IMP

Process View

Homo sapiens

26 genes annotated in human

regulation of type i interferon production

Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of type i interferon production"

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Name	Description	Probability	Func Analog Organism
IRAK1	interleukin-1 receptor-associated kinase 1	0.973
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.904
MYD88	myeloid differentiation primary response gene (88)	0.805
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.695
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.650
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.600	Human
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.509	Human
SP110	SP110 nuclear body protein	0.494
PILRA	paired immunoglobin-like type 2 receptor alpha	0.454
TRIM21	tripartite motif containing 21	0.432	Human
STAT1	signal transducer and activator of transcription 1, 91kDa	0.389
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.324
IRF1	interferon regulatory factor 1	0.322
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.313	Human
TBK1	TANK-binding kinase 1	0.280
CYLD	cylindromatosis (turban tumor syndrome)	0.279
CHUK	conserved helix-loop-helix ubiquitous kinase	0.224	Human
TICAM2	toll-like receptor adaptor molecule 2	0.213
PIAS4	protein inhibitor of activated STAT, 4	0.202
STAT2	signal transducer and activator of transcription 2, 113kDa	0.183
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.179	Human
RANBP3	RAN binding protein 3	0.137
IRF3	interferon regulatory factor 3	0.137	Human Mouse
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.132	Human
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.129
IRF7	interferon regulatory factor 7	0.120
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.116
BIRC3	baculoviral IAP repeat containing 3	0.107
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.097
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.092
MAVS	mitochondrial antiviral signaling protein	0.068
NLRC5	NLR family, CARD domain containing 5	0.066
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.062
ZNF263	zinc finger protein 263	0.062
MED15	mediator complex subunit 15	0.059
TRAF2	TNF receptor-associated factor 2	0.057
TRIM5	tripartite motif containing 5	0.057	Human
SIGLEC7	sialic acid binding Ig-like lectin 7	0.056
CALCOCO2	calcium binding and coiled-coil domain 2	0.055
TRIM39	tripartite motif containing 39	0.051	Human
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.048
PTAFR	platelet-activating factor receptor	0.048
NLRP3	NLR family, pyrin domain containing 3	0.047
CCR1	chemokine (C-C motif) receptor 1	0.046
PARP12	poly (ADP-ribose) polymerase family, member 12	0.044	Human
KAT2B	K(lysine) acetyltransferase 2B	0.044
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.043
MEFV	Mediterranean fever	0.043
TRIM25	tripartite motif containing 25	0.041
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.041
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.040
TMEM173	transmembrane protein 173	0.037
TRIM26	tripartite motif containing 26	0.037
IRF9	interferon regulatory factor 9	0.036	Human
IRF2	interferon regulatory factor 2	0.036	Human
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.035
ZNF473	zinc finger protein 473	0.035
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.035
TLR4	toll-like receptor 4	0.033	Human Mouse
PML	promyelocytic leukemia	0.029
ZNFX1	zinc finger, NFX1-type containing 1	0.029
TYMP	thymidine phosphorylase	0.029
TANK	TRAF family member-associated NFKB activator	0.029
TRAF6	TNF receptor-associated factor 6	0.028
BRAP	BRCA1 associated protein	0.028
TNRC6C	trinucleotide repeat containing 6C	0.027
NLRC4	NLR family, CARD domain containing 4	0.025
NOD2	nucleotide-binding oligomerization domain containing 2	0.025
HK3	hexokinase 3 (white cell)	0.025
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.025
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.025
CD40	CD40 molecule, TNF receptor superfamily member 5	0.024
IRF8	interferon regulatory factor 8	0.023	Human
IFI35	interferon-induced protein 35	0.023
MR1	major histocompatibility complex, class I-related	0.022
CSK	c-src tyrosine kinase	0.022
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.022
FAS	Fas (TNF receptor superfamily, member 6)	0.022
PRKD2	protein kinase D2	0.021
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.021
C19orf66	chromosome 19 open reading frame 66	0.021
TARBP2	TAR (HIV-1) RNA binding protein 2	0.020
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.019
TLR2	toll-like receptor 2	0.019
TLR1	toll-like receptor 1	0.019	Human
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.019
RTP4	receptor (chemosensory) transporter protein 4	0.019
IFI44	interferon-induced protein 44	0.019
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.018
UBA7	ubiquitin-like modifier activating enzyme 7	0.017
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.017
CD33	CD33 molecule	0.017
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.017
POLR3H	polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)	0.017
BAX	BCL2-associated X protein	0.017
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.017
IRF2BP2	interferon regulatory factor 2 binding protein 2	0.016
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.016
TRIM32	tripartite motif containing 32	0.016
SP100	SP100 nuclear antigen	0.016
FBXO33	F-box protein 33	0.016
IRAK2	interleukin-1 receptor-associated kinase 2	0.016
TRIM52	tripartite motif containing 52	0.016
PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.016
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.015
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.015
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.015
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.015
VNN2	vanin 2	0.015
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.015
IRF5	interferon regulatory factor 5	0.015	Human
BATF	basic leucine zipper transcription factor, ATF-like	0.015
TRIM17	tripartite motif containing 17	0.014	Human
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.014
IL4R	interleukin 4 receptor	0.014
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.014	Human
AOAH	acyloxyacyl hydrolase (neutrophil)	0.014
CD300C	CD300c molecule	0.014
BTK	Bruton agammaglobulinemia tyrosine kinase	0.014
SAMD9	sterile alpha motif domain containing 9	0.014
PHF11	PHD finger protein 11	0.013
IL15	interleukin 15	0.013
IRAK4	interleukin-1 receptor-associated kinase 4	0.013
TRIM41	tripartite motif containing 41	0.013	Human
STAP2	signal transducing adaptor family member 2	0.013
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
CYTH4	cytohesin 4	0.013
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.013	Human
DTX3L	deltex 3-like (Drosophila)	0.013
TMEM140	transmembrane protein 140	0.013
HSPH1	heat shock 105kDa/110kDa protein 1	0.013
POLR3E	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	0.013
SIRPB1	signal-regulatory protein beta 1	0.013
TRIM43	tripartite motif containing 43	0.012
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.012
ADAR	adenosine deaminase, RNA-specific	0.012
FKBP5	FK506 binding protein 5	0.012
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.012
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.012
TRAF5	TNF receptor-associated factor 5	0.012
BTN3A3	butyrophilin, subfamily 3, member A3	0.012
CD86	CD86 molecule	0.012
TRIM34	tripartite motif containing 34	0.012
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.012
CD28	CD28 molecule	0.012
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.012
FPR2	formyl peptide receptor 2	0.012
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.011	Human
C1orf38	chromosome 1 open reading frame 38	0.011
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.011
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.011
SLC15A3	solute carrier family 15, member 3	0.011
TNRC6A	trinucleotide repeat containing 6A	0.011
OASL	2'-5'-oligoadenylate synthetase-like	0.011
RNF11	ring finger protein 11	0.011
TRIM35	tripartite motif containing 35	0.011
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.011
TRIM8	tripartite motif containing 8	0.011
MCOLN1	mucolipin 1	0.011
IFIH1	interferon induced with helicase C domain 1	0.010
AZI2	5-azacytidine induced 2	0.010
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.010
IL15RA	interleukin 15 receptor, alpha	0.010
ETV7	ets variant 7	0.010
IGSF6	immunoglobulin superfamily, member 6	0.010
CD180	CD180 molecule	0.010	Human
TRAFD1	TRAF-type zinc finger domain containing 1	0.010
APOL3	apolipoprotein L, 3	0.010