo box B3a 0.705
sox1a SRY-box containing gene 1a 0.699
nkx6.2 NK6 transcription factor related, locus 2 0.699
dla deltaA 0.695
mnx1 motor neuron and pancreas homeobox 1 0.693
pdx1 pancreatic and duodenal homeobox 1 0.686
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.685
sfrp1a secreted frizzled-related protein 1a 0.685
flh floating head 0.669
tbx16 T-box gene 16 0.660
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.659
her5 hairy-related 5 0.651
eya1 eyes absent homolog 1 0.628
ahctf1 AT hook containing transcription factor 1 0.623
dbx1a developing brain homeobox 1a 0.622
hoxb1b homeo box B1b 0.613
sox2 SRY-box containing gene 2 0.613
hoxd4a homeo box D4a 0.612
gbx2 gastrulation brain homeo box 2 0.573
wif1 wnt inhibitory factor 1 0.552
neurod neurogenic differentiation 0.552
cdx4 caudal type homeo box transcription factor 4 0.552
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.526
gbx1 gastrulation brain homeobox 1 0.524
shhb sonic hedgehog b 0.522
notch2 notch homolog 2 0.520
mab21l2 mab-21-like 2 0.516
wnt11r wingless-type MMTV integration site family, member 11, related 0.514
six3b sine oculis homeobox homolog 3b 0.501
gro1 groucho 1 0.496
wnt2 wingless-type MMTV integration site family member 2 0.481
evx1 even-skipped homeobox 1 0.472
raraa retinoic acid receptor, alpha a 0.462
neurod4 neurogenic differentiation 4 0.452
tal1 T-cell acute lymphocytic leukemia 1 0.449
hlxb9la homeo box HB9 like a 0.443
foxa2 forkhead box A2 0.442
eng2a engrailed 2a 0.439
meis2.1 myeloid ecotropic viral integration site 2.1 0.426
atoh1b atonal homolog 1b 0.415
rarab retinoic acid receptor, alpha b 0.392
hmx3 homeo box (H6 family) 3 0.391
fezf2 FEZ family zinc finger 2 0.384
prox1 prospero-related homeobox gene 1 0.378
alcama activated leukocyte cell adhesion molecule a 0.371
fgfr1a fibroblast growth factor receptor 1a 0.370
isl2a islet2a 0.368
notch3 notch homolog 3 0.361
oep one-eyed pinhead 0.348
atoh1a atonal homolog 1a 0.346
otpb orthopedia homolog b 0.339
osr1 odd-skipped related 1 (Drosophila) 0.333
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.332
fgf4 fibroblast growth factor 4 0.323
pax4 paired box 4 0.316
olfm2 olfactomedin 2 0.310
eng2b engrailed 2b 0.307
hoxc6a homeo box C6a 0.299
gcga glucagon a and glucagon a-like 0.284
lef1 lymphocyte enhancer binding factor 1 0.282
dld deltaD 0.282
nanos3 nanos homolog 3 0.276
bactin2 bactin2 0.274
eve1 even-skipped-like1 0.273
spry2 sprouty homolog 2 0.272
fgf3 fibroblast growth factor 3 0.270
fgfr4 fibroblast growth factor receptor 4 0.270
metrn meteorin, glial cell differentiation regulator 0.270
tfap2a transcription factor AP-2 alpha 0.269
nkx2.3 NK2 transcription factor related 3 0.267
sec13 SEC13 homolog (S. cerevisiae) 0.267
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HNF4A hepatocyte nuclear factor 4, alpha 0.963
NOTCH3 notch 3 0.939
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.929
POU5F1 POU class 5 homeobox 1 0.760
BMPR1A bone morphogenetic protein receptor, type IA 0.681
BMPR1B bone morphogenetic protein receptor, type IB 0.345
FOXA2 forkhead box A2 0.302
SETD8 SET domain containing (lysine methyltransferase) 8 0.270
CDX2 caudal type homeobox 2 0.255
RUNX1 runt-related transcription factor 1 0.235
SOX1 SRY (sex determining region Y)-box 1 0.197
EGFR epidermal growth factor receptor 0.175
FOXF2 forkhead box F2 0.161
SMAD3 SMAD family member 3 0.157
IGF1R insulin-like growth factor 1 receptor 0.152
ONECUT1 one cut homeobox 1 0.147
BAX BCL2-associated X protein 0.143
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.139
FGF10 fibroblast growth factor 10 0.132
TAL1 T-cell acute lymphocytic leukemia 1 0.131
INSR insulin receptor 0.122
HNF1B HNF1 homeobox B 0.114
CD177 CD177 molecule 0.108
NOTCH2 notch 2 0.079
MYOD1 myogenic differentiation 1 0.075
GATA2 GATA binding protein 2 0.075
MNX1 motor neuron and pancreas homeobox 1 0.074
CCND1 cyclin D1 0.068
FGF1 fibroblast growth factor 1 (acidic) 0.067
PTCH1 patched 1 0.066
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.064
NOG noggin 0.059
CDK6 cyclin-dependent kinase 6 0.058
RBPMS RNA binding protein with multiple splicing 0.056
NKX6-1 NK6 homeobox 1 0.055
IL6R interleukin 6 receptor 0.054
PITX2 paired-like homeodomain 2 0.054
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.054
COL2A1 collagen, type II, alpha 1 0.053
IGF2R insulin-like growth factor 2 receptor 0.052
EEF2 eukaryotic translation elongation factor 2 0.051
ITGB1BP3 integrin beta 1 binding protein 3 0.051
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.051
FOXF1 forkhead box F1 0.050
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.050
PTF1A pancreas specific transcription factor, 1a 0.048
HOXD12 homeobox D12 0.047
HNF1A HNF1 homeobox A 0.046
NKX2-2 NK2 homeobox 2 0.046
CREBBP CREB binding protein 0.045
LHX5 LIM homeobox 5 0.045
CDT1 chromatin licensing and DNA replication factor 1 0.043
FEV FEV (ETS oncogene family) 0.043
SIM2 single-minded homolog 2 (Drosophila) 0.042
PDX1 pancreatic and duodenal homeobox 1 0.041
B9D2 B9 protein domain 2 0.040
CARD11 caspase recruitment domain family, member 11 0.040
PROX1 prospero homeobox 1 0.040
HDAC2 histone deacetylase 2 0.038
GATA4 GATA binding protein 4 0.037
SOX2 SRY (sex determining region Y)-box 2 0.036
IL6 interleukin 6 (interferon, beta 2) 0.036
HOXD11 homeobox D11 0.036
FOXL1 forkhead box L1 0.036
BOP1 block of proliferation 1 0.035
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.033
ZFYVE9 zinc finger, FYVE domain containing 9 0.033
RPL8 ribosomal protein L8 0.032
FGF3 fibroblast growth factor 3 0.031
HIC1 hypermethylated in cancer 1 0.030
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.030
NKX3-2 NK3 homeobox 2 0.030
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.030
GFI1B growth factor independent 1B transcription repressor 0.030
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.029
FZD10 frizzled homolog 10 (Drosophila) 0.029
GJD2 gap junction protein, delta 2, 36kDa 0.029
EN2 engrailed homeobox 2 0.028
HOXB9 homeobox B9 0.028
POU4F2 POU class 4 homeobox 2 0.028
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.028
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.027
KLF4 Kruppel-like factor 4 (gut) 0.027
MYT1 myelin transcription factor 1 0.027
FOXB1 forkhead box B1 0.026
HOXD13 homeobox D13 0.026
SMAD6 SMAD family member 6 0.026
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.026
AHR aryl hydrocarbon receptor 0.026
EN1 engrailed homeobox 1 0.026
ACAN aggrecan 0.025
PYY peptide YY 0.025
MARCKSL1 MARCKS-like 1 0.025
PCNA proliferating cell nuclear antigen 0.025
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.024
NOTCH1 notch 1 0.024
DLX4 distal-less homeobox 4 0.023
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.022
KDM1A lysine (K)-specific demethylase 1A 0.022
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.022
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.997
Fgfr2 fibroblast growth factor receptor 2 0.996
Otx2 orthodenticle homolog 2 (Drosophila) 0.993
Pax3 paired box gene 3 0.992
Gli3 GLI-Kruppel family member GLI3 0.990
Pitx2 paired-like homeodomain transcription factor 2 0.988
Pax6 paired box gene 6 0.983
Pax2 paired box gene 2 0.975
Neurod1 neurogenic differentiation 1 0.968
Onecut1 one cut domain, family member 1 0.963
Hes1 hairy and enhancer of split 1 (Drosophila) 0.950
Ptf1a pancreas specific transcription factor, 1a 0.948
Emx2 empty spiracles homolog 2 (Drosophila) 0.943
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.943
Fgf8 fibroblast growth factor 8 0.926
Fgf10 fibroblast growth factor 10 0.915
Foxc1 forkhead box C1 0.913
Pdx1 pancreatic and duodenal homeobox 1 0.913
Pten phosphatase and tensin homolog 0.912
Bmp4 bone morphogenetic protein 4 0.900
Hand2 heart and neural crest derivatives expressed transcript 2 0.889
Isl1 ISL1 transcription factor, LIM/homeodomain 0.885
Bglap bone gamma carboxyglutamate protein 0.866
Gata4 GATA binding protein 4 0.828
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.819
Foxg1 forkhead box G1 0.816
Fgfr1 fibroblast growth factor receptor 1 0.812
Lepr leptin receptor 0.799
Hand1 heart and neural crest derivatives expressed transcript 1 0.788
Pax8 paired box gene 8 0.786
Sox9 SRY-box containing gene 9 0.777
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.774
Lmx1a LIM homeobox transcription factor 1 alpha 0.767
Gli2 GLI-Kruppel family member GLI2 0.764
Nkx2-1 NK2 homeobox 1 0.757
Gsc goosecoid homeobox 0.708
Lhx3 LIM homeobox protein 3 0.677
Nodal nodal 0.670
Gbx2 gastrulation brain homeobox 2 0.667
Lhx1 LIM homeobox protein 1 0.660
Twist2 twist homolog 2 (Drosophila) 0.648
Sox4 SRY-box containing gene 4 0.605
En1 engrailed 1 0.572
Insm1 insulinoma-associated 1 0.556
Eya1 eyes absent 1 homolog (Drosophila) 0.537
Emx1 empty spiracles homolog 1 (Drosophila) 0.535
Tcfap2a transcription factor AP-2, alpha 0.530
Nog noggin 0.513
Smad6 MAD homolog 6 (Drosophila) 0.513
Sox2 SRY-box containing gene 2 0.510
Tbx1 T-box 1 0.500
Grb10 growth factor receptor bound protein 10 0.485
Sycn syncollin 0.475
Foxa2 forkhead box A2 0.465
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.449
Notch1 Notch gene homolog 1 (Drosophila) 0.444
Sim1 single-minded homolog 1 (Drosophila) 0.437
Sox3 SRY-box containing gene 3 0.416
Hes5 hairy and enhancer of split 5 (Drosophila) 0.416
Fgf15 fibroblast growth factor 15 0.411
Hoxd11 homeobox D11 0.396
Neurog3 neurogenin 3 0.395
Mesp1 mesoderm posterior 1 0.386
Hmx3 H6 homeobox 3 0.381
Uncx UNC homeobox 0.366
Foxf1a forkhead box F1a 0.361
Zeb1 zinc finger E-box binding homeobox 1 0.356
2210010C04Rik RIKEN cDNA 2210010C04 gene 0.353
Dll1 delta-like 1 (Drosophila) 0.351
Tbx3 T-box 3 0.347
T brachyury 0.346
Pitx1 paired-like homeodomain transcription factor 1 0.344
Kl klotho 0.323
Meox2 mesenchyme homeobox 2 0.311
Pou3f4 POU domain, class 3, transcription factor 4 0.306
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.305
Otp orthopedia homolog (Drosophila) 0.302
Smad3 MAD homolog 3 (Drosophila) 0.291
Kiss1 KiSS-1 metastasis-suppressor 0.284
Lmx1b LIM homeobox transcription factor 1 beta 0.281
Pou3f3 POU domain, class 3, transcription factor 3 0.281
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.268
Sox17 SRY-box containing gene 17 0.268
Chrd chordin 0.261
Hoxa11 homeobox A11 0.257
Sox7 SRY-box containing gene 7 0.247
Col1a1 collagen, type I, alpha 1 0.247
Bmp7 bone morphogenetic protein 7 0.242
Pitx3 paired-like homeodomain transcription factor 3 0.242
Foxd3 forkhead box D3 0.242
Neurog2 neurogenin 2 0.239
Zfpm2 zinc finger protein, multitype 2 0.238
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.237
Npas2 neuronal PAS domain protein 2 0.237
Wnt3a wingless-related MMTV integration site 3A 0.235
Foxd2 forkhead box D2 0.235
Nkx6-1 NK6 homeobox 1 0.227
Sox11 SRY-box containing gene 11 0.225
Pthlh parathyroid hormone-like peptide 0.225
Lhx5 LIM homeobox protein 5 0.221
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lgals3 lectin, galactoside-binding, soluble, 3 0.035
Vim vimentin 0.029
Foxa3 forkhead box A3 0.028
Cd36 CD36 molecule (thrombospondin receptor) 0.027
Anxa5 annexin A5 0.026
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.024
S100a11 S100 calcium binding protein A11 (calizzarin) 0.023
Fgfr2 fibroblast growth factor receptor 2 0.021
Arhgap23 Rho GTPase activating protein 23 0.021
Chia chitinase, acidic 0.020
Glra1 glycine receptor, alpha 1 0.019
S100a10 S100 calcium binding protein A10 0.018
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.017
Arpc1b actin related protein 2/3 complex, subunit 1B 0.017
Hes5 hairy and enhancer of split 5 (Drosophila) 0.016
Stc1 stanniocalcin 1 0.016
Uox urate oxidase 0.016
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.015
Ahsg alpha-2-HS-glycoprotein 0.015
Galr1 galanin receptor 1 0.014
Capn8 calpain 8 0.014
Gast gastrin 0.014
Anxa2 annexin A2 0.013
Prkar2a protein kinase, cAMP dependent regulatory, type II alpha 0.013
Pspn persephin 0.013
Cuzd1 CUB and zona pellucida-like domains 1 0.013
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.013
Nfasc neurofascin 0.013
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.013
Nfya nuclear transcription factor-Y alpha 0.013
Asgr1 asialoglycoprotein receptor 1 0.012
A1bg alpha-1-B glycoprotein 0.012
Mc5r melanocortin 5 receptor 0.011
RGD1562618 similar to RIKEN cDNA 6030419C18 gene 0.011
Gata6 GATA binding protein 6 0.011
Pnliprp2 pancreatic lipase-related protein 2 0.011
Insrr insulin receptor-related receptor 0.011
Tcfe2a transcription factor E2a 0.011
Clcn5 chloride channel 5 0.011
Clps colipase, pancreatic 0.011
Igfals insulin-like growth factor binding protein, acid labile subunit 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism