IMP

Process View

Homo sapiens

2 genes annotated in human

fc receptor signaling pathway

A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fc receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "fc receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
SYK	spleen tyrosine kinase	0.994
VEGFA	vascular endothelial growth factor A	0.981
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.940
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.904	Human
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.769
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.724
PLCG1	phospholipase C, gamma 1	0.622
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.436
LAT	linker for activation of T cells	0.434
SLA	Src-like-adaptor	0.326
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.325
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.238	Mouse
PDGFA	platelet-derived growth factor alpha polypeptide	0.176
EGFR	epidermal growth factor receptor	0.167
TFF1	trefoil factor 1	0.160
NRP1	neuropilin 1	0.160
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.158
PDGFC	platelet derived growth factor C	0.143
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.135
CDH5	cadherin 5, type 2 (vascular endothelium)	0.128
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.128
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.121
FGFR1	fibroblast growth factor receptor 1	0.115
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.095
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.094
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.089
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.073
BCAR1	breast cancer anti-estrogen resistance 1	0.070
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.068
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.065	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.064	Human
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.062	Human
FYN	FYN oncogene related to SRC, FGR, YES	0.062
CD33	CD33 molecule	0.060
UBASH3B	ubiquitin associated and SH3 domain containing B	0.058
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.055
CAV1	caveolin 1, caveolae protein, 22kDa	0.053
PGF	placental growth factor	0.051
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.047
LST1	leukocyte specific transcript 1	0.044
FYB	FYN binding protein	0.038
SOS1	son of sevenless homolog 1 (Drosophila)	0.037
GAB1	GRB2-associated binding protein 1	0.036
INSR	insulin receptor	0.034
TYROBP	TYRO protein tyrosine kinase binding protein	0.034
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.032	Mouse Rat
CD163	CD163 molecule	0.031
AIF1	allograft inflammatory factor 1	0.031
KITLG	KIT ligand	0.030
HK3	hexokinase 3 (white cell)	0.029
PECAM1	platelet/endothelial cell adhesion molecule	0.029
GRB7	growth factor receptor-bound protein 7	0.029
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.029
VAV1	vav 1 guanine nucleotide exchange factor	0.029
LCK	lymphocyte-specific protein tyrosine kinase	0.028
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.025
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.025
RNASE6	ribonuclease, RNase A family, k6	0.024
BLNK	B-cell linker	0.022
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.022
LY86	lymphocyte antigen 86	0.021
PTEN	phosphatase and tensin homolog	0.020
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.020
CPA3	carboxypeptidase A3 (mast cell)	0.020
FLT4	fms-related tyrosine kinase 4	0.019	Human
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.018
SOS2	son of sevenless homolog 2 (Drosophila)	0.018
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.018
CD93	CD93 molecule	0.018
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.018
GAB2	GRB2-associated binding protein 2	0.018
PLEK	pleckstrin	0.017
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.017
SH3BP2	SH3-domain binding protein 2	0.016
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.016
MPEG1	macrophage expressed 1	0.016
CD37	CD37 molecule	0.016
VSIG4	V-set and immunoglobulin domain containing 4	0.015
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.015
CYTH4	cytohesin 4	0.015
PILRA	paired immunoglobin-like type 2 receptor alpha	0.015
NCKAP1L	NCK-associated protein 1-like	0.014
TFRC	transferrin receptor (p90, CD71)	0.014
LDLR	low density lipoprotein receptor	0.014
CYBB	cytochrome b-245, beta polypeptide	0.014
CCR1	chemokine (C-C motif) receptor 1	0.014
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.014
ARHGAP32	Rho GTPase activating protein 32	0.014
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.013
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.013
SASH3	SAM and SH3 domain containing 3	0.013
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.013
PRKCQ	protein kinase C, theta	0.013
TBXAS1	thromboxane A synthase 1 (platelet)	0.013
F13A1	coagulation factor XIII, A1 polypeptide	0.013
CSF1R	colony stimulating factor 1 receptor	0.013	Human
SIRPB1	signal-regulatory protein beta 1	0.013
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.013
CD53	CD53 molecule	0.012
BIN2	bridging integrator 2	0.012
BTK	Bruton agammaglobulinemia tyrosine kinase	0.012
CMIP	c-Maf-inducing protein	0.012
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.012
PARVG	parvin, gamma	0.012
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.012
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.012
HCK	hemopoietic cell kinase	0.011
EPOR	erythropoietin receptor	0.011
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.011
CD68	CD68 molecule	0.011
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.011
IGSF6	immunoglobulin superfamily, member 6	0.011
LRRC25	leucine rich repeat containing 25	0.011
FPR1	formyl peptide receptor 1	0.011
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.011
STAB1	stabilin 1	0.011
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.011
HSPG2	heparan sulfate proteoglycan 2	0.011
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.010
CCR2	chemokine (C-C motif) receptor 2	0.010
IL4R	interleukin 4 receptor	0.010
CD300LF	CD300 molecule-like family member f	0.010	Human
CD22	CD22 molecule	0.010
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.010