IMP

Process View

Homo sapiens

3 genes annotated in human

response to peptidoglycan

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to peptidoglycan"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to peptidoglycan" (in gray)

Name	Description	Probability	Func Analog Organism
MYD88	myeloid differentiation primary response gene (88)	0.997	Mouse
IRAK2	interleukin-1 receptor-associated kinase 2	0.994
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.993
IRAK1	interleukin-1 receptor-associated kinase 1	0.944	Mouse
BIRC3	baculoviral IAP repeat containing 3	0.920
IRF7	interferon regulatory factor 7	0.879
TRAF6	TNF receptor-associated factor 6	0.786
STAT2	signal transducer and activator of transcription 2, 113kDa	0.764
PELI3	pellino homolog 3 (Drosophila)	0.706
ZC3H12A	zinc finger CCCH-type containing 12A	0.622
IRAK3	interleukin-1 receptor-associated kinase 3	0.611	Mouse
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.482
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.342
TLR2	toll-like receptor 2	0.283
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.213
CD14	CD14 molecule	0.206
BIRC2	baculoviral IAP repeat containing 2	0.201
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.198
RIPK2	receptor-interacting serine-threonine kinase 2	0.170	Mouse
IL8	interleukin 8	0.147
IRF1	interferon regulatory factor 1	0.125	Human
MAVS	mitochondrial antiviral signaling protein	0.110
IL6R	interleukin 6 receptor	0.107
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.094
CHN2	chimerin (chimaerin) 2	0.089
TLR4	toll-like receptor 4	0.085
TRIM21	tripartite motif containing 21	0.083
SIAH2	seven in absentia homolog 2 (Drosophila)	0.081
NLRC4	NLR family, CARD domain containing 4	0.080
SOD2	superoxide dismutase 2, mitochondrial	0.079
CXCL2	chemokine (C-X-C motif) ligand 2	0.077
SH3RF3	SH3 domain containing ring finger 3	0.072	Fly
NOD1	nucleotide-binding oligomerization domain containing 1	0.067
NOD2	nucleotide-binding oligomerization domain containing 2	0.064
IRAK4	interleukin-1 receptor-associated kinase 4	0.063
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.060
STAP2	signal transducing adaptor family member 2	0.057
PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	0.056
ZNFX1	zinc finger, NFX1-type containing 1	0.056
CXCL3	chemokine (C-X-C motif) ligand 3	0.052
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.051
IL1B	interleukin 1, beta	0.050
NCKAP1	NCK-associated protein 1	0.050
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.046
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.042
TRAF3	TNF receptor-associated factor 3	0.039
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.038
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.037
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.037
ICAM1	intercellular adhesion molecule 1	0.036
STAT1	signal transducer and activator of transcription 1, 91kDa	0.036
TRIM22	tripartite motif containing 22	0.036
OCRL	oculocerebrorenal syndrome of Lowe	0.036
SH3RF1	SH3 domain containing ring finger 1	0.033	Fly
IRF8	interferon regulatory factor 8	0.033	Human
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.032
FHOD1	formin homology 2 domain containing 1	0.032
ADAR	adenosine deaminase, RNA-specific	0.031
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.031
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.030
NCF2	neutrophil cytosolic factor 2	0.030
IFI35	interferon-induced protein 35	0.027
ISG20	interferon stimulated exonuclease gene 20kDa	0.027
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.027
SPOP	speckle-type POZ protein	0.027
CCL20	chemokine (C-C motif) ligand 20	0.026
ANG	angiogenin, ribonuclease, RNase A family, 5	0.025
PYDC2	pyrin domain containing 2	0.024
TMEM173	transmembrane protein 173	0.022
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.022
IRF2	interferon regulatory factor 2	0.022
BCL3	B-cell CLL/lymphoma 3	0.021
CD40	CD40 molecule, TNF receptor superfamily member 5	0.021
PYCARD	PYD and CARD domain containing	0.021
ZC3H12C	zinc finger CCCH-type containing 12C	0.021
IL15RA	interleukin 15 receptor, alpha	0.020
DTX3L	deltex 3-like (Drosophila)	0.020
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.020
TOLLIP	toll interacting protein	0.020
ELF4	E74-like factor 4 (ets domain transcription factor)	0.019
HLA-B	major histocompatibility complex, class I, B	0.018
PELI1	pellino homolog 1 (Drosophila)	0.018
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.018
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.018
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.017
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.017
ARHGAP15	Rho GTPase activating protein 15	0.017
BCL2A1	BCL2-related protein A1	0.016
HCK	hemopoietic cell kinase	0.016
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.016
CD83	CD83 molecule	0.016
CCL4	chemokine (C-C motif) ligand 4	0.016
TYMP	thymidine phosphorylase	0.016
ARFIP2	ADP-ribosylation factor interacting protein 2	0.016
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.016
DOCK8	dedicator of cytokinesis 8	0.016
IL1R1	interleukin 1 receptor, type I	0.015
STX11	syntaxin 11	0.015
TNIP2	TNFAIP3 interacting protein 2	0.015
TLR5	toll-like receptor 5	0.015
TREM1	triggering receptor expressed on myeloid cells 1	0.015
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.015
PML	promyelocytic leukemia	0.015
CD93	CD93 molecule	0.014
TRAFD1	TRAF-type zinc finger domain containing 1	0.014
DOCK1	dedicator of cytokinesis 1	0.014
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.014
IL15	interleukin 15	0.013
PTX3	pentraxin 3, long	0.013
UNKL	unkempt homolog (Drosophila)-like	0.013
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.013
HRH1	histamine receptor H1	0.013
APOL6	apolipoprotein L, 6	0.013
PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	0.013
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.013
C19orf66	chromosome 19 open reading frame 66	0.013
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.013
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.013
PELI2	pellino homolog 2 (Drosophila)	0.013
CCL2	chemokine (C-C motif) ligand 2	0.012
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.012
IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	0.012
SQSTM1	sequestosome 1	0.012
PARP12	poly (ADP-ribose) polymerase family, member 12	0.012
GBP1	guanylate binding protein 1, interferon-inducible	0.012
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.012
TRIM14	tripartite motif containing 14	0.012
GPR84	G protein-coupled receptor 84	0.012
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.012
WARS	tryptophanyl-tRNA synthetase	0.011
AQP9	aquaporin 9	0.011
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.011
FPR2	formyl peptide receptor 2	0.011
XIAP	X-linked inhibitor of apoptosis	0.011
PRDM1	PR domain containing 1, with ZNF domain	0.011
TP53BP1	tumor protein p53 binding protein 1	0.011
IRF9	interferon regulatory factor 9	0.011	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.011
DOCK2	dedicator of cytokinesis 2	0.011
KIF2B	kinesin family member 2B	0.010
SYNJ2	synaptojanin 2	0.010
MEFV	Mediterranean fever	0.010
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.010
RNF19B	ring finger protein 19B	0.010
CXCL10	chemokine (C-X-C motif) ligand 10	0.010
TNIP1	TNFAIP3 interacting protein 1	0.010
ARL2BP	ADP-ribosylation factor-like 2 binding protein	0.010
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.010
HLA-E	major histocompatibility complex, class I, E	0.010