IMP

Process View

Homo sapiens

18 genes annotated in human

negative regulation of chromosome segregation

GO:0051985

Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of chromosome segregation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of chromosome segregation" (in gray)

Name	Description	Probability	Func Analog Organism
CDK2	cyclin-dependent kinase 2	0.925	Yeast
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.821	Fly
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.531	Yeast
CCNA2	cyclin A2	0.494
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.410
ANAPC4	anaphase promoting complex subunit 4	0.356
CCNB1	cyclin B1	0.311
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.292
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.247
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.239
ZWINT	ZW10 interactor	0.229
BRCA2	breast cancer 2, early onset	0.210
SMC3	structural maintenance of chromosomes 3	0.207
CASC5	cancer susceptibility candidate 5	0.187
STAG2	stromal antigen 2	0.171
RAD21	RAD21 homolog (S. pombe)	0.111
CCNE1	cyclin E1	0.102	Fly
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.094
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.087
STAG1	stromal antigen 1	0.085
SKP2	S-phase kinase-associated protein 2 (p45)	0.077
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.075
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.071	Worm Fly
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.069
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.058	Fly
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.044
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.044
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.042
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.041
CBX5	chromobox homolog 5	0.041
SKA1	spindle and kinetochore associated complex subunit 1	0.037
CDK1	cyclin-dependent kinase 1	0.036	Yeast
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.034
C13orf34	chromosome 13 open reading frame 34	0.033
PLK1	polo-like kinase 1	0.031
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.030
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.028
SKA2	spindle and kinetochore associated complex subunit 2	0.027
ZNF207	zinc finger protein 207	0.026
SKA3	spindle and kinetochore associated complex subunit 3	0.025
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.023
CDKN3	cyclin-dependent kinase inhibitor 3	0.023
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.022
ATMIN	ATM interactor	0.022
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.021
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.020
FXR2	fragile X mental retardation, autosomal homolog 2	0.019
KIF18A	kinesin family member 18A	0.019
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.018	Yeast
CCNB2	cyclin B2	0.018
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.017
STRN3	striatin, calmodulin binding protein 3	0.017
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.017
HERC2	hect domain and RLD 2	0.016
SMC1A	structural maintenance of chromosomes 1A	0.016
TCP1	t-complex 1	0.015
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.015
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.015
ANAPC11	anaphase promoting complex subunit 11	0.014
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.014
MYST1	MYST histone acetyltransferase 1	0.014
PRNP	prion protein	0.014
KIF14	kinesin family member 14	0.014
LBR	lamin B receptor	0.014
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.014
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.013
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.013
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.013
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.013
PARP3	poly (ADP-ribose) polymerase family, member 3	0.013
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.013
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.013
RFWD2	ring finger and WD repeat domain 2	0.013
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.012
APC	adenomatous polyposis coli	0.012
TP53BP1	tumor protein p53 binding protein 1	0.012
SMC4	structural maintenance of chromosomes 4	0.012
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.012
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.012
KIF5B	kinesin family member 5B	0.012
HIST1H4A	histone cluster 1, H4a	0.012
TTK	TTK protein kinase	0.011	Yeast
BTRC	beta-transducin repeat containing	0.011
ANKRD52	ankyrin repeat domain 52	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
SGOL2	shugoshin-like 2 (S. pombe)	0.011
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.011
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.011
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.011
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.011
EP300	E1A binding protein p300	0.011
MAD2L1BP	MAD2L1 binding protein	0.011
C19orf39	chromosome 19 open reading frame 39	0.011
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.011
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.011
ATM	ataxia telangiectasia mutated	0.011
CCDC99	coiled-coil domain containing 99	0.010
USP49	ubiquitin specific peptidase 49	0.010	Human
CENPE	centromere protein E, 312kDa	0.010	Mouse
ZFR	zinc finger RNA binding protein	0.010
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.010
USP44	ubiquitin specific peptidase 44	0.010