IMP

Process View

Homo sapiens

4 genes annotated in human

Multi-species View

negative regulation of jak stat cascade

GO:0046426

Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of jak stat cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of jak stat cascade" (in gray)

Name	Description	Probability	Func Analog Organism
GHR	growth hormone receptor	0.986
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.857	Human
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.856
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.819
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.709
SOCS2	suppressor of cytokine signaling 2	0.502	Mouse
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.501
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.484
PTPRB	protein tyrosine phosphatase, receptor type, B	0.440
CD44	CD44 molecule (Indian blood group)	0.400
CAV2	caveolin 2	0.385
JAK2	Janus kinase 2	0.283
EZR	ezrin	0.264	Human
PTEN	phosphatase and tensin homolog	0.216
SCHIP1	schwannomin interacting protein 1	0.193
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.146
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.136
EPOR	erythropoietin receptor	0.131
TBC1D10A	TBC1 domain family, member 10A	0.126
SOCS1	suppressor of cytokine signaling 1	0.104	Zebrafish Mouse
RHOA	ras homolog gene family, member A	0.099
EGFR	epidermal growth factor receptor	0.092
PROX1	prospero homeobox 1	0.079
PLCG1	phospholipase C, gamma 1	0.078
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.075
STAT5A	signal transducer and activator of transcription 5A	0.074
CUL2	cullin 2	0.074
APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	0.071
COMMD1	copper metabolism (Murr1) domain containing 1	0.067
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.066
PTPRF	protein tyrosine phosphatase, receptor type, F	0.055
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.050
F2R	coagulation factor II (thrombin) receptor	0.047
IRS1	insulin receptor substrate 1	0.047
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.045
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.043
RNF11	ring finger protein 11	0.039
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.039
SOCS3	suppressor of cytokine signaling 3	0.036
IGF1R	insulin-like growth factor 1 receptor	0.036
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.035
GRB10	growth factor receptor-bound protein 10	0.034
MSN	moesin	0.034	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.033
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.032
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.031
CUL5	cullin 5	0.028
PRKCDBP	protein kinase C, delta binding protein	0.028
BAK1	BCL2-antagonist/killer 1	0.028
MED28	mediator complex subunit 28	0.025
EIF1B	eukaryotic translation initiation factor 1B	0.025
STAMBP	STAM binding protein	0.025
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.024
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.023
FEM1B	fem-1 homolog b (C. elegans)	0.023
GRB2	growth factor receptor-bound protein 2	0.023
STAT5B	signal transducer and activator of transcription 5B	0.022
BCR	breakpoint cluster region	0.022
ZYX	zyxin	0.022
TXNRD1	thioredoxin reductase 1	0.021
ESRRG	estrogen-related receptor gamma	0.021
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.021
KDM5A	lysine (K)-specific demethylase 5A	0.021
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.020
PTK2	PTK2 protein tyrosine kinase 2	0.019
INSR	insulin receptor	0.019
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.019
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.019
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.019
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.018
CLIC4	chloride intracellular channel 4	0.018
TSG101	tumor susceptibility gene 101	0.018
LAT	linker for activation of T cells	0.017
CD59	CD59 molecule, complement regulatory protein	0.017
GRB7	growth factor receptor-bound protein 7	0.017
ADRB2	adrenergic, beta-2-, receptor, surface	0.017
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.017
SOCS4	suppressor of cytokine signaling 4	0.016	Fly
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.016
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.016
SDPR	serum deprivation response	0.016
PPARG	peroxisome proliferator-activated receptor gamma	0.016
ITGA1	integrin, alpha 1	0.016
GJA1	gap junction protein, alpha 1, 43kDa	0.015
BCAR1	breast cancer anti-estrogen resistance 1	0.015
ITM2B	integral membrane protein 2B	0.015
ZYG11B	zyg-11 homolog B (C. elegans)	0.015
NF2	neurofibromin 2 (merlin)	0.014
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.014
SERINC3	serine incorporator 3	0.014
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.014
NSF	N-ethylmaleimide-sensitive factor	0.014
INTS5	integrator complex subunit 5	0.014
HELZ	helicase with zinc finger	0.014
ZNF652	zinc finger protein 652	0.013
YPEL5	yippee-like 5 (Drosophila)	0.013
ZNF148	zinc finger protein 148	0.013
CISH	cytokine inducible SH2-containing protein	0.013
LAMP2	lysosomal-associated membrane protein 2	0.013
NEK7	NIMA (never in mitosis gene a)-related kinase 7	0.013
PDGFC	platelet derived growth factor C	0.013
JUP	junction plakoglobin	0.013
GAB1	GRB2-associated binding protein 1	0.013
ANXA5	annexin A5	0.012
CAPN1	calpain 1, (mu/I) large subunit	0.012
TOM1L1	target of myb1 (chicken)-like 1	0.012
AHNAK	AHNAK nucleoprotein	0.012
ACVR1	activin A receptor, type I	0.012
GNG10	guanine nucleotide binding protein (G protein), gamma 10	0.012
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.012
PROCR	protein C receptor, endothelial	0.012
DUSP7	dual specificity phosphatase 7	0.012
SCARB2	scavenger receptor class B, member 2	0.012
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.011
JAK1	Janus kinase 1	0.011
BLZF1	basic leucine zipper nuclear factor 1	0.011
VEZF1	vascular endothelial zinc finger 1	0.011
HNF1A	HNF1 homeobox A	0.011
PIAS3	protein inhibitor of activated STAT, 3	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.011
ZNF638	zinc finger protein 638	0.011
EDNRB	endothelin receptor type B	0.011
PRRC2C	proline-rich coiled-coil 2C	0.010
PDLIM1	PDZ and LIM domain 1	0.010
ANXA1	annexin A1	0.010
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.010
IQGAP1	IQ motif containing GTPase activating protein 1	0.010
ACTN4	actinin, alpha 4	0.010
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.010
TNRC6B	trinucleotide repeat containing 6B	0.010