IMP

Process View

Homo sapiens

20 genes annotated in human

negative regulation of protein complex disassembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein complex disassembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein complex disassembly" (in gray)

Name	Description	Probability	Func Analog Organism
IRAK2	interleukin-1 receptor-associated kinase 2	0.814	Human
TPM2	tropomyosin 2 (beta)	0.506	Worm
MYH9	myosin, heavy chain 9, non-muscle	0.365
TRIM63	tripartite motif containing 63	0.294
IRAK1	interleukin-1 receptor-associated kinase 1	0.226	Human
FLNA	filamin A, alpha	0.223
RACGAP1	Rac GTPase activating protein 1	0.214
ACTN1	actinin, alpha 1	0.199
APC	adenomatous polyposis coli	0.198
TEX11	testis expressed 11	0.189
MYD88	myeloid differentiation primary response gene (88)	0.170
PDLIM7	PDZ and LIM domain 7 (enigma)	0.164
SASS6	spindle assembly 6 homolog (C. elegans)	0.164
EXOC1	exocyst complex component 1	0.142
TPM1	tropomyosin 1 (alpha)	0.125	Worm
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.124
MARK2	MAP/microtubule affinity-regulating kinase 2	0.109
INCENP	inner centromere protein antigens 135/155kDa	0.102
TRAF6	TNF receptor-associated factor 6	0.098
CKS2	CDC28 protein kinase regulatory subunit 2	0.096
CDK2	cyclin-dependent kinase 2	0.088
RIPK3	receptor-interacting serine-threonine kinase 3	0.086
KIF1B	kinesin family member 1B	0.085
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.083
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.081
PSEN2	presenilin 2 (Alzheimer disease 4)	0.080
ZYX	zyxin	0.080
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.078
FLNB	filamin B, beta	0.077
RAD21	RAD21 homolog (S. pombe)	0.076
EXOC2	exocyst complex component 2	0.075
GLIS2	GLIS family zinc finger 2	0.071
TPM4	tropomyosin 4	0.070	Worm
MYPN	myopalladin	0.069
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.066
CCNB2	cyclin B2	0.059	Human
CNN2	calponin 2	0.057
KIF20A	kinesin family member 20A	0.057
ANKRD28	ankyrin repeat domain 28	0.055
CENPE	centromere protein E, 312kDa	0.054
LBR	lamin B receptor	0.054
ADRBK1	adrenergic, beta, receptor kinase 1	0.047
PELI3	pellino homolog 3 (Drosophila)	0.046
HABP4	hyaluronan binding protein 4	0.045
XPO1	exportin 1 (CRM1 homolog, yeast)	0.044
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.043
STK3	serine/threonine kinase 3	0.039
KIF23	kinesin family member 23	0.038
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.037
CCNB1	cyclin B1	0.037
PBK	PDZ binding kinase	0.034
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.033
TTN	titin	0.033
GAS2L3	growth arrest-specific 2 like 3	0.032	Human
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.032
TNIP1	TNFAIP3 interacting protein 1	0.031
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.030
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.030
LMNA	lamin A/C	0.030
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.030
IRAK3	interleukin-1 receptor-associated kinase 3	0.030
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.030
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.030
BIRC5	baculoviral IAP repeat containing 5	0.029
CDK1	cyclin-dependent kinase 1	0.029
CORO1C	coronin, actin binding protein, 1C	0.028
CCDC85A	coiled-coil domain containing 85A	0.027
MYL9	myosin, light chain 9, regulatory	0.027
SUFU	suppressor of fused homolog (Drosophila)	0.027
DEK	DEK oncogene	0.024
HMGB2	high mobility group box 2	0.024
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.024
CENPJ	centromere protein J	0.024
ERBB2IP	erbb2 interacting protein	0.023
EXOC7	exocyst complex component 7	0.023
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.023
CD2AP	CD2-associated protein	0.022
SVIL	supervillin	0.022
WASL	Wiskott-Aldrich syndrome-like	0.022
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.022
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.022
KIF5B	kinesin family member 5B	0.022
SQSTM1	sequestosome 1	0.021
ACTA1	actin, alpha 1, skeletal muscle	0.020
KIF4A	kinesin family member 4A	0.020
ZRANB1	zinc finger, RAN-binding domain containing 1	0.020
AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.020
CKAP5	cytoskeleton associated protein 5	0.019
CCNE1	cyclin E1	0.019
GRB2	growth factor receptor-bound protein 2	0.019
GPSM2	G-protein signaling modulator 2	0.019
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.019
VCL	vinculin	0.019
NBR1	neighbor of BRCA1 gene 1	0.018
TMPO	thymopoietin	0.018
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.018
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.018
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.018
MYCBP2	MYC binding protein 2	0.018
CYLD	cylindromatosis (turban tumor syndrome)	0.017
SOS1	son of sevenless homolog 1 (Drosophila)	0.017
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.017	Yeast Fly
CCNA2	cyclin A2	0.016
FOXM1	forkhead box M1	0.016
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.015
WDR1	WD repeat domain 1	0.015	Yeast
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.015
KBTBD10	kelch repeat and BTB (POZ) domain containing 10	0.015
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.015
KIF20B	kinesin family member 20B	0.015
MACF1	microtubule-actin crosslinking factor 1	0.015	Fly
PTK2	PTK2 protein tyrosine kinase 2	0.015
SPAG9	sperm associated antigen 9	0.014
TAGLN2	transgelin 2	0.014
PINK1	PTEN induced putative kinase 1	0.014
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.014
DCK	deoxycytidine kinase	0.014
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.013
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.013
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.013
LASP1	LIM and SH3 protein 1	0.013
CALD1	caldesmon 1	0.013
CNN1	calponin 1, basic, smooth muscle	0.013
KIF2C	kinesin family member 2C	0.013
ZNF414	zinc finger protein 414	0.013
CD164	CD164 molecule, sialomucin	0.012
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.012
STRN3	striatin, calmodulin binding protein 3	0.012
ZC3H12A	zinc finger CCCH-type containing 12A	0.012
ARHGAP19	Rho GTPase activating protein 19	0.012
SIRT2	sirtuin 2	0.012
TNIK	TRAF2 and NCK interacting kinase	0.012
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.012
CP110	CP110 protein	0.012
MZT1	mitotic spindle organizing protein 1	0.012
CSNK2B	casein kinase 2, beta polypeptide	0.012
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.011
ZFP106	zinc finger protein 106 homolog (mouse)	0.011
NCOR2	nuclear receptor corepressor 2	0.011
OPTN	optineurin	0.011
ANKRD17	ankyrin repeat domain 17	0.011
PRKD2	protein kinase D2	0.011
STK4	serine/threonine kinase 4	0.011
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.011
CSRP1	cysteine and glycine-rich protein 1	0.011
CAPNS1	calpain, small subunit 1	0.011
DST	dystonin	0.011	Fly
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.011
WASF2	WAS protein family, member 2	0.011
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.011
CDKN3	cyclin-dependent kinase inhibitor 3	0.011
CD14	CD14 molecule	0.011
PELI1	pellino homolog 1 (Drosophila)	0.011
RAB10	RAB10, member RAS oncogene family	0.011
FRYL	FRY-like	0.011
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.011
FAM190B	family with sequence similarity 190, member B	0.010
WEE1	WEE1 homolog (S. pombe)	0.010
MZT2B	mitotic spindle organizing protein 2B	0.010
CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1	0.010	Mouse Fly
MRPL20	mitochondrial ribosomal protein L20	0.010
ECT2	epithelial cell transforming sequence 2 oncogene	0.010
SACM1L	SAC1 suppressor of actin mutations 1-like (yeast)	0.010
TJP2	tight junction protein 2 (zona occludens 2)	0.010
LYPLA1	lysophospholipase I	0.010