The network for 'regulation of signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of signaling

Any process that modulates the frequency, rate or extent of a signaling process.

Danio rerio
Name Description Probability Func Analog Organism
chd chordin 1.000
pkd2 polycystic kidney disease 2 0.988
fgf8a fibroblast growth factor 8 a 0.987
tbx1 T-box 1 0.986
pax2a paired box gene 2a 0.985
bmp2b bone morphogenetic protein 2b 0.971
lft1 lefty1 0.966
efnb2a ephrin B2a 0.948
shha sonic hedgehog a 0.941
dld deltaD 0.940
fras1 Fraser syndrome 1 0.939
brd4 bromodomain containing 4 0.931
bmp4 bone morphogenetic protein 4 0.922
flh floating head 0.919
rarab retinoic acid receptor, alpha b 0.903
gli2a GLI-Kruppel family member GLI2a 0.899
ntla no tail a 0.885
tfap2a transcription factor AP-2 alpha 0.882
fgf3 fibroblast growth factor 3 0.874
furina furin (paired basic amino acid cleaving enzyme) a 0.866
nrp2b neuropilin 2b 0.858
evx1 even-skipped homeobox 1 0.853
boc brother of CDO 0.849
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.839
dusp6 dual specificity phosphatase 6 0.830
ascl1a achaete-scute complex-like 1a (Drosophila) 0.824
eve1 even-skipped-like1 0.821
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.808
alcamb activated leukocyte cell adhesion molecule b 0.806
vent ventral expressed homeobox 0.805
pdgfaa platelet-derived growth factor alpha a 0.802
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.793
fbn2b fibrillin 2b 0.792
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.786
gli1 GLI-Kruppel family member 1 0.783
dkk1b dickkopf 1b 0.780
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.776
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.771
bmp2a bone morphogenetic protein 2a 0.768
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.767
sox2 SRY-box containing gene 2 0.756
frem3 Fras1 related extracellular matrix 3 0.746
foxa2 forkhead box A2 0.743
bdnf brain-derived neurotrophic factor 0.739
sox9b SRY-box containing gene 9b 0.734
gsc goosecoid 0.726
tal1 T-cell acute lymphocytic leukemia 1 0.719
ptpra protein tyrosine phosphatase, receptor type, A 0.717
otpa orthopedia homolog a 0.713
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.706
crabp2a cellular retinoic acid binding protein 2, a 0.706
bmp1a bone morphogenetic protein 1a 0.704
smad5 MAD homolog 5 (Drosophila) 0.697
bmp7a bone morphogenetic protein 7a 0.696
nadl1.2 neural adhesion molecule L1.2 0.696
rag1 recombination activating gene 1 0.694
gata5 GATA-binding protein 5 0.689
wnt5b wingless-type MMTV integration site family, member 5b 0.688
bcl2l1 bcl2-like 1 0.684
sox19a SRY-box containing gene 19a 0.683
cdh2 cadherin 2, neuronal 0.679
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.675
sox10 SRY-box containing gene 10 0.668
chsy1 chondroitin sulfate synthase 1 0.664
fzd5 frizzled homolog 5 0.662
wls wntless homolog (Drosophila) 0.645
bmper BMP binding endothelial regulator 0.645
twist1a twist1a 0.641
tbx20 T-box 20 0.640
hoxa13b homeo box A13b 0.631
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.627
irx3a iroquois homeobox protein 3a 0.627
ntn1b netrin 1b 0.609
vax1 ventral anterior homeobox 1 0.609
sulf2 sulfatase 2 0.606
flt4 fms-related tyrosine kinase 4 0.604
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.602
jag2 jagged 2 0.599
snai1a snail homolog 1a (Drosophila) 0.593
nrg2a neuregulin 2a 0.590
gli3 GLI-Kruppel family member GLI3 0.588
fn1 fibronectin 1 0.586
vasa vasa homolog 0.584
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.578
twist3 twist3 0.576
lhx1a LIM homeobox 1a 0.565
smo smoothened homolog (Drosophila) 0.561
ihha Indian hedgehog homolog a 0.560
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.556
aplnrb apelin receptor b 0.554
tp53bp2 tumor protein p53 binding protein, 2 0.552
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.550
runx2b runt-related transcription factor 2b 0.550
igf1rb insulin-like growth factor 1b receptor 0.543
hmx1 H6 homeo box 1 0.542
fgfr1b fibroblast growth factor receptor 1b 0.536
per3 period homolog 3 (Drosophila) 0.532
jun jun proto-oncogene 0.530
sox9a SRY-box containing gene 9a 0.529
mapk3 mitogen-activated protein kinase 3 0.523
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.957
egl-18 Protein EGL-18 0.919
pkg-1 Protein PKG-1 0.878
odr-3 Protein ODR-3 0.855
pry-1 Protein PRY-1 0.836
lag-1 Protein LAG-1 0.749
K10D6.4 Protein K10D6.4 0.736
sma-6 Protein SMA-6 0.717
eor-1 Protein EOR-1 0.713
wrm-1 Protein WRM-1 0.675
spc-1 Protein SPC-1 0.667
mig-5 Protein MIG-5 0.632
che-3 Protein CHE-3 0.626
eps-8 Protein EPS-8 0.623
plc-1 Protein PLC-1 0.620
goa-1 Protein GOA-1 0.617
pxf-1 Protein PXF-1 0.585
jnk-1 Protein JNK-1 0.557
ptr-14 Protein PTR-14 0.551
nhr-67 Protein NHR-67 0.551
let-60 Protein LET-60 0.549
itr-1 Protein ITR-1 0.540
par-5 Protein PAR-5 0.528
cam-1 Protein CAM-1 0.511
egl-15 Protein EGL-15 0.506
eef-1A.1 Protein EEF-1A.1 0.473
che-13 Protein CHE-13 0.472
che-2 Protein CHE-2 0.468
abl-1 Protein ABL-1 0.467
hlh-2 Protein HLH-2 0.467
soc-2 Protein SOC-2 0.458
itx-1 Protein ITX-1 0.456
sax-3 Protein SAX-3 0.454
magu-4 Protein MAGU-4 0.447
sax-7 Protein SAX-7 0.441
pha-4 Protein PHA-4 0.436
osm-5 Protein OSM-5 0.435
nhr-34 Protein NHR-34 0.432
unc-9 Protein UNC-9 0.416
unc-104 Protein UNC-104 0.413
npp-7 Protein NPP-7 0.403
dpy-22 Protein DPY-22 0.400
R151.8 Protein R151.8 0.398
unc-32 Protein UNC-32 0.397
pat-3 Protein PAT-3 0.396
nhr-6 Protein NHR-6 0.395
let-23 Protein LET-23 0.395
unc-62 Protein UNC-62 0.388
grk-2 Protein GRK-2 0.379
msp-76 Protein MSP-76 0.378
hmg-1.2 Protein HMG-1.2 0.377
R90.1 Protein R90.1 0.375
zyg-8 Protein ZYG-8 0.370
hgrs-1 Protein HGRS-1 0.368
egl-30 Protein EGL-30 0.365
lin-25 Protein LIN-25 0.363
daf-11 Protein DAF-11 0.360
sgt-1 Protein SGT-1 0.349
unc-40 Protein UNC-40 0.348
sem-5 Protein SEM-5 0.339
faah-1 Protein FAAH-1 0.334
akt-1 Protein AKT-1 0.332
pop-1 Protein POP-1 0.326
osm-6 Protein OSM-6 0.316
unc-79 Protein UNC-79 0.316
T27A3.1 Protein T27A3.1 0.315
egg-6 Protein EGG-6 0.315
stt-3 Protein STT-3 0.311
dpy-26 Protein DPY-26 0.308
unc-26 Protein UNC-26 0.306
ain-1 Protein AIN-1 0.297
vps-33.1 Protein VPS-33.1 0.296
alx-1 Protein ALX-1 0.295
dnj-12 Protein DNJ-12 0.293
let-19 Protein LET-19 0.285
C52E12.4 Protein C52E12.4 0.284
ceh-20 Protein CEH-20 0.283
daf-14 Protein DAF-14 0.283
unc-6 Protein UNC-6 0.282
hda-3 Protein HDA-3 0.280
egl-27 Protein EGL-27 0.280
sur-2 Protein SUR-2 0.277
dnc-2 Protein DNC-2 0.277
F28E10.1 Protein F28E10.1 0.277
ace-1 Protein ACE-1 0.276
gdi-1 Protein GDI-1 0.275
msp-40 Protein MSP-40 0.273
gpb-1 Protein GPB-1 0.268
mbk-1 Protein MBK-1 0.265
inx-8 Protein INX-8 0.263
ida-1 Protein IDA-1 0.262
nipi-3 Protein NIPI-3 0.261
unc-52 Protein UNC-52 0.259
let-607 Protein LET-607 0.258
csnk-1 Protein CSNK-1 0.258
bar-1 Protein BAR-1 0.256
daf-19 Protein DAF-19 0.256
crml-1 Protein CRML-1 0.253
cid-1 Protein CID-1 0.249
Y44E3A.6 Protein Y44E3A.6 0.249
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
BCK1 Bck1p 0.987
CLA4 Cla4p 0.950
FAR11 Far11p 0.695
STE50 Ste50p 0.605
KSS1 Kss1p 0.551
AKL1 Akl1p 0.530
ROM2 Rom2p 0.530
FAR1 Far1p 0.513
PBS2 Pbs2p 0.477
RRI1 Rri1p 0.463
PPH21 Pph21p 0.455
FUS3 Fus3p 0.447
MSN2 Msn2p 0.431
SLT2 Slt2p 0.429
VPS21 Vps21p 0.406
TPK1 Tpk1p 0.395
SSK2 Ssk2p 0.351
PIK1 Pik1p 0.341
VPS64 Vps64p 0.335
SHO1 Sho1p 0.334
TPK2 Tpk2p 0.319
VPS27 Vps27p 0.307
SPT16 Spt16p 0.304
SKP1 Skp1p 0.300
HSP60 Hsp60p 0.295
CDC34 Cdc34p 0.292
BCY1 Bcy1p 0.280
RHO1 Rho1p 0.279
ENA5 Ena5p 0.278
KOG1 Kog1p 0.271
LSP1 Lsp1p 0.265
PRB1 Prb1p 0.248
TPS1 Tps1p 0.247
BCK2 Bck2p 0.247
SLG1 Slg1p 0.242
MKT1 Mkt1p 0.241
MON1 Mon1p 0.239
CRZ1 Crz1p 0.236
HOG1 Hog1p 0.222
TSA2 Tsa2p 0.216
DUG2 Dug2p 0.210
SRO7 Sro7p 0.209
ERP4 Erp4p 0.206
RAS1 Ras1p 0.199
CDC53 Cdc53p 0.197
CCS1 Ccs1p 0.195
SEC4 Sec4p 0.195
VPS30 Vps30p 0.191
TIF6 Tif6p 0.190
DID4 Did4p 0.188
ICE2 Ice2p 0.184
YGL036W hypothetical protein 0.182
RTT106 Rtt106p 0.181
YPT1 Ypt1p 0.181
IRA1 Ira1p 0.177
STE2 Ste2p 0.177
BEM2 Bem2p 0.177
COP1 Cop1p 0.176
YAK1 Yak1p 0.176
GDI1 Gdi1p 0.175
GYL1 Gyl1p 0.175
SNF8 Snf8p 0.174
CDC25 Cdc25p 0.174
RLM1 Rlm1p 0.173
RUD3 Rud3p 0.170
OSH2 Osh2p 0.169
BET3 Bet3p 0.167
STE5 Ste5p 0.165
SSK22 Ssk22p 0.165
PTC1 Ptc1p 0.165
OLE1 Ole1p 0.165
SLM2 Slm2p 0.162
RIO2 Rio2p 0.161
INP52 Inp52p 0.158
STE18 Ste18p 0.157
YPT10 Ypt10p 0.154
SEC21 Sec21p 0.147
TRS65 Trs65p 0.143
RGD1 Rgd1p 0.143
VPS36 Vps36p 0.141
SIR4 Sir4p 0.140
CSI1 Csi1p 0.138
IZH4 Izh4p 0.136
PEX5 Pex5p 0.131
PMT5 Pmt5p 0.131
DID2 Did2p 0.131
YOL087C hypothetical protein 0.131
PEP5 Pep5p 0.128
LCB4 Lcb4p 0.128
PEX12 Pex12p 0.127
CMP2 Cmp2p 0.125
ATG11 Atg11p 0.124
PEX4 Pex4p 0.124
NBP2 Nbp2p 0.123
SUB2 Sub2p 0.123
SSK1 Ssk1p 0.123
PPE1 Ppe1p 0.122
FUM1 Fum1p 0.122
SEC2 Sec2p 0.121
PEX10 Pex10p 0.119