IMP

Process View

Homo sapiens

17 genes annotated in human

protein kinase c signaling

A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein kinase c signaling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein kinase c signaling" (in gray)

Name	Description	Probability	Func Analog Organism
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.985	Human
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.920	Human
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.911	Human
NRP1	neuropilin 1	0.817
TRAF1	TNF receptor-associated factor 1	0.779
VEGFA	vascular endothelial growth factor A	0.744
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.565	Human
PGF	placental growth factor	0.444	Human
ARHGAP1	Rho GTPase activating protein 1	0.361
MPDZ	multiple PDZ domain protein	0.339
ABI2	abl-interactor 2	0.322
TRAF5	TNF receptor-associated factor 5	0.313
DLG1	discs, large homolog 1 (Drosophila)	0.313
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.257
CD40	CD40 molecule, TNF receptor superfamily member 5	0.207
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.180
PDGFC	platelet derived growth factor C	0.165
PDGFA	platelet-derived growth factor alpha polypeptide	0.120	Human
CHDH	choline dehydrogenase	0.108
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.105
CDH5	cadherin 5, type 2 (vascular endothelium)	0.104
TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.097
CAV1	caveolin 1, caveolae protein, 22kDa	0.073
TRAF2	TNF receptor-associated factor 2	0.073
PTPRB	protein tyrosine phosphatase, receptor type, B	0.068
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.066
EZR	ezrin	0.060
BCAR1	breast cancer anti-estrogen resistance 1	0.055
TRAF3	TNF receptor-associated factor 3	0.054
RHOA	ras homolog gene family, member A	0.050	Yeast
ARRB1	arrestin, beta 1	0.050
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.046	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.046
LAT	linker for activation of T cells	0.040
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.037
SNX33	sorting nexin 33	0.034
PTEN	phosphatase and tensin homolog	0.031
TRADD	TNFRSF1A-associated via death domain	0.029
SCRIB	scribbled homolog (Drosophila)	0.028
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.027
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.027
VHL	von Hippel-Lindau tumor suppressor	0.026
PLCG1	phospholipase C, gamma 1	0.025
STC2	stanniocalcin 2	0.025
TNF	tumor necrosis factor	0.024
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.024
USP46	ubiquitin specific peptidase 46	0.024
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.023
KITLG	KIT ligand	0.022
ZMYND11	zinc finger, MYND-type containing 11	0.022
LDLR	low density lipoprotein receptor	0.021
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.021
FGF18	fibroblast growth factor 18	0.019
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.019
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.019
SLA	Src-like-adaptor	0.019
PTPRA	protein tyrosine phosphatase, receptor type, A	0.018
LBX1	ladybird homeobox 1	0.018
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.018
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.018
ARRB2	arrestin, beta 2	0.017
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.017
RHOC	ras homolog gene family, member C	0.016	Yeast
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.016
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.016
IGFBP3	insulin-like growth factor binding protein 3	0.015
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.015
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.015
MSN	moesin	0.015
WNT2	wingless-type MMTV integration site family member 2	0.014	Human
ZBTB48	zinc finger and BTB domain containing 48	0.014
AKAP10	A kinase (PRKA) anchor protein 10	0.014
FZD1	frizzled homolog 1 (Drosophila)	0.014
SPRR2A	small proline-rich protein 2A	0.014
FGFR1	fibroblast growth factor receptor 1	0.013
INSR	insulin receptor	0.013
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.013
NUMB	numb homolog (Drosophila)	0.013
IHH	Indian hedgehog	0.012
PECAM1	platelet/endothelial cell adhesion molecule	0.012
TIFA	TRAF-interacting protein with forkhead-associated domain	0.012
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.012
ARRDC3	arrestin domain containing 3	0.012
TBC1D10A	TBC1 domain family, member 10A	0.012
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.012
COL6A1	collagen, type VI, alpha 1	0.012
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.012
EGFR	epidermal growth factor receptor	0.012
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.012	Human
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.011
FLT4	fms-related tyrosine kinase 4	0.011
AXL	AXL receptor tyrosine kinase	0.011
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.011
RHOG	ras homolog gene family, member G (rho G)	0.011
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.011
ZFAND5	zinc finger, AN1-type domain 5	0.010
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.010
SNAP23	synaptosomal-associated protein, 23kDa	0.010
BMP8A	bone morphogenetic protein 8a	0.010
COL2A1	collagen, type II, alpha 1	0.010
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.010
SH3PXD2A	SH3 and PX domains 2A	0.010
JUP	junction plakoglobin	0.010
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.010